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BPC-157 & TB-500 Blend and its Potential for Wound Repair
What Is BPC-157?
BPC-157 is a peptide sequence of about 15 amino acids derived from the human gastric juice. BPC-157 has been the epicenter of encouraging research since its discovery. The peptide has numerous health benefits and has shown its effect on multiple body tissues. These issues include:
• Nervous System
Seeing as all these structures and tissues tend to get injured during physical activities such as sports, the peptide BPC-157 can show positive results in healing from these injuries upon its application.
How does BPC-157 Work?
The mechanism by which pentadecapeptide BPC-157 accelerates healing is not clearly understood. Research suggests that the healing action of BPC-157 can be a combination of a variety of these factors. These include upregulation of growth factors, proangiogenic effects, and nitric oxide (NO) synthesis. BPC-157 may also control the functions of collagen fragments. Research also suggests that BPC-157 has a connection with bone morphogenic proteins.
Properties of the Peptide BPC-157
The peptide BPC-157 is a small pentadecapeptide sequence from the much larger human gastric juice protein called the BPC. Since it has a highly stable structure, the peptide is very resistant to the degenerating effects of hydrolysis and enzyme metabolism. It is highly soluble in water and thus, does not need a particular carrier for its proper absorption in the body. It has a healing effect on wounds, particularly tendon and ligament tears and injuries.
Uses of Peptide BPC-157
The peptide BPC-157 has not only been used in sports injuries, but it has also been found to have positive implications in some other clinical scenarios like:
• Healing of gastric ulcers
• Correction of segmental bone defects
• Healing of corneal injuries
• Correction of colon-colon anastomosis and colocutaneous fistulas
• Healing skin burns
• treatment of various inflammatory conditions, particularly IBD and Crohn’s Disease
• Relieving pain from muscle sprains and ligament tears
What is TB-500?
TB-500 is a synthetically produced peptide derived from its naturally occurring parent peptide called the thymosin-beta peptide. It is a healing peptide present in the majority of the tissues present in mammalian bodies.
The TB-500 peptide is naturally produced by the thymus gland and has a high concentration in bodily fluids. It has tremendous healing properties in various tissue injuries like cornea, skin, or ligaments.
How Does TB-500 Work?
The healing properties of the peptide TB-500 are due to its ability to upregulate the protein actin. Since actin is the major protein involved in the proliferation and cellular migration, which are critical steps in the growth of new tissue, TB-500 aids recovery from injury. Overall, TB-500 also improves angiogenesis, has significant anti-inflammatory properties, and optimizes healing and recovery.
Uses of Peptide TB-500
Due to its healing properties, the use of peptide TB-500 has been implicated in various clinical conditions such as:
• Healing skin burns and injuries
• Anti-inflammatory effect
• Healing muscle injuries
• Aiding the recovery of slow-healing wounds such as those resulting from tendon and ligament injuries
• Promoting and enhancing flexibility
Potential of BPC-157 & TB-500 Blend in Wound Repair
Having described the healing properties of both peptides separately, extensive research reveals that using BPC-157 and TB-500 simultaneously for wound healing and regeneration purposes can prove to be highly fruitful. Although both the peptides act via different mechanisms, their combined use can bring about a synergistic change in wound healing.
How BPC-157 & TB-500 Bring About Cellular Migration and Wound Healing
Fibroblasts are the essential cells that trigger wound healing in all tissue types. Fibroblasts are the cells that produce extracellular matrix. However, these cells are produced far away from the site where they are required. For them to reach their desired location, they need a carrier. The carrier is usually a protein acting as a regulator of this process of cellular migration. This stage is where the peptides BPC-157 & TB-500 come into the picture. Both these peptides upregulate actin production. BPC-157 Brings about this upregulation via increased genetic transcription of the actin protein. At the same time, TB-500 acts as a binding protein to the actin. By binding to the actin protein, TB-500 accumulates where it is most required. Together, both these peptides increase the quantity of the actin and improve its function. Therefore, the synergistic action of both the peptides enhances the rate at which actin protein and various other cells of the immune system migrate to the site of injury.
To conclude, a combination of BPC-157 & TB-500 blend can have tremendous future research implications for wound, muscle, and bone repair.
Disclaimer: The products mentioned are not for human or animal consumption. All the information shared in this article is for educational purposes only.
Dr. Usman (BSc, MBBS, MaRCP) completed his studies in medicine at the Royal College of Physicians, London. He is an avid researcher with more than 30 publications in internationally recognized peer-reviewed journals. Dr. Usman has worked as a researcher and a medical consultant for reputable pharmaceutical companies such as Johnson & Johnson and Sanofi.