Fragment 176-191 as a Synthetic Agent in Human Growth Hormone

by | Jun 29, 2022 | Research

Fragment 176-191, termed Lipolytic Fragment, is the modified version of AOD 9604. It is a small chunk of the human growth hormone. According to research, Fragment 176-191 mimics the fat-burning effects of the parent protein. Fragment 176-191 increases insulin levels without increasing insulin-like growth factor-1 (IGF-1) levels, negatively affecting carbohydrate metabolism, altering insulin sensitivity, and increasing long bone growth. Scientists believe that the fat-burning ability of Fragment 176-191 could make it a vital ancillary for producing anti-obesity medications.
Fragment 176-191 peptide is injectable and is known as a concentrated and stabilized version of the growth hormone-releasing factor—GRF, which can cause a rapid increase in bodily growth hormone 12.5 times stronger. Fragment 176-191 can stimulate protein synthesis, increase vascularity via nitrogen retention, increase bone mineral density and modify aging effects. It can improve sleep and increase strength via hyperplasia.


The Functions/Roles of Fragment 176-191


1. Fragment 176-191 can Lower Blood Sugar Levels:

Research shows that Fragment 176-191 is the most potent synthetic equivalent of the human growth hormone for reducing blood sugar levels. This effect is secondary to the increase in plasma insulin levels. Research is ongoing to determine if Frag 176-191 could treat prediabetes and type II diabetes.


2. Fragment 176-191 Can Increase the Regeneration of Cartilage:

Though interest in Frag 176-191 is primarily for its lipolytic functions, research is ongoing to determine its other benefits.
In 2015, research from Korea showed that Frag 176-191 increases the effects of hyaluronic acid injections that can promote cartilage regeneration.
Studies in rabbits showed that the weekly injection of Frag 176-191 increases cartilage growth laboratory standards, and its combination with hyaluronic acid produces a more potent effect. The overall result proves that administering Frag 176-191 alone and alongside hyaluronic acid can reduce the disabilities following osteoarthritis. Scientists believe that it may amount to the introduction of advanced therapies for osteoarthritis and may alleviate surgical needs.


3. The Potential Roles of Fragment 176-191 in Fat-Burning and Weight Loss:

Fragment 176-191 is commonly referred to as Lipolytic Fragment because of its fat-reducing effect and weight-loss properties. This function is mediated by increased beta-3 adrenergic receptor production (𝛃3-AR or ADRB3). The agonist action of ADRB3 is to accelerate fat burning in fatty tissues and thermogenesis in skeletal muscles. Mouse models genetically induced to not produce ADRB3 cannot respond to the lipolytic effects of hGH or Frag 176-191.
Research shows that the fat-burning effect of Frag 176-191 is accompanied by energy expenditure and weight reduction, amounting to about 50% of reduced weight gain in animals with obesity over administration for three weeks. Notably, the weight reduction effect is evident only in mice with obesity. In lean mice, they maintained their standard body weight even on exposure to Frag 176-191. These results prove that specific lipolysis pathways are responsible for overriding the effect of ADRB3 when the body weight is normal or near normal.


Other potential functions

In 2013, scientific research established a Journal of Endocrinology and Metabolism targeted at accessing the rate and significance of the adverse effects associated with Fragment 176-191. This research found that the IV and oral administration of Fragment 176-191, when in comparison with placebo, resulted in no noticeable changes in:
● Glucose levels
● Glucose tolerance
● IGF-1 levels
● Insulin sensitivity
● Laboratory parameters
● Physical findings and
● Rates of adverse events such as headache
This result proves that Fragment 176-191 offers robust benefits of the human growth hormone without associated adverse effects. This research offers insight into human growth regulation, fat deposition, and energy homeostasis. It proves that fat loss is possible without modulating energy homeostasis in other nutrient pathways, paving the way for deep examinations and methods of regulating human energy.
It is vital to note that the human growth hormone is known for its anabolic effects on muscles; however, its synthetic version — Fragment 176-191 can bypass anabolism. This is advantageous because its lipolytic effects cannot produce acromegaly or any condition linked to the administration of the human growth hormone. Scientific research proves that Fragment 176-191 does not promote cell proliferation.

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