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GHK-CU (Copper) (50mg)
$64.00
GHK-CU (Copper) peptides are Synthesized and Lyophilized in the USA.
Discount per Quantity
Quantity | 5 - 9 | 10 + |
---|---|---|
Discount | 5% | 10% |
Price | $60.80 | $57.60 |
FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
FREE - USPS priority shipping
Description
GHK-Cu Peptide
GHK-Cu is a naturally prevalent peptide that was first purified from blood plasma. It has been identified in saliva and urine as well. Experimental research in GHK-Cu indicates the peptide has the potential to impact healing and immune functions.[1] The peptide has been studied for mitigating cell aging action, inducing protein synthesis, free-radical damage control, bacterial infection prevention and the function of skin fibroblasts.
Specifications
Molecular Formula: C14H24N6O4
Molecular Weight: 340.38 g/mol
Sequence: Gly-His-LysCu.xHAc
GHK-Cu Research
GHK-Cu and Skin
GHK-Cu is a natural component of blood, studied for its potential impact on dermal regeneration pathways. Research in skin cultures has suggested that GHK may stimulate the synthesis as well as breaking down of collagen, glycosaminoglycans, and other extracellular matrix components like proteoglycans and chondroitin sulfate. The potential appears to be partially mediated through the positive action of GHK-Cu recruitment on fibroblasts, endothelial cells, and immune cells. The peptide appears to attract these cells to the wound site and coordinate their activity in repairing the damage. The peptide has also been researched for its potential modulation of collagen synthesis. Research in the roles of GHK-Cu suggest its actions may be mediated partially via an expression of transforming growth factor Beta. It is likely that the peptide works through various biochemical pathways and may modify gene expression. Studies in mice suggest that GHK-Cu may increase the rate of wound healing in burns to the extent of about 33%.[1] The peptide not only appears to recruit immune cells and fibroblasts to sites of injury, but may promote the development of new blood vessels at these sites.
GHK-Cu and Cognitive, Nervous System Functions
The mechanism behind neuronal death, which occurs in degenerative diseases such as Alzheimer’s, is poorly understood. Studies have suggested GHK-Cu’s potential to inhibit loss in neuronal function, involved in such diseases.[2] In these studies, the molecule has been observed to enhance angiogenesis in the nervous system, potentially stimulate nerve outgrowth, and decrease inflammation in the central nervous system. There is further scientific studies supporting the theory that it may alter the expression profiles of pathological genes and help to reset a state of controlled function in dysfunctional systems. Natural GHK-Cu expression is considered to naturally decrease. Some scientists believe that GHK-Cu is possibly neuroprotective against natural insults like gene dysregulation. The peptide has been suggested to protect neurons in rat brains from apoptosis through the well-known miR-339-59/VEGFA pathway, which is considered to be active after brain bleeds and stroke. In the rat models, GHK-Cu was reported to improve the neurological deficits in the brain, reducing swelling, and preventing neuronal death associated with over-expression of miR-339-5p.
GHK-Cu and Bacteria
GHK-Cu in combination with certain fatty acids may create a potentially antimicrobial compound acting against bacteria and fungi considered to interfere with tissue repair processes. Research in research models of diabetes has suggested that GHK-Cu may exert action, with findings reporting a combination of standard care and GHK-Cu to induce a 40% increase in wound closure and a 27% reduction in infection rates as opposed to control groups.[3] Similar results have also been noted from studies in research models of ischemic wounds. Researchers report that “GHK-Cu improved healing of ischemic wounds and suppresses inflammation by lowering the level of acute-phase inflammatory cytokines such as TGF-beta and TNF-alpha.”
GHK-Cu and Lungs
Studies in murine models have suggested that GHK-Cu may protect the lungs against fibrosis.[4] The study has also explored the mechanistic action of the peptide. It was observed to modulate TNF-alpha and IL-6 levels, both of which are considered to function as inflammatory molecules and affect the extracellular matrix and smooth muscles of the lungs. The peptide may reduce lung inflammation, thereby enhancing collagen production and preventing fibrotic remodeling. GHK-Cu was also suggested to be effective in murine research models of acute respiratory distress syndrome (ARDS), an inflammatory lung condition that can aggravate very fast and be fatal. ARDS is linked with injury and infection. Once again, the suggested underlying mechanism of the peptide action is by decreasing the expression of TNF-alpha and IL-6.[5]
GHK-Cu and Pain Perception
In rat models, the exposure of GHK-Cu was reported to exhibit a concentration-dependent impact on pain-induced behavior. The peptide appeared to deliver analgesic effects mediated through increased levels of the natural painkiller L-lysine.[6] The researchers reported that “It was found the L-lysine residue plays the key role in these effects, because they were observed under the influence of L-lysine [introduction] in [concentrations] close to its equimolar content in the studied tripeptide.” Similar studies have suggested the potential of the peptide to enhance levels of L-arginine, another analgesic amino acid.[7]
Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.
References
- Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018 Jul 7;19(7):1987. doi: 10.3390/ijms19071987. PMID: 29986520; PMCID: PMC6073405.
- Pickart L, Vasquez-Soltero JM, Margolina A. The Effect of the Human Peptide GHK on Gene Expression Relevant to Nervous System Function and Cognitive Decline. Brain Sci. 2017 Feb 15;7(2):20. doi: 10.3390/brainsci7020020. PMID: 28212278; PMCID: PMC5332963.
- Pickart L, Vasquez-Soltero JM, Margolina A. The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: implications for cognitive health. Oxid Med Cell Longev. 2012;2012:324832. doi: 10.1155/2012/324832. Epub 2012 May 10. PMID: 22666519; PMCID: PMC3359723.
- Zhou XM, Wang GL, Wang XB, Liu L, Zhang Q, Yin Y, Wang QY, Kang J, Hou G. GHK Peptide Inhibits Bleomycin-Induced Pulmonary Fibrosis in Mice by Suppressing TGFβ1/Smad-Mediated Epithelial-to-Mesenchymal Transition. Front Pharmacol. 2017 Dec 12;8:904. doi: 10.3389/fphar.2017.00904. PMID: 29311918; PMCID: PMC5733019.
- Park JR, Lee H, Kim SI, Yang SR. The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice. Oncotarget. 2016 Sep 6;7(36):58405-58417. doi: 10.18632/oncotarget.11168. PMID: 27517151; PMCID: PMC5295439.
- Sever’yanova LА, Dolgintsev ME. Effects of Tripeptide Gly-His-Lys in Pain-Induced Aggressive-Defensive Behavior in Rats. Bull Exp Biol Med. 2017 Dec;164(2):140-143. doi: 10.1007/s10517-017-3943-3. Epub 2017 Nov 27. PMID: 29181666
- Sever’yanova LА, Plotnikov DV. Binding of Glyprolines to L-Arginine Inverts Its Analgesic and Antiagressogenic Effects. Bull Exp Biol Med. 2018 Sep;165(5):621-624. doi: 10.1007/s10517-018-4227-2. Epub 2018 Sep 17. PMID: 30225713
Dr. Usman (BSc, MBBS, MaRCP) completed his studies in medicine at the Royal College of Physicians, London. He is an avid researcher with more than 30 publications in internationally recognized peer-reviewed journals. Dr. Usman has worked as a researcher and a medical consultant for reputable pharmaceutical companies such as Johnson & Johnson and Sanofi.
Additional information
Brand | Biotech Peptides |
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28 reviews for GHK-CU (Copper) (50mg)
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Oscar Tremblay –
Delivery was much faster than expected
Nelson Violet –
Always had a good experience. Thank you
Sawyer Myers –
Just amazing
Addison Long –
Excellent service, thank you!
Melanie Cruz –
Exceeded my expectations completely
Alexander Y. –
I’ve ordered from Biotech numerous times and it always arrived quickly. CS is great too. I once ordered the wrong product and they quickly updated my order. The new product was a little less expensive so they threw in an additional vial for less than the cost of one vial. Great company overall. My go to at the moment.
Enton Lok –
Big fan here. Just wish there were more shipping options.
Kelly Fagen –
No BS transaction. Im happy
Patricia Paiz –
Consistent product and fullfillment. All the information offered before purchase and the after-sale support and guidance are really appreciated.
Kelley Vincent –
Always a pleasure to do business with you. Customer service is always helpful, fast, and friendly if I encounter any issues!
Gary Roisentul –
Very happy with my orders. Have ordered from them since the beginning of September, haven’t let me down yet
Derek Lin –
Hoping in the future they expand more!
Roger Kale –
Very reliable, Biotechs my go to!
Tracy Graham –
I’ve been trying to get into the site for two days now and it keeps glitching or something. Hopefully it will be back soon
David Cohen –
So good I even recommended it to my research friends
Jay Rendon –
Glad I ordered from here! Can’t wait to get my shipment and so far the process has been easy with this company.
Sam Jost –
Real good company, I like that they are quick with restocks.
Steve M. –
I’ve been very happy with their service and product thus far.
Micheal Tan –
The reviews on this site got me very interested in trying what you guys have to offer
Steve Moris –
Got some free Bac water even though I didn’t meet the minimum purchase.
Heather Bowen –
I was a first time customer last week and I called CS to ask a few questions. Dani was kind enough to take my order and even suggest a product I didn’t order, but that would fit in combination with the compound I got.
Erick Hesselink –
Peptides are of the highest quality. Being based in Southern California it is wonderful that they are so close to my lab and shipments arrive well before expected.
Linda Devins –
Biotech works fast. I had placed an order in the morning and recieved the peptides the next afteroon.
Eli Amin –
Quality has not gone down at all since they came about around a year and a half ago. Still as happy as ever with the peptides. Research has given great results with these as well.
rob Antimore –
Hard to write reviwes about peptides unless you’ve been working with them a while. I just recieved my 4th round of peptide orders from here and I can say they are the best I have ever had to work with. Results are always great and they are high end peptides for a great cost.
Aurauz Azima –
Taylor is always helpful and knows how to fix any issues that I have ever come across.
Mickey Lee –
Had no issues with customs, got my peptides on time.
Pat Riordan –
Pepide selection has grown in the past year! Happy cause I can get what I need all from one place now.