GHK Basic (Tripeptide-1) (Topical) (200mg)


NSC661251, NSC-661251

Discount per Quantity

5 - 95%$137.75
10 +10%$130.50
SKU: GHK-Basic-Tripeptide-1-Topical-200mg Category:


What Is GHK Basic Peptide?

GHK is a copper peptide occurring naturally in a tripeptide glycyl-L-histidyl-L-lysine copper complex.
It has two variants; with and without Cu. GHK has a strong affinity for copper (II). It’s synthesized naturally from saliva, human plasma, and urine. In cases of injury, GHK is released from tissues.
GHK affects genes that control an organism’s response to injury and stress. It’s essential for tissue remodeling, anti-inflammatory, anti-pain, anti-anxiety, anti-cancer action, blood vessel growth, and nerve outgrowth. A decrease in the regenerative capacity of an organism can be traced to a decline in GHK-level.
GHK in human plasma is about 200ng/ml at the age of 20. It declines to 80ng/mL as the individual ages to about 60. Its functions extend to GHK’s role in infection control, hair growth, increase in collagen, elastin cancer, facial cosmetic use, wound healing, and glycosaminoglycan synthesis.


Molecular Formula: C14H24CuN6O4+29

Molecular Weight: 403.9242g/mol

PubChem: CID 54608178

Synonyms: NSC661251, NSC-661251

Reconstitution: Required

Differences between GHK and GHK-cu?

GHK can influence the genes responsible for an organism’s response to injury and stress. It plays a role in tissue remodeling, anti-inflammatory, antioxidant, anti-anxiety, anti-pain, blood vessel growth, etc. Its sequence is inherent in SPARC protein and collagen molecules.
Copper, on the other hand, is a transitional element of utmost importance to organisms with a cell membrane, extending from microorganisms to humans. Other than its conversion from oxidized Cu (II) to reduced Cu (I), it is a vital cofactor in a series of biochemical reactions accompanied by electron transfer. The changes in copper oxidation state are an advantage, as dozens of enzymes adopt it in catalyzing critical biochemical reactions such as detoxification, blood clotting, cellular respiration, antioxidant defense, and connective tissue regeneration. Copper is also vital in iron metabolism and embryonic development, as it is essential for most metabolic reactions that occur in fetal life, oxygenation, and other biological processes.

GHK Research

Effects of GHK on Cancer Control
Tumor suppressor gene or antioncogene, growth regulatory, and DNA repair genes are essential in cancer suppression.
Following research by Hong et al. GHK, at 1੫mol and securine at 18੫mol were linked to wound healing and skin remodeling. The two molecules significantly reversed the gene expressions of affected patients.
Subsequently, researchers suggested that they might have therapeutic effects on patients prone to metastasis.

Effects of GHK on Insulin and Insulin-like Genes
The insulin family, in minimal amounts, increases longevity, but high levels of insulin and insulin-like proteins can reduce longevity. In addition to this, GHK stimulates the production of three genes in this system and suppresses six genes.
The gene expression data suggest that GHK suppresses six of nine insulin/IGF-1 receptors. In vitro experiments show that reduced insulin/IGF-1 signaling due to mutations can decelerate the dwindling process of aging and lengthen lifespan in several organisms and perhaps humans.

GHK and Tissue Repair
GHK plays a vital role in the repair of tissues. It is done by either using creams containing copper peptides or adopting systemic healing. Copper peptides lessen fine lines, wrinkles, and sagging skin by accelerating the production of elastin and collagen. They also enhance glycosaminoglycans production. This enhancement includes higher production of hyaluronic acid.
It aids in the moisturization and hydration of the skin. Copper peptide enhances the flow of blood to the scalp. Letting the follicles grow hair in the typical terrain.
According to Campbell et al., GHK enhances the production of TGF beta and members of the same species that initiate the repair process. The peptide, with the aid of TGF beta, resets the gene expression of fibroblasts in COPD patients.

Effects of GHK on Fibrinogen Synthesis
Fibrinogen is a glycoprotein complex composed of three polypeptide chains: alpha, beta, and gamma. The peptide acts to suppress the beta chain of fibrinogen. As a result, inadequate FGB actively stops fibrinogen synthesis because fibrinogen synthesis is dependent on equal amounts of the three polypeptide chains.
The overall fibrinogen synthesis declines due to the effects of the GHK exerted on the FGB gene and IL-6 production.

Other Effects of GHK
1. The peptide can activate DNA repair genes: As the aging progresses, DNA damage begins to amass. In addition to this, GHK acts to reset the activity of DNA repair genes, diminishing the dwindling effects of aging.
2. GHK as an antioxidant: GHK initiates 14 antioxidant genes and represses two pro-oxidant genes. As a result, the effects of free radicals and toxic end products, such as, atherosclerosis, cancer, and cataracts, are reduced or annulled.
3. Effects of ht peptide on Ubiquitin/Proteasome System (UPS): UPS is known to abolish damaged proteins. GHK stimulates gene expression in 41 UPS and suppresses only 1 UPS gene. As a result, UPS appears to reduce aging effects.


GHK possesses measurable amounts of positive effects but begins to dwindle with age. The positive effects and functions are as aforementioned.
The side effects exerted by GHK are minimal, ranging from low oral to notable subcutaneous bioavailability in mice.

All orders ship same day if placed by 2pm PST. Peptides synthesized and lyophilized in the USA.
This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law. Only qualified and licensed professionals should handle these products. Any information found on Biotech Peptides is strictly for educational purposes only. Refer to our terms and conditions for more details.

Additional information


Biotech Peptides


There are no reviews yet.

Be the first to review “GHK Basic (Tripeptide-1) (Topical) (200mg)”