GHK-Cu (Topical) (200mg)

GHK-Cu (Topical) Peptide

GHK-Cu (copper tripeptide) is a naturally occurring plasma peptide. The research impacts of these carrier peptides appear to deliver copper to the skin extracellular matrix to bring about enzymatic wound-healing pathways as well as a possible increase in endogenous collagen and decorin production. GHK-Cu (Copper Peptide) is a tripeptide that scientists assert is naturally present in blood plasma. Scientific studies carried out in different research laboratories worldwide have explored the various biological roles played by tripeptides. GHK-Cu exhibits some potential to influence various biological pathways, including an apparent induction of tissue repair, attraction of immune cells, antioxidant and anti-inflammatory characteristics, activation of collagen and glycosaminoglycan synthesis in skin fibroblasts, and possible promotion of blood vessel growth. Recent studies indicate its potential role in stem cell biology and anti-tumor defense as well.

Specifications

Molecular Formula: C₁₄H₂₄N₆O₄

Molecular Weight: 340.38 g/mol

Sequence: Gly-His-LysCu.xHAc

GHK-Cu (Topical) Peptide Research

Studies have observed that 2% GHK-Cu gel yielded positive results in research models of diabetes when examined in the context of rapid tissue healing. The study findings posit that the peptide appeared to enhance the percentage of ulcer closure from 60.8% to 98.5% and decrease the infection rate from 34% to 7%.^[1] 

GHK-Cu and Fibroblasts
Recent research has suggested the molecular mechanisms of the copper-peptide. Pollard et al. posited that GHK-Cu might restore the function of fibroblasts damaged by radiation and thus may help to accelerate cell repair and regenerative processes.^[5] The researchers posited that “An early increase in basic fibroblast growth factor and vascular endothelial growth factor production by GHK-Cu-treated irradiated fibroblasts may improve wound healing.” Further studies in the copper peptide GHK-Cu have supported this hypothetical activity of copper peptide GHK-Cu within fibroblasts. Abdulghani et al. noted that a compound containing GHK-Cu appeared to improve collagen in research models of photodamage.^[2] The peptide was observed to induce greater results than the control group exposed to a solution of Vitamin C and Retinoic Acid.

Leyden et al. conducted a 12-week study of the possible impacts of GHK-Cu peptide.^[3] The study reported significant improvement in skin laxity and a reduction in depth of creases and wrinkles along the skin surface. It appeared to increase skin density and thickness compared to placebo.

Finkley et al. conducted a parallel 12-week study.^[4] Experts observed in the study that GHK-Cu compound appeared to have induced dermal Keratinocyte proliferation, as was observed in the histological analysis of biopsies. Copper peptide GHK-Cu and its analogs were observed to potentially stimulate hair follicle development as well. Research is ongoing.

GHK-Cu and Nerve Regeneration
In 2005, Ahmed et al. suggested that tripeptide may also promote nerve regeneration.^[6] In the study, GHK-Cu appeared to increase the production rate of nerve growth factor expression of integrins and increased the regeneration rate of myelinated nerve fibers.

GHK-Cu and Stem Cells
In 2009, research findings from a group of researchers from the Seoul National University (Republic of Korea) highlighted that the copper-peptide GHK-Cu appeared to stimulate the proliferation of Keratinocytes and increased the expression of integrins. The researchers also reported the presence of p63 protein in the epidermal stem cells. P63 is considered to be a significant marker of stem cell and anti-senescence protein. The authors concluded that GHK-copper may help restore the proliferative potential of epidermal stem cells and increase their potential to repair tissue.

GHK-Cu and Cancer Cells
In 2010, Hong Y. et al. (Department of Colorectal Surgery, Singapore General Hospital, Singapore) observed the potential of GHK-Cu to reverse the synthesis of a group of genes that play a role in the metastatic spreading of colon cancer.^[7] GHK-Cu peptide was observed to yield results within the study conditions at a low concentration. The researchers also concluded that “Gly-His-Lys and securinine could reverse the differential expressions of these genes significantly, suggesting that they have combinatorial … effect on the metastasis-prone [cases].”

Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.

References