GHK-CU (Copper) (50mg)

(28 customer reviews)

$64.00

GHK-CU (Copper) peptides are Synthesized and Lyophilized in the USA.

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Quantity 5 - 910 +
Discount 5%10%
Price $60.80$57.60
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(Required for reconstitution)
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SKU: GHK-CU-40mg Category:

Description

GHK-Cu Peptide

GHK-Cu is a naturally occurring peptide that was first purified from blood plasma, though its traces have also been identified in both saliva and urine. Experimental research in GHK-Cu indicates the peptide may host the potential to impact tissue repair and affect certain immunological functions.[1] The peptide has been studied for its potential in mitigating cell aging, inducing protein synthesis, minimizing free-radical damage, preventing bacterial infection, and improving the function of skin fibroblasts. Research in this multifaceted peptide is still ongoing.

Specifications

Molecular Formula: C14H24N6O4

Molecular Weight: 340.38 g/mol

Sequence: Gly-His-LysCu.xHAc

GHK-Cu Research

GHK-Cu and Skin Cells
GHK-Cu is a natural component of blood and has been studied for its potential impact on dermal regeneration pathways. Research in skin cultures has suggested that GHK may stimulate the synthesis as well as the breaking down of collagen, glycosaminoglycans, and other components of the skin’s extracellular matrix like proteoglycans and chondroitin sulfate. This potential appears to be partially mediated through the positive action of GHK-Cu recruitment on fibroblasts, endothelial cells, and immune cells. The peptide appears to attract these cells to the wound site and coordinates their activity in repairing the damage. The peptide has also been researched for its potential modulation of collagen synthesis. Research in the roles of GHK-Cu suggests its actions may be mediated partially via an expression of transforming growth factor Beta. It is likely that the peptide works through various biochemical pathways and may modify gene expression. Studies in mice suggest that GHK-Cu may increase the rate of wound healing in burns by as much as 33%.[1] The peptide appears to recruit immune cells and fibroblasts to sites of injury and may promote the development of new blood vessels at these sites.

GHK-Cu and Cognitive, Nervous System Functions
The mechanism behind neuronal death, which occurs in degenerative diseases such as Alzheimer’s, is poorly understood. Studies have suggested GHK-Cu’s potential to inhibit loss in neuronal function, which has been associated with such diseases.[2] In these studies, the molecule has been observed to enhance angiogenesis in the nervous system, to potentially stimulate nerve outgrowth, and decrease inflammation in the central nervous system. Further scientific studies support the theory that it may alter the expression profiles of pathological genes and help reset a state of controlled function in dysfunctional systems. Natural GHK-Cu expression is considered to naturally decrease. Some scientists believe that GHK-Cu may possibly exert neuroprotective action against natural insults like gene dysregulation. The peptide has been suggested to protect neurons in rat brains from apoptosis through the well-known miR-339-59/VEGFA pathway, which is considered to become active after brain bleeds and stroke. In the rat models, GHK-Cu was reported to improve the neurological deficits in the brain, reducing swelling and preventing neuronal death associated with over-expression of miR-339-5p.

GHK-Cu and Bacteria
GHK-Cu, in combination with certain fatty acids, may create a potentially antimicrobial compound acting against bacteria and fungi that is considered to interfere with tissue repair processes. Diabetes research has suggested that GHK-Cu may exert such action, with findings reporting a combination of standard procedure and GHK-Cu to induce a 40% increase in wound closure and a 27% reduction in infection rates as opposed to control groups.[3] Similar results have also been noted from studies in ischemic wounds. Researchers report that “GHK-Cu improved healing of ischemic wounds and suppresses inflammation by lowering the level of acute-phase inflammatory cytokines such as TGF-beta and TNF-alpha.”

GHK-Cu and Lungs
Studies in murine models have suggested that GHK-Cu may protect the lungs against fibrosis.[4] The study has also explored the mechanistic action of the peptide. It was observed to modulate TNF-alpha and IL-6 levels, both of which are considered to function as inflammatory molecules and may affect the extracellular matrix and smooth muscles of the lungs. The peptide may reduce lung inflammation, thereby enhancing collagen production and preventing fibrotic remodeling. GHK-Cu was also suggested to be effective in murine research models of acute respiratory distress syndrome (ARDS). This inflammatory lung condition may become aggravated very fast and may be fatal. ARDS is linked with injury and infection. Once again, the suggested underlying mechanism of the peptide action is decreasing the expression of TNF-alpha and IL-6.[5]

In another study, GHK-Cu was investigated for its potential actions on inflammation within a murine model of emphysema induced by cigarette smoke (CS). The experimentation with GHK-Cu appeared to reduce inflammation in the lung tissues of these models. This action was indicated by a decrease in inflammatory cytokines such as IL-1β and TNF-α in the bronchoalveolar lavage fluid, suggesting that GHK-Cu may have an inhibitory action on these proinflammatory markers. Furthermore, the study noted an apparent reduction in myeloperoxidase (MPO) activity, which is primarily found in neutrophils and is an enzyme involved in the model’s response to inflammation. These findings suggest that GHK-Cu might potentially attenuate the inflammatory response triggered by CS exposure. The mechanism behind the potential anti-inflammatory action of GHK-Cu may be associated with its influence on the NF-κB pathway, a key regulator of inflammation. The study observed that GHK-Cu exposure possibly suppresses the activation of NF-κB by modifying the phosphorylation of its inhibitor IκBα, thereby reducing the expression of inflammatory mediators. Additionally, the pre-exposure with GHK-Cu was posited to decrease i-NOS levels through the NF-κB pathway, linking it further to anti-inflammatory processes.[6]

GHK-Cu and Pain Perception
In rat models, the exposure of GHK-Cu was reported to exhibit a concentration-dependent impact on pain-induced behavior. The peptide appeared to deliver analgesic effects mediated through increased levels of the natural painkiller L-lysine.[7] The researchers reported that “It was found the L-lysine residue plays the key role in these effects, because they were observed under the influence of L-lysine [introduction] in [concentrations] close to its equimolar content in the studied tripeptide.” Similar studies have suggested the potential of the peptide to enhance levels of L-arginine, another analgesic amino acid.[8]

GHK-Cu and Oxidative Stress
One research hypothesis suggests that GHK may contribute to reducing the release of iron from ferritin, which catalyzes lipid peroxidation. Specifically, data indicates that GHK may restrict the formation of iron complexes in damaged tissues, potentially reducing inflammation.[9] The proposed mechanism of GHK involves its interaction with the pathways controlling iron release from ferritin, potentially reducing iron release by approximately 87%. This reduction may theoretically lessen inflammation and oxidative stress in impacted tissues. Furthermore, a palmitoylated form of the compound, Pal-GHK, may also decrease the generation of reactive oxygen species and inflammatory cytokines, while potentially enhancing the activity of antioxidant enzymes. In a study conducted using a mouse model, Pal-GHK appeared to inhibit the activation of the Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-κB) and p38 mitogen-activated protein kinase (MAPK) signaling pathways. Both pathways play significant roles in the inflammatory process.[10] NF-κB is a protein complex that functions as a transcription factor, regulating the expression of genes involved in immune and inflammatory responses. The p38 MAPK pathway is considered to be heavily involved in cellular responses to stress and inflammation. Pal-GHK might inhibit p38 MAPK activation by obstructing the upstream kinases that activate this pathway or interfering with the signaling molecules responsible for its phosphorylation. Such inhibition might diminish the inflammatory response, reducing cellular stress. This, in turn, may result in decreased infiltration of inflammatory cells into lung tissues in murine models, alongside lower levels of tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) production, further mitigating tissue damage.

Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.

 

References

  1. Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018 Jul 7;19(7):1987. doi: 10.3390/ijms19071987. PMID: 29986520; PMCID: PMC6073405.
  2. Pickart L, Vasquez-Soltero JM, Margolina A. The Effect of the Human Peptide GHK on Gene Expression Relevant to Nervous System Function and Cognitive Decline. Brain Sci. 2017 Feb 15;7(2):20. doi: 10.3390/brainsci7020020. PMID: 28212278; PMCID: PMC5332963.
  3. Pickart L, Vasquez-Soltero JM, Margolina A. The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: implications for cognitive health. Oxid Med Cell Longev. 2012;2012:324832. doi: 10.1155/2012/324832. Epub 2012 May 10. PMID: 22666519; PMCID: PMC3359723.
  4. Zhou XM, Wang GL, Wang XB, Liu L, Zhang Q, Yin Y, Wang QY, Kang J, Hou G. GHK Peptide Inhibits Bleomycin-Induced Pulmonary Fibrosis in Mice by Suppressing TGFβ1/Smad-Mediated Epithelial-to-Mesenchymal Transition. Front Pharmacol. 2017 Dec 12;8:904. doi: 10.3389/fphar.2017.00904. PMID: 29311918; PMCID: PMC5733019.
  5. Park JR, Lee H, Kim SI, Yang SR. The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice. Oncotarget. 2016 Sep 6;7(36):58405-58417. doi: 10.18632/oncotarget.11168. PMID: 27517151; PMCID: PMC5295439.
  6. Zhang, Q., Yan, L., Lu, J., & Zhou, X. (2022). Glycyl-L-histidyl-L-lysine-Cu2+ attenuates cigarette smoke-induced pulmonary emphysema and inflammation by reducing oxidative stress pathway. Frontiers in molecular biosciences, 9, 925700. https://doi.org/10.3389/fmolb.2022.925700
  7. Sever’yanova LА, Dolgintsev ME. Effects of Tripeptide Gly-His-Lys in Pain-Induced Aggressive-Defensive Behavior in Rats. Bull Exp Biol Med. 2017 Dec;164(2):140-143. doi: 10.1007/s10517-017-3943-3. Epub 2017 Nov 27. PMID: 29181666
  8. Sever’yanova LА, Plotnikov DV. Binding of Glyprolines to L-Arginine Inverts Its Analgesic and Antiagressogenic Effects. Bull Exp Biol Med. 2018 Sep;165(5):621-624. doi: 10.1007/s10517-018-4227-2. Epub 2018 Sep 17. PMID: 30225713
  9. Miller, D. M., DeSilva, D., Pickart, L., & Aust, S. D. (1990). Effects of glycyl-histidyl-lysyl chelated Cu(II) on ferritin dependent lipid peroxidation. Advances in experimental medicine and biology, 264, 79–84. https://doi.org/10.1007/978-1-4684-5730-8_11
  10. Sakuma, S., Ishimura, M., Yuba, Y., Itoh, Y., & Fujimoto, Y. (2018). The peptide glycyl-ʟ-histidyl-ʟ-lysine is an endogenous antioxidant in living organisms, possibly by diminishing hydroxyl and peroxyl radicals. International journal of physiology, pathophysiology and pharmacology, 10(3), 132–138.
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Biotech Peptides

28 reviews for GHK-CU (Copper) (50mg)

  1. Oscar Tremblay

    Delivery was much faster than expected

  2. Nelson Violet

    Always had a good experience. Thank you

  3. Sawyer Myers

    Just amazing

  4. Addison Long

    Excellent service, thank you!

  5. Melanie Cruz

    Exceeded my expectations completely

  6. Alexander Y.

    I’ve ordered from Biotech numerous times and it always arrived quickly. CS is great too. I once ordered the wrong product and they quickly updated my order. The new product was a little less expensive so they threw in an additional vial for less than the cost of one vial. Great company overall. My go to at the moment.

  7. Enton Lok

    Big fan here. Just wish there were more shipping options.

  8. Kelly Fagen

    No BS transaction. Im happy

  9. Patricia Paiz

    Consistent product and fullfillment. All the information offered before purchase and the after-sale support and guidance are really appreciated.

  10. Kelley Vincent

    Always a pleasure to do business with you. Customer service is always helpful, fast, and friendly if I encounter any issues!

  11. Gary Roisentul

    Very happy with my orders. Have ordered from them since the beginning of September, haven’t let me down yet

  12. Derek Lin

    Hoping in the future they expand more!

  13. Roger Kale

    Very reliable, Biotechs my go to!

  14. Tracy Graham

    I’ve been trying to get into the site for two days now and it keeps glitching or something. Hopefully it will be back soon

  15. David Cohen

    So good I even recommended it to my research friends

  16. Jay Rendon

    Glad I ordered from here! Can’t wait to get my shipment and so far the process has been easy with this company.

  17. Sam Jost

    Real good company, I like that they are quick with restocks.

  18. Steve M.

    I’ve been very happy with their service and product thus far.

  19. Micheal Tan

    The reviews on this site got me very interested in trying what you guys have to offer

  20. Steve Moris

    Got some free Bac water even though I didn’t meet the minimum purchase.

  21. Heather Bowen

    I was a first time customer last week and I called CS to ask a few questions. Dani was kind enough to take my order and even suggest a product I didn’t order, but that would fit in combination with the compound I got.

  22. Linda Devins

    Biotech works fast. I had placed an order in the morning and recieved the peptides the next afteroon.

  23. Eli Amin

    Quality has not gone down at all since they came about around a year and a half ago. Still as happy as ever with the peptides. Research has given great results with these as well.

  24. rob Antimore

    Hard to write reviwes about peptides unless you’ve been working with them a while. I just recieved my 4th round of peptide orders from here and I can say they are the best I have ever had to work with. Results are always great and they are high end peptides for a great cost.

  25. Aurauz Azima

    Taylor is always helpful and knows how to fix any issues that I have ever come across.

  26. Mickey Lee

    Had no issues with customs, got my peptides on time.

  27. Pat Riordan

    Pepide selection has grown in the past year! Happy cause I can get what I need all from one place now.

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