What is CJC-1295 DAC peptide?
CJC-1295 DAC is a synthetic analogue of growth hormone releasing hormone (GHRH) that enhances plasma levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1). Drug affinity complex (DAC) is an additive component which helps to prolong the half-life of CJC-1295 in plasma.
CJC-1295 DAC SPECIFICATIONS
AKA: CJC 1295 with DAC
Molecular Formula: C152H252N44O42
Molecular Weight: 3647.954 g/mol
PubChem: CID 56841945
Researchers have created several synthetic modifications of growth hormone-releasing hormone (GHRH) which retain certain selective traits of the hormone while eliminating others. CJC-1295 happens to be one of such synthetic analogues that comprise the first 29 amino acids of GHRH. Interestingly, it happens to be a maleimide derivative of 1-29 residues of hGRF and helps to produce a GH secretagogue which has greater solubility, is easier to synthesize in larger volumes, and maintains the biological effects of GH.
CJC 1295 Versus CJC-1295 DAC
CJC-1295 DAC shares similarity with other GHRH analogues like Sermorelin as both are derivatives of the first 29 amino acids of GHRH. It also happens to be closest to, but not identical, to modified GRF (1-29).The similarity and the fact that CJC-1295 was created along with DAC creates confusion between the peptides.
DAC is attached to CJC-1295, through a lysine linker, to protect the peptide during its circulation in the bloodstream. DAC facilitates the association of peptides with blood proteins such as albumin. This enhances their half-life compared to similar peptides such as GRF (1-29). DAC conjugated CJC-1295 was addressed as only CJC-1295 by Conjuchem Biotechnologies, the company that developed DAC. The non-DAC conjugated variant of the peptide being also available under the same name led to confusion between the two varieties.
CJC-1295 and Growth Hormone Release
The peptide triggers the release of GH as it is a synthetic analogue for the natural GHRH. Mice models have shown that a single administration of the peptide can induce almost 2-10 times higher production of GH. GH expression reaches maximum level after 2 hours of the peptide administration and the effect is maintained up to about six days later. The peptide maintains the natural physiological level of GH, unlike other secretagogues. In other words, CJC-1295 acts as a physiological GHRH and helps to maintain the natural biological high and low expression pattern in GH levels.
CJC-1295 maintains the physiological level of the hormone while enhancing its release in the blood. This ensures to bring about the benefits of GH without enhancing its adverse side effects. CJC-1295 has been shown to maintain the physiological regulation of GH on protein synthesis, fat metabolism, blood sugar, hypertrophy, bone density, hyperplasia, and myocardial function.
CJC-1295 and Infertility
Studies from early 1990s indicate that CJC-1295 and other GRF analogues can improve female infertility. Mice models of superovulation have proven that GH and IGF-1 levels increase in blood around the time of ovulation. Thus the treatment including CJC-1295 and GRF analogues can promote ovulation in female patients possibly through IGF-1 and GH expression cycle. Use of GH secretagogues like CJC-1295 is sufficient to promote proper ovulation. Scientists have further suggested the use of these analogues to improve sperm production and thus treat male infertility through proper research is required to test the hypothesis.
Research has highlighted that can restore the physiological release of GH in mice lacking in normal GH physiology. Therefore the peptide can be potentially used to treat growth anomalies in different mammalian species including human beings. Maintenance of the circadian cycle of GH release happens to be crucial to bring about appropriate production of downstream hormones, such as insulin-like growth factor-1 (IGF-1).
CJC-1295 DAC Peptide Summary
CJC-1295 is a growth hormone secretagogue which has been developed to possess a long half-life in plasma and it helps to restore and maintain the inherent physiologic expression rhythm of GH. The molecule has been able to achieve both the objectives with which it was created. However, it has been of less interest to researchers due to the prevalence of number of such hormone analogues and the proprietorship on the molecule structure. Interestingly, now as it can be manufactured at will, the peptide is expected to renew research interest especially owing to its potential in infertility treatment.
It has shown mild adverse effects, low oral and fantastic subcutaneous availability in mice models. However, the dose administered to mice (per kg) does not scale up for human use. The molecule sold by Biotech Peptides is strictly used for research only and not for human consumption. Only a licensed researcher is capable of purchasing the drug. Buy CJC-1295 DAC Peptide, only if you are a licensed researcher.