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CJC-1295 DAC (5mg)
CJC-1295 DAC peptides are Synthesized and Lyophilized in the USA.
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What is the CJC-1295 DAC peptide?
CJC-1295 DAC is a synthetic analog of growth hormone-releasing hormone (GHRH) that has the potential to enhance plasma levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1). Drug affinity complex (DAC) is an additive component that helps to prolong the half-life of CJC-1295 in plasma.
AKA: CJC 1295 with DAC
Molecular Formula: C152H252N44O42
Molecular Weight: 3647.954 g/mol
PubChem: CID 56841945
Researchers have created several synthetic modifications of growth hormone-releasing hormone (GHRH), which retain certain selective traits of the hormone while eliminating others. CJC-1295 happens to be one of such synthetic analogs that comprise the first 29 amino acids of GHRH. Interestingly, it happens to be a maleimide derivative of 1-29 residues of hGRF. This helps produce a GH secretagogue with greater solubility, which is easier to synthesize in larger volumes and appears to maintain the biological effects of GH.
CJC-1295 vs. CJC-1295 with DAC
CJC-1295 DAC shares similarities with other GHRH analogs like Sermorelin, as both are derivatives of the first 29 amino acids of GHRH. It is also closest to, but not identical, to modified GRF (1-29). The similarity and the fact that CJC-1295 was created along with DAC creates confusion between the peptides. Through a lysine linker, DAC is attached to CJC-1295 to protect the peptide during its circulation in the bloodstream. DAC facilitates the association of peptides with blood proteins such as albumin. This appears to enhance their half-life compared to similar peptides such as GRF (1-29).
CJC-1295 and Growth Hormone Release
The peptide is intended to trigger the release of GH, as it is a synthetic analog for the natural GHRH. Mice model experiments have reported that a single administration of the peptide may induce almost 2-10 times higher production of GH. GH expression appears to reach a maximum level after 2 hours of the peptide administration, and the effect is maintained up to about six days later. The peptide appears to maintain the natural physiological level of GH, unlike other secretagogues. In other words, CJC-1295 has the potential to perform as a physiological GHRH and maintain the natural biological high and low expression pattern in GH levels. CJC-1295 appears to maintain the physiological level of the hormone while enhancing its release in the blood. This effect would ensure that GH brings about the benefits without enhancing its adverse side effects. CJC-1295 has been studied in relation to physiological regulation of GH on protein synthesis, fat metabolism, blood sugar, hypertrophy, bone density, hyperplasia, and myocardial function.
CJC-1295 and Infertility
Studies from the early 1990s suggest that CJC-1295 and other GRF analogs may improve female infertility. Mice models of superovulation have proven that GH and IGF-1 levels increase in blood around the time of ovulation. Thus the treatment, including CJC-1295 and GRF analogs may promote ovulation in female patients, possibly through IGF-1 and GH expression cycle. The use of GH secretagogues like CJC-1295 may be sufficient to promote proper ovulation. Scientists have further suggested the use of these analogs to improve sperm production and thus treat male infertility, though proper research is required to test the hypothesis.
CJC-1295 and Growth
Research has suggested that CJC-1295 may restore the physiological release of GH in mice lacking normal GH physiology. Jette et al. notes that “CJC-1295, showed a 4-fold increase in GH area under the curve over a 2-h period.” The peptide may potentially be used to treat growth anomalies in different mammalian species. Maintenance of the circadian cycle of GH release happens to be crucial to bringing about appropriate production of downstream hormones, such as insulin-like growth factor-1 (IGF-1).
CJC-1295 DAC Peptide Summary
CJC-1295 is a growth hormone secretagogue that has been developed to possess a long half-life in plasma. It may help restore and maintain the inherent physiologic expression rhythm of GH. The peptide has been of less interest to researchers due to the prevalence of number of such hormone analogs and the proprietorship on the molecule structure. Interestingly, now as it can be manufactured at will, the peptide is expected to renew research interest, especially owing to its potential in infertility treatment. Experimental studies have documented mild adverse effects, low oral and fantastic subcutaneous availability in mice models. However, the dose administered to mice (per kg) does not scale up for human use.
- Alba M, Fintini D, Sagazio A, Lawrence B, Castaigne JP, Frohman LA, Salvatori R. Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1290-4. doi: 10.1152/ajpendo.00201.2006. Epub 2006 Jul 5. PMID: 16822960.
- Gautam D, Jeon J, Starost MF, Han SJ, Hamdan FF, Cui Y, Parlow AF, Gavrilova O, Szalayova I, Mezey E, Wess J. Neuronal M3 muscarinic acetylcholine receptors are essential for somatotroph proliferation and normal somatic growth. Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6398-403. doi: 10.1073/pnas.0900977106. Epub 2009 Mar 30. PMID: 19332789; PMCID: PMC2662962.
- Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab. 2006 Mar;91(3):799-805. doi: 10.1210/jc.2005-1536. Epub 2005 Dec 13. PMID: 16352683.
- Guo S, Li Z, Yan L, Sun Y, Feng Y. GnRH agonist improves pregnancy outcome in mice with induced adenomyosis by restoring endometrial receptivity. Drug Des Devel Ther. 2018 Jun 7;12:1621-1631. doi: 10.2147/DDDT.S162541. PMID: 29922037; PMCID: PMC5995291.
- Jetté L, Léger R, Thibaudeau K, Benquet C, Robitaille M, Pellerin I, Paradis V, van Wyk P, Pham K, Bridon DP. Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog. Endocrinology. 2005 Jul;146(7):3052-8. doi: 10.1210/en.2004-1286. Epub 2005 Apr 7. PMID: 15817669.
Dr. Usman (BSc, MBBS, MaRCP) completed his studies in medicine at the Royal College of Physicians, London. He is an avid researcher with more than 30 publications in internationally recognized peer-reviewed journals. Dr. Usman has worked as a researcher and a medical consultant for reputable pharmaceutical companies such as Johnson & Johnson and Sanofi.
Oliver Walsh –
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Excellent customer service and excellent products. Would recommend.
James Miner –
Best company I’ve dealt with so far for my peptide needs. Thanks for the gift!
Samantha Bennett –
I like the no DAC version much better (MOD GRF 1-29)
Charlotte Wood –
Just recently switched over to Biotech Peptides. I like to experiment with different companies and try them all out. They are for sure in my top 3 companies to reach out to!
Jason Power –
GOOD QUALITY, LIKE HOW I GOT FREE BAC WATER BECAUSE MY ORDER WAS OVER 150. WISH THEY GAVE MORE BUT ILL TAKE IT
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I love this company and I would love to maybe see some packages or some stuff? Like two peptides for the price of one or maybe some bundles
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I have been purchasing Biotech peptides since May of 2021. I am very happy with them all around. Anytime i have had issues such as vials breaking or not recieving the prodcuts on time they are quick and on top of it. Never had to call twice in order to get things done. Keep it up.
Robbyn Moore –
Great communication on their part. I had ordered cjc 1295 Dac 5 mg. I Had placed the order yesterday(tuesday) and I got an email this morning saying that unfortuntly they were out of stock of that item. But they did have the substitute for it which was Mod grf. Very appreciative and like the fact that they put customer satisfaction first and called to let me know rather than keeping me waiting till a restock or cancleing my order all together.
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Never had a bad peptide from them. Always the purest quality.
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Delivered quick! Like the fast pace.
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everything came quick.
Benjamin M. –
Biotech Peptides has been my peptide provider since mid 2021. I have been satisifed with their service and am very happy with the qulaity of the peptides. It is a great place to order in bulk from as well.
Mel Jenkins –
Found out about Biotech Peptide back in October. I’ve liked them so far. My only fear now is with the heat coming in how the peptides will hold up and not get ruined with this heat and transportation.
melody hirton –
Always have the peptides I need in stock, great prices as well. Have not had to ever reach out to customer services regarding any issues.
Dean coleman –
They have a nice selection of peptides but I do notice they have a bit of a hard time keeping up with supplies
Jack Altinay –
I needed help with placing my order and decided to call it in. Took no time to get in contact with someone and they took their time and explained the peptides to me and let me know if what I needed was in stock as well. Thankfully they had everything and they even took my payment over the phone! Easy process and fast delivery. I got my peptides within 2 days of ordering!
Hector Villa –
Bac water they send is also pretty great quality.
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Arnold Cano –
Biotech surpasses my expectations every time! From the time they process it, pack it up, and ship it has probably been a day or less. Have had an instance or two when it did take a while to come but a lot of my orders from other places did as well. Could be a seasonal issue.
Mark Ducker –
As long as you follow the instructiona for proper storage they’ll last a while which means you’ll save some money.
Alex Materman –
Shelf life is good. The vial sizes are perfect as well.
Anna Chang –
Qaulity is great. I did see they’re starting to add peptide they didn’t have before. Also their topical selection is growing too.
Eric Soto –
My order was delivered when quoted, everything looked to be in perfect condition. Nothing looked abnormal about it just the standard packaging. Happy there was no excess advertisements in the box either. Stocked that the process went as smooth as possible.
Moana Galala –
Taylor is great at what they do! Very knowledgable about peptides and can answer almost every question I have.
Marisol Lopez –
Had a vial come in broken. I emailed customer service and got a fast reply from Danny. He was able to sort out the issue and sent me a new batch as I wasnt sure if there could be any other issue with the rest. This was my 5th time ordering from biotech and my first time having an issue like this. Happy it was handled quickly!
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Cameron Quon –
Highly recommend Taylor or Danny to help you out if you have an issue. Fast at taking care of it and know what they’re doing.
Ben Thompson –
Peptides are great, pure as can be.
Akash Patel –
Store it correctly and they’ll last you awhile. I tend to not use too much of the orders so I love the store it and use it at a later time. I’d be careful to not thaw and refreeze them a lot cause then the peptides could just be useless. Use when needed.
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Products came in tact. No peptides were missing. They did also send an extra Bac water which was a nice bonus!
Connor Jackson –
Can’t believe how fast everything came!!
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I like that when I call their number i’m not on hold for a long period of time and get issues handled quickly rather than in hours.
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Biotech is a great source for peptides, can’t go wrong
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No bad peptides here, Purity is amazing, have rarely come by a company like this.