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Hexarelin (5mg)

(27 customer reviews)

$49.00

Hexarelin peptides are Synthesized and Lyophilized in the USA.

Discount per Quantity

Quantity 5 - 910 +
Discount 5%10%
Price $46.55$44.10
Orders over $200 receive:
FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
FREE - USPS priority shipping
SKU: Hexarelin-5mg Category:

Description

What is the Hexarelin peptide?

Hexarelin (also known as Examorelin) is a synthetic analog of ghrelin and exhibits a high degree of similarity to GHRP-6. The only difference between Hexarelin and GHRP-6 is the inclusion of two methyl groups in the structure of GHRP-6. Like other ghrelin analogs, this peptide remains active both orally and sublingually and displays high selectivity in its mode of action.[1] It has been extensively studied in relation to cardiac cell survival after ischemia and nutrient deprivation.

Specifications

Molecular Formula: C47H58N12O6

Molecular Weight: 887.05 g/mol

Sequence: His-2-Me-D-Trp-Ala-Trp-D-Phe-Lys-NH2

PubChem: CID 6918297

CAS Number: 140703-51-1

Reconstitution: Required

Research

Hexarelin and Muscle Protection
The peptide has been observed to protect muscle cells and is not useful specifically for the heart alone. Studies in Hexarelin and GHRP-6 observe how the peptides may control calcium flow and mitochondrial dysfunction in muscles of rats suffering from cachexia (extreme weight loss due to illness or chemotherapy).[2] The researchers report that the secretagogue can “protect skeletal muscle from mitochondrial damage and improve lean mass recovery.” It also appears to keep muscle cells viable by maintaining mitochondrial integrity. Through its energy supply, Mitochondria help muscles carry out day-to-day functions. It has been observed that calcium ion regulation is often disturbed due to chemotherapy and is one of the principal causes for altered muscle mass and lean body mass during cancer treatment. However, Hexarelin and GHRP-6 may help to reestablish proper calcium regulation post-chemotherapy.

Hexarelin and Cardiac Functions
Hexarelin appears to affect the heart through its association with the CD36 receptor and the growth hormone secretagogue receptor (GHSR). Research conducted on murine models observe that the peptide appears to protect cardiac cells from injury in the backdrop of cardiac arrest.[3] The scientists even note that hexarelin “may be a promising therapeutic agent for some cardiovascular conditions.” Researchers suggest that the peptide interacts with the aforesaid receptors and prevents apoptosis of the cardiac cells. The peptide may help improve cardiac function, increasing the number of surviving cardiac cells and reducing the levels of malondialdehyde (cardiac cell death marker). Interestingly, the study also suggested GHRP-6 to be partially superior in function compared to ghrelin. Hexarelin has also been observed to ameliorate oxidative stress in cardiac cells during cardiac failure as well as to prevent myocardial remodeling in rats.[4] Cardiac remodeling causes a decrease in cardiac function and can be fatal. However, GHRP-6 or Hexarelin treated rats appeared to show significant improvement in their cardiac function compared to the untreated controls. The molecular mechanisms underlying the function of the peptide involve an increase of phosphatase and tension homologue (PTEN) activity and subsequent reduction in protein kinase B levels. While PTEN regulates cellular regeneration, protein kinase B helps to modulate cell survival. GHRP-6 and Hexaralin may mediate cardiac remodeling by switching the nervous system response from sympathetic (includes increased blood pressure, heart rate, etc.) to parasympathetic. This regulation would help to improve short-term health and reduce the need for prolonged cardiac medication. Moreover, when treated with the peptide following cardiac arrest, studies with rat models observed a significant decrease in scar tissue arising from cardiac tissue healing.
The peptide may have the potential for assisting in numerous cardiac damages as its mode of action is not specific to protection against heart attack. Studies in rat models of diabetes have also observed Hexarelin to potentially improve cardiac function by altering the processing of calcium and potassium by cardiac muscle cells.[5]

Hexarelin and Fat
Dyslipidemia is the physiological condition of elevated fat levels in the blood. Interestingly, it also happens to be an independent contributing factor for the onset of diabetes, even in lean and externally fit individuals. A detailed understanding of the condition throws light on the association of human physiology with modern diets. GHRP-6 and Hexarelin studies have observed the peptides’ potential to correct dyslipidemia in the backdrop of insulin resistance (the first step in the pathway to diabetes).[6] The peptide may also help to reduce blood sugar and insulin resistance in rats. In future, it may be a potential alternative to the existing lipid medications to treat severe dyslipidemia.

Promising Research in Hexarelin

Cardiac disorders are the leading cause of death in most developed countries. Peptides such as Hexarelin have helped scientists explore the complexities of cardiac conditions, which eventually lead to cardiac failure and death. Studies involving the peptide have revealed a number of new pathways for understanding the role of the heart in health and disease.[7] Hexarelin has the potential to be used as a part of novel therapies for addressing serious physiological conditions. These include cardiac remodeling issues, which have been challenging to address in the past. Studies in Hexarelin report the peptide to exhibit moderate side effects, low oral bioavailability, and excellent subcutaneous bioavailability in mice models of research. Per kg dosage in mice does not match up to humans.

References

  1. Ghigo E, Arvat E, Gianotti L, Grottoli S, Rizzi G, Ceda GP, Boghen MF, Deghenghi R, Camanni F. Short-term administration of intranasal or oral Hexarelin, a synthetic hexapeptide, does not desensitize the growth hormone responsiveness in human aging. Eur J Endocrinol. 1996 Oct;135(4):407-12. doi: 10.1530/eje.0.1350407. PMID: 8921821.
  2. Bresciani E, Rizzi L, Coco S, Molteni L, Meanti R, Locatelli V, Torsello A. Growth Hormone Secretagogues and the Regulation of Calcium Signaling in Muscle. Int J Mol Sci. 2019 Sep 5;20(18):4361. doi: 10.3390/ijms20184361. PMID: 31491959; PMCID: PMC6769538.
  3. Mao Y, Tokudome T, Kishimoto I. The cardiovascular action of hexarelin. J Geriatr Cardiol. 2014 Sep;11(3):253-8. doi: 10.11909/j.issn.1671-5411.2014.03.007. PMID: 25278975; PMCID: PMC4178518.
  4. McDonald H, Peart J, Kurniawan N, Galloway G, Royce S, Samuel CS, Chen C. Hexarelin treatment preserves myocardial function and reduces cardiac fibrosis in a mouse model of acute myocardial infarction. Physiol Rep. 2018 May;6(9):e13699. doi: 10.14814/phy2.13699. PMID: 29756411; PMCID: PMC5949285.
  5. Mosa RM, Zhang Z, Shao R, Deng C, Chen J, Chen C. Implications of ghrelin and hexarelin in diabetes and diabetes-associated heart diseases. Endocrine. 2015 Jun;49(2):307-23. doi: 10.1007/s12020-015-0531-z. Epub 2015 Feb 4. PMID: 25645463.
  6. Mosa R, Huang L, Wu Y, Fung C, Mallawakankanamalage O, LeRoith D, Chen C. Hexarelin, a Growth Hormone Secretagogue, Improves Lipid Metabolic Aberrations in Nonobese Insulin-Resistant Male MKR Mice. Endocrinology. 2017 Oct 1;158(10):3174-3187. doi: 10.1210/en.2017-00168. PMID: 28977588; PMCID: PMC5659698.
  7. Imbimbo BP, Mant T, Edwards M, Amin D, Dalton N, Boutignon F, Lenaerts V, Wüthrich P, Deghenghi R. Growth hormone-releasing activity of hexarelin in humans. A dose-response study. Eur J Clin Pharmacol. 1994;46(5):421-5. doi: 10.1007/BF00191904. PMID: 7957536.
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Additional information

Brand

Biotech Peptides

27 reviews for Hexarelin (5mg)

  1. Freya Cruz

    Really fast and reliable

  2. Daniel Harris

    Highly recommend Biotech! High quality services!

  3. Ethan Roberts

    Still great, from a long time customer. This company has become my no1 supplier

  4. Avani Ross

    Just as advertised

  5. Hayden Foster

    Appreciate the friendly care from Alex in Customer service. I am new to working with peptides. He took his time with me and explained any confusions I had in terms of the size of the product. Thanks for clearing that all up

  6. Orion Quinn

    I have never found such a wide range of products before. You can find anything you’re searching for on just one site

  7. Piper Boyle

    Excellent service and high-quality products. I would highly recommend if you are in need of peptides

  8. Andy Mlodoch

    I keep coming back again and again. Keep up the good job

  9. Ana Parra

    They provided excellent service. This was my first buy from them, but I’ll certainly be back.

    Although the most costly shipping option was a little pricey, it was worth it in my case. I was nonetheless surprised at how quickly my item came, even though I had chosen that option

  10. Brent Wentzel

    I am very pleased with my package. Thank you Biotech

  11. Brooke Davis

    Trustworthy and great employees!

  12. Keith Batista

    I have researched a bunch of peptide companies and I swear I’ve never read more amazing reviews than here. Every company has had a least one big mess-up. It’s rare to find a company with few bad reviews, but now that I’m here, I’m sticking with it

  13. Monica Cardenas

    No esperaba que los péptidos fueran tan fácilmente accesibles de donde soy, pero gracias a Biotech puedo comprarlos cuando quiera. gracias bp

  14. June Wang

    Their products lived up to expectations. Pure and legit.

  15. Lauren Green

    Compared to other peptide sellers, I actually like the products here. Everything I’ve ordered from here gave great results in my experiments. I suggest only getting your products from this company.

  16. Sandra Owen

    Ten out of ten would recommend

  17. Gary Hanson

    Pretty good company, fast turn around.

  18. Nate Moinster

    At one point my order got stuck in customs and they solved the problem immediately. I like that they make it easy to order overseas

  19. Will Hunter

    Got an awesome promo code for the next few purchases when my products came a little damaged due to transit! They also sent some new peptides to replace the damaged ones.

  20. Abe Turner

    I don’t even remember how I came across you, but I’m so glad I did. Seven months buying from you and still going

  21. Elias Leal

    No complaints. 10/10.

  22. Monty Daryl

    They are great for buying in bulk!!

  23. Arnold hanson

    Been with you guys for while. Liking everything. Even your blog page is neat.

  24. Robert Sanchez

    Great find. Good prices and high quality peptides!

  25. Andrew Carrlilo

    The only place I buy peptides

  26. Brian Munzlinger

    They are easy to get in contact with. I don’t wait long for someone to email or call me to settle an issue that has come up. In the past I have spoken with Danny or Jamie and they had great customer service!

  27. Hayden Cole

    Great products, glad they’ve expanded and have added more peptides to their site.

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