Molecular Formula: C47H58N12O6
Molecular Weight: 887.05 g/mol
PubChem: CID 6918297
CAS Number: 140703-51-1
What is Hexarelin peptide?
Hexarelin (also known as Examorelin) is a synthetic analog of ghrelin and shows a high degree of similarity to GHRP-6. The only difference between hexarelin and GHRP-6 is the inclusion of two methyl groups in the structure of GHRP-6. Like other ghrelin analogs, this peptide remains active both orally and sublingually and displays high selectivity in its mode of action. It has been extensively studied because of its impact on cardiac cell survival after ischemia and nutrient deprivation.
1. Protects Muscle
The peptide has been observed to protect muscle cells and is not useful specifically for the heart alone. GHRP-6 controls calcium flow and mitochondrial dysfunction in muscles of rats suffering from cachexia (extreme weight loss due to illness or chemotherapy). It also helps to keep muscle cells viable by maintaining mitochondrial integrity. Through its energy supply, Mitochondria help the muscles carry out their day-to-day functions. It has been observed that calcium ion regulation is often disturbed due to chemotherapy and is one of the principal causes for altered muscle mass and lean body mass during cancer treatment. However, GHRP-6 may help to reestablish proper calcium regulation post-chemotherapy.
2. Protects the Heart
Hexarelin directly affects the heart through its association with the CD36 receptor and the growth hormone secretagogue receptor (GHSR). Research conducted on murine models has shown that the peptide protects cardiac cells from injury in the backdrop of cardiac arrest. It interacts with the aforesaid receptors and prevents apoptosis of the cardiac cells. The peptide helps improve cardiac function, increasing the number of surviving cardiac cells and reducing the levels of malondialdehyde (cardiac cell death marker). Interestingly, the study also proves GHRP-6 to be partially superior in function compared to ghrelin.
The peptide has also been observed to ameliorate oxidative stress in cardiac cells during cardiac failure as well as to prevent myocardial remodeling in rats. Cardiac remodeling causes a decrease in cardiac function and can be fatal. However, GHRP-6 treated rats demonstrate significant improvement in their cardiac function compared to the untreated controls. The molecular mechanisms underlying the function of this peptide involve an increase of phosphatase and tension homologue (PTEN) activity and subsequent reduction in protein kinase B levels. While PTEN regulates cellular regeneration, protein kinase B helps to modulate cell survival.
GHRP-6 mediates cardiac remodeling by switching the nervous system response from sympathetic (includes increased blood pressure, heart rate, etc.) to parasympathetic. This regulation helps to improve short-term health and outcomes and reduces the need for prolonged cardiac medication. Moreover, when treated with the peptide following cardiac arrest, rats also demonstrate a significant decrease in scar tissue arising from cardiac tissue healing.
The peptide can thus be utilized for numerous cardiac damages as its mode of action is not specific to protection against heart attack. Studies in rat models of diabetes have also observed hexarelin to improve cardiac function by altering the processing of calcium and potassium by cardiac muscle cells.
3. Hexarelin Peptide Improves Fat Measures
Dyslipidemia is the physiological condition of elevated fat levels in the blood. Interestingly, it also happens to be an independent contributing factor for the onset of diabetes, even in lean and externally fit individuals, especially in the first world nations. A detailed understanding of the condition throws light on the association of human physiology with modern diets. GHRP-6 has been observed to correct dyslipidemia in the backdrop of insulin resistance (the first step in the pathway to diabetes). The peptide also helps to reduce blood sugar and insulin resistance in rats. It can therefore be used as an alternative to the existing lipid medications to treat severe dyslipidemia.
Heavily Researched Peptide
The cardiac disorder is the leading cause of death in most developed countries. Peptides such as hexarelin have helped scientists explore the complexities of cardiac conditions, which eventually lead to cardiac failure and death. Studies involving the peptide have revealed a number of new pathways for understanding the role of the heart in health and disease. Hexarelin has the potential to be used as a part of novel therapies for addressing serious physiological conditions. These include cardiac remodeling issues, which have been challenging to address in the past.
Hexarelin exhibits moderate side effects, low oral bioavailability, and excellent subcutaneous bioavailability in mice models of research. Per kg dosage in mice does not match up to humans.