MGF (Mechano-Growth Factor) (5mg)

(28 customer reviews)


MGF peptides are Synthesized and Lyophilized in the USA.

Discount per Quantity

Quantity 5 - 910 +
Discount 5%10%
Price $56.05$53.10
Orders over $200 receive:
FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
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SKU: MGF-5mg Category:


What is the MGF Peptide?

Mechano-Growth Factor (MGF) is an alternative name for the Insulin-like Growth Factor-1Eb (IGF-1Eb) an isoform of IGF-1. It has been studied for its potential in the remodeling of muscles, cellular survival, and cellular proliferation.[1] New studies on this specific isoform highlight its potential for activating satellite cells in skeletal muscle, suggesting that this particular isoform may also activate satellite cells in skeletal muscle, protect neurons, and helps to overcome the age-related loss of muscle mass.[2] The principal function of MGF is its possible efficacy in the reparation of severe muscle wear and tear, especially that caused by injury or exercise. The peptide levels may increase significantly after muscle injury. Further, its concentration appears to correspond with skeletal muscle growth and differentiation as found in rodent models.

MGF Specifications

AKA: Mechano-Growth Factor

Molecular Formula: C124H204N42O41S1

Molecular Weight: 2971.99 g/mol

Sequence: yr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys-Cys

Reconstitution: Required


Mechano-Growth Factor (MGF) and Inflammation
Inflammatory cells such as macrophages and the specific signaling molecules released, bring about muscle regeneration. Macrophages have been observed to produce MGF in the backdrop of muscle inflammation. IGF-1Ea (MGF) not only appears to exhibit anti-inflammatory effects but also extends the life of macrophages. The specific relevance of this effect is hitherto known, but it is speculated that the use of external MGF may improve the rate of muscle cell healing through macrophage modulation.[3]

Mechano-Growth Factor (MGF) and Age
IGF-1 has multiple variants, and the synthesis of these isoforms gets influenced by different factors. The splicing and formation of different splice variants of IGF-1 are affected by developmental factors, hormones like growth and steroid hormones, and age. Age, in particular, is a crucial deciding factor for the regulation of IGF-1 splicing. The predominant variants in young men are class 1 and class 2, whereas elderly people show prevalence of class 1Ea. The switch in the predominant splice variant acts as a relevant starting point and helps to understand the biology of aging better. The overall significance of this change in terms of obvious signs of aging isn’t clear, but it offers an experimental starting point for understanding better the aging process. It has been suggested that MGF may reduce the loss of muscles with age progression though an in-depth study is essential.

Mechano-Growth Factor (MGF) and Cardiac Cells
The peptide was reported by researchers to potentially protect cardiac muscles from ischemia in sheep models of myocardial infarction (heart attack). The work found a 35% decrease in cardiomyocyte compromise after MGF was used following cardiac arrest.[4] The researchers also concluded that “the E domain of MGF protects the myocardium against ischaemia, thus improving cardiac function post-MI.” This finding is of great relevance as minimal medical interventions could alleviate the impact of a heart attack while it was still occurring. The use of MGF may be a simple and safe alternative compared to stents or clot-dissolving drugs that have far-reaching complications. The molecule has opened up a new experimental approach to the treatment of acute myocardial infarction. It may reduce the impact of the heart attack by one-third when given to first responders. The peptide has the potential for improved benefits since heart attack is the highest cause of adult deaths in developed countries worldwide.

Mechano-Growth Factor (MGF) and Muscle Growth
MGF appears to promote hypertrophy and repair of muscle by stimulating muscle stem cells (called satellite cells). Research in murine models observed a 25% increase in the size of mean muscle fiber following MGF administration for three weeks.[5] The researchers outline that “The discovery of MGF and muscle IGF-1 provides a link between physical activity and gene expression. This underlines the need for the elderly to remain active as the locally produced growth factors supplement the circulating IGF-1 levels.” The peptide is speculated to improve muscle conditions in degenerative diseases and stimulate the benefits of exercise on muscles. The latter speculation stems from the underlying importance of muscle mass in baseline metabolism. Boosting muscle mass improves basal metabolism and aids in fat burning. Thus the ability to increase lean body mass helps combat serious issues like obesity and allied health hazards. Duchenne Muscular Dystrophy (DMD), a severe degenerative muscular disease, is often treated by transplanting precursors of muscle cells (called myogenic precursor cells). The transplantation helps to improve dystrophin production and ameliorates the disease conditions. Unfortunately, low survival rates post-transplant have never made the procedure therapeutically viable. Mouse studies have observed that MGF may help survive the precursor cells, thus making the transplantation successful.[6] Therefore the use of the peptide may become a choice of DMD treatment alongside transplantation and not just a niche alternative.

Mechano-Growth Factor (MGF) and Brain Development
Studies on the brains of developing mice have observed the presence of MGF as early as 2010. The study sheds light on the neuroprotective potential of the peptide.[7] Researchers find that MGF appears to be over-expressed in hypoxic brains of rats in the regions of the brain which undergo neuron regeneration. The influence of the peptide on neuron health was suggested in the murine model of ALS (Lou Gehrig’s Disease). ALS leads to loss of motor neurons and overall progressive body of weakness. Treatment with MGF appeared to improve both the symptoms mentioned above. MGF has been suggested to be better than other IGF-1 isoforms in the regeneration of regions of adult brains after global ischemia. MGF may show potential to be used in the treatment of ALS.

Mechano-Growth Factor (MGF) and Cartilage
Cartilage, one of the most crucial connective tissues of our body, can get damaged due to injury, the repeated strain on a joint (osteoarthritis), or inflammatory conditions (e.g., rheumatoid arthritis). Unfortunately, cartilage does not recover well for various reasons, including inadequate blood supply and a lack of stem cells necessary for significant tissue regeneration. Studies have observed MGF to be capable of helping in more effective cartilage regeneration. MGF may promote the survival of chondrocytes (primarily involved in cartilage health and recovery) following mechanical stimuli. In the backdrop of physical stress and damage to the cartilage tissue, MGF may boost the survival and migration of chondrocytes (via YAP signaling and other pathways) to injury sites.[8] Chondrocyte movement helps in better cartilage repair and restoration of function. The peptide has been observed to hold potential for preventing injury and disability over a long time span. Overloading chondrocytes causes apoptosis leading to disc degeneration in the human spine under continued mechanical stress in the spine. MGF may help to inhibit the apoptosis of these cells, inhibiting disc degeneration of the spine. The use of the molecule as a supplement against spinal disc degeneration is an area of active study.

Mechano-Growth Factor (MGF) Research Direction

MGF has been researched for its potential to promote the protection of neurons and muscles as well as cartilage regeneration and hence may hold therapeutic importance. Therefore, it is a potential candidate for pharmaceutical development, and the peptide may be used in several path-breaking treatments over the next decade. In addition, new roles of MGF are being unraveled regularly. Experimental studies report MGF to exhibit minimal side effects, low oral bioavailability, and excellent subcutaneous bioavailability in mice. The dosage necessary for mice (per kg) does not scale to humans.


  1. Yang SY & Goldspink G (2002). Different roles of the IGF-IEc peptide (MGF) and mature IGF-I in myoblast proliferation and differentiation. FEBS Lett 522, 156-160.
  2. Hill M & Goldspink G (2003). Expression and splicing of the insulin­like growth factor gene in rodent muscle is associated with muscle satellite (stem) cell activation following local tissue damage. J Physiol 549, 409-418.
  3. Sun KT, Cheung KK, Au SWN, Yeung SS, Yeung EW. Overexpression of Mechano-Growth Factor Modulates Inflammatory Cytokine Expression and Macrophage Resolution in Skeletal Muscle Injury. Front Physiol. 2018 Jul 26;9:999. doi: 10.3389/fphys.2018.00999. PMID: 30140235; PMCID: PMC6094977.
  4. Carpenter V, Matthews K, Devlin G, Stuart S, Jensen J, Conaglen J, Jeanplong F, Goldspink P, Yang SY, Goldspink G, Bass J, McMahon C. Mechano-growth factor reduces loss of cardiac function in acute myocardial infarction. Heart Lung Circ. 2008 Feb;17(1):33-9. doi: 10.1016/j.hlc.2007.04.013. Epub 2007 Jun 19. PMID: 17581790.
  5. Goldspink G, Yang SY. Effects of activity on growth factor expression. Int J Sport Nutr Exerc Metab. 2001 Dec;11 Suppl:S21-7. doi: 10.1123/ijsnem.11.s1.s21. PMID: 11915923.
  6. Goldspink G, Yang SY, Skarli M & Vrbova G (1996). Local growth regulation is associated with an isoform of IGF-I that is expressed in normal muscles but not in dystrophic muscles. J Physiol 495, 162.
  7. Zabłocka B, Goldspink PH, Goldspink G, Górecki DC. Mechano-Growth Factor: an important cog or a loose screw in the repair machinery? Front Endocrinol (Lausanne). 2012 Nov 1;3:131. doi: 10.3389/fendo.2012.00131. PMID: 23125840; PMCID: PMC3485521.
  8. Song Y, Xu K, Yu C, Dong L, Chen P, Lv Y, Chiang MYM, Li L, Liu W, Yang L. The use of mechano growth factor to prevent cartilage degeneration in knee osteoarthritis. J Tissue Eng Regen Med. 2018 Mar;12(3):738-749. doi: 10.1002/term.2493. Epub 2017 Oct 6. PMID: 28599103.
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28 reviews for MGF (Mechano-Growth Factor) (5mg)

  1. Amelia Diaz

    Excellent delivery and quality

  2. London Wright

    Truly professional service

  3. Lynch Clara

    Trustworthy and reliable provider of researched and tested products. I was nervous about trying, but it was great knowing I had the chance to buy from a trusted and dependable supplier

  4. Beckett Black

    Always on time. Products work as they should

  5. Lydia Sullivan

    User-friendly site. I am looking forward to testing out these products and I hope I have encountered a long-term reliable source for my research

  6. Thuy Dan T.

    Lovely staff, friendly, on top of their work as well1

  7. Matt Gandee

    Great service, products, discounts, and sales!!!!!!!!!

  8. Mark Miller

    Fast and easy. Very cool

  9. Patrick Khafajizad

    Wish to see a bit more research-oriented articles. Like professionally. I love the general, informative ones, but I’d also be interested in very techinal ones as well

  10. Aaron Beyk

    Five stars all the way

  11. Leon Liu

    Check out PEG-MGF. Much better than MGF

  12. Lana Harir

    Never difficult getting products in, they restock pretty often.

  13. Justin Mondo

    Outstanding services. I am really impressed

  14. Kirk Kohler

    Been a few days since my Peptides came in and I got to say i’m glad I decided to buy from biotech.

  15. Gabe Diaz

    I don’t like leaving reviews, but I think that this company is worthy of it. I ordered from them a total of 6 times and only once I had a problem with the shipping, which they resolved by the next day.

  16. Harry Johnson

    Like the Bac water that they send, good stuff!

  17. Oliver M.

    The different quantities on vials are really helpful. I’d add one more size, but other than that everything’s perfect

  18. Zac Henricks

    When my package was held at customs which was frustrating as the peptides can get ruined due to the time outside of its typical temperature. I contacted Biotech about the issue and I believe I was speaking to Jaimie. They could do nothing about the fact it was stuck there but he was able to resend me a package as they were sure as well the peptides would be no good.

  19. felipe sanchez

    No tengo ninguna queja. Estoy muy contento de haber encontrado una empresa a la que puedo comprar en mi país. La calidad también es muy alta y los productos son legítimos, sin estafa.

  20. jake wilkerson

    Since BP emerged on the market, the company I work for hasn’t changed peptide suppliers, even after doing extensive study on other companies.

  21. Nick kesler

    There were only a few places I could get this on the internet, and they either seemed shady or were too pricey. You guys had the best price around!

  22. Johnny ly

    I am a new customer and I am still juggling between Biotech and another company. So far the customer experience has been quite the same but the quickness of delivery goes to biotech.

  23. Jarret Brady

    Loyal customer since 2021. Their peptides are great!

  24. Matty Schultz

    Had no issues with shipping out to Canada, quality is spectacular.

  25. Edwin Reyna

    I placed my biggest order yet and everything came intact, plus, as a thank you gift for such a vast order, they threw in some additional Bac water. I will order again

  26. Joe Hersholt

    I switched suppliers in march of last year and I never switched again. Fantastic company, fantastic products, fantastic service.

  27. Jutin Morse

    Everything is just perfect. Couldn’t have asked for more. Products were delivered in a timely matter and everything looked to be in good conditions.

  28. Brian Dufelmeier

    Nice peptides. I buy a few peptides every few months and they seem to last well when stored properly. I always follow the standard method and peptides prove to hold their quality.

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