What is GHRP-6 Peptide?
GHRP-6 acts as a powerful stimulant that helps release of natural growth hormone (GH) from the anterior pituitary gland. In addition, it also acts as a ghrelin/growth hormone receptor agonist and is amongst the ghrelin analogs developed in recent decades. It has demonstrated a positive influence on cardiac muscle cells, scar formation, memory formation, sex motivation, and the neurons associated with Parkinson’s disease. The peptide is orally and sublingually active and moderately to highly specific in its action.
Molecular Formula: C46H56N12O6
Molecular Weight: 873.032 g/mol
PubChem: CID 9919153
CAS Number: 87616-84-0
1. GHRP-6 Improves Memory
Scientists have been investigating the role of physical activity in learning and memory formation. It has been observed that physical activity such as exercise helps to enhance cognitive learning, particularly when it is done immediately following a learning activity. However, the precise mechanism remains unknown.
Initially, exercise was thought to help cognition through improved blood circulation in the brain and increased growth hormone production. Studies on rodent models have highlighted how GHRP-6 helps to consolidate newly created memories and transforms short-term memories into long-term storage. Significant scientific observations further prove the role of ghrelin/GHRP-6 in spatial learning tasks. Therefore, growth hormone secretagogues such as ghrelin bring about exercise-induced cognitive improvements. Hence, the role of GH may be possibly indirect and perhaps secondary to these peptides.
2. Protects Brain Tissue
The role of GHRP-6 in the amelioration of stroke has been studied using appropriate animal models. The timely administration of the peptide not only protects brain tissue from reduced blood supply (following a stroke) but also helps in recovery from memory lapses due to stroke. At a molecular level, the peptide and its analogs prevent apoptosis of the central nervous system neurons, thereby preventing genetic reprogramming and inflammation.
3. Protects Parkinson’s Neurons
A study conducted in 2018 highlighted the prevalence of ghrelin receptors in substantia nigra, a part of the brain known to get affected by Parkinson’s disease. Patients who were genetically predisposed to the disease also showed a significant reduction in ghrelin receptors in their substantia nigra. It was observed that genetically modulated rats also exhibit Parkinson’s symptoms when an antagonist is administered. Therefore, agonists like GHRP-6 may prove to be beneficial in the treatment of Parkinson’s disease. Scientists hypothesize that the peptide associated with receptors present in the substantia nigra, decreases neuronal apoptosis and thus subsides or ameliorates the onset of this disease.
4. GHRP-6 Peptide Reduces Cardiac Problems
GHRP-6 was found to inhibit free radical-mediated cytotoxicity of cardiac cells in porcine models. It can be used to develop drugs that will help protect the viable cardiac tissues from damage after cardiac arrest. Such a medication would be helpful not only in reducing the chances of death but also in overcoming any long-term adverse effects caused by cardiac arrest.
5. Alters Sex Motivation and Mood
Studies on male rats have highlighted the role of ghrelin receptors in the central nervous system in modulating sexual behavior and motivation. Increased amounts of ghrelin have shown the ability to stimulate sexual impulses. GHRP-6 and its modified counterpart (which can antagonize the ghrelin receptor) have proven that ghrelin receptors in specific brain areas influence sexual and reward-seeking conduct. The above findings can be extrapolated to hunger and other stimulation beyond sex and are applicable in conditions like hypoactive sexual desire.
There is also data to suggest that ghrelin can influence mood as part of its impact on motivation. The peptide and its analogs help improve brain function associated with mood upliftment, stress relief, and overcoming depression in murine models. GHRP-6 can thus be used treat stress, depression, anxiety, and related mood disorders.
6. Improves Skin Appearance and Reduces Scaring
GHRP-6 promotes the survival of diverse kinds of cells by decreasing programmed cell death. The peptide is also associated with the CD36 receptor and helps to promote blood vessel growth, particularly in wounds. GHRP-6 has proven to be effective in faster wound closure in rats. It helps in rapid wound healing and the formation of extracellular matrix proteins such as collagen, promoting the overall correct organization of tissue around a scar and thus reducing the appearance of scar marks.
Hypertrophic scars, like keloids, occur due to improper deposition of matrix proteins. GHRP-6 blocks this aberrant wound healing process and is a boon for people who delay surgery to avoid such painful after-effects and aesthetic changes. GHRP-6 has demonstrated minimal to moderate side effects, low oral bioavailability, and excellent subcutaneous bioavailability in murine models of study. The dosage (per kg) required in mice does not match up to that required for humans.