Mod GRF 1-29 (CJC-1295 no DAC) (2mg)

(26 customer reviews)

$22.00

Mod GRF 1-29 peptides are Synthesized and Lyophilized in the USA.

Discount per Quantity

Quantity5 - 910 +
Discount5%10%
Price$20.90$19.80
Orders over $300 receive:
FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
FREE - USPS priority shipping
SKU: Mod-GRF-1-29-2mg Category:

Description

What is the Mod GRF (1-29) Peptide?

Mod GRF (1-29) is a synthetic peptide analog of growth hormone-releasing hormone (GHRH). It was first developed in the 1980s when studies revealed that the first 29 amino acids of GHRH possessed all of the biological roles associated with the full-length 44 residue protein.[1] The initially designed peptide, known as GRF (1-29), is the shortest segment of GHRH, which apparently have all the properties of the full-length hormone. A different truncated synthetic form of GHRH known as Sermorelin or GRF 1-29 also has 29 amino acids. Modified GRF (1-29) undergoes alteration to include four substituted amino groups in its chain. These amino modifications appear to protect the peptide from both oxidation and degradation during manufacture and transport and in vivo. The modification further appears to increase the peptide’s binding affinity to GHRH receptors. Though GRF happens to be biologically potent like GHRH, the duration of action is restricted due to a short half-life (less than 10 minutes). As a result, researchers have modified it to enhance its half-life with better therapeutic potential. Modified GRF (1-29) is also known as Mod GRF or tetra-substituted GRF (1-29). The latter name clarifies that the modified peptide differs from GRF (1-29) as a result of changes in four of its amino acids. Modified GRF (1-29) is identical to CJC-1295 without DAC.

Modified GRF 1-29 Specifications

AKA: Mod GRF (1-29)

Molecular Formula: C152H252N44O42

Molecular Weight: 3367.95 g/mol

Sequence: H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2

PubChem: CID 56841945

CAS Number: 863288-34-0

Reconstitution: Required

Research

Modified GRF appears to mediate the same biological effects as GHRH, including muscle growth (hypertrophy), improved bone development, enhanced lipolysis, accelerated metabolism, and wound healing. Researchers also report its potential to exhibit a positive influence on the immune system and blood sugar regulation.

Mod GRF (1-29) and Cardiac Function
Research in rodent models has observed that Modified GRF and other GHRH derivatives may improve the capacity of the heart to pump blood even after a heart attack.[2] The scientists reveal that “Various studies demonstrate that GHRH agonists promote repair of cardiac tissue, producing improvement of ejection fraction and reduction of infarct size in rats, reduction of infarct scar in swine, and attenuation of cardiac hypertrophy in mice, suggesting clinical applications.” This could be of immense potential in improving the quality of life and reducing death over the long term in patients diagnosed with cardiac failure. Modified GRF may be effective in treating pulmonary hypertension, cardiac failure, heart attack, and diverse congenital heart conditions, though research is ongoing.

Mod GRF (1-29) and the Intestine
Early studies suggested that growth hormone (GH) is beneficial for Crohn’s disease, short bowel syndrome, and other inflammatory bowel conditions. Unfortunately, the adverse effects of long-term use exceed the benefits of the hormone. Thus, researchers have looked into GHRH analogs for mediating a similar effect. Research in monkeys suggest that Mod GRF acts by binding with vasoactive intestinal peptide (VIP) receptors and therefore may improve bowel motility, as improved bowel movement is of crucial relevance in inflammatory bowel diseases associated with constipation.[3] The researchers report that “These results suggest that the substituted GRF analog, GRF-6, likely causes the diarrheal side-effects in monkeys by interacting with the VPAC(1)-R.” The peptide appears to interact with VIPC1, present on the smooth muscle of the reproductive, gastrointestinal as well as urinary systems. These conditions trigger a great deal of morbidity and are difficult to address due to the lack of alternative medicine options.[4]

Mod GRF (1-29) and Thyroid and Growth Hormones
Malfunctioning of the thyroid gland is often associated with concomitant issues in GH release. Studies focusing on patients suffering from hypothyroidism, treated the subjects with Modified GF to explore the above hypothesis. It has been observed that individuals who receive the thyroid replacement hormone demonstrate stronger reactions to GRF, proving a link between thyroid hormone and GH.[5] Thus, peptides like modified GRF may contribute towards a better understanding of human physiology. Modified GRF is reported to exhibit milder side effects, low oral bioavailability, and excellent subcutaneous bioavailability in mice.

References

  1. Wehrenberg WB, Ling N. In vivo biological potency of rat and human growth hormone-releasing factor and fragments of human growth hormone-releasing factor. Biochem Biophys Res Commun. 1983 Sep 15;115(2):525-30. doi: 10.1016/s0006-291x(83)80176-4. PMID: 6414471.
  2. Schally AV, Zhang X, Cai R, Hare JM, Granata R, Bartoli M. Actions and Potential Therapeutic Applications of Growth Hormone-Releasing Hormone Agonists. Endocrinology. 2019 Jul 1;160(7):1600-1612. doi: 10.1210/en.2019-00111. PMID: 31070727
  3. Ito T, Igarashi H, Pradhan TK, Hou W, Mantey SA, Taylor JE, Murphy WA, Coy DH, Jensen RT. GI side-effects of a possible therapeutic GRF analogue in monkeys are likely due to VIP receptor agonist activity. Peptides. 2001 Jul;22(7):1139-51. doi: 10.1016/s0196-9781(01)00436-3. PMID: 11445245.
  4. Waelbroeck M, Robberecht P, Coy DH, Camus JC, De Neef P, Christophe J. Interaction of growth hormone-releasing factor (GRF) and 14 GRF analogs with vasoactive intestinal peptide (VIP) receptors of rat pancreas. Discovery of (N-Ac-Tyr1,D-Phe2)-GRF(1-29)-NH2 as a VIP antagonist. Endocrinology. 1985 Jun;116(6):2643-9. doi: 10.1210/endo-116-6-2643. PMID: 2859987.
  5. Valcavi R, Jordan V, Dieguez C, John R, Manicardi E, Portioli I, Rodriguez-Arnao MD, Gomez-Pan A, Hall R, Scanlon MF. Growth hormone responses to GRF 1-29 in patients with primary hypothyroidism before and during replacement therapy with thyroxine. Clin Endocrinol (Oxf). 1986 Jun;24(6):693-8. doi: 10.1111/j.1365-2265.1986.tb01666.x. PMID: 3098458.
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Biotech Peptides

26 reviews for Mod GRF 1-29 (CJC-1295 no DAC) (2mg)

  1. Eric Wilson

    Best quality peptides

  2. Allie Thompson

    Up to now everything was good. Past orders were great and they have the best prices I’ve found

  3. Elliot Duffy

    Im simply leaving this review because Im impressed with the generosity of whoever it was that put together my order. I ordered 10 vials and was sent an extra 2 for free. Thank you.

  4. Liam Culhane

    The products are always shipped with the same secure packaging and professionally wrapped.

  5. Towers Greg

    I am very impressed with the stock of this company. Rarely have I seen something out of stock and even if it was, in max 2 days it got restocked. That’s what I love about this company. You never have to wait for anything for too long.

  6. Ana Snyder

    Have been ordering from Biotech for a few months now. have had 2 instances where I needed to call and update the order and another instance where the wrong product was sent. They sent the correct product and even gave a discount code for 20% for that one!

  7. Cesar Navarro

    i am in love with the packaging design. Compared to other companies, yours is a pleasure to look at

  8. Taylor Stophlet

    I appreciate their efficnecy and care with the peptides. Have ordered a few times and never had any broken or tarnished products yet.

  9. Alex Noren

    Love the blends. very effective way of testing more peptides at once

  10. Allen Detterman

    From A to Z, great customer service by their employees.

  11. Ellis Khan

    Just placed my first order. H’ave heard great things about this company, can’t wait to get my peptides in and test them out.

  12. Alexis Paytas

    I recommended Biotech to everyone who inquires about a reliable peptide site. Biotech employees are always answering their phones and emails when you need them and don’t play a long waiting game either. Staff has been very informative and helpful when ever I have had to make a call as well.

  13. Lexi Ward

    Always a pleasure doing busniess with them!

  14. sam oren

    Sent me free bac water even when I didnt meet the minimum buy and sent a disocunt code.

  15. Vinny Lopez

    Great customer service and overall experience. They even sent me two free Bac waters!

  16. Kristy Blake

    Both the peptides and the service were top-notch, and I couldn’t be more pleased.

  17. Toni Lee

    To my surprise, they’ll be able to ship it to my home country. Whenever I have a question, their CS is there and ready to answer all my questions. Customs were no problem, and it was all done safely.

  18. jarod buckley

    The abundance of peptides is something I like. There aren’t many bells and whistles, but it’s simple enough for me to navigate.They appear to have deals going on all year long, and they’d even emailed me promotional coupons. Vials arrive in excellent shape and the items seem to be of high quality.

  19. Vishnu Prasad

    Had an okay experience with them. I love their products, but I think they are the same as any other company.

  20. Kendal Bacher

    Best prices I’ve found.

  21. Hyran Garza

    I placed a big order and everything got to me intact in just a few days. I was not expecting delivery that fast!

  22. Raul Mancha jr

    Worth buying. Most other places have ridiculous prices but not here.

  23. NJ Leon

    Been with them for a while and products don’t disappoint. What can though is the wait for restocks at times, can take just a bit too long.

  24. Ric Cohen

    Everything you want from a good peptide supplier is here at biotech peptides.

  25. Ash Abbot

    My order arrived one day late due to some post office mix-up and they sent me a coupon code for 15% off my next order via email.

  26. Chase Burow

    This is my second time buying this and I am pretty sure not the last. Very good stuff

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