IGF-1 LR3 RECEPTOR GRADE SPECIFICATIONS
Molecular Weight: 9111 da
Sequence: MFPAMP LSSLF VNGPR TLCGA ELVDA LQFVC GDRGF YFNKP TGYGS SSRRA PQTGIV DECCFR SCDLRR LEMY CAPLK PAKSA
CAS Number: 946870-92-4
What is Receptor Grade IGF-1 LR3 peptide?
Receptor Grade IGF-1 LR3 peptide is a prime research reagent which is used in studies for cellular growth, IGF receptors and IGF binding proteins. It is more powerful than rH IGF-1 and Media Grade IGF-1 LR3 in-vitro because of the significant improvement in its biological activity (since it exhibits stronger affinity for the IGF receptor). This enhanced biological activity is the distinguishing factor between Receptor Grade IGF-1 LR3 and Media Grade (standard) IGF-1 LR3. Media grade IGF-1 LR3 is routinely used in commercial cell culture as compared to mammalian cell culture. It is also used as a research reagent (at an economical cost) for studies where biological potency is not crucial. Receptor Grade IGF-1 LR3 should be the reagent of choice to achieve optimum results when performing any animal study, in-vitro cell based assays as well as commercial production. Growth of mammalian cells in the presence of low concentrations of Long R3 IGF-1 results in better productivity as compared to standard concentrations of insulin and/or standard IGF-1. IGF-1 LR3 is more capable of inducing the type 1 IGF receptor and thereby promotes an elevated level of intracellular signaling, cellular proliferation and apoptosis inhibition.
Receptor Grade IGF-1 LR3 is therefore biologically more potent than standard IGF-1 LR3, in-vitro.
Hence, Receptor Grade IGF-1 LR3 is capable of delivering superior results in comparison to standard IGF-1 LR3.
IGFB Binding and the Increased Biological Activity of Long R3 IGF-1
IGF-1 LR3 peptide brings about a more pronounced effect than IGF-1 by resisting the association of IGFB. The prolonged duration of action helps to mediate the same biological effects while using smaller doses of the receptor. Certain IGF-1 derivatives, including the GPE derivative, comprising of only the last three N-terminal amino acids of the IGF-1 protein, have demonstrated therapeutic effects in neurological damages such as stroke. However, majority of the research aimed to unravel the effects of IGF-1 derivatives have been executed in non-human animal models or cell culture.
Insulin Like Growth Factor Receptor Interactions
IGF-1 interacts with at least two cell surface receptors: IGF-1 receptor (IGF-1R) and the insulin receptor. The IGF-1R is referred to as the “physiologic” receptor due to its significantly higher affinity (approximately 100 times higher) for IGF-1 as compared to the insulin receptor. Association of IGF-1 and IGF-1R leads to changes in metabolism, prevention of cell death (apoptosis), promotion of cell growth (hypertrophy), differentiation and cell division (hyperplasia), normal development, and even malignant growth. IGF-1R has been involved in diverse types of cancer such as prostate, breast, and lung cancer. IGF-1 also stimulates insulin receptor and activates it, thereby promoting the uptake of glucose from the bloodstream by cells. IGF-1 displays a three-fold influence on muscle cells. At the onset, IGF-1 promotes an increase in the number of muscle cells which is also known as hyperplasia. Secondly, IGF-1 strongly influences the life span of satellite cells of the skeletal muscles. Satellite cells provide nutritional support to muscle cells, thereby helping them to operate efficiently. IGF-1 thus helps to build muscle tissue by improving lifespan of these cells. Finally, IGF-1 promotes the differentiation of myoblasts. In other words, it encourages the commitment of stem cell progeny from non-specific pluripotent stem cells to dedicated muscle tissue. To conclude, IGF-1 improves muscle development by enhancing the rate at which generic stem cells are transformed into muscle cells.
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