PEG-MGF (Pegylated MGF) (5mg)

(31 customer reviews)


Discount per Quantity

5 - 95%$65.55
10 +10%$62.10
SKU: PEG-MGF-5mg Category:


What is PEG-MGF Peptide?

Pegylated Mechano-growth factor (PEG-MGF) is a truncated and partially modified variant of insulin-like growth factor 1 (IGF-1). It stimulates myoblast (muscle cell) proliferation and differentiation. It has further been explored in increasing endurance, stimulating the function of the immune system, and decreasing cholesterol and total body fat control. PEG-MGF also hastens wound healing by improving immune function related to healing.
Attachment of polyethylene glycol moiety to another chemical compound is termed pegylation. Pegylation increases the plasma stability of a compound like MGF by decreasing its clearance in the kidneys as well as masks its immunogenicity. Pegylation is thus a common, safe, and advantageous modification. MGF has a shorter half-life in blood, contrary to muscles. Hence, pegylation of the peptide overcomes its rapid clearance from the body.
Skeletal Muscle
PEG-MGF Research in Heart Muscle Repair
Bone Repair and Growth
Protecting Cartilage
Dental Applications
PEG-MGF Peptide and Potential Neuroprotective Effects


AKA: Pegylated MGF, Pegylated Mechano Growth Factor

Molecular Formula: C121H200N42O39

Molecular Weight: 2888.16 g/mol

Sequence: Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys

PubChem: SID 178101669

Reconstitution: Required

Peptide Research

Skeletal Muscle
Muscle injuries are frequent in sports and can range from strains and sprains to extreme avulsion injuries. Sometimes they require surgical intervention with a not-so-perfect outcome and prolonged recovery. Murine studies prove that direct injection of MGF in the muscles decreases pro-inflammatory hormone production, reduces oxidative stress, and protects the muscle cells.
Sun et al. also highlighted the regulation of muscle inflammation by MGF and the recruitment of neutrophils and macrophages to injury sites. The research mentioned above is based on prior reports of induction of IGF-1Ea and IGF-1Eb (both closely related to MGF) by exercise-induced muscle injury.
This receptor stimulation reduces aging, improves lean body mass, and better energy balance in humans. This function suggests that PEG-MGF can produce effects similar to IGF-1 leading to improved muscle repair, enhanced fat metabolism, and overall increases in lean body mass.
MGF increases mean muscle fiber size in exercising mice by about 25% when administered through the intramuscular route. Authors Goldspink and Jakeman consider it a concerning limitation as the peptide would require direct administration into every muscle to treat hypertrophy. The increased plasma stability of PEG-MGF resolves the challenge of multiple intramuscular injections.

PEG-MGF Research in Heart Muscle Repair
Research carried out in the department of bioengineering at the University of Illinois has observed that MGF inhibits hypoxia-induced programmed cell death of cardiac muscles. The peptide promotes regeneration and healing after a cardiac attack by recruiting cardiac stem cells to the site of tissue injury. Rats treated with MGF within eight hours of hypoxia suffered less cell death and greater stem cell recruitment compared to placebo controls. Dr. Doroudian, the lead author of the research, suggests that the nanorod-mediated MGF delivery to the damaged cardiac tissues provides localized, long-term therapy of the bioactive peptide to damaged tissues.
Localized delivery of MGF further controls pathologic hypertrophy post-cardiac arrest. Rats treated with PEG-MGF showed better hemodynamics and less cardiac remodeling than untreated ones. Carpenter et al. have also demonstrated a 35% approximate reduction of cardiomyocyte injury (post-heart attack) upon this peptide treatment.

Bone Repair and Growth
PEG-MGF has been observed to promote osteoblast proliferation and hasten bone repair in rabbits. Rabbits treated with high doses of MGF showed equivalent bone healing in just four weeks compared to controls in six weeks duration. The findings highlight the potential to use the peptide in faster bone healing in patients.

Protecting Cartilage
MGF can improve the function of chondrocytes, the cells essential for cartilage health and deposition. Studies in mice show that MGF promotes the migration of chondrocytes from bone, their site of origin, into cartilage where they function. PEG-MGF is suitable for this milieu because it could be injected into compromised joint spaces and remain for an extended duration. Theoretically, a single injection could be effective for weeks or even months compared to the limited duration of standard MGF in minutes or perhaps hours.

Dental Applications
Human periodontal ligament cell culture studies indicate that the pegylated peptide can improve osteogenic differentiation and enhance MMP-1 and MMP-2 expression. These factors improve the repair of the ligaments that attach the tooth to bone and provide alternatives to tooth extractions and implants. The peptide can even salvage damaged or avulsed teeth after they get surgically re-implanted.

PEG-MGF Peptide and Potential Neuroprotective Effects
Alexander Walker, Editorial Assistant at BioMed Central, has recently reviewed a study based on the long-term effects of elevated levels of MGF in the brain and central nervous system. The work reveals how increased MGF decreases the effects of age-related neuron degeneration. Thus the mice administered with the peptide maintain their cognitive ability and function optimally for long into old age. As per Walker, “the efficacy of MGF in the brain is age-dependent,” as the mice in the study had shown better outcomes initially and over the long-term, if the peptide overexpression occurred earlier in life.
MGF use improves muscle weakness and decreases the loss of motor neurons in murine models of ALS. According to Dluzniewska et al., it is naturally produced in the brain after hypoxic injury and is over-expressed in the segments with highest neuronal damage. External MGF administration can help to alleviate the impact of various neurological diseases. PEG-MGF exhibits minimal side effects, low oral bioavailability, and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not match up to humans.

All orders ship same day if placed by 2pm PST.  Synthesized and lyophilized in the USA.
This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law.  Only qualified and licensed professionals should handle these products.  Any information found on Biotech Peptides is strictly for educational purposes only.  Refer to our terms and conditions for more details.

Additional information


Biotech Peptides

31 reviews for PEG-MGF (Pegylated MGF) (5mg)

  1. Henry Reyes

    This is the only place I use for supplying peptides. The best prices and best quality on the market. Very pure and reliable

  2. Jerick Ray

    Excellent products and company

  3. Miles Simpson

    Just here to say thanks to the team at Biotech peptides. Ive purchased several of their peptides and trust me they’re effective!

  4. Jerick Ray

    Waiting on products to arrive. Shopping was easy and quick

  5. Ariana Malik

    returning customer here, company is quick easy and reliable. love it.

  6. Anthony Holland

    Exceptional products. The peptides here speak for themselves. 100% satisfied.

  7. Stephenie Smith

    Would love it if you guys supplied lab equipment as well

  8. Paul Khrab

    It’s a good company, nice employees

  9. Amelia Diaz

    Este producto vale absolutamente cada dólar.

  10. Shelley Miller

    I’ve been shopping around for a good peptide company for a while now and I think I found it! Good quality products, good customer service, timely shipping, and better value than most other companies.

  11. Wendell Shultz

    Highly thoughtful company

  12. Shuming Qian

    We just receently switched over to use Biotech peptides as our product source in August of 2021. They have been nothing but resourcful and always have what we need in stock. I have had to call customer service before in order to correct orders or to add on. We order in bulk quite frequently and they have never been late or delayed the process. They have even set up a discount code for us as we make a few purchases a month.

  13. Inga Moiseeva

    I have to make dozens of orders a week. So I have dealth with my fair share of business. Biotech is the easiest company to deal with. No nonsence, stright to the point if I’m ever emailing or calling to fix an order or if something went wrong.

  14. Liz Cholertin Liz Cholertin

    I highly recommend getting your products here. The quality is great and simple to use

  15. Remy H

    Super easy to get in contact with. I noticed they charged me twice after I placed my order. Danny was the guy I was emailing with and they fixed that up right away. I guess I didn’t allow the payment to go through and clicked twice so system miscalculated. Glad it didn’t take too much time out of my day.

  16. Tobias Kerr

    I was a little upset due to my order coming in completly ruined. You can tell the peptides we bad due to the heat. I’m based in Arizona so maybe during the trip from the peptide facility to my lab something went wrong. Nevertheless, I had a deadline and unfortunatly I can’t meet it. I called to let them know what happened and they offered to resend the products and give me a discount code for the next buy. I just wish they had some sort of cooling method in the package to help keep the tempurture where it should be.

  17. Hanna Byrne

    The peptides exceeded my expectations! By far top 3 peptides sources for me.

  18. Diana Donovan

    Always sending promotionals and here and there I have got samples of different products!!!

  19. Harris Chase

    Thanks for working with me and sending me a new batch of peptides when they arrived broken. Major props for getting it to me overnight!

  20. mikle white

    I would love to see more stacks, more diverse ones. Other than that everything is near to perfect

  21. Jay Quinn

    Never purchased better products anywhere. Hight quality peptides right here

  22. ANDI B.

    Process was as easy as possible! My expectations were exceeded, the merchandise arrived earlier than planned, and I am delighted with the outcomes.

  23. dave goodman

    Whether by accident or design, a Q&A area on your website or even live assistance sessions would be very appreciated. CS may find it difficult to respond to so many inquiries, and other individuals may prefer to handle their issues in writing than than by the phone

  24. Axel Gutnab

    Peptides are amazing for the listed price.

  25. Andrew Monesi

    I called their customer service and they were nice enough to explain to me the difference between Peg-MGF and just MGF. Very knowledgeable staff.

  26. Racha Kabbani

    I recently discovered you guys and I placed my first order. I am very excited to start working on my project with these! Will be back with an update

  27. Jeremy Hill

    5/5 stars

  28. Boris M.

    Had a lot of questions about the MGF vs. PegMGF and they helped a lot with a bunch of info and also referred me to their blog where they have a load of useful data

  29. Evan Dixon

    I have been conducting research on this product for a really long time now and all I can say is that it is worth the price. My research on healing as well is moving forward and passing my expectations.I am way ahead of schedule since the peptides are fantastic in quality and don’t weaken my research.

  30. Mitch DiCecco

    The MGF and Peg-MGF you buy from here are unmatched. I know because I tried using this peptide from 4 other companies and they failed, some mildly, others horribly. This is very stable.

  31. Parker Bullard

    Lately I have only been looking at peptides here and buying from here as well. Others are usually lacking in supplies.

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