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PEG-MGF (Pegylated MGF) (5mg)

PEG-MGF (Pegylated MGF) (5mg)

(32 customer reviews)

$79.00

PEG-MGF (Pegylated MGF) peptides are Synthesized and Lyophilized in the USA.

Discount per Quantity

Quantity 5 - 910 +
Discount 5%10%
Price $75.05$71.10
Orders over $200 receive:
FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
FREE - USPS priority shipping
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SKU: PEG-MGF-5mg Category:

Description

What is the PEG-MGF peptide?

Pegylated Mechano-growth factor (PEG-MGF) is a truncated and partially modified variant of insulin-like growth factor 1 (IGF-1). It appears to stimulate myoblast (muscle cell) proliferation and differentiation. It has further been researched for its potential to increase endurance, stimulating the function of the immune system, and decreasing cholesterol and total body fat control. PEG-MGF may also hasten wound healing via immune function regulation. Attachment of polyethylene glycol moiety to another chemical compound is termed “Pegylation”. Pegylation appears to increase the plasma stability of a compound like MGF by decreasing its clearance in the kidneys as well as potentially masking its immunogenicity. Pegylation may be considered a common, and typically advantageous modification. MGF appears to have a shorter half-life in blood, contrarily in muscles. Hence, the pegylation of the peptide may overcome its rapid clearance from the body.

Specifications

AKA: Pegylated MGF, Pegylated Mechano Growth Factor

Molecular Formula: C121H200N42O39

Molecular Weight: 2888.16 g/mol

Sequence: Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys

PubChem: SID 178101669

Reconstitution: Required

PEG-MGF Research

PEG-MGF and Skeletal Muscle
Muscle injuries are frequent in sports and can range from strains and sprains to extreme avulsion injuries. Sometimes they require surgical intervention with a not-so-perfect outcome and prolonged recovery. Murine studies suggest that direct adminstration of MGF in the muscles may decrease pro-inflammatory hormone production, reduce oxidative stress, and protect the muscle cells.[1] The scientists reveal that “Although MGF overexpression did not obviously affect muscle regeneration outcomes, the findings are novel and provide insights on the physiological roles of MGF in muscle regeneration.” Researchers Sun et al. also suggested that muscle inflammation may be regulated by MGF, as well as the recruitment of neutrophils and macrophages to injury sites. The research mentioned above is based on prior reports of induction of IGF-1Ea and IGF-1Eb (both closely related to MGF) by exercise-induced muscle injury. This receptor stimulation may reduce aging, improve lean body mass, and better energy balance in humans. This function suggests that PEG-MGF can produce effects similar to IGF-1 leading to improved muscle repair, enhanced fat metabolism, and overall increases in lean body mass. A research experiment in MGF reported an increase mean muscle fiber size in exercising mice by about 25% when administered through the intramuscular route. Researchers Goldspink and Jakeman considered it a concerning limitation as the peptide might require direct administration into every muscle to treat hypertrophy.[2] The increased plasma stability of PEG-MGF could potentially resolve the challenge of multiple intramuscular injections.

PEG-MGF and Heart Muscle Repair
Research carried out in the department of bioengineering at the University of Illinois observed that MGF may inhibit hypoxia-induced programmed cell death of cardiac muscles.[3] The peptide appears to promote regeneration and healing after a cardiac attack by recruiting cardiac stem cells to the site of tissue injury. Rats treated with MGF within eight hours of hypoxia appeared to sugger less cell death and greater stem cell recruitment compared to placebo controls. Dr. Doroudian, the lead author of the research, suggests that the nanorod-mediated MGF delivery to the damaged cardiac tissues provides localized, long-term therapy of the bioactive peptide to damaged tissues.
Localized delivery of MGF may further controls pathologic hypertrophy post-cardiac arrest. Rats treated with PEG-MGF appeared to exhibit better hemodynamics and less cardiac remodeling than untreated ones. Carpenter et al. have also reported a 35% approximate reduction of cardiomyocyte injury (post-heart attack) upon this peptide treatment.

PEG-MGF and Bone Repair, Growth
PEG-MGF has been observed to promote osteoblast proliferation and hasten bone repair in rabbits. Rabbits treated with high doses of MGF appeared to exhibit equivalent bone healing in just four weeks compared to controls in six weeks duration. The findings highlight the potential to use the peptide in faster bone healing in patients.

PEG-MGF and Cartilage
MGF may also improve the function of chondrocytes, the cells essential for cartilage health and deposition. Studies in mice suggest that MGF promotes the migration of chondrocytes from bone – their site of origin – into cartilage where they appear to function.[4] The researchers also noted that “The results also demonstrate that the degeneration of OA cartilage can be delayed by MGF treatment partially via unfolded protein response regulated by protein kinase RNA-like endoplasmic reticulum kinase and suggest a potential therapeutic application of MGF for OA treatment.” PEG-MGF is suitable for this milieu because it may be administered into compromised joint spaces and remain for an extended duration. Theoretically, a single administration could be effective for weeks or even months compared to the limited duration of standard MGF in minutes or perhaps hours.

PEG-MGF and Dental Applications
Human periodontal ligament cell culture studies indicate that the pegylated peptide may be able to improve osteogenic differentiation and enhance MMP-1 and MMP-2 expression.[5] These factors improve the repair of the ligaments that attach the tooth to bone and provide alternatives to tooth extractions and implants. The peptide may even salvage damaged or avulsed teeth after they get surgically re-implanted.

PEG-MGF and Neuroprotection
Alexander Walker, Editorial Assistant at BioMed Central, has reviewed a study based on the long-term effects of elevated levels of MGF in the brain and central nervous system.[6] The work observes how increased MGF apparently decreases the effects of age-related neuron degeneration. Mice administered with the peptide appeared to maintain their cognitive ability and function optimally for long into old age. As per Walker, “the efficacy of MGF in the brain is age-dependent,” as the mice in the study had shown better outcomes initially and over the long-term, if the peptide over-expression occurred earlier in life. MGF use may improve muscle weakness and decrease the loss of motor neurons in murine models of ALS. According to Dluzniewska et al., it is naturally produced in the brain after hypoxic injury and is over-expressed in the segments with highest neuronal damage.[7] External MGF administration may help to alleviate the impact of various neurological diseases. Experimental research reports that PEG-MGF appears to exhibit minimal side effects, low oral bioavailability, and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not match up to humans.

References

  1. Sun KT, Cheung KK, Au SWN, Yeung SS, Yeung EW. Overexpression of Mechano-Growth Factor Modulates Inflammatory Cytokine Expression and Macrophage Resolution in Skeletal Muscle Injury. Front Physiol. 2018 Jul 26;9:999. doi: 10.3389/fphys.2018.00999. PMID: 30140235; PMCID: PMC6094977.
  2. Goldspink G. Research on mechano growth factor: its potential for optimising physical training as well as misuse in doping. Br J Sports Med. 2005 Nov;39(11):787-8; discussion 787-8. doi: 10.1136/bjsm.2004.015826. PMID: 16244184; PMCID: PMC1725070.
  3. Carpenter V, Matthews K, Devlin G, Stuart S, Jensen J, Conaglen J, Jeanplong F, Goldspink P, Yang SY, Goldspink G, Bass J, McMahon C. Mechano-growth factor reduces loss of cardiac function in acute myocardial infarction. Heart Lung Circ. 2008 Feb;17(1):33-9. doi: 10.1016/j.hlc.2007.04.013. Epub 2007 Jun 19. PMID: 17581790.
  4. Song Y, Xu K, Yu C, Dong L, Chen P, Lv Y, Chiang MYM, Li L, Liu W, Yang L. The use of mechano growth factor to prevent cartilage degeneration in knee osteoarthritis. J Tissue Eng Regen Med. 2018 Mar;12(3):738-749. doi: 10.1002/term.2493. Epub 2017 Oct 6. PMID: 28599103.
  5. Chen JT, Wang Y, Zhou ZF, Wei KW. [Mechano-growth factor regulated cyclic stretch-induced osteogenic differentiation and MMP-1, MMP-2 expression in human periodontal ligament cells by activating the MEK/ERK1/2 pathway]. Shanghai Kou Qiang Yi Xue. 2019 Feb;28(1):6-12. Chinese. PMID: 31080992.
  6. Tang JJ, Podratz JL, Lange M, Scrable HJ, Jang MH, Windebank AJ. Mechano growth factor, a splice variant of IGF-1, promotes neurogenesis in the aging mouse brain. Mol Brain. 2017 Jul 7;10(1):23. doi: 10.1186/s13041-017-0304-0. PMID: 28683812; PMCID: PMC5501366.
  7. Dluzniewska J, Sarnowska A, Beresewicz M, Johnson I, Srai SK, Ramesh B, Goldspink G, Górecki DC, Zabłocka B. A strong neuroprotective effect of the autonomous C-terminal peptide of IGF-1 Ec (MGF) in brain ischemia. FASEB J. 2005 Nov;19(13):1896-8. doi: 10.1096/fj.05-3786fje. Epub 2005 Sep 6. PMID: 16144956.
All orders ship same day if placed by 12 PST.
This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law.  Only qualified and licensed professionals should handle these products.  Any information found on Biotech Peptides is strictly for educational purposes only.  Refer to our terms and conditions for more details.

Additional information

Brand

Biotech Peptides

32 reviews for PEG-MGF (Pegylated MGF) (5mg)

  1. Henry Reyes –

    This is the only place I use for supplying peptides. The best prices and best quality on the market. Very pure and reliable

  2. Jerick Ray –

    Excellent products and company

  3. Miles Simpson –

    Just here to say thanks to the team at Biotech peptides. Ive purchased several of their peptides and trust me they’re effective!

  4. Jerick Ray –

    Waiting on products to arrive. Shopping was easy and quick

  5. Ariana Malik –

    returning customer here, company is quick easy and reliable. love it.

  6. Anthony Holland –

    Exceptional products. The peptides here speak for themselves. 100% satisfied.

  7. Stephenie Smith –

    Would love it if you guys supplied lab equipment as well

  8. Paul Khrab –

    It’s a good company, nice employees

  9. Amelia Diaz –

    Este producto vale absolutamente cada dólar.

  10. Shelley Miller –

    I’ve been shopping around for a good peptide company for a while now and I think I found it! Good quality products, good customer service, timely shipping, and better value than most other companies.

  11. Wendell Shultz –

    Highly thoughtful company

  12. Shuming Qian –

    We just receently switched over to use Biotech peptides as our product source in August of 2021. They have been nothing but resourcful and always have what we need in stock. I have had to call customer service before in order to correct orders or to add on. We order in bulk quite frequently and they have never been late or delayed the process. They have even set up a discount code for us as we make a few purchases a month.

  13. Inga Moiseeva –

    I have to make dozens of orders a week. So I have dealth with my fair share of business. Biotech is the easiest company to deal with. No nonsence, stright to the point if I’m ever emailing or calling to fix an order or if something went wrong.

  14. Liz Cholertin Liz Cholertin –

    I highly recommend getting your products here. The quality is great and simple to use

  15. Remy H –

    Super easy to get in contact with. I noticed they charged me twice after I placed my order. Danny was the guy I was emailing with and they fixed that up right away. I guess I didn’t allow the payment to go through and clicked twice so system miscalculated. Glad it didn’t take too much time out of my day.

  16. Tobias Kerr –

    I was a little upset due to my order coming in completly ruined. You can tell the peptides we bad due to the heat. I’m based in Arizona so maybe during the trip from the peptide facility to my lab something went wrong. Nevertheless, I had a deadline and unfortunatly I can’t meet it. I called to let them know what happened and they offered to resend the products and give me a discount code for the next buy. I just wish they had some sort of cooling method in the package to help keep the tempurture where it should be.

  17. Hanna Byrne –

    The peptides exceeded my expectations! By far top 3 peptides sources for me.

  18. Diana Donovan –

    Always sending promotionals and here and there I have got samples of different products!!!

  19. Harris Chase –

    Thanks for working with me and sending me a new batch of peptides when they arrived broken. Major props for getting it to me overnight!

  20. mikle white –

    I would love to see more stacks, more diverse ones. Other than that everything is near to perfect

  21. Jay Quinn –

    Never purchased better products anywhere. Hight quality peptides right here

  22. ANDI B. –

    Process was as easy as possible! My expectations were exceeded, the merchandise arrived earlier than planned, and I am delighted with the outcomes.

  23. dave goodman –

    Whether by accident or design, a Q&A area on your website or even live assistance sessions would be very appreciated. CS may find it difficult to respond to so many inquiries, and other individuals may prefer to handle their issues in writing than than by the phone

  24. Axel Gutnab –

    Peptides are amazing for the listed price.

  25. Andrew Monesi –

    I called their customer service and they were nice enough to explain to me the difference between Peg-MGF and just MGF. Very knowledgeable staff.

  26. Racha Kabbani –

    I recently discovered you guys and I placed my first order. I am very excited to start working on my project with these! Will be back with an update

  27. Jeremy Hill –

    5/5 stars

  28. Boris M. –

    Had a lot of questions about the MGF vs. PegMGF and they helped a lot with a bunch of info and also referred me to their blog where they have a load of useful data

  29. Evan Dixon –

    I have been conducting research on this product for a really long time now and all I can say is that it is worth the price. My research on healing as well is moving forward and passing my expectations.I am way ahead of schedule since the peptides are fantastic in quality and don’t weaken my research.

  30. Mitch DiCecco –

    The MGF and Peg-MGF you buy from here are unmatched. I know because I tried using this peptide from 4 other companies and they failed, some mildly, others horribly. This is very stable.

  31. Parker Bullard –

    Lately I have only been looking at peptides here and buying from here as well. Others are usually lacking in supplies.

  32. Bradley Bankuti –

    Very good experience with this website so far. Orders have been quick to ship and issues have always been resolved quickly

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