Receptor Grade IGF-1 LR3 (1mg)

(27 customer reviews)


IGF-1 LR3 peptides are Synthesized and Lyophilized in the USA.

Discount per Quantity

Quantity 5 - 910 +
Discount 5%10%
Price $94.05$89.10
Orders over $200 receive:
FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
FREE - USPS priority shipping
SKU: IGF-1-LR3-1mg Category:


What is the Receptor Grade IGF-1 LR3 Peptide?

Receptor Grade IGF-1 LR3 is an altered variant of insulin-like growth factor-1; the complete name of the peptide is insulin-like growth factor-1 long arginine 3. IGF-1 derivatives have played important roles in research studies on cell proliferation, cell division, and cell-to-cell communication. Despite showing physiological effects similar to the parent protein, Receptor Grade IGF-1 LR3 does not interact with IGF binding proteins as strongly as IGF-1. Hence, it appears to stay in the bloodstream for longer durations (about 120 times longer) as compared to native IGF-1. The structural modifications in IGF-1 LR3 may have contributed to its increased half-life in the blood. The peptide is created by the inclusion of 13 amino acids to the N-terminus of native IGF-1 and by replacing the glutamic acid at position 3 to arginine.[1]


Molecular Formula: C400H625N111O115S9

Molecular Weight: 9117.60 g/mol


CAS Number: 946870-92-4

Reconstitution: Required

Receptor Grade IGF-1 LR3 Research

Receptor Grade IGF-1 LR3 and Cell Division
Like IGF-1, research suggests that Receptor Grade IGF-1 LR3 may act as a stimulus for cell division and proliferation, primarily affecting connective tissues of the muscle and bone and cell division in the liver, kidney, skin, lung, nerve, and blood tissues. IGF-1 is best considered to be a maturation hormone because of its apparent influence in cell proliferation, differentiation, and maturation, helping them to carry out their specialized functions. The longer life span of Receptor Grade IGF-1 LR3 in the blood makes it a more potent molecule as compared to IGF-1. A single dose of Receptor Grade IGF-1 LR3 appears to provide about three times as much cellular activation compared to a similar dose of IGF-1.[2] Researchers report that “The response with LR3IGF-I was particularly striking because this peptide binds 3-fold less well than IGF-I to the type 1 IGF receptor.“ It is important to remember that IGF-1 LR3 peptide and every IGF-1 derivative have not been observed to mediate cellular enlargement (hypertrophy), and instead may participate in cell division and proliferation (hyperplasia). For instance, in the case of muscle, studies suggest Receptor Grade IGF-1 LR3 would not cause enlargement of muscle cells, rather simply increasing the total number of muscle cells.

Receptor Grade IGF-1 LR3 and Myostatin
Myostatin (also known as growth differentiation factor 8) is a muscle protein that primarily suppresses the growth and differentiation of muscle cells. Myostatin is, thus crucial in protection from unregulated hypertrophy and proper healing post-injury. However, some situations that demand inhibition of myosin. Blocking of myosin can be helpful in conditions like Duchenne Muscular Dystrophy (DMD) or in people who suffer from loss of muscle due to prolonged immobility. In such cases, blocking the natural enzyme could help slow down muscle breakdown, maintain strength, and avoid morbidity. Studies conducted in mouse models of DMD have suggested that Receptor Grade IGF-1 LR3 and other IGF-1 derivatives may overcome the adverse effects of Myostatin to protect muscle cells and prevent apoptosis.[3] The scientists note that “results together suggest that myostatin suppresses both basal and IGF-1-stimulated proliferation of both WAT and BAT preadipocytes, actions that are again similar to those in muscle satellite cells”. Receptor Grade IGF-1 LR3, due to its long stability, may be effective in counteracting Myostatin by activating MyoD, a muscle protein that is normally triggered by exercise (e.g., weight lifting).

Receptor Grade IGF-1 LR3 and Metabolism, Diabetes
Researchers suggest that Receptor Grade IGF-1 LR3 indirectly boosts fat burning by associating with the IGF-1R receptor and the insulin receptor. These interactions may improve glucose uptake from the blood by muscle, nerve, and liver cells. This potential would result in an overall reduction in blood sugar levels, which then trigger adipose tissue as well as the liver to initiate catabolism of glycogen and triglycerides. Overall, this leads to a decrease in adipose tissue and net energy consumption (i.e. net catabolism). Given its role in controlling blood sugar levels, Receptor Grade IGF-1 LR3 may reduce insulin levels and the need for exogenous insulin in diabetes.  In a majority of the patients, this brings about a 10% reduction in insulin requirements to maintain the same blood sugar levels.[4] Receptor Grade IGF-1 LR3 thus helps understand insulin regulation in patients with decreased insulin sensitivity. It also highlights possible ways to prevent type 2 diabetes.

Receptor Grade IGF-1 LR3 and Longevity Research
Studies observe that Receptor Grade IGF-1 LR3 may promote tissue repair and upkeep of the body, making it a protective molecule against cellular damage and the effects of aging. Research in cows and pigs indicate that Receptor Grade IGF-1 LR3 administration may overcome the effects of aging, prolong life and reduce disability. Ongoing research in mice has focused on the potential of Receptor Grade IGF-1 LR3 in preventing the progression of a wide range of conditions such as muscle atrophy, dementia, and kidney disease.[5]

Receptor Grade IGF-1 LR3 and Glucocorticoid Signaling
Glucocorticoids, produced essentially from the adrenal glands, also act as important clinical medications which help to control pain and decrease inflammation in autoimmune diseases, cancer, and neurological injuries, to name a few. However, glucocorticoids have numerous undesirable side effects, such as muscle wasting, fat gain, and deterioration of bone density. Thus, Receptor Grade IGF-1 LR3 is being explored as an option to reduce the side effects of glucocorticoids and thereby mediate a more effective therapy. Studies have shown minimal to moderate side effects, low oral bioavailability, and excellent subcutaneous bioavailability in mice.[6] Per kg dosage in mice does not scale up to the dosage which can be required for humans.



  1. Assefa B, Mahmoud AM, Pfeiffer AFH, Birkenfeld AL, Spranger J, Arafat AM. Insulin-Like Growth Factor (IGF) Binding Protein-2, Independently of IGF-1, Induces GLUT-4 Translocation and Glucose Uptake in 3T3-L1 Adipocytes. Oxid Med Cell Longev. 2017;2017:3035184. doi: 10.1155/2017/3035184. Epub 2017 Dec 20. PMID: 29422987; PMCID: PMC5750484.
  2. Tomas FM, Knowles SE, Owens PC, Chandler CS, Francis GL, Read LC, Ballard FJ. Insulin-like growth factor-I (IGF-I) and especially IGF-I variants are anabolic in dexamethasone-treated rats. Biochem J. 1992 Feb 15;282 ( Pt 1)(Pt 1):91-7. doi: 10.1042/bj2820091. PMID: 1371669; PMCID: PMC1130894.
  3. Li N, Yang Q, Walker RG, Thompson TB, Du M, Rodgers BD. Myostatin Attenuation In Vivo Reduces Adiposity, but Activates Adipogenesis. Endocrinology. 2016 Jan;157(1):282-91. doi: 10.1210/en.2015-1546. Epub 2015 Nov 18. PMID: 26580671; PMCID: PMC4701895.
  4. Bailes J, Soloviev M. Insulin-Like Growth Factor-1 (IGF-1) and Its Monitoring in Medical Diagnostic and in Sports. Biomolecules. 2021 Feb 4;11(2):217. doi: 10.3390/biom11020217. PMID: 33557137; PMCID: PMC7913862.
  5. AsghariHanjani N, Vafa M. The role of IGF-1 in obesity, cardiovascular disease, and cancer. Med J Islam Repub Iran. 2019 Jun 17;33:56. doi: 10.34171/mjiri.33.56. PMID: 31456980; PMCID: PMC6708115.
  6. Philippou A, Barton ER. Optimizing IGF-I for skeletal muscle therapeutics. Growth Horm IGF Res. 2014 Oct;24(5):157-63. doi: 10.1016/j.ghir.2014.06.003. Epub 2014 Jun 19. PMID: 25002025; PMCID: PMC4665094.
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This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law.  Only qualified and licensed professionals should handle these products.  Any information found on Biotech Peptides is strictly for educational purposes only.  Refer to our terms and conditions for more details.

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Biotech Peptides

27 reviews for Receptor Grade IGF-1 LR3 (1mg)

  1. Emma Martin

    Very qualitative products

  2. Scarlett Rivera

    Always satisfied with the products, service and shopping platform

  3. Elliot Duffy

    Quality products and fast delivery. Can’t really ask for more

  4. A. Jimenez

    Fast and accurate service with the best and very competitive prices.

  5. Lydia Sullivan

    Would love it if you guys advertised more deals or sales!

  6. Rolf Steiner

    Fast delivery, excellent product

  7. Larry Ray Reed

    Your packaging is neat and gets the job done. Peptides came in safe and sound.

  8. Aki Kadomatsu

    They take a lot of my companies peptide budget!

  9. Sonia Pierce

    I wish I knew about peptides earlier. I’m relatively new to this area of research, but it has held up my interest tremendously and I thank BP for always making themselves available to answer my questions and teach me all I need to know

  10. Kat Creedon

    They sometimes take a while to respond to emails, but always do eventually. Aside from that, no criticism whatsoever

  11. Sarah Yan

    This product gives great feedback in my experiments. Also great shipping times, was worried that the shipping would take longer or they would take longer to ship the products out but does not seem like it.

  12. Mai Yang

    Have always had a good experience with them. Peptides are consistently top quality and I do notice a change in my research results.

  13. Emmit Coddy

    Was browsing their page and saw they had a pretty good easter promotion! Love myself a deal.

  14. Will Jacobs


  15. Andy Vale

    Customer service is as good as I have been hearing. I had an issue with my order. It seems like they missed a peptide order and sent me double of one of the others. I emailed them but decided it might be a good time to see if I can get a hold of them via telephone. Low and be hold I got in contact with someone right away. I explained to them that i got my order and everything is in. good condition but that they sent me double of one order and forgot about the other completely. I waited on hold for maybe 2 minutes and they came back informing me that they just placed a free order now to be sent over night. Told me to keep the extra that they sent over as well. After we hung up I was surprised to see that they even sent a discount code for my next order.

  16. Alisa Rodrigez

    Ofrecen tantos códigos de descuento y realmente ayuda con un pedido grande. Gracias BP

  17. Annie Haas

    They have blog posts describing every item they now sell. Love this as a quick way of brushing up my information on peptides I don’t know much about.

  18. denny wolfe

    Fantastic business. Vials were all in good condition and looked like their pictures.

  19. Felix Peters

    Great things have happened to me throughout my time working with Biotech. First time I’ve ordered anything from them. Yes, I think they’d benefit from a new package design.

  20. Richard Dail

    My stuff arrived to me in a damaged state! Contacted them and got on the line with Jamie. They were able to handle the situation and had a new batch of peptides ready to be shipped out for me. I couldn’t be happier with both the peptides and the service.

  21. Jen Mones

    I’ve never seen anything run out of stock, and even if it did, it was refilled in no more than two days at most. There’s hardly a lengthy wait for anything here.

  22. Aaron Alrich

    1000/10 for this company.

  23. Bran Schmitz

    They have so many peptides that you don’t even have to visit multiple sites for all you need. You can buy it all from here.

  24. Kay Watts

    Research is better since using BP

  25. Vee Fragoso

    Was looking for a new peptide site and found you guys. Ecstatic about the prices! Most places are costing way too much now and you guys are one of the only few places that have reasonable prices.

  26. Travis Wayne

    I will not buy from any other company, Biotech has all my necessary peptide here and they get them out faster than any peptide company I have used in the past.

  27. Andre Callender

    Amazing restock schedule. Never saw them out of stock for products I needed

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