MGF (Mechano-Growth Factor) (5mg)

(28 customer reviews)


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Quantity5 - 910 +
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FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
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SKU: MGF-5mg Category:



AKA: Mechano-Growth Factor

Molecular Formula: C124H204N42O41S1

Molecular Weight: 2971.99 g/mol

Sequence: yr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys-Cys

Reconstitution: Required

What is MGF Peptide?

Mechano-growth factor (MGF) is an alternative name for the insulin-like growth factor-1Eb (IGF-1Eb) isoform of IGF-1. It plays a significant role in the remodeling of muscles, cellular survival, and cellular proliferation. New studies on this specific isoform highlight its role in activating satellite cells in skeletal muscle, suggesting that this particular isoform can also activate satellite cells in skeletal muscle, protect neurons, and helps to overcome the age-related loss of muscle mass.
The principal function of MGF is to promote the repair of severe muscle wear and tear, especially that caused by injury or exercise. The peptide levels increase significantly after muscle injury. Further, its concentration also corresponds with skeletal muscle growth and differentiation as found in rodent models.

MGD Peptide effects

1. Mechano-Growth Factor and Inflammation
Inflammatory cells such as macrophages and the specific signaling molecules released to bring about muscle regeneration. Macrophages have been observed to produce MGF in the backdrop of muscle inflammation. IGF-1Ea (MGF) not only exhibits anti-inflammatory effects but also extends the life of macrophages. The specific relevance of this effect is hitherto known, but it is speculated that the use of external MGF can improve the rate of muscle cell healing through macrophage modulation.

2. MGF Levels Affected by Age
IGF-1 has multiple variants, and the synthesis of these isoforms gets influenced by different factors. The spicing and formation of different splice variants of IGF-1 are affected by developmental factors, hormones like growth and steroid hormones, and age. Age, in particular, is a crucial deciding factor for the regulation of IGF-1 splicing. The predominant variants in young men are class 1 and class 2, whereas elderly people show prevalence of class 1Ea. The switch in the predominant splice variant acts as a relevant starting point and helps to understand the biology of aging better. The overall significance of this change in terms of obvious signs of aging isn’t clear, but it offers an experimental starting point for understanding better the aging process. It has been suggested that MGF can reduce the loss of muscles with age progression though an in-depth study is essential.

3. Mechano-Growth Factor and Cardiac Cells
The peptide was found to protect cardiac muscles from ischemia in sheep models of myocardial infarction (heart attack). The work found a 35% decrease in cardiomyocyte compromise after MGF was used following cardiac arrest. This finding is of great relevance as minimal medical interventions could alleviate the impact of a heart attack while it was still occurring. The use of MGF is a simple and safe alternative compared to stents or clot-dissolving drugs that have far-reaching complications. The molecule has opened up a new approach to the treatment of acute myocardial infarction. It reduces the impact of the heart attack by one-third when given to first responders. The peptide has the potential for improved benefits since heart attack is the highest cause of adult deaths in developed countries worldwide.

4. MGF Research, Muscle Growth, and Optimized Physical Training
MGF promotes hypertrophy and repair of muscle by stimulating muscle stem cells (called satellite cells). Research in murine models show a 25% increase in the size of mean muscle fiber following intramuscular MGF injection for three weeks. The peptide is speculated to improve muscle conditions in degenerative diseases and stimulate the benefits of exercise on muscles. The latter speculation stems from the underlying importance of muscle mass in baseline metabolism. Boosting muscle mass improves basal metabolism and aids in fat burning. Thus the ability to increase lean body mass helps combat serious issues like obesity and allied health hazards.
Duchenne muscular dystrophy (DMD), a severe degenerative muscular disease, is often treated by transplanting precursors of muscle cells (called myogenic precursor cells). The transplantation helps to improve dystrophin production and ameliorates the disease conditions. Unfortunately, low survival rates post-transplant have never made the procedure therapeutically viable. Mouse studies have shown that MGF helps survive the precursor cells, thus making the transplantation successful. Therefore the use of the peptide could become the main choice of DMD treatment alongside transplantation and not just a niche alternative.

5. MGF in Brain Development and Neuron Health
Studies on the brains of developing mice have shown the presence of MGF as early as 2010. The study sheds light on the neuroprotective role of the peptide. MGF is overexpressed in hypoxic brains of rats in the regions of the brain which undergo neuron regeneration. The influence of the peptide on neuron health was evident from the murine model of ALS (Lou Gehrig’s Disease). ALS leads to loss of motor neurons and overall progressive body of weakness. Treatment with MGF improves both the symptoms mentioned above. MGF has been found to be better than other IGF-1 isoforms in the regeneration of regions of adult brains after global ischemia. MGF thus shows potential to be used in the treatment of ALS.

6. Mechano-Growth Factor and Cartilage
Cartilage, one of the most crucial connective tissues of our body, can get damaged due to injury, the repeated strain on a joint (osteoarthritis), or inflammatory conditions (e.g., rheumatoid arthritis). Unfortunately, cartilage does not recover well for various reasons, including inadequate blood supply and a lack of stem cells necessary for significant tissue regeneration. Studies have shown MGF to be capable of helping in more effective cartilage regeneration.
MGF promotes the survival of chondrocytes (primarily involved in cartilage health and recovery) following mechanical stimuli. In the backdrop of physical stress and damage to the cartilage tissue, MGF boosts the survival and migration of chondrocytes (via YAP signaling and other pathways) to injury sites. The chondrocyte movement helps in better cartilage repair and restoration of function.
The peptide has been observed to be both therapeutic and effective in preventing injury and disability over a long time span. Overloading chondrocytes causes apoptosis leading to disc degeneration in the human spine under continued mechanical stress in the spine. MGF can help to inhibit the apoptosis of these cells, inhibiting disc degeneration of the spine. The use of the molecule as a supplement against spinal disc degeneration is an area of active study.

Mechano-Growth Factor Research Direction

MGF has been observed to promote the protection of neurons and muscles as well as cartilage regeneration and hence holds a lot of therapeutic importance. Therefore, it is a potential candidate for pharmaceutical development, and the peptide can be used in several path-breaking treatments over the next decade. In addition, new roles of MGF are being unraveled regularly.
MGF exhibits minimal side effects, low oral bioavailability, and excellent subcutaneous bioavailability in mice. The dosage necessary for mice (per kg) does not scale to humans.

All orders ship same day if placed by 2pm PST.  Synthesized and lyophilized in the USA.
This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law.  Only qualified and licensed professionals should handle these products.  Any information found on Biotech Peptides is strictly for educational purposes only.  Refer to our terms and conditions for more details.

Additional information


Biotech Peptides

28 reviews for MGF (Mechano-Growth Factor) (5mg)

  1. Amelia Diaz

    Excellent delivery and quality

  2. London Wright

    Truly professional service

  3. Lynch Clara

    Trustworthy and reliable provider of researched and tested products. I was nervous about trying, but it was great knowing I had the chance to buy from a trusted and dependable supplier

  4. Beckett Black

    Always on time. Products work as they should

  5. Lydia Sullivan

    User-friendly site. I am looking forward to testing out these products and I hope I have encountered a long-term reliable source for my research

  6. Thuy Dan T.

    Lovely staff, friendly, on top of their work as well1

  7. Matt Gandee

    Great service, products, discounts, and sales!!!!!!!!!

  8. Mark Miller

    Fast and easy. Very cool

  9. Patrick Khafajizad

    Wish to see a bit more research-oriented articles. Like professionally. I love the general, informative ones, but I’d also be interested in very techinal ones as well

  10. Aaron Beyk

    Five stars all the way

  11. Leon Liu

    Check out PEG-MGF. Much better than MGF

  12. Lana Harir

    Never difficult getting products in, they restock pretty often.

  13. Justin Mondo

    Outstanding services. I am really impressed

  14. Kirk Kohler

    Been a few days since my Peptides came in and I got to say i’m glad I decided to buy from biotech.

  15. Gabe Diaz

    I don’t like leaving reviews, but I think that this company is worthy of it. I ordered from them a total of 6 times and only once I had a problem with the shipping, which they resolved by the next day.

  16. Harry Johnson

    Like the Bac water that they send, good stuff!

  17. Oliver M.

    The different quantities on vials are really helpful. I’d add one more size, but other than that everything’s perfect

  18. Zac Henricks

    When my package was held at customs which was frustrating as the peptides can get ruined due to the time outside of its typical temperature. I contacted Biotech about the issue and I believe I was speaking to Jaimie. They could do nothing about the fact it was stuck there but he was able to resend me a package as they were sure as well the peptides would be no good.

  19. felipe sanchez

    No tengo ninguna queja. Estoy muy contento de haber encontrado una empresa a la que puedo comprar en mi país. La calidad también es muy alta y los productos son legítimos, sin estafa.

  20. jake wilkerson

    Since BP emerged on the market, the company I work for hasn’t changed peptide suppliers, even after doing extensive study on other companies.

  21. Nick kesler

    There were only a few places I could get this on the internet, and they either seemed shady or were too pricey. You guys had the best price around!

  22. Johnny ly

    I am a new customer and I am still juggling between Biotech and another company. So far the customer experience has been quite the same but the quickness of delivery goes to biotech.

  23. Jarret Brady

    Loyal customer since 2021. Their peptides are great!

  24. Matty Schultz

    Had no issues with shipping out to Canada, quality is spectacular.

  25. Edwin Reyna

    I placed my biggest order yet and everything came intact, plus, as a thank you gift for such a vast order, they threw in some additional Bac water. I will order again

  26. Joe Hersholt

    I switched suppliers in march of last year and I never switched again. Fantastic company, fantastic products, fantastic service.

  27. Jutin Morse

    Everything is just perfect. Couldn’t have asked for more. Products were delivered in a timely matter and everything looked to be in good conditions.

  28. Brian Dufelmeier

    Nice peptides. I buy a few peptides every few months and they seem to last well when stored properly. I always follow the standard method and peptides prove to hold their quality.

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