Description
Melanotan 2 SPECIFICATIONS
AKA: MT-2
Molecular Formula: C50H69N15O9
Molecular Weight: 1024.19 g/mol
Sequence: Ac-Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1)-NH2
PubChem: CID 92432
CAS Number: 121062-08-6
Reconstitution: Required
What is Melanotan 2 Peptide?
Melanotan 2 (MT-2) is a synthetic analog of the human alpha-melanocyte-stimulating hormone (alpha-MSH). A study conducted at the University of Arizona observed the involvement of alpha-MSH in skin darkening and sexual arousal in rodents. This finding then led to the development of MT-2 in the 1980s by a team of researchers at the university. Originally formulated as a sunless tanning agent, MT-2 was eventually to have multiple functions such as:
– induce skin tanning,
– increasing sexual stimulation,
– decreasing compulsive behavior,
– controlling addiction,
– regulating hunger,
– reducing glucagon synthesis
– reversing traits of autism.
MT-2 Research
Melanotan 2 and Melanocortin Signaling
Melanotan 2 associates with melanocortin receptors to mediate its biological function. There are five known melanocortin receptors, each involved in a different function. MT-2 binds essentially to MC-4R and MC-1R and weakly to MC-3R.
– MC-1R: Exists on melanocytes; stimulation of MC-1R triggers hair and skin darkening.
– MC-2R: Found in the adrenal glands, stimulates the secretion of adrenal hormones, such as cortisol after binding of cognate ligand.
– MC-3R: MC-3R has been observed to regulate appetite control and energy regulation, but we don’t have further details about this receptor.
– MC-4R: Stimulation of MC-4R causes changes in feeding and sexual action, male erectile function, and energy homeostasis.
– MC-5R: MC-5R is expressed in sweat glands and islet cells of the pancreas.
MT-2 and Autism
Autism, though incurable, can be managed with oxytocin treatment. MT-2, which is known to promote oxytocin release, was studied in murine model of autism spectrum disorder (ASD).The work aimed to explore the possibility of autism management using MT-2. The peptide administration helps reverse the decreased communication, affected social interaction, and repetitive behavior observed in the affected mice. At a molecular level, MT-2 treatment enhanced the expression of oxytocin receptors in the affected areas of the mice brain, thus establishing a direct correlation between ASD-mediated behavior and oxytocin signaling.
The studies highlight the specific hormonal pathways that trigger the development of the disease and novel therapeutic pathways to combat ASD. Thus researchers can develop a complete model of ASD, which would be useful in both prevention and treatment of the condition.
Melanotan 2, Impulse Control and Alcohol Intake
MC-4R receptor has been observed to influence impulse control. Previous findings show that MT-2 administration promotes water uptake and reduces the consumption of alcohol in rats that prefer alcohol consumption. Naltrexone and Melanotan 2 combination suppresses binge uptake of ethanol in rats synergistically up to seven-fold.
The various observations show that the peptide regulates the basic process of desire and craving in the mammalian brain apart from being effective in alcohol-associated disorders. Hence, it gives a deeper understanding of oxytocin regulation in impulsive behavior. This can further help in lifestyle changes of human beings ranging from work to relationships.
MT-2 and Hunger
MT-2 has been observed to regulate food preference, hunger behavior, and fat storage in animal models through interaction with the melanocortin-4 receptor (MC-4R). MT-2 acts as an agonist for MC-4R. Mice treated with MT-2 not only take up significantly less food but also ignore fatty foods in terms of their preference. Similarly, mice mutant of the MC-4R receptor consume fatty foods almost exclusively and are resistant to the effects of the Melanotan 2 peptide.
The effects of MT-2 can be compared to those of the hormone leptin, sometimes known as “the satiety hormone,” because it controls cravings and food intake. Leptin, however, has never been successful in the treatment of obesity, even in leptin-deficient individuals. This is likely due to the presence of two pathways for satiety, called leptin-dependent and leptin-independent pathways. Research suggests MT-2 stimulates the pathways and therefore is more effective in controlling hunger. The observation confirmed that MC-4R stimulation by MT-2 also induces gene expression of the leptin target thyrotropin-releasing hormone (TRH). Both MT-2 and leptin induce expression of TRH in the paraventricular nucleus of the hypothalamus, a region of the brain which regulates feelings of satiety and food intake. However, only elevated levels of MT-2 can cross into the central nervous system to influence TRH expression.
Melanotan 2 and Diabetes
Elevated blood sugar levels, hypersecretion of glucagon hormones, and production of ketone bodies mark the pathogenesis of diabetes. Leptin is known to counteract these pathogenic alterations. The mode of action of leptin is independent of insulin and hence is explored as an alternative treatment for diabetes.
Scientific proof shows that leptin and MT-2 mediate similar effects through melanocortin receptors. This is significant as leptin’s mode of action is restricted to the brain, and it cannot cross the blood-brain barrier as readily as MT-2. Thus, exogenous leptin cannot reach CNS, and thereby its efficacy as a drug is limited. This makes Melanotan 2 peptide a preferred treatment choice for a more effective outcome.
Erectile Dysfunction Research
Vascular issues often contribute to erectile dysfunction (ED). ED can be effectively treated usinng sildenafil (Viagra) and other drugs that improve blood flow to the erectile muscles and reduce vascular resistance. Erectile dysfunction (ED) is often attributed to vascular issues. ED can be effectively treated in most men via sildenafil (Viagra) and other drugs that improve blood flow by reducing vascular resistance. However, all forms of ED do not stem from vascular resistance. Hence Viagra is not effective against such forms of ED as well as against hypoactive sexual desire disorder in the majority of women. MT-2 is an effective alternative due to its influence on CNS. About eighty percent of men with ED who did not respond to Viagra have shown improvement upon MT-2 use. The peptide has also been actively studied to treat both male and female sexual desire disorders.
Future MT-2 Research
Melanotan 2 is an extensively studied peptide, specifically for human behavior, impulse control, and sexual desire. The peptide, in different forms, has been investigated in clinical trials, though challenges with routes of administration have forced scientists to reconsider its clinical use. There is active and ongoing research to unravel the benefits of this particular peptide.
MT-2 exhibits minimal to moderate side effects, low oral bioavailability, and excellent subcutaneous bioavailability in mice. The administered dosage (per kg) in mice does not match the dosage required for humans.
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nice peptides. Came in perfect condition.
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Very reasonable prices
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CJ String –
I discovered promising results using this peptide in my research
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I get all of my products from here, they always carry many different types of peptides you can choose from. Also the quality is pretty good!
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Not one remotely bad experience in the past nine months.
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I’d shop here again, wish they’d come up with bundle options like buy 3 of one and 3 of another for the same price? Not sure but just throwing that out there!
Eli Lee –
I was recommended to them by my old professor. He told me their peptides are pretty good quality and that it may help my research better than the last place I was getting peptides from. They are so far proving to support his statement.
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Really high quality Peptides from what I have seen thus far. Product really checks out.
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These folks were fantastic to work with. The phone calls helped a lot, and the promptness of the transactions and the lightning-fast delivery of the packages gives you a lot of trust.
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For as long as I can remember, I’ve been a subscriber to BP. I’m a loyal customer who’s always putting new orders. The high quality of the results never ceases to amaze me. There were no issues with the delivery.
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Estoy muy feliz de comprar en esta empresa. Mi investigación ha sido asombrosa desde que compré de esta compañía.
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Had some peptides left over from my last experiment and its been a couple of weeks and they are still in great condition!
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Never changing suppliers again. Biotech is the way to go
Lori Woodard –
Never had an issue with storing these peptides. They are high purity and easy to handle
Tony Brontsema –
my packages came on time, They even sent out a discount code in there!
Albert A –
Everything came on time, I would suggest another form of packaging. Nothing was broken but you can tell the vials we’re moving around a lot.
Jose Duarte –
I ordered with them when they first came about. Peptides were good, prices were good too. Over a year later had a another project that needed this blend and gave them a try again. Peptides are still the same good quality. Prices may have gone up a bit.
Nikki Green –
Noticed the improvments on shipping!! Have not had any mistakes or breaks in the last few times I have ordered with them.
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I prefer to buy this product here at Biotech. Quality is better!
Justin Hekmat –
Peptides are pure and show to be effective on my research. I like the variety of options they have as well.
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Prices are amazing, still the lowest I have found with good quality peptides. I like that you also take sooo many different types of payment methods.
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They have a lot of topical options as well which seems to be lacking some other places.
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Keep going with the great service Biotech!
Kevin Chau –
Great results come from this in research, if used consistently and as instructed for the peptides.
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Great stuff! No complaints on the peptides. I do think some work on the way it’s packaged is needed.
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Taylor was able to set me up a great deal for my order. Had to order in bulk for lab supplys and it was the quickest I’ve been on the phone with any peptide company.
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Deals are good!! I feel like every month there’s a new peptide on sale.
Jackie Martinez –
In the year that i’ve been with them i’ve only had a few minor issues with them regarding my payment not going through. Real easy process though as they called me anytime that did happen and we got it sorted right away. Awsome service!
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Nothing came broken which is always a plus in my book. Quality is good, better than most other places
Neil Barber –
I was surprised at how fast the products got to me. Very nice delivery
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Peptide is amazing, can’t wait to get my hands on it.
Heesung Moon –
Always in stock with this one! Never had a long wait even when it was out!
Alex Sullivan –
Read an article on the blog and decided I’d like to do some research with this peptide and try something new.
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Best Mel 2 Blend out there right now!
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You pay for what you get! Peptides that are actually pure and possibly best quality that I have encountered.
Em Sheng –
I unfortunately had a few vials come in broken. Was able to contact someone to get a refund on those peptides. I do want to note they offered to send a new one but I was on a schedule and just wasn’t worth delaying.
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Got an extra Bac water in my order!
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After experimenting with this product I saw better results in my projects. Will try other products from here in the future as well!