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Melanotan 2 (2mg & 10mg)

(58 customer reviews)

$12.00 – $39.00

Melanotan 2 peptides are Synthesized and Lyophilized in the USA.

Discount per Quantity

Quantity5 - 910 +
Discount5%10%
Price$11.40 – $37.05$10.80 – $35.10
Orders over $300 receive:
FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
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SKU: Melanotan-2-10mg Category:

Description

What is the Melanotan 2 Peptide?

Melanotan 2 (MT-2) is a synthetic analog of the human alpha-melanocyte-stimulating hormone (alpha-MSH). A study conducted at the University of Arizona observed the involvement of alpha-MSH in skin darkening and sexual arousal in rodents.[1] The researchers demonstrated โ€œthat MT-II has tanning activity in humans given only 5 low doses every other day.โ€ This finding then led to the development of MT-2 in the 1980s by a team of researchers at the university. Originally formulated as a sunless tanning agent, MT-2 was eventually to exhibit potential in functions such as:
– inducing skin tanning,
– increasing sexual stimulation,
– decreasing compulsive behavior,
– controlling addiction,
– regulating hunger,
– reducing glucagon synthesis
– reversing traits of autism.

Specifications

AKA: MT-2

Molecular Formula: C50H69N15O9

Molecular Weight: 1024.19 g/mol

Sequence: Ac-Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1)-NH2

PubChem: CID 92432

CAS Number: 121062-08-6

Reconstitution: Required

Research

Melantotan 2 (MT-2) and Melanocortin Signaling
Melanotan 2 appears to associate with Melanocortin receptors to mediate its biological function. There are five known Melanocortin receptors, each involved in a different function. Studies observe that MT-2 appears to bind essentially to MC-4R and MC-1R and weakly to MC-3R.[2]
– MC-1R: Exists on melanocytes; stimulation of MC-1R may trigger hair and skin darkening.
– MC-2R: Found in the adrenal glands, may stimulate the secretion of adrenal hormones, such as cortisol after binding of cognate ligand.
– MC-3R: MC-3R has been observed to regulate appetite control and energy regulation, but we donโ€™t have further details about this receptor.
– MC-4R: Stimulation of MC-4R may cause changes in feeding and sexual action, male erectile function, and energy homeostasis.
– MC-5R: MC-5R is expressed in sweat glands and islet cells of the pancreas.

Melantotan 2 (MT-2) and Autism
Autism, though incurable, may be managed with oxytocin treatment. MT-2, which has been researched in relation to oxytocin release, was studied in a murine model of autism spectrum disorder (ASD).[3] The work aimed to explore the possibility of autism management using MT-2.ย  The peptide administration appeared to help reverse the decreased communication, affected social interaction, and repetitive behavior observed in the affected mice. At a molecular level, MT-2 treatment appeared to enhance the expression of oxytocin receptors in the affected areas of the mice brain, establishing a direct correlation between ASD-mediated behavior and oxytocin signaling. The studies highlight the specific hormonal pathways that trigger the development of the disease and novel therapeutic pathways to combat ASD. Thus researchers may develop a complete model of ASD, which would be useful in both prevention and treatment of the condition.

Melantotan 2 (MT-2), Impulse Control and Alcohol Intake
The MC-4R receptor has been observed to influence impulse control. Previous findings indicate that MT-2 administration may promote water uptake and reduce the consumption of alcohol in rats that prefer alcohol consumption.[4] Naltrexone and Melanotan 2 combination appears to supress binge uptake of ethanol in rats synergistically up to seven-fold. The various observations suggest that the peptide regulates the basic process of desire and craving in the mammalian brain apart from being effective in alcohol-associated disorders. It helps illustrate a better understanding of oxytocin regulation in impulsive behavior. This research can further help in lifestyle changes of human beings ranging from work to relationships.

Melantotan 2 (MT-2) and Hunger
MT-2 studies observed the peptide’s apparent ability to regulate food preference, hunger behavior, and fat storage in animal models through interaction with the melanocortin-4 receptor (MC-4R).[5] The researchers revealed that โ€œbrain MC4R is intimately involved in the control of food intake and body weight and provide evidence that selective activation of MC4R causes anorexia that is not secondary to aversive effects.โ€ MT-2 appears to act as an agonist for MC-4R. Mice treated with MT-2 were reported to not only take up significantly less food but also ignore fatty foods in terms of their preference. Similarly, mice mutants of the MC-4R receptor consume fatty foods almost exclusively and appear to be resistant to the effects of the Melanotan 2 peptide. The alleged effects of MT-2 can be compared to those of the hormone leptin, sometimes known as โ€œthe satiety hormone,โ€ because it controls cravings and food intake. Leptin, however, has never been successful in the treatment of obesity, even in leptin-deficient individuals. This is likely due to the presence of two pathways for satiety, called leptin-dependent and leptin-independent pathways. Research suggests MT-2 may stimulate the pathways and therefore would be more effective in controlling hunger. Experimental observations further suggest that MC-4R stimulation by MT-2 also may induce gene expression of the leptin target thyrotropin-releasing hormone (TRH). Both MT-2 and leptin may induce expression of TRH in the paraventricular nucleus of the hypothalamus, a region of the brain which regulates feelings of satiety and food intake. However, only elevated levels of MT-2 appear to cross into the central nervous system to influence TRH expression.

Melantotan 2 (MT-2) and Diabetes
Elevated blood sugar levels, hypersecretion of glucagon hormones, and production of ketone bodies mark the pathogenesis of diabetes. Leptin is known to counteract these pathogenic alterations. The mode of action of leptin is independent of insulin and hence is explored as an alternative treatment for diabetes.[6] Scientific research posits that leptin and MT-2 may mediate similar effects through Melanocortin receptors. This is significant as leptinโ€™s mode of action is restricted to the brain, and it cannot cross the blood-brain barrier as readily as MT-2. Thus, exogenous leptin cannot reach CNS, and thereby its efficacy as a medicine is limited.

Melantotan 2 (MT-2) and Erectile Dysfunction
Vascular issues often contribute to erectile dysfunction (ED). ED can be effectively treated using medicines that improve blood flow to the erectile muscles and reduce vascular resistance. However, all forms of ED do not stem from vascular resistance. Therefore, medicines that increase blood flow may be ineffective against such forms of ED as well as against hypoactive sexual desire disorder in the majority of women. MT-2 may be an alternative due to its suggested influence on CNS. Research studies reported that eighty percent of men with ED who did not respond to traditional medicines reported improvement upon MT-2 use.[7] The peptide has also been actively studied to treat both male and female sexual desire disorders.

Melanotan 2 is an extensively studied peptide, specifically for behavior, impulse control, and sexual desire. The peptide, in different forms, has been investigated in clinical trials, though challenges with routes of administration have forced scientists to reconsider its clinical use. There is active and ongoing research to unravel the benefits of this particular peptide. MT-2 research reports the peptide to exhibit minimal to moderate side effects, low oral bioavailability, and excellent subcutaneous bioavailability in mice.[8]

References

  1. Dorr RT, Lines R, Levine N, Brooks C, Xiang L, Hruby VJ, Hadley ME. Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study. Life Sci. 1996;58(20):1777-84. doi: 10.1016/0024-3205(96)00160-9. PMID: 8637402.
  2. Yeo GSH, Chao DHM, Siegert AM, Koerperich ZM, Ericson MD, Simonds SE, Larson CM, Luquet S, Clarke I, Sharma S, Clรฉment K, Cowley MA, Haskell-Luevano C, Van Der Ploeg L, Adan RAH. The melanocortin pathway and energy homeostasis: From discovery to obesity therapy. Mol Metab. 2021 Jun;48:101206. doi: 10.1016/j.molmet.2021.101206. Epub 2021 Mar 6. PMID: 33684608; PMCID: PMC8050006.
  3. Minakova E, Lang J, Medel-Matus JS, Gould GG, Reynolds A, Shin D, Mazarati A, Sankar R. Melanotan-II reverses autistic features in a maternal immune activation mouse model of autism. PLoS One. 2019 Jan 10;14(1):e0210389. doi: 10.1371/journal.pone.0210389. PMID: 30629642; PMCID: PMC6328175.
  4. Navarro M, Carvajal F, Lerma-Cabrera JM, Cubero I, Picker MJ, Thiele TE. Evidence that Melanocortin Receptor Agonist Melanotan-II Synergistically Augments the Ability of Naltrexone to Blunt Binge-Like Ethanol Intake in Male C57BL/6J Mice. Alcohol Clin Exp Res. 2015 Aug;39(8):1425-33. doi: 10.1111/acer.12774. Epub 2015 Jun 24. PMID: 26108334; PMCID: PMC4515169.
  5. Benoit SC, Schwartz MW, Lachey JL, Hagan MM, Rushing PA, Blake KA, Yagaloff KA, Kurylko G, Franco L, Danhoo W, Seeley RJ. A novel selective melanocortin-4 receptor agonist reduces food intake in rats and mice without producing aversive consequences. J Neurosci. 2000 May 1;20(9):3442-8. doi: 10.1523/JNEUROSCI.20-09-03442.2000. PMID: 10777807; PMCID: PMC6773132.
  6. Heijboer AC, van den Hoek AM, Pijl H, Voshol PJ, Havekes LM, Romijn JA, Corssmit EP. Intracerebroventricular administration of melanotan II increases insulin sensitivity of glucose disposal in mice. Diabetologia. 2005 Aug;48(8):1621-6. doi: 10.1007/s00125-005-1838-8. Epub 2005 Jun 22. PMID: 15971058.
  7. Wessells H, Fuciarelli K, Hansen J, Hadley ME, Hruby VJ, Dorr R, Levine N. Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: double-blind, placebo controlled crossover study. J Urol. 1998 Aug;160(2):389-93. PMID: 9679884.
  8. Giuliano F, Clรฉment P, Droupy S, Alexandre L, Bernabรฉ J. Melanotan-II: Investigation of the inducer and facilitator effects on penile erection in anaesthetized rat. Neuroscience. 2006;138(1):293-301. doi: 10.1016/j.neuroscience.2005.11.008. Epub 2005 Dec 19. PMID: 16360286.
All orders ship same day if placed by 2pm PST.
This product is strictly for research/laboratory use only.ย  Human or animal use and/or consumption is strictly prohibited by law.ย  Only qualified and licensed professionals should handle these products.ย  Any information found on Biotech Peptides is strictly for educational purposes only.ย  Refer to our terms and conditions for more details.

Additional information

Brand

Biotech Peptides

Size

10 mg, 2 mg

58 reviews for Melanotan 2 (2mg & 10mg)

  1. Beatriz Davis –

    They had exactly what I was looking for. I had no problems ordering and checking-out

  2. Raelynn Baker –

    No instructions included but after a bit of research it was quite easy to find.

  3. Aria Parker –

    This is literally my favorite online site to order from form. Not ever have I had a bad experience with them. Can’t rave enough about them. Higly recommended!!!!

  4. Rory Nolan –

    They are very responsive. All questions are answered quickly and all needs are met immediately. Customer service definitely gives this site a mom and pop feel

  5. Hanna Byrne –

    nice peptides. Came in perfect condition.

  6. Eric Wilson –

    Very reasonable prices

  7. Gabriel Miller –

    The same day shipping is a huge plus. I needed this last second before my trip but luckily I received it just in time.

  8. Dominique Khan –

    Im impressed with the special accomodations that were made due to my travels. I was not going to get my order in time before I left the country and one thing you dont wanna do with peptides is leave them out in the sun. Whether they are in a box or not it is still harmful. Store your stuff in the freezer kids. I just wanna thank the customer service and shippping department for upgrading me to overnight shipping for free. You guys are a blessing.

  9. Kirsten Mitchell –

    I love the small business feel and service. Very helpful and friendly. They even threw in a free ipamorelin when they noticed that I had paid for postage twice (very kind of them).

  10. Sarah Monk –

    Very happy with Biotech Peptides!

  11. Kris Blanco –

    Spent some time on the phone with them and Im just glad they were educated on the products they were selling!!

  12. Polina Vasileva –

    Can’t say much about this product since it did not arrive yet, but the ordering process was really fast and easy. I’ll be back with an update after trying out the product

  13. Gary O’Neal –

    Biotech Peptides is a great company. Everything’s of the best and highest quality

  14. Isabella Gelbero –

    I love how you keep introducing new peptides and everytime I check, there’s articles about every one on them. You’re really well organized

  15. CJ String –

    I discovered promising results using this peptide in my research

  16. Yermakova Sasha –

    I get all of my products from here, they always carry many different types of peptides you can choose from. Also the quality is pretty good!

  17. Evan Aiono –

    Not one remotely bad experience in the past nine months.

  18. Ethan Pierre –

    I’d shop here again, wish they’d come up with bundle options like buy 3 of one and 3 of another for the same price? Not sure but just throwing that out there!

  19. Eli Lee –

    I was recommended to them by my old professor. He told me their peptides are pretty good quality and that it may help my research better than the last place I was getting peptides from. They are so far proving to support his statement.

  20. Austin Lopez –

    Shopped at many different peptide companies. Their peptides are the best so far. Customer service is fine, feel like everywhere is the same in that sense.

  21. Freddy Splindler –

    Really high quality Peptides from what I have seen thus far. Product really checks out.

  22. Nick Lee –

    These folks were fantastic to work with. The phone calls helped a lot, and the promptness of the transactions and the lightning-fast delivery of the packages gives you a lot of trust.

  23. Steve Summers –

    For as long as I can remember, I’ve been a subscriber to BP. I’m a loyal customer who’s always putting new orders. The high quality of the results never ceases to amaze me. There were no issues with the delivery.

  24. Alena Perez –

    Estoy muy feliz de comprar en esta empresa. Mi investigaciรณn ha sido asombrosa desde que comprรฉ de esta compaรฑรญa.

  25. Fred Romano –

    Had some peptides left over from my last experiment and its been a couple of weeks and they are still in great condition!

  26. Kevin Mark –

    Highly recommend buying from biotech. Products get in quick and last a while.

  27. Niko Kovach –

    Never changing suppliers again. Biotech is the way to go

  28. Lori Woodard –

    Never had an issue with storing these peptides. They are high purity and easy to handle

  29. Tony Brontsema –

    my packages came on time, They even sent out a discount code in there!

  30. Albert A –

    Everything came on time, I would suggest another form of packaging. Nothing was broken but you can tell the vials we’re moving around a lot.

  31. Jose Duarte –

    I ordered with them when they first came about. Peptides were good, prices were good too. Over a year later had a another project that needed this blend and gave them a try again. Peptides are still the same good quality. Prices may have gone up a bit.

  32. Nikki Green –

    Noticed the improvments on shipping!! Have not had any mistakes or breaks in the last few times I have ordered with them.

  33. Kelli Jones –

    I prefer to buy this product here at Biotech. Quality is better!

  34. Justin Hekmat –

    Peptides are pure and show to be effective on my research. I like the variety of options they have as well.

  35. Natalie Welch –

    Love the constant promo codes they send out! Helps save a buck here and there!

  36. Darby Dunlop –

    Prices are amazing, still the lowest I have found with good quality peptides. I like that you also take sooo many different types of payment methods.

  37. Jonah Canter –

    They have a lot of topical options as well which seems to be lacking some other places.

  38. Farrnam Kachouei –

    Fantastic service and peptides!

  39. Hoa Nguyen-Vu –

    Keep going with the great service Biotech!

  40. Kevin Chau –

    Great results come from this in research, if used consistently and as instructed for the peptides.

  41. Wayne Pham –

    Great stuff! No complaints on the peptides. I do think some work on the way it’s packaged is needed.

  42. Hughes wilson –

    Taylor was able to set me up a great deal for my order. Had to order in bulk for lab supplys and it was the quickest I’ve been on the phone with any peptide company.

  43. Roberto Valentino –

    Deals are good!! I feel like every month there’s a new peptide on sale.

  44. Jackie Martinez –

    In the year that i’ve been with them i’ve only had a few minor issues with them regarding my payment not going through. Real easy process though as they called me anytime that did happen and we got it sorted right away. Awsome service!

  45. Ivan Foronda –

    Nothing came broken which is always a plus in my book. Quality is good, better than most other places

  46. Neil Barber –

    I was surprised at how fast the products got to me. Very nice delivery

  47. Adrian Moreno –

    Peptide is amazing, can’t wait to get my hands on it.

  48. Heesung Moon –

    Always in stock with this one! Never had a long wait even when it was out!

  49. Alex Sullivan –

    Read an article on the blog and decided I’d like to do some research with this peptide and try something new.

  50. Heston Jayasinghe –

    Best Mel 2 Blend out there right now!

  51. Sebastian Luke –

    The peptides are nice quality, better than most other places!

  52. Ryan Caollado –

    Great site, great company

  53. Bradley Parker –

    You pay for what you get! Peptides that are actually pure and possibly best quality that I have encountered.

  54. Em Sheng –

    I unfortunately had a few vials come in broken. Was able to contact someone to get a refund on those peptides. I do want to note they offered to send a new one but I was on a schedule and just wasn’t worth delaying.

  55. Javier Ramirez –

    Got an extra Bac water in my order!

  56. AJ Faghihi –

    A legit company that works with the customers instead of against them. I have had a few instances here and there where peptides went missing, or went out of stock after I bought and paid for them. Every time they have worked with me to come to a solution and fix the issue and made it a priority to get me my peptides or my money back.

  57. Kennt Cabrera –

    I wish they had more sales or maybe better ones, because most of the products are okay priced and not the best sale options. The good thing about their discount code though is that It works when I apply it on sale peptides.

  58. Jason Anderosn –

    After experimenting with this product I saw better results in my projects. Will try other products from here in the future as well!

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