Pentapeptide-18 (Leuphasyl) (Topical) (200mg)


Pentapeptide-18 (Leuphasyl) peptides are Synthesized and Lyophilized in the USA.

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What is the Pentapeptide-18 (Leuphasyl) (Topical) peptide?

Pentapeptide-18 is the synthetic equivalent of enkephalin, consisting of five amino acids (Tyr-D-Ala-Gly-Phe-Leu). Research suggests that it may penetrate the skin and prevent the prevalence of lines and wrinkles following facial muscle movements.[1] In animal models and in vitro studies, Pentapeptide-18 appears to exhibit similar effects to those seen with Botox. Pentapeptide-18 is the synthetic equivalent of enkephalins—an endorphin peptide responsible for the regulation of nociception in the human body. Scientific studies show that Pentapeptide-18 may also influence mood, behavior, movement, and pain perception.


Sequence: Tyr-D-Ala-Gly-Phe-Leu

Molecular Formula: C29H39N5O7

Molecular Weight: 569.65 g/mol

PubChem: CID 44568

Synonyms: Leuphasyl; NSC-374895

Reconstitution: Required

Pentapeptide-18 Research

Pentapeptide-18 (Leuphasyl) Experimental Studies
Pentapeptide-18 research in animal models suggest that it may inhibit electrical impulses at the neuromuscular junction—the synaptic space which connects the terminal end of a motor nerve and a muscle. Due to this, Pentapeptide-18 may cause a decrease in muscle tone and contraction in the exact manner botox does,[2] thus preventing the prevalence of wrinkles and fine lines. Pentapeptide-18 appears to differ from botox in that, Pentapeptide-18 (Leuphasyl) may be applied in lotion form.  Studies report that Pentapeptide-18 appeared to decrease wrinkles by a range of 28% – 34.7%.[3] he researchers “evaluated the regression of the wrinkles between the eyebrows using an imagistic method: pro-derm Analyser.” Scientists suggest that Pentapeptide-18 (Leuphasyl) may be more potent than botox in reducing wrinkles and fine lines in animal models, making Pentapeptide-18 (Leuphasyl) appealing not just in cosmetics but also in medical cases involving muscular spasms, such as migraine.

Pentapeptide-18 a synthetic equivalent of Enkephali, and appears to mimic the effects of enkephalin. Enkephalins are endorphin peptides present in animals and are responsible for regulating the movement, perception of pain, mood, behavior, and neuroendocrine functions.[4] Scientists explain that also “The enkephalins are one of the three peptide systems that also include beta-endorphins and dynorphins.”
Pentapeptide-18 (Leuphasyl) appears to connect enkephalin receptors to nerve cells, causing acetylcholine to be released into the synaptic gap. Pentapeptide-18 (Leuphasyl) appears to cause ACH release by directly modulating synaptic vesicle fusion. After ACH release, Pentapeptide-18 (Leuphasyl) appears to bind to ACH receptors and induce muscle cramps, after which Pentapeptide-18 may immediately inhibit the reaction. There is no concrete explanation as to how Pentapeptide-18 (Leuphasyl) does this, but it does appear to function to reduce the prevalence of wrinkles and fine lines on the skin while it interferes with neuromuscular signaling.

Cited earlier, scientific research in animal models reported that Pentapeptide-18 appeared to reduce the prevalence of wrinkles by a range of 28% – 34.7%, comparative to botox which appears to only reduces wrinkles by 2% to 9%.[5] In vivo experiments by Dr. Howard Maibach, Professor of Dermatology at the University of California, reported that after administering Pentapeptide-18 (Leuphasyl) for 28 days, 5% of Pentapeptide-18 alone appeared to reduce wrinkles by about 11%,[6] while 5% of Pentapeptide-18 (Leuphasyl) in combination with 5% of Argireline appeared to reduce wrinkles on average to about 25%, at maximum values of about 47%. The mean wrinkle reductions were 11.64% vs. 16.26% vs. 24.62% for Pentapeptide-18, Argireline, and their combination respectively. In this context, Pentapeptide-18 (Leuphasyl) may prevent the prevalence of as many wrinkles as possible, while the attached molecule—GHK-cu and Argireline may as an ancillary to reduce the lines formed. Pentapeptide-18 is generally considered by researchers to be preferable to botox because it may be incorporated into cream form for topical application. Pentapeptide-18 may be incorporated into cream form due to its apparent ability to penetrate skin cells, according to in vitro experiments. It is important to note that botox is not only applicable in cosmetic procedures. Its functions span out to the reduction of muscle spasms following migraines. Pentapeptide-18 may also be helpful in treating several pain syndromes. Scientists believe that Leuphasyl may be a vital ancillary for developing more potent pain-control medications as its existence may result in improved treatment for migraines and pain following headaches in the future.

Potential Functions of Pentapeptide-18 (Leuphasyl)
● Pentapeptide-18 may improve the microcirculation of blood and can help with conditions emerging from microvascular disorders.
● It may strengthen blood circulation.
● It appears to function to alleviate inflammation.
● It may assist the skin resist pouching, and dilute fine lines and crow’s feet around the eyes. These benefits may reverse aging symptoms.
● It may act to delay the effects of premature aging by bettering the elasticity and firmness of the skin.
● Pentapeptide-18 may also hydrate, protect, and smoothen the skin.


Pentapeptide-18 (Leuphasyl) is a synthetic peptide that is produced based on enkephalins. It consists of five amino acid sequences. Pentapeptide-18 (Leuphasyl) may penetrate the skin and prevent the prevalence of fine lines and wrinkles. According to studies, it may imitate enkephalins by modifying signals at the neuromuscular junction, lowering muscle tone and contractions. Despite the benefits associated with Leuphasyl, it is important to note that it is a research chemical/peptide, limited to educational and scientific purposes—not for human use.


  1. Puig, A., Garcia-Anton, J., Perez, R. & Mangues, M. Eyeseryl and Leuphasyl: Synthetic Peptides as Advanced Cosmetic Actives. Available at:
  2. Montiel, A. V. F., Puche, J. C. & Montiel, A. P. Cosmetic or dermopharmaceutical composition comprising enkephalin-derived peptides for reducing and/or eliminating facial wrinkles. (2015).
  3. Dragomirescu, Anca O., et al. “The efficiency and safety of leuphasyl—a botox-like peptide.” Cosmetics 1.2 (2014): 75-81.
  4. Cullen JM, Cascella M. Physiology, Enkephalin. [Updated 2022 Mar 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from:
  5. Wilson, A. J., Chin, B. C., Hsu, V. M., Mirzabeigi, M. N. & Percec, I. Digital Image Correlation: A Novel Dynamic Three-Dimensional Imaging Technique for Precise Quantification of the Dynamic Rhytid and Botulinum Toxin Type A Efficacy. Plast. Reconstr. Surg. 135, 869e–876e (2015)
  6. Hostynek JJ, Dreher F, Maibach HI. Human skin retention and penetration of a copper tripeptide in vitro as function of skin layer towards anti-inflammatory therapy. Inflamm Res. 2010 Nov;59(11):983-8. doi: 10.1007/s00011-010-0214-4. Epub 2010 Aug 13. PMID: 20703511; PMCID: PMC2945467.
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