Pentapeptide-18 (Leuphasyl) (Topical) (200mg)


Leuphasyl; NSC-374895

Discount per Quantity

5 - 95%$204.25
10 +10%$193.50
SKU: Pentapeptide-18-Leuphasyl-Topical-200mg Category:


What Is Pentapeptide-18 (Leuphasyl) (Topical)?

Pentapeptide-18 is the synthetic equivalent of enkephalin, consisting of five amino acids (Tyr-D-Ala-Gly-Phe-Leu). Research proves that it can penetrate the skin and prevent the prevalence of lines and wrinkles following facial muscle movements. In animal models and in vitro studies, Pentapeptide-18 has similar effects to those seen with Botox.
Pentapeptide-18 is the synthetic equivalent of enkephalins—an endorphin peptide responsible for the regulation of nociception in the human body.
Scientific studies show that Pentapeptide-18 can influence mood, behavior, movement, and pain perception.


Sequence: Tyr-D-Ala-Gly-Phe-Leu

Molecular Formula: C29H39N5O7

Molecular Weight: 569.65 g/mol

PubChem: CID 44568

Synonyms: Leuphasyl; NSC-374895

Reconstitution: Required

Pentapeptide-18 (Leuphasyl) Research

The Benefits of Pentapeptide-18
Previous Pentapeptide-18 research in animal models show that it can inhibit electrical impulses at the neuromuscular junction—the synaptic space which connects the terminal end of a motor nerve and a muscle. Due to this, Pentapeptide-18 can cause a decrease in muscle tone and contraction in the exact manner botox does. Thus preventing the prevalence of wrinkles and fine lines. Pentapeptide-18 differs from botox in that, Pentapeptide-18 (Leuphasyl) is applied in lotion form. Meanwhile, botox is given as an injection.
Studies show that Pentapeptide-18 can decrease wrinkles by 28% to 34.7%. Scientists suggest that Leuphasyl may be more potent than botox in reducing wrinkles and fine lines in animal models. This property has made Leuphasyl extremely appealing not just in cosmetics but also in medical cases involving muscular spasms such as migraine.
Pentapeptide-18 a synthetic equivalent of Enkephalin can mimic the effects of enkephalin.
Enkephalins are endorphin peptides present in animals and are responsible for regulating the movement, perception of pain, mood, behavior, and neuroendocrine functions.
Pentapeptide-18 (Leuphasyl) connects enkephalin receptors to nerve cells, causing acetylcholine to be released into the synaptic gap. Leuphasyl causes ach release by directly modulating synaptic vesicle fusion. After ach release, Leuphasyl binds to ach receptors and induces muscle cramps, after which Pentapeptide-18 immediately comes into play-acting to inhibit the reaction.
There is no concrete explanation as to how Leuphasyl does this, but it functions to reduce the prevalence of wrinkles and fine lines on the skin while it interferes with neuromuscular signaling.
Scientific research in animal models shows that Pentapeptide-18 can reduce the prevalence of wrinkles by 28% to 34.7%, while botox only reduces wrinkles by 2% to 9%. This proves that Leuphasyl is a more potent peptide in reducing wrinkles compared to botox.
In vivo experiments by Dr. Howard Maibach, Professor of Dermatology at the University of California, show that after administering Pentapeptide-18 (Leuphasyl) for 28 days, 5% of Leuphasyl alone reduced wrinkles by about 11%. While 5% of Leuphasyl in combination with 5% of Argireline reduced wrinkles on average to about 25%, at maximum values of about 47%.
The mean wrinkle reductions were 11.64% vs. 16.26% vs. 24.62% for Leuphasyl, Argireline, and their combination respectively. In this context, Leuphasyl prevents the prevalence of as many wrinkles as possible, while the attached molecule—GHK-cu and Argireline act as an ancillary to reduce the lines formed.
Pentapeptide-18 is preferred to botox because it is incorporated into cream form for topical application. Unlike botox, which can only be administered via injections at specific sites by trained medical personnel. Pentapeptide-18 is incorporated into cream form due to its ability to penetrate skin cells, according to in vitro experiments.
It is important to note that botox is not only applicable in cosmetic procedures. Its functions span out to the reduction of muscle spasms following migraines. Pentapeptide-18 is also helpful in treating several pain syndromes.
Scientists believe that Pentapeptide-18 (Leuphasyl) can be a vital ancillary for developing more potent pain-control medications as its existence may result in improved treatment for migraines and pain following headaches in the future.

Other Benefits of Pentapeptide-18 (Leuphasyl)
● Pentapeptide-18 can improve the microcirculation of blood and can help with conditions emerging from microvascular disorders.
● It can strengthen blood circulation.
● It functions to alleviate inflammation.
● It helps the skin resist pouch and dilute fine lines and crow’s feet around the eyes. These benefits can help reverse aging and its signs.
● It can act to delay the effects of premature aging by bettering the elasticity and firmness of the skin.
● Pentapeptide-18 can also hydrate, protect, and smoothen the skin.


Pentapeptide-18 (Leuphasyl) is a synthetic peptide that is produced based on enkephalins. It consists of five amino acid sequences. Pentapeptide-18 (Leuphasyl) can penetrate the skin and prevent the prevalence of fine lines and wrinkles.
According to studies, it can imitate enkephalins by modifying signals at the neuromuscular junction, lowering muscle tone and contractions.
Despite the benefits associated with pentapeptide-18, it is important to note that it is a research chemical/peptide, limited to educational and scientific purposes—not for human consumption.

All orders ship same day if placed by 2pm PST. Peptides synthesized and lyophilized in the USA.
This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law. Only qualified and licensed professionals should handle these products. Any information found on Biotech Peptides is strictly for educational purposes only. Refer to our terms and conditions for more details.

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