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PNC-27 (5mg)
$142.00
PNC-27 peptides are Synthesized and Lyophilized in the USA.
Discount per Quantity
Quantity | 5 - 9 | 10 + |
---|---|---|
Discount | 5% | 10% |
Price | $134.90 | $127.80 |
FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
FREE - USPS priority shipping
Description
PNC-27 Peptide
PNC-27 is a synthetic peptide initially developed for its proposed inhibitive action on cancer cell proliferation. It is a member of the PNC family of probe proteins and is designed to attach to malformed cancer cells and induce cell necrosis, but bypass normal functioning cells. The PNC-27 peptide contains the HDM2 binding domain and transmembrane domain corresponding to residue 1226 on p53. Researchers suggest that it exhibits potential to bind to and kill cancer cells through membrane lysis or cell membrane destruction. Research studies have suggested that the PNC-27 peptide may be selective in targeting specific cancer cell types, prompting further research within the context of pancreatic cancer, breast cancer, leukemia, melanoma, and other cancer strains.[1]
The PNC protein was first developed in 2000. The PNC-27 peptide appears to be a non-toxic compound, attaching to and puncturing the membranes of individual cancer cells. As a result, rapid implosion may occur, leading to immediate cell death due to differences in osmotic pressure inside and outside the tumor cells. PNC-27 appears to have this potential through an affinity for binding to a protein called HDM2. Cancer cells typically display HDM2 in their cell membranes.[2] According to the researchers “PNC-27 targets HDM-2 in the membranes of cancer cells, allowing it to induce membranolysis of these cells selectively.” Immediately after exposure to the PNC-27 peptide, studies have observed that the peptide appears to move to HDM2. Binding to them creates pores or holes in the cell membrane, causing “membrane lysis” or death of the cell membrane. This process, in turn, may lead to the destruction of cancer cells. Research is ongoing.
Specifications
Molecular Formula: C188H293N53O44
Molecular Weight: 4031.7
Sequence: H-Pro-Pro-Leu-Ser-Gln-Glu-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu-Lys-Lys-Trp-Lys-Met-Arg-Arg-Asn-Gln-Phe-Trp-Val-Lys-Val-Gln-Arg-Gly-OH
Synonyms: membrane residency peptide (MRP)
PNC-27 Peptide Research
In a paper published by the American Association for Cancer Research, Dr. Ehsan Sarafraz Yazdi et al. observed in-depth how the PNC-27 peptide appeared to exert its effects, and what its apparent novel mechanism of action meant for cancer research in 2010.[3] The authors reported that the mechanism of action for PNC-27 may be due to the formation of oligomeric pores in the plasma membrane of tumor cells. Oligomeric pores are not formed in untransformed or non-tumor cells. In addition, the researchers pointed out that MDM2 as a target molecule has been observed to result in PNC-27 selectivity over cancer cells due to its mislocalization of the plasma membrane of cancer cells.
Researchers found in a 2009 study that the three-dimensional structure of the p53 residue of PNC-27 might be directly superimposed on the design of the same residue bound to HDM2.[5] As a result, researchers may be able to use PNC-27 and target HDM2 with the membrane of cancer cells. In particular, cancer cells appear to exhibit significant levels of HDM2 in their membranes, whereas non-transformed or non-cancerous cells do not appear to have substantial levels of HDM2. This process might allow the PNC-27 peptide to target cancer cells without selectively damaging the surrounding tissue.
In further experiments, transplantation of HDM2 containing a membrane localization signal into non-transformed cells that are less susceptible to PNC-27 has appeared to make these cells more sensitive to PNC-27. As a result, this provides further support to the hypothesis that the PNC-27 peptide may selectively attack HDM2 in the membrane of cancer cells, destroying them by membrane lysis while leaving functioning cells intact.
In 2010 studies observed that PNC-27 appeared to have a possible cancer cell destruction impact as a whole peptide and no fragment.[6] The researchers commented that “This interaction increases the lifetime of PNC-27.” Researchers hypothesized that the peptide may form membrane holes in the cancer cell membrane, with the study set to determine whether some pores (component) or peptide may be produced. In the experiment, researchers suggested that a total peptide exerts an impact on the cell membrane of cancer cells. Furthermore, it was observed that other transformed cells or non-trans cell cells appeared to recover around cancer cells. From the experimental results, the researchers indicate that the PNC-27 peptide appears to target a specific marker in the film of cancer cells. In addition, this mechanism of action may extend the life of the PNC-27 peptide. Research is still ongoing.
Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.
References
- Davitt K, Babcock BD, Fenelus M, Poon CK, Sarkar A, Trivigno V, Zolkind PA, Matthew SM, Grin’kina N, Orynbayeva Z, Shaikh MF, Adler V, Michl J, Sarafraz-Yazdi E, Pincus MR, Bowne WB. The anti-cancer peptide, PNC-27, induces tumor cell necrosis of a poorly differentiated non-solid tissue human leukemia cell line that depends on expression of HDM-2 in the plasma membrane of these cells. Ann Clin Lab Sci. 2014 Summer;44(3):241-8. PMID: 25117093.
- Sarafraz-Yazdi E, Bowne WB, Adler V, Sookraj KA, Wu V, Shteyler V, Patel H, Oxbury W, Brandt-Rauf P, Zenilman ME, Michl J, Pincus MR. Anticancer peptide PNC-27 adopts an HDM-2-binding conformation and kills cancer cells by binding to HDM-2 in their membranes. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):1918-23. doi: 10.1073/pnas.0909364107. Epub 2010 Jan 11. PMID: 20080680; PMCID: PMC2836618.
- Sarafraz-Yazdi, Ehsan, et al. “MDM2 protein variants expression in the plasma membrane of cancer cells: A target for anticancer peptide PNC-27.” Cancer Research 70.8_Supplement (2010): 5770-5770.
- Aguon, Paul Muna, et al. “Experimental PNC-27 Therapy and Massive GI Hemorrhage: A Complication or Coincidence?: 1879.” Official journal of the American College of Gastroenterology| ACG 112 (2017): S1035-S1036.
- Sarafraz-Yazdi, E., Adler, V., Bowne, W., Sookraj, K., North, A., Niharny, P., … & Michl, J. (2009). Abstract# 884: Mechanism of action of PNC-27/-28 anti-cancer peptides. Cancer Research, 69(9_Supplement), 884-884
- Sookraj KA, Bowne WB, Adler V, Sarafraz-Yazdi E, Michl J, Pincus MR. The anti-cancer peptide, PNC-27, induces tumor cell lysis as the intact peptide. Cancer Chemother Pharmacol. 2010 Jul;66(2):325-31. doi: 10.1007/s00280-009-1166-7. Epub 2010 Feb 25. PMID: 20182728.
Dr. Usman (BSc, MBBS, MaRCP) completed his studies in medicine at the Royal College of Physicians, London. He is an avid researcher with more than 30 publications in internationally recognized peer-reviewed journals. Dr. Usman has worked as a researcher and a medical consultant for reputable pharmaceutical companies such as Johnson & Johnson and Sanofi.
Additional information
Brand | Biotech Peptides |
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37 reviews for PNC-27 (5mg)
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Jade Hughes –
Personally I think the packaging could be better, my peptides have never broke or had any cracks but a more secure box could mean no breaks at all??
Chris Wong –
It is always a quick and efficient procedure with them. My item arrived more quicker than expected, and the quality is excellent.
Elija Stevenson –
They have high quality products, Like that it’s a US based company as well!
tim wesson –
I struggled to find this product for so long and I think it is a bit pricey, but I think it’s worth it, since it can be so hard to find. It also works great in my research.
kai chen –
Amazing company, very happy with the service I have been having for the past 7 months I have been with them.
Kenneth Turner –
I’ve tried a couple other businesses before this one, and although the items were good, the customer service, which I believe to be a critical component of overall customer happiness, was lacking. I left them behind and came to you. Excellent customer service and kind staff.
Chris Calvo –
My payment did not go through and was grateful that instead of going hours going back and forth through email the customer service representative called and let me know right away and we were able to solve it right there and then.
Grayson woods –
All my products were dleivered when stated and nothing was missing.
Bradley Mobeck –
You guys have definitely won me over
Alvaro Villa –
I ran into an issue with payment. It didn’t go through and luckily their rep Taylor emailed me to let me know the situation. We were able to fix it quickly and I got my peptides in time.
EJ McCoy –
Great stuff man.
Greg Mathews –
Had some left over from my last project, if you follow the directions they have a great shelf life!
Josh Espinoza –
Packaged great, even had the fragile sign on the box so it’s taken care of carefully.
Brandon Effler –
After doing some research I decided to use Biotech as my peptide supplier. The peptides were great for what they cost.
Tucker Steil –
Great service, staff really knows their stuff.
Harry Bhangu –
My number one go to spot for peptides. Recently switched over to biotech as our lab orderes in bulk frequently and they seem to be the only one that can handle our needs.
Kenny Hernandez –
BP always coming trough with the best products! Let’s go!
Ken Shahryar –
They have a great variety of peptides, more than some other sites.
Riley Kmiecik –
Great company overall. Ten out of ten
Harees Sam –
You get better customer service here than other places
Thomas Smith –
Peptides came in perfect condition, was a little worried with the heat since I’m on the other side of the country and how the travel/heat would effect the peptides but they were all good!
Brandon Bellen –
Fantastic quality
Steven King –
Products are good, better than most on the market
Chance Moreno –
I am very happy with everything I’ve ordered from them up until now
Jesse Alcala –
Danny was gracious and patient enough to deal with me and fix my payment issue. I had not chnaged my card and it expired. Danny called to let me know so we were able to get that fixed and was able to replace my order as it got canacled.
Matt Goldberg –
Very easy and convienent check out process, had all my info stored already.
Chris Massoud –
Jamie was able to help redo my purchase as I had to cancel the one I previously made. I had ordered the wrong peptides!
Zahaan Jasani –
No issues with biotechs products. Quality has remained great and I have been purchasing from them for over a year now.
Griffin Riggs –
Got a free bac water and I wasn’t even at the minimum for the buy!
Cameron Mahlknecht –
Site was easy to maneuver and simple check out process. Got to give them props for the different payment options, not something you see everywhere. Made sure to get the standard shipment since it seems like they get products shipped out pretty fast anyway.
Tony Provenzano –
Wish they had a way to let us know about restocks. Hate having to check in everyday for it.
Jonovan Jeffery –
Biotech Peptides has great products! Been doing research with peptides for a long time and they are one of the best to work with.
Jordan Powell –
Just great at service and getting the job done
Bryan J –
Nice find! Lot of peptide options and surprisingly a lot of topical options as well.
Ben Gugerty –
Definitely the best price-quality ratio out of all of the peptide suppliers I have come across so far. You’re getting a great product for a lot less.
Conor Hurst –
I usually survey the internet for so long to find this product and once I did, I ordered it in batch. Everything came in perfect and I have no complaints at all
Hank Landry –
Have been looking a lot on the internet for quality PNC and I have finally found it. If you’re considering buying this, it is well worth it