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Syn-AKE (Topical) (200mg)
Syn-AKE peptides are Synthesized and Lyophilized in the USA.
Discount per Quantity
|Quantity||5 - 9||10 +|
FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
FREE - USPS priority shipping
What is the Syn-AKE peptide?
Syn-AKE is a topical peptide, also known as tripeptide-3 or dipeptide diaminobutyroyl benzyl amide diacetate. Syn-AKE appears to be an effective synthetic peptide ingredient, mimicking the effects of a Walgerin 1 peptide (which is 21 amino acids in length) from Temple Viper venom (a venomous snake found in Southeast Asia). It is a small synthetic peptide developed to reduce the appearance of laughter lines and wrinkles. Syn-AKE may be used as a serum or added to skincare products. Researchers suggest Syn-AKE to be able to reduce transmission between muscles and nerves, working similarly to Botox to relax muscles and thus lessen wrinkles in skin in animal models. According to Pentapharm, “the Syn-Ake invokes its action by blocking the muscle nAChR in a reversible manner by blocking the ion channel. As a result, the Na+ uptake is substantially disturbed, and the muscles remain relaxed.” The number of laughter and expression lines increases with age. Syn-AKE may enable the face to relax and reduce wrinkles. New studies have suggested that when Syn-AKE is used earlier, it may help delay the appearance of wrinkles. The peptide may can reduce signal transmission between muscles and nerves. Studies report the effectiveness of Syn-AKE to be remarkable; indicating it may reduce the depth of facial wrinkles in just a few days and have excellent skin-soothing properties. A study involving over 40 volunteers observed these results. During this test, the use of Syn-AKE twice a day appeared to reduce forehead wrinkles by up to 50% in just 2 days.
Molecular Formula: C23H37N5O7
Molecular Weight: 495.57 g/mol
Sequence: β-Ala-Pro-Dab-NHBn .2Acetate
PubChem: CID 71465152
CAS Number: 823202-99-9
How Does Syn-AKE Work?
Syn-AKE studies indicate that the peptide may reduce the number of muscular movements in the face and reduce cellular mobility; this helps the skin smooth out. The synthetic equivalent of venom in the peptide appears to temporarily relax the muscles in the face, potentially even preventing the apparition of new wrinkles and improving the condition of existing ones. Wrinkles and lines around the eyes, mouth, and forehead form due to repeated movements of the muscles. With time, the skin loses elasticity. As a result, it can no longer return to its initial smooth appearance. Syn-AKE appears to combat this, and may be applied to the neck, forehead, neck, and areas around the lips and eyes. Syn-AKE may be used regularly because it is assumed by researchers to exhibit a cumulative effect, and wears off if not used regularly. Syn-AKE appears to be a competitive antagonist of acetylcholine receptors in the muscles. In other words, it may compete with acetylcholine to attach to the acetylcholine receptors. Acetylcholine is one of the significant primary neurotransmitters used by the nervous system. It sends signals from the nerves to the muscles. Once released, muscles take that as a signal to contract. Each muscle contracts countless times in a day. Age and excessive muscle contractions of the facial muscles result in visible signs of skin aging. Syn-AKE appears to occupy and block the acetylcholine receptors. As a result, acetylcholine may never reach its receptors. The muscles do not get a signal to contract without acetylcholine. As a result, they remain in a smooth and relaxed state. Over time, the relaxed muscles lead to the reversal of visible signs of skin aging. The mechanism of action of Syn-AKE is similar to that of botox. Additionally, the antagonism of acetylcholine receptors caused by the peptide is 100% reversible. These features make Syn-AKE potentially effective and safe to use in the aesthetic industry.
Focus of Syn-AKE peptide Research
Syn-AKE has been studied for its potential effects, such as anti-aging, anti-wrinkle, smile and frown lines, skin tightening, firmness, and lifts. The studies “demonstrate that this uniquely formulated line treatment was well tolerated and provided both immediate and long-term improvements in the appearance of fine and coarse wrinkles.” Researchers have focused on specific areas of study to determine the full potential of the peptide, as outlined below:
● Anti-aging Effects: Syn-AKE appears to have an anti-aging effect, particularly when performing action against expression lines. Syn-AKE may relax the facial muscles and help smoothen the skin overlying the muscles.
● Wrinkle Smoothing: Wrinkles result from excessive contraction of facial muscles. Due to its ability to relax muscles, it can help prevent wrinkles. Research observed that test subjects noticed a remarkable reduction in facial wrinkles after only 4 weeks of using Syn-AKE.
● Relaxing: The peptide appears to be excellent for relaxing the face without losing the ability to express the features. This potential gives it an upper hand over other treatments like botox and fillers.
● Wrinkle Delay: Syn-AKE appears to aid and delay the appearance of wrinkles when used earlier. It may also possess an age-freezing effect.
● Skin Elasticity: It may help in improving skin elasticity, which causes skin to look younger, supple, and radiant.
Syn-AKE Safety Profile
Syn-AKE contains venom from the temple viper snake, however it has appeared to be safe for human use, as reported by studies and researchers. Venom has been used historically in various applications to treating illness and supplementing products There has been a significant amount of research into the potential applications of synthetic venoms to treat various ailments in recent times. Researchers in this peptide have reported that Syn-AKE may exhibit potential mild side effects such as itching, stinging, slight swelling or redness, freezing sensations. The peptide is available for research purposes only.
- Munawar A, Ali SA, Akrem A, Betzel C. Snake Venom Peptides: Tools of Biodiscovery. Toxins (Basel). 2018;10(11):474. Published 2018 Nov 14. doi:10.3390/toxins10110474.
- Zhmak, Maxim Nurgayanovich, et al. “Peptide inhibitors of nicotinic acetylcholine receptor.” U.S. Patent No. 9,550,808. 24 Jan. 2017.
- Balaev, A. N., K. A. Okhmanovich, and V. N. Osipov. “A shortened, protecting group free, synthesis of the anti-wrinkle venom analogue Syn-Ake® exploiting an optimized Hofmann-type rearrangement.” Tetrahedron Letters 55.42 (2014): 5745-5747.
- Chhipa, Nadim MR, and B. Chaudhari. “Toxin as a Medicine.” Journal of Current Pharmaceutical Research 9.1 (2012): 11-8.
- Trookman, Nathan S., et al. “Immediate and long-term clinical benefits of a topical treatment for facial lines and wrinkles.” The Journal of clinical and aesthetic dermatology 2.3 (2009): 38.
Dr. Usman (BSc, MBBS, MaRCP) completed his studies in medicine at the Royal College of Physicians, London. He is an avid researcher with more than 30 publications in internationally recognized peer-reviewed journals. Dr. Usman has worked as a researcher and a medical consultant for reputable pharmaceutical companies such as Johnson & Johnson and Sanofi.
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