Syn-AKE (Topical) (200mg)

(9 customer reviews)


Syn-AKE peptides are Synthesized and Lyophilized in the USA.

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Quantity 5 - 910 +
Discount 5%10%
Price $199.50$189.00
Orders over $200 receive:
FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
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SKU: Syn-AKE-topical-200mg Category:


Syn-AKE Peptide

Syn-AKE is a topical peptide, also known as tripeptide-3 or dipeptide diaminobutyroyl benzyl amide diacetate. Syn-AKE, a synthetic peptide ingredient, appears to mimic the effects of a Walgerin-1 peptide (which is 21 amino acids in length) from Temple Viper venom (a venomous snake found in Southeast Asia). Researchers suggest Syn-AKE may act to reduce transmission between muscles and nerves, working similarly to botulinum toxin to relax muscles and thus reduce instances of creasing and wrinkle development along skin surfaces, as suggested in animal model research.[1] According to Pentapharm, “the Syn-Ake invokes its action by blocking the muscle nAChR in a reversible manner by blocking the ion channel. As a result, the Na+ uptake is substantially disturbed, and the muscles remain relaxed.”


Molecular Formula: C23H37N5O7

Molecular Weight: 495.57 g/mol

Sequence: β-Ala-Pro-Dab-NHBn .2Acetate

Syn-AKE Research

Syn-AKE studies indicate that the peptide may reduce the number of muscular movements and reduce cellular mobility. The synthetic equivalent of venom in the peptide appears to temporarily reduce contractile force in certain muscle groups. Syn-AKE appears to be a competitive antagonist of acetylcholine receptors in the muscles.[3] In other words, it may compete with acetylcholine to attach to the acetylcholine receptors. Acetylcholine is considered to be a primary neurotransmitter, signaling from nerves to muscles. Syn-AKE appears to occupy and block the acetylcholine receptors, thereby inhibiting the muscular impulse. Over time, the relaxed muscles may reduce the natural creasing that occurs across the skin surface.[4] Syn-AKE has been studied for its potential impact primarily within the context of skin and muscle cells.[5] Research in the peptide is still ongoing.

Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.



  1. Munawar A, Ali SA, Akrem A, Betzel C. Snake Venom Peptides: Tools of Biodiscovery. Toxins (Basel). 2018;10(11):474. Published 2018 Nov 14. doi:10.3390/toxins10110474.
  2. Zhmak, Maxim Nurgayanovich, et al. “Peptide inhibitors of nicotinic acetylcholine receptor.” U.S. Patent No. 9,550,808. 24 Jan. 2017.
  3. Balaev, A. N., K. A. Okhmanovich, and V. N. Osipov. “A shortened, protecting group free, synthesis of the anti-wrinkle venom analogue Syn-Ake® exploiting an optimized Hofmann-type rearrangement.” Tetrahedron Letters 55.42 (2014): 5745-5747.
  4. Chhipa, Nadim MR, and B. Chaudhari. “Toxin as a Medicine.” Journal of Current Pharmaceutical Research 9.1 (2012): 11-8.
  5. Trookman, Nathan S., et al. “Immediate and long-term clinical benefits of a topical treatment for facial lines and wrinkles.” The Journal of clinical and aesthetic dermatology 2.3 (2009): 38.
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This product is strictly for research/laboratory use only. Human or animal use and/or consumption is strictly prohibited by law. Only qualified and licensed professionals should handle these products. Any information found on Biotech Peptides is strictly for educational purposes only. Refer to our terms and conditions for more details.

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Biotech Peptides

9 reviews for Syn-AKE (Topical) (200mg)

  1. HUNTER Coleman

    Decently valued, been with them since last April/May. Haven’t ordered from anywhere else to be honest.

  2. Art Decker

    Been with them over a year. Everything has been great. I have rarely had to contact customer service for anything.

  3. A. Jimenez

    New to researching with peptides and heard this was a good place to shop for some quality products. Glad I was recommended here.

  4. Beckett Black

    Real fast response time with their CS email!

  5. greg foster

    Biotech is my sole peptide supplier. Super reliable and always have what I need in stock.

  6. J.G. Aultman

    Shipment is quick, have not experinced products coming in later than the expected date with them.

  7. Jeremy Cobos

    Jamie is the representative I go to for all my troubles. They got the job done and were able to get me a special code as I’m a consistent bulk buyer.

  8. Joe Park

    Possibly the best peptide company I have come across. I order in bulk for our lab and Biotech’s team has been nothing but helpful when placing orders!

  9. Kyle Hughes

    Shopped arround a bit but Biotech is by far my number one place to get peptides. Prices are great and quality is even better.

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