Fragment 176-191 (5mg)

(18 customer reviews)

Original price was: $47.00.Current price is: $44.00.

Fragment 176-191 peptides are Synthesized and Lyophilized in the USA.

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Price $41.80$39.60
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Fragment 176-191 Peptide

Fragment 176-191 peptide (Frag 176-191) is a short segment of growth hormone (hGH) and is sometimes referred to as the “lipolytic fragment.” The name was coined from initial research on animal systems, which suggested that Fragment 176-191 may potentially increase fat cell metabolism in genetically engineered obese mice. Growth hormone (hGH) supplementation is considered by scientists to generally suppress carbohydrate metabolism, alter sensitivity towards insulin, promote long bone growth, and heighten insulin-like growth factor-1 (IGF-1) levels. Extensive animal studies have suggested that this synthetic fragment may mimic the lipolytic action of hGH without other actions.[1] Fragment 176-191 peptide is also available in 10mg.


Molecular Formula: C78H125N23O23S2

Molecular Weight: 1817.1 g/mol

Sequence: Tyr-Leu-Arg-Ile-Val-Gin-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe

Other Known Titles: Frag 176-191

Fragment 176-191 Research

Fragment 176-191 Structure
Fragment 176-191 is the shortened C-terminal fragment of hGH, encompassing a sequence of 16 amino acids. Researchers who synthesized the peptide assert that the structure corresponds to the final 16 amino acids of the hGH molecule and the peptide, therefore, is speculated to act as the “lipolytic fragment” of hGH. The designation “lipolytic” indicates that this fragment may have characteristics that facilitate the degradation of lipids or fats. In an aim to improve the stability of this peptide, the first amino acid in the sequence of hGH Fragment 176-191 has been replaced with tyrosine. As a result, this altered peptide is sometimes also known as Fragment tyr-hGH 177-191 or AOD 9604. Incorporating tyrosine at the N-terminus is thought to bolster the peptide’s stability. Additionally, preliminary data suggests a naturally occurring disulfide bond between two cysteine amino acids in the original hGH and in Frag 176-191. This disulfide bond is presumed to play a role in maintaining the structural integrity of the molecule, thereby possibly enhancing its resilience and capacity to resist degradation under various environmental conditions, such as exposure to gastric acids and digestive enzymes.[2]

Fragment 176-191 and Cartilage
Experimental research in Fragment 176-191 suggests its potential in cartilage regeneration.[3] To investigate the potential action of this peptide on knee osteoarthritis, scientists employed a model to mimic the condition by damaging knee cartilage by introducing type II collagenase. This particular enzyme is speculated to act in degrading the cartilage cellular matrix, mimicking the pathological changes seen in osteoarthritis. After inducing cartilage damage, the damaged knee models were organized into four distinct groups for 4-7 weeks: the researchers exposed the first group to a control compound saline (Group 1), the second was exposed to hyaluronic acid (Group 2), the third experimental group was exposed to Fragment 176-191 peptide (Group 3), and the fourth group was exposed to a combination of Fragment 176-191 peptide and hyaluronic acid (Group 4). To assess the potential actions of these experimental interventions, the severity of cartilage damage was systematically evaluated using both morphological and histopathological methods. Additionally, the extent of lameness was measured eight weeks post-initiation of the experimental protocols, providing insights into the functional outcomes of the interventions. The researchers commented, “Mean gross morphological and histopathological scores were significantly higher in Group 1 than in Groups 2, 3, and 4, and the scores were significantly lower in Group 4 than in Groups 2 and 3. The lameness period in Group 4 was significantly shorter than those in Groups 1, 2, and 3.” The findings indicate that both the hyaluronic acid and the Fragment 176-191 peptide may exhibit superior potential compared to saline in promoting cartilage regeneration. This hypothesis stems from the posited interactions between these two compounds, where hyaluronic acid may support moisture retention and lubrication, while Fragment 176-191 may play a role in the regeneration and repair of the model tissues.

Fragment 176-191 and Hypoglycemia
The C terminal end of hGH principally has been considered to bring about hypoglycemic (low blood sugar) levels in murine models.[4] Screening of at least six different fragments obtained from the C terminal section of hGH has suggested that Fragment 176-191 may be a potentially effective synthetic derivative of hGH in research on blood sugar control. The hypoglycemic potential is considered secondary to maintaining an increased expression of insulin in blood plasma.

Fragment 176-191 and Fat Cells
The fat cell dissolution potential of Fragment 176-191 stems from research hypothesizing the peptide’s capacity to increase the production of beta-3 adrenergic receptors (3-AR or ADRB3).[5] More specifically, the researchers posted that Fragment 176-191 may be “capable of increasing the repressed levels of beta(3)-AR RNA in obese mice to levels comparable with those in lean mice.” An elevated density of beta-3 adrenergic receptors on adipocyte membranes potentially heightens these cells’ sensitivity to lipolytic cues. This implies that although Fragment 176-191 might not interact directly with ADRB3, the increased number of these receptors might amplify the lipolytic activity prompted by endogenous catecholamines, notably adrenaline, which is posited to activate these receptors directly. Thus, agonist activity of the Fragment 176-191 peptide upon interaction with ADRB3 appeared to directly enhance fat burning in adipose tissue. Fragment 176-191 might initiate additional cellular signaling pathways that may indirectly enhance fat metabolism. For example, it might influence processes that either elevate the production of key enzymes involved in lipolysis or potentially enhance the cell’s responsiveness to lipolytic signals through the regulation of secondary messengers within the cell. Here, lipolysis is the process of fat breakdown occurring in adipocytes, primarily driven by lipolytic enzymes. Secondary messengers are intracellular molecules believed to intensify signals from cell surface receptors to the internal biochemical systems. This amplification is crucial for orchestrating intricate cellular reactions to external signals. Research indicates that genetically modified mice that lack ADRB3 may be resistant to the action of hGH / Fragment 176-191. One experimental study observed that Fragment 176-191 exposure appeared to induce up to 50% weight reduction in obese mice over three weeks. Interestingly, the peptide appeared to mediate weight reduction only in obese mice but not in lean mice during the same span of exposure. The results suggest that secondary pathways may be involved in energy homeostasis, which may be capable of maintaining fat reserve in lean mice by overriding the ADRB3 pathway.

Fragment 176-191 and Fat Tissue Mass
In the realm of scientific inquiry, the potential of Fragment 176-191 in reducing total levels of fat mass has been probed using rigorously structured clinical trials, such as the METAOD005 study. This specific trial aimed to assess the efficacy of the peptide in reducing adipose tissue over a period of 12 weeks. Preliminary findings suggest that test subjects in one of the Fragment 176-191 groups may have experienced a notable reduction in fat tissue mass, with an average weight loss of approximately 5.7 pounds. Furthermore, there is a tentative suggestion that this peptide might positively influence lipid and glucose metabolism. However, additional studies are necessary to thoroughly explore these possibilities.[6]

Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.



  1. Habibullah MM, Mohan S, Syed NK, Makeen HA, Jamal QMS, Alothaid H, Bantun F, Alhazmi A, Hakamy A, Kaabi YA, Samlan G, Lohani M, Thangavel N, Al-Kasim MA. Human Growth Hormone Fragment 176-191 Peptide Enhances the Toxicity of Doxorubicin-Loaded Chitosan Nanoparticles Against MCF-7 Breast Cancer Cells. Drug Des Devel Ther. 2022 Jun 27;16:1963-1974. doi: 10.2147/DDDT.S367586. PMID: 35783198; PMCID: PMC9249349.
  2. Moré, M. I., & Kenley, D. (2014). Safety and metabolism of AOD9604, a novel nutraceutical ingredient for improved metabolic health. Journal of Endocrinology and Metabolism, 4(3), 64-77.
  3. Kwon DR, Park GY. Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model. Ann Clin Lab Sci. 2015 Summer;45(4):426-32. PMID: 26275694.
  4. Ng FM, Bornstein J. Hyperglycemic action of synthetic C-terminal fragments of human growth hormone. Am J Physiol. 1978 May;234(5):E521-6. doi: 10.1152/ajpendo.1978.234.5.E521. PMID: 645904.
  5. Heffernan M, Summers RJ, Thorburn A, Ogru E, Gianello R, Jiang WJ, Ng FM. The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice. Endocrinology. 2001 Dec;142(12):5182-9. doi: 10.1210/endo.142.12.8522. PMID: 11713213.
  6. Stier, H., Vos, E., & Kenley, D. (2013). Safety and Tolerability of the Hexadecapeptide AOD9604 in Humans. Journal of Endocrinology and Metabolism, 3(1-2), 7-15.
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This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law.  Only qualified and licensed professionals should handle these products.  Any information found on Biotech Peptides is strictly for educational purposes only.  Refer to our terms and conditions for more details.

Dr. Usman

Dr. Usman (BSc, MBBS, MaRCP) completed his studies in medicine at the Royal College of Physicians, London. He is an avid researcher with more than 30 publications in internationally recognized peer-reviewed journals. Dr. Usman has worked as a researcher and a medical consultant for reputable pharmaceutical companies such as Johnson & Johnson and Sanofi.

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Biotech Peptides

18 reviews for Fragment 176-191 (5mg)

  1. Emily Roy

    Ordering was simple

  2. Christopher Adams

    Very pure and legit products. The best I have tried until now. I will only order from them from now on. Very reliable source

  3. Dean McCaughan

    they are the only company that offers custom synthesis and thats something new in this industry

  4. Alex Lin

    the quantity discounts justify the cost. happy customer here

  5. Loren Brinley

    These guys go above and beyond in everything they do. I’m definitely a customer for life, I don’t care how much they cost (their prices are great anyway), the peace of mind I have with this team is worth double the price of their product alone.

  6. Kevin Jones

    The product works great and the shipping was fast. I just ordered my 3rd bottle

  7. Susan Onuoha

    This whole experience was so great that I felt I had to come back and write a review. I was recommended to this place by a colleague who has been shopping here for a while. They told me this was the first place where they didn’t have trouble getting products in and did not have to deal with an automated service that gets them nowhere when you need a rep to help you out. So the place i typically order from was out of stock of the product I needed and decided to see if they would have it. After checking it out, they were also out of stock but I did see a few products that would be helpful in future research so I decided to order those. The payment was processed, got my shipping number and was informed that because I ordered before 2 pm that it would be shipped out the same day. Amazing because that means it’s less likely to get a damaged product with the temp and all that. The product came in two days and everything was in perfect condition and ready to go. I’ll definitely wait and see if they restock and try those out as well.

  8. William Poulson

    I wish all companies had CS like them!

  9. Barb Ruess

    The whole process is easy. Check out is a breeze since my information is already saved and all I need to do is click a few buttons. It is a headache sometimes to have to always type in the address, card number, and details, and also like that I can see what I ordered previously.

  10. John Malvin

    I appreciate the promo code they sent me after my first purchase !!

  11. Bob Marshall

    The company is legit. Have had to deal with BS from other companies with fraud products. Biotech has proved in the past 6 months that I’ve been using them that the peptides are of excellent quality and help my research rather than hinder it.

  12. Ian Marshall

    Customer service is always quick. I had an instance where I was charged for my order two times. I was able to get in contact with someone right away to fix that and get the charge cleared.

  13. Juan Carlo Romero

    Prices are avg but the products are 100% above average.

  14. Nicholas Porter

    My peptides came in with no issues. Been with them for a while and have not had any major complaints.

  15. lawrence gonzales

    Noticed this peptide has been out of stock for a bit but noticed you restocked it and jumped to but it. Got to be quick with them.

  16. Annie Matthews

    Wish they had a way to let me know when peptides are back in stock. It gets frustrating having to check back in everyday to see if there’s been one or not.

  17. David Polito

    Got them within 2 days and Im on the other side of the country. No breaks or damage.

  18. Ryan Garrison

    Customer service can’t be beat, they train the employees well

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