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Fragment 176-191 (5mg)

(18 customer reviews)

$44.00

Fragment 176-191 peptides are Synthesized and Lyophilized in the USA.

Discount per Quantity

Quantity 5 - 910 +
Discount 5%10%
Price $41.80$39.60
Orders over $200 receive:
FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
FREE - USPS priority shipping
SKU: Fragment-176-191-5mg Category:

Description

Fragment 176-191 Peptide

Fragment 176-191 peptide (Frag 176-191) is a short segment of growth hormone (hGH) and is sometimes referred to as the “lipolytic fragment.” The name was coined from initial research on animal systems which suggested that Fragment 176-191 holds the potential to enhance fat metabolism in genetically engineered obese mice. Growth hormone (hGH) supplementation may supress carbohydrate metabolism, alter sensitivity towards insulin, promote long bone growth, and heighten insulin-like growth factor-1 (IGF-1) levels. Extensive animal studies have suggested that the synthetic fragment may enhance the lipolytic action of hGH without inducing ancillary impacts. The peptide is also available in 10mg.

Specifications

Other Known Titles: Frag 176-191

Molecular Formula: C78H125N23O23S2

Molecular Weight: 1817.1 g/mol

Sequence: Tyr-Leu-Arg-Ile-Val-Gin-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe

Fragment 176-191 Research

Fragment 176-191 and Cartilage
Experimental research in Fragment 176-191 suggests its potential in cartilage regeneration. Researchers engaged in the study of synthetic peptides suggest that they may bring about cartilage regeneration through hyaluronic acid. Research in rabbits has observed that weekly exposure to Fragment 176-191 appeared to improve cartilage growth (within laboratory measures), and its co-introduction with hyaluronic acid (HA) appeared to be even more impactful.

Fragment 176-191 and Hypoglycemia
The C terminal end of hGH principally has been considered to bring about hypoglycemic (low blood sugar) levels in the mice’s bodies. Screening of at least six different fragments obtained from the C terminal section of hGH has suggested that Fragment 176-191 may be an effective synthetic derivative of hGH in research on blood sugar control. The hypoglycemic potential is secondary to maintaining an increased expression of insulin in blood plasma.

Fragment 176-191 and Fat Cells
The fat cell dissolution potential of Fragment 176-191 stems from the peptide’s hypothetical potential to increase the production of beta-3 adrenergic receptors (3-AR or ADRB3). Agonist activity of the Fragment 176-191 peptide upon interaction with ADRB3 appeared to directly enhance fat burning in adipose tissue, and may also trigger skeletal muscle thermogenesisscle. Research indicates that genetically modified mice that lack ADRB3 may be resistant to the action of hGH / Fragment 176-191. One experimental study observed that exposure to Fragment 176-191 appeared to cause up to 50% weight reduction in obese mice over three weeks. Interestingly, the peptide appeared to mediate weight reduction only in obese mice but not in lean mice during the same span of exposure. The results suggest that there may be secondary pathways involved in energy homeostasis which may be capable of maintaining fat reserve in lean mice by overriding ADRB3 pathway.

Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.

 

References

  1. Habibullah MM, Mohan S, Syed NK, Makeen HA, Jamal QMS, Alothaid H, Bantun F, Alhazmi A, Hakamy A, Kaabi YA, Samlan G, Lohani M, Thangavel N, Al-Kasim MA. Human Growth Hormone Fragment 176-191 Peptide Enhances the Toxicity of Doxorubicin-Loaded Chitosan Nanoparticles Against MCF-7 Breast Cancer Cells. Drug Des Devel Ther. 2022 Jun 27;16:1963-1974. doi: 10.2147/DDDT.S367586. PMID: 35783198; PMCID: PMC9249349.
  2. Heffernan M, Summers RJ, Thorburn A, Ogru E, Gianello R, Jiang WJ, Ng FM. The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice. Endocrinology. 2001 Dec;142(12):5182-9. doi: 10.1210/endo.142.12.8522. PMID: 11713213.
  3. Heffernan MA, Jiang WJ, Thorburn AW, Ng FM. Effects of oral administration of a synthetic fragment of human growth hormone on lipid metabolism. Am J Physiol Endocrinol Metab. 2000 Sep;279(3):E501-7. doi: 10.1152/ajpendo.2000.279.3.E501. PMID: 10950816.
  4. Ng FM, Bornstein J. Hyperglycemic action of synthetic C-terminal fragments of human growth hormone. Am J Physiol. 1978 May;234(5):E521-6. doi: 10.1152/ajpendo.1978.234.5.E521. PMID: 645904.
  5. Kwon DR, Park GY. Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model. Ann Clin Lab Sci. 2015 Summer;45(4):426-32. PMID: 26275694.
All orders ship same day if placed by 12 PST.
This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law.  Only qualified and licensed professionals should handle these products.  Any information found on Biotech Peptides is strictly for educational purposes only.  Refer to our terms and conditions for more details.

Additional information

Brand

Biotech Peptides

18 reviews for Fragment 176-191 (5mg)

  1. Emily Roy

    Ordering was simple

  2. Christopher Adams

    Very pure and legit products. The best I have tried until now. I will only order from them from now on. Very reliable source

  3. Dean McCaughan

    they are the only company that offers custom synthesis and thats something new in this industry

  4. Alex Lin

    the quantity discounts justify the cost. happy customer here

  5. Loren Brinley

    These guys go above and beyond in everything they do. I’m definitely a customer for life, I don’t care how much they cost (their prices are great anyway), the peace of mind I have with this team is worth double the price of their product alone.

  6. Kevin Jones

    The product works great and the shipping was fast. I just ordered my 3rd bottle

  7. Susan Onuoha

    This whole experience was so great that I felt I had to come back and write a review. I was recommended to this place by a colleague who has been shopping here for a while. They told me this was the first place where they didn’t have trouble getting products in and did not have to deal with an automated service that gets them nowhere when you need a rep to help you out. So the place i typically order from was out of stock of the product I needed and decided to see if they would have it. After checking it out, they were also out of stock but I did see a few products that would be helpful in future research so I decided to order those. The payment was processed, got my shipping number and was informed that because I ordered before 2 pm that it would be shipped out the same day. Amazing because that means it’s less likely to get a damaged product with the temp and all that. The product came in two days and everything was in perfect condition and ready to go. I’ll definitely wait and see if they restock and try those out as well.

  8. William Poulson

    I wish all companies had CS like them!

  9. Barb Ruess

    The whole process is easy. Check out is a breeze since my information is already saved and all I need to do is click a few buttons. It is a headache sometimes to have to always type in the address, card number, and details, and also like that I can see what I ordered previously.

  10. John Malvin

    I appreciate the promo code they sent me after my first purchase !!

  11. Bob Marshall

    The company is legit. Have had to deal with BS from other companies with fraud products. Biotech has proved in the past 6 months that I’ve been using them that the peptides are of excellent quality and help my research rather than hinder it.

  12. Ian Marshall

    Customer service is always quick. I had an instance where I was charged for my order two times. I was able to get in contact with someone right away to fix that and get the charge cleared.

  13. Juan Carlo Romero

    Prices are avg but the products are 100% above average.

  14. Nicholas Porter

    My peptides came in with no issues. Been with them for a while and have not had any major complaints.

  15. lawrence gonzales

    Noticed this peptide has been out of stock for a bit but noticed you restocked it and jumped to but it. Got to be quick with them.

  16. Annie Matthews

    Wish they had a way to let me know when peptides are back in stock. It gets frustrating having to check back in everyday to see if there’s been one or not.

  17. David Polito

    Got them within 2 days and Im on the other side of the country. No breaks or damage.

  18. Ryan Garrison

    Customer service can’t be beat, they train the employees well

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