Fragment 176-191 peptide is a short segment of human growth hormone (hGH) and is sometimes referred to as the “lipolytic fragment.” The name was coined from initial research on animal systems which suggested that Fragment 176-191 holds the potential to enhance fat metabolism in genetically engineered obese mice. Human growth hormone (hGH) treatment has several adverse effects on the body, such as suppressing carbohydrate metabolism, altered sensitivity towards insulin, promotion of long bone growth, and heightened insulin-like growth factor-1 (IGF-1) levels. Extensive animal studies have suggested that the synthetic fragment may enhance the lipolytic effects of hGH without inducing the same side effects. Therefore, the peptide may potentially be used for anti-obesity treatments.
Frag 176-191, Fat Burning and Weight Loss The fat-burning potential of Frag 176-191 stems from the peptide’s hypothetical ability to increase the production of beta-3 adrenergic receptors (3-AR or ADRB3). Agonist activity of the Fragment 176-191 peptide upon interaction with ADRB3 appeared to directly enhance fat burning in adipose tissue, and may also trigger skeletal muscle thermogenesisscle. Research indicates that genetically modified mice that lack ADRB3 are resistant to the effect of hGH / Fragment 176-191. One experimental study observed that treatment of Fragment 176-191 appeared to cause up to 50% weight reduction in obese mice over three weeks. Interestingly, the peptide appeared to mediate weight reduction only in obese mice but not in lean mice during the same span of treatment. The results suggest that there may be secondary pathways involved in energy homeostasis which are capable of maintaining fat reserve in lean mice by overriding ADRB3 pathway.
Frag 176-191 and blood sugar levels The C terminal end of hGH principally has been observed to bring about hypoglycemic (low blood sugar) levels in the mice’s bodies. Screening of at least six different fragments obtained from the C terminal section of hGH has suggested that Fragment 176-191 may be the most effective synthetic derivative of hGH for decreasing blood sugar levels. The hypoglycemic function is secondary to maintaining an increased expression of insulin in blood plasma. These functions suggest that Frag 176-191 has the potential to treat prediabetes and type-2 diabetes.
Frag 176-191 and cartilage regeneration Experimental research in Frag 176-191 suggests its ability to promote cartilage regeneration. Researchers engaged in the study of synthetic peptides suggest that they may bring about cartilage regeneration like hyaluronic acid treatment. Research in rabbits has observed that weekly administration of Fragment 176-191 appeared to improve cartilage growth (within laboratory measures), and its co-administration with hyaluronic acid (HA) appeared to be even more effective. Fragment 176-191 both independently and in combination with HA may help to improve the conditions of osteoarthritis. Thus there is the reason to include Frag 176-191 in the scope of beneficial treatments which may overcome the requirement of surgery.
Summarization of Research Areas of Frag 176-191
The principal areas of research on Fragment 176-191 explore its role in fat metabolism and weight loss. The findings have led to further research in the domain of the mechanism of energy homeostasis in the body. The secondary areas of interest include the effect of Fragment 176-191 in the repair of cartilage and connective tissue regeneration.
All orders ship same day if placed by 2pm PST. Synthesized and lyophilized in the USA.
This product is strictly for research/laboratory use only. Human or animal use and/or consumption is strictly prohibited by law. Only qualified and licensed professionals should handle these products. Any information found on Biotech Peptides is strictly for educational purposes only. Refer to our terms and conditions for more details.
Dr. Usman (BSc, MBBS, MaRCP) completed his studies in medicine at the Royal College of Physicians, London. He is an avid researcher with more than 30 publications in internationally recognized peer-reviewed journals. Dr. Usman has worked as a researcher and a medical consultant for reputable pharmaceutical companies such as Johnson & Johnson and Sanofi.
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Biotech Peptides
18 reviews for Fragment 176-191 (5mg)
Rated 5 out of 5
Emily Roy –
Ordering was simple
Rated 5 out of 5
Christopher Adams –
Very pure and legit products. The best I have tried until now. I will only order from them from now on. Very reliable source
Rated 5 out of 5
Dean McCaughan –
they are the only company that offers custom synthesis and thats something new in this industry
Rated 5 out of 5
Alex Lin –
the quantity discounts justify the cost. happy customer here
Rated 5 out of 5
Loren Brinley –
These guys go above and beyond in everything they do. I’m definitely a customer for life, I don’t care how much they cost (their prices are great anyway), the peace of mind I have with this team is worth double the price of their product alone.
Rated 5 out of 5
Kevin Jones –
The product works great and the shipping was fast. I just ordered my 3rd bottle
Rated 5 out of 5
Susan Onuoha –
This whole experience was so great that I felt I had to come back and write a review. I was recommended to this place by a colleague who has been shopping here for a while. They told me this was the first place where they didn’t have trouble getting products in and did not have to deal with an automated service that gets them nowhere when you need a rep to help you out. So the place i typically order from was out of stock of the product I needed and decided to see if they would have it. After checking it out, they were also out of stock but I did see a few products that would be helpful in future research so I decided to order those. The payment was processed, got my shipping number and was informed that because I ordered before 2 pm that it would be shipped out the same day. Amazing because that means it’s less likely to get a damaged product with the temp and all that. The product came in two days and everything was in perfect condition and ready to go. I’ll definitely wait and see if they restock and try those out as well.
Rated 5 out of 5
William Poulson –
I wish all companies had CS like them!
Rated 5 out of 5
Barb Ruess –
The whole process is easy. Check out is a breeze since my information is already saved and all I need to do is click a few buttons. It is a headache sometimes to have to always type in the address, card number, and details, and also like that I can see what I ordered previously.
Rated 5 out of 5
John Malvin –
I appreciate the promo code they sent me after my first purchase !!
Rated 5 out of 5
Bob Marshall –
The company is legit. Have had to deal with BS from other companies with fraud products. Biotech has proved in the past 6 months that I’ve been using them that the peptides are of excellent quality and help my research rather than hinder it.
Rated 5 out of 5
Ian Marshall –
Customer service is always quick. I had an instance where I was charged for my order two times. I was able to get in contact with someone right away to fix that and get the charge cleared.
Rated 5 out of 5
Juan Carlo Romero –
Prices are avg but the products are 100% above average.
Rated 5 out of 5
Nicholas Porter –
My peptides came in with no issues. Been with them for a while and have not had any major complaints.
Rated 5 out of 5
lawrence gonzales –
Noticed this peptide has been out of stock for a bit but noticed you restocked it and jumped to but it. Got to be quick with them.
Rated 4 out of 5
Annie Matthews –
Wish they had a way to let me know when peptides are back in stock. It gets frustrating having to check back in everyday to see if there’s been one or not.
Rated 5 out of 5
David Polito –
Got them within 2 days and Im on the other side of the country. No breaks or damage.
Rated 5 out of 5
Ryan Garrison –
Customer service can’t be beat, they train the employees well
Emily Roy –
Ordering was simple
Christopher Adams –
Very pure and legit products. The best I have tried until now. I will only order from them from now on. Very reliable source
Dean McCaughan –
they are the only company that offers custom synthesis and thats something new in this industry
Alex Lin –
the quantity discounts justify the cost. happy customer here
Loren Brinley –
These guys go above and beyond in everything they do. I’m definitely a customer for life, I don’t care how much they cost (their prices are great anyway), the peace of mind I have with this team is worth double the price of their product alone.
Kevin Jones –
The product works great and the shipping was fast. I just ordered my 3rd bottle
Susan Onuoha –
This whole experience was so great that I felt I had to come back and write a review. I was recommended to this place by a colleague who has been shopping here for a while. They told me this was the first place where they didn’t have trouble getting products in and did not have to deal with an automated service that gets them nowhere when you need a rep to help you out. So the place i typically order from was out of stock of the product I needed and decided to see if they would have it. After checking it out, they were also out of stock but I did see a few products that would be helpful in future research so I decided to order those. The payment was processed, got my shipping number and was informed that because I ordered before 2 pm that it would be shipped out the same day. Amazing because that means it’s less likely to get a damaged product with the temp and all that. The product came in two days and everything was in perfect condition and ready to go. I’ll definitely wait and see if they restock and try those out as well.
William Poulson –
I wish all companies had CS like them!
Barb Ruess –
The whole process is easy. Check out is a breeze since my information is already saved and all I need to do is click a few buttons. It is a headache sometimes to have to always type in the address, card number, and details, and also like that I can see what I ordered previously.
John Malvin –
I appreciate the promo code they sent me after my first purchase !!
Bob Marshall –
The company is legit. Have had to deal with BS from other companies with fraud products. Biotech has proved in the past 6 months that I’ve been using them that the peptides are of excellent quality and help my research rather than hinder it.
Ian Marshall –
Customer service is always quick. I had an instance where I was charged for my order two times. I was able to get in contact with someone right away to fix that and get the charge cleared.
Juan Carlo Romero –
Prices are avg but the products are 100% above average.
Nicholas Porter –
My peptides came in with no issues. Been with them for a while and have not had any major complaints.
lawrence gonzales –
Noticed this peptide has been out of stock for a bit but noticed you restocked it and jumped to but it. Got to be quick with them.
Annie Matthews –
Wish they had a way to let me know when peptides are back in stock. It gets frustrating having to check back in everyday to see if there’s been one or not.
David Polito –
Got them within 2 days and Im on the other side of the country. No breaks or damage.
Ryan Garrison –
Customer service can’t be beat, they train the employees well