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Fragment 176-191 (5mg)

Fragment 176-191 (5mg)

(18 customer reviews)

$44.00

Fragment 176-191 peptides are Synthesized and Lyophilized in the USA.

Discount per Quantity

Quantity 5 - 910 +
Discount 5%10%
Price $41.80$39.60
Orders over $200 receive:
FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
FREE - USPS priority shipping
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SKU: Fragment-176-191-5mg Category:

Description

What is the Fragment 176-191 peptide?

Fragment 176-191 peptide is a short segment of human growth hormone (hGH) and is sometimes referred to as the “lipolytic fragment.” The name was coined from initial research on animal systems which suggested that Fragment 176-191 holds the potential to enhance fat metabolism in genetically engineered obese mice.[1] Human growth hormone (hGH) treatment has several adverse effects on the body, such as suppressing carbohydrate metabolism, altered sensitivity towards insulin, promotion of long bone growth, and heightened insulin-like growth factor-1 (IGF-1) levels. Extensive animal studies have suggested that the synthetic fragment may enhance the lipolytic effects of hGH without inducing the same side effects.[2] Therefore, the peptide may potentially be used for anti-obesity treatments.

Specifications

AKA: Frag 176-191

Molecular Formula: C78H125N23O23S2

Molecular Weight: 1817.1 g/mol

Sequence: Tyr-Leu-Arg-Ile-Val-Gin-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe

CAS Number: 66004-57-7

Reconstitution: Required

Fragment 176-191 Research

Frag 176-191, Fat Burning and Weight Loss
The fat-burning potential of Frag 176-191 stems from the peptide’s hypothetical ability to increase the production of beta-3 adrenergic receptors (3-AR or ADRB3). Agonist activity of the Fragment 176-191 peptide upon interaction with ADRB3 appeared to directly enhance fat burning in adipose tissue, and may also trigger skeletal muscle thermogenesis. Research indicates that genetically modified mice that lack ADRB3 are resistant to the effect of hGH / Fragment 176-191. One experimental study observed that treatment of Fragment 176-191 appeared to cause up to 50% weight reduction in obese mice over three weeks. Interestingly, the peptide appeared to mediate weight reduction only in obese mice but not in lean mice during the same span of treatment.[3] The scientists also posit that “AOD-9401 increased in vitro lipolytic activity and decreased lipogenic activity in isolated adipose tissue from obese rodents and humans.” The results suggest that there may be secondary pathways involved in energy homeostasis which are capable of maintaining fat reserve in lean mice by overriding ADRB3 pathway.

Frag 176-191 and blood sugar levels
The C terminal end of hGH principally has been observed to bring about hypoglycemic (low blood sugar) levels in the mice’s bodies. Screening of at least six different fragments obtained from the C terminal section of hGH has suggested that Fragment 176-191 may be the most effective synthetic derivative of hGH for decreasing blood sugar levels.[4] The hypoglycemic function is secondary to maintaining an increased expression of insulin in blood plasma. These functions suggest that Frag 176-191 has the potential to treat prediabetes and type-2 diabetes.

Frag 176-191 and cartilage regeneration
Experimental research in Frag 176-191 suggests its ability to promote cartilage regeneration. Researchers engaged in the study of synthetic peptides suggest that they may bring about cartilage regeneration like hyaluronic acid treatment. Research in rabbits has observed that weekly administration of Fragment 176-191 appeared to improve cartilage growth (within laboratory measures), and its co-administration with hyaluronic acid (HA) appeared to be even more effective.[5] Fragment 176-191 both independently and in combination with HA may help to improve the conditions of osteoarthritis. The researchers concluded that “Intra-articular AOD9604 injections using ultrasound guidance enhanced cartilage regeneration, and combined AOD9604 and HA injections were more effective than HA or AOD9604 injections alone in the collagenase-induced knee OA rabbit model.” Thus there is the reason to include Frag 176-191 in the scope of beneficial treatments which may overcome the requirement of surgery.

Summarization of Research Areas of Fragment 176-191

The principal areas of research on Fragment 176-191 explore its role in fat metabolism and weight loss. The findings have led to further research in the domain of the mechanism of energy homeostasis in the body. The secondary areas of interest include the effect of Fragment 176-191 in the repair of cartilage and connective tissue regeneration.

References

  1. Habibullah MM, Mohan S, Syed NK, Makeen HA, Jamal QMS, Alothaid H, Bantun F, Alhazmi A, Hakamy A, Kaabi YA, Samlan G, Lohani M, Thangavel N, Al-Kasim MA. Human Growth Hormone Fragment 176-191 Peptide Enhances the Toxicity of Doxorubicin-Loaded Chitosan Nanoparticles Against MCF-7 Breast Cancer Cells. Drug Des Devel Ther. 2022 Jun 27;16:1963-1974. doi: 10.2147/DDDT.S367586. PMID: 35783198; PMCID: PMC9249349.
  2. Heffernan M, Summers RJ, Thorburn A, Ogru E, Gianello R, Jiang WJ, Ng FM. The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice. Endocrinology. 2001 Dec;142(12):5182-9. doi: 10.1210/endo.142.12.8522. PMID: 11713213.
  3. Heffernan MA, Jiang WJ, Thorburn AW, Ng FM. Effects of oral administration of a synthetic fragment of human growth hormone on lipid metabolism. Am J Physiol Endocrinol Metab. 2000 Sep;279(3):E501-7. doi: 10.1152/ajpendo.2000.279.3.E501. PMID: 10950816.
  4. Ng FM, Bornstein J. Hyperglycemic action of synthetic C-terminal fragments of human growth hormone. Am J Physiol. 1978 May;234(5):E521-6. doi: 10.1152/ajpendo.1978.234.5.E521. PMID: 645904.
  5. Kwon DR, Park GY. Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model. Ann Clin Lab Sci. 2015 Summer;45(4):426-32. PMID: 26275694.
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This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law.  Only qualified and licensed professionals should handle these products.  Any information found on Biotech Peptides is strictly for educational purposes only.  Refer to our terms and conditions for more details.

Additional information

Brand

Biotech Peptides

18 reviews for Fragment 176-191 (5mg)

  1. Emily Roy –

    Ordering was simple

  2. Christopher Adams –

    Very pure and legit products. The best I have tried until now. I will only order from them from now on. Very reliable source

  3. Dean McCaughan –

    they are the only company that offers custom synthesis and thats something new in this industry

  4. Alex Lin –

    the quantity discounts justify the cost. happy customer here

  5. Loren Brinley –

    These guys go above and beyond in everything they do. I’m definitely a customer for life, I don’t care how much they cost (their prices are great anyway), the peace of mind I have with this team is worth double the price of their product alone.

  6. Kevin Jones –

    The product works great and the shipping was fast. I just ordered my 3rd bottle

  7. Susan Onuoha –

    This whole experience was so great that I felt I had to come back and write a review. I was recommended to this place by a colleague who has been shopping here for a while. They told me this was the first place where they didn’t have trouble getting products in and did not have to deal with an automated service that gets them nowhere when you need a rep to help you out. So the place i typically order from was out of stock of the product I needed and decided to see if they would have it. After checking it out, they were also out of stock but I did see a few products that would be helpful in future research so I decided to order those. The payment was processed, got my shipping number and was informed that because I ordered before 2 pm that it would be shipped out the same day. Amazing because that means it’s less likely to get a damaged product with the temp and all that. The product came in two days and everything was in perfect condition and ready to go. I’ll definitely wait and see if they restock and try those out as well.

  8. William Poulson –

    I wish all companies had CS like them!

  9. Barb Ruess –

    The whole process is easy. Check out is a breeze since my information is already saved and all I need to do is click a few buttons. It is a headache sometimes to have to always type in the address, card number, and details, and also like that I can see what I ordered previously.

  10. John Malvin –

    I appreciate the promo code they sent me after my first purchase !!

  11. Bob Marshall –

    The company is legit. Have had to deal with BS from other companies with fraud products. Biotech has proved in the past 6 months that I’ve been using them that the peptides are of excellent quality and help my research rather than hinder it.

  12. Ian Marshall –

    Customer service is always quick. I had an instance where I was charged for my order two times. I was able to get in contact with someone right away to fix that and get the charge cleared.

  13. Juan Carlo Romero –

    Prices are avg but the products are 100% above average.

  14. Nicholas Porter –

    My peptides came in with no issues. Been with them for a while and have not had any major complaints.

  15. lawrence gonzales –

    Noticed this peptide has been out of stock for a bit but noticed you restocked it and jumped to but it. Got to be quick with them.

  16. Annie Matthews –

    Wish they had a way to let me know when peptides are back in stock. It gets frustrating having to check back in everyday to see if there’s been one or not.

  17. David Polito –

    Got them within 2 days and Im on the other side of the country. No breaks or damage.

  18. Ryan Garrison –

    Customer service can’t be beat, they train the employees well

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