What Is Fragment 176-191 peptide?
Fragment 176-191 peptide is a short segment of human growth hormone (hGH) and is sometimes referred to as the “lipolytic fragment.” The name was coined due to research on animal systems which has proven that Fragment 176-191 enhances fat metabolism in genetically engineered obese mice. Human growth hormone (hGH) treatment has several adverse effects on the body, such as suppressing carbohydrate metabolism, altered sensitivity towards insulin, promotion of long bone growth, and heightened insulin-like growth factor-1(GF-1) levels. Extensive animal studies have shown that the synthetic fragment enhances the lipolytic effects of hGH without inducing the same side effects. Hence the peptide can be used for anti-obesity treatments.
Fragment 176-191 SPECIFICATIONS
AKA: Frag 176-191
Molecular Formula: C78H125N23O23S2
Molecular Weight: 1817.1 g/mol
CAS Number: 66004-57-7
Physiological effects of Frag 176-191
1. Burning of fat and Weight Loss
The fat-burning action of frag 176-191 is brought about by increasing the production of beta-3 adrenergic receptors (3-AR or ADRB3). Agonist activity of the fragment upon interaction with ADRB3 directly enhances fat burning in adipose tissue and triggers skeletal muscle thermogenesisscle. Genetically modified mice that lack ADRB3 are resistant to the effect of hGH / fragment 176-191.
Studies have shown treatment of fragment 176-191 causes up to 50% weight reduction in obese mice over three weeks. Interestingly, the peptide mediates weight reduction only in obese mice but not in lean mice during the same span of treatment. The results suggest that there are secondary pathways involved in energy homeostasis which are capable of maintaining fat reserve in lean mice by overriding ADRB3 pathway.
2. Decrease in Blood Sugar
The C terminal end of hGH principally has been observed to bring about hypoglycemic (low blood sugar) levels in the mice’s bodies. Screening of at least six different fragments obtained from the C terminal section of hGH has shown that fragment 176-191 is the most effective synthetic derivative of hGH for decreasing blood sugar levels. The hypoglycemic function is secondary to maintaining an increased expression of insulin in blood plasma. These functions prove that the fragment has the potential to treat prediabetes and type-2 diabetes.
3. Promotion of Cartilage Regeneration
Among other beneficial effects of Frag 176-191 is the ability of cartilage regeneration. An article published by a Korean group in 2015 revealed that synthetic peptides could bring about cartilage regeneration like hyaluronic acid treatment. Research in rabbits has highlighted that weekly injections of Fragment 176-191 improve cartilage growth (within laboratory measures), and its co-administration with hyaluronic acid (HA) happens to be more effective. Fragment 176-191 both independently and in combination with HA helps to improve the conditions of osteoarthritis. Thus there is the scope of a better and more beneficial treatment involving this synthetic fragment which will overcome the requirement of surgery.
Research on Fragment 176-191 peptide
The principal areas of research on Fragment 176-191 explore its role in fat metabolism and weight loss. The findings have led to further research on the interesting domain of the mechanism of energy homeostasis in the body. The secondary areas of interest include the effect of Fragment 176-191 in the repair of cartilage and connective tissue regeneration.