Fragment 176-191 (5mg)

(18 customer reviews)


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5 - 95%$41.80
10 +10%$39.60
SKU: Fragment-176-191-5mg Category:


What Is Fragment 176-191 peptide?

Fragment 176-191 peptide is a short segment of human growth hormone (hGH) and is sometimes referred to as the “lipolytic fragment.” The name was coined due to research on animal systems which has proven that Fragment 176-191 enhances fat metabolism in genetically engineered obese mice. Human growth hormone (hGH) treatment has several adverse effects on the body, such as suppressing carbohydrate metabolism, altered sensitivity towards insulin, promotion of long bone growth, and heightened insulin-like growth factor-1(GF-1) levels. Extensive animal studies have shown that the synthetic fragment enhances the lipolytic effects of hGH without inducing the same side effects. Hence the peptide can be used for anti-obesity treatments.

Fragment 176-191 SPECIFICATIONS

AKA: Frag 176-191

Molecular Formula: C78H125N23O23S2

Molecular Weight: 1817.1 g/mol

Sequence: Tyr-Leu-Arg-Ile-Val-Gin-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe

CAS Number: 66004-57-7

Reconstitution: Required

Physiological effects of Frag 176-191

1. Burning of fat and Weight Loss
The fat-burning action of frag 176-191 is brought about by increasing the production of beta-3 adrenergic receptors (3-AR or ADRB3). Agonist activity of the fragment upon interaction with ADRB3 directly enhances fat burning in adipose tissue and  triggers skeletal muscle thermogenesisscle. Genetically modified mice that lack ADRB3 are resistant to the effect of hGH / fragment 176-191.
Studies have shown treatment of fragment 176-191 causes up to 50% weight reduction in obese mice over three weeks. Interestingly, the peptide mediates weight reduction only in obese mice but not in lean mice during the same span of treatment. The results suggest that there are secondary pathways involved in energy homeostasis which are capable of maintaining fat reserve in lean mice by overriding ADRB3 pathway.

2. Decrease in Blood Sugar
The C terminal end of hGH principally has been observed to bring about hypoglycemic (low blood sugar) levels in the mice’s bodies. Screening of at least six different fragments obtained from the C terminal section of hGH has shown that fragment 176-191 is the most effective synthetic derivative of hGH for decreasing blood sugar levels. The hypoglycemic function is secondary to maintaining an increased expression of insulin in blood plasma. These functions prove that the fragment has the potential to treat prediabetes and type-2 diabetes.

3. Promotion of Cartilage Regeneration
Among other beneficial effects of Frag 176-191 is the ability of cartilage regeneration. An article published by a Korean group in 2015 revealed that synthetic peptides could bring about cartilage regeneration like hyaluronic acid treatment. Research in rabbits has highlighted that weekly injections of Fragment 176-191 improve cartilage growth (within laboratory measures), and its co-administration with hyaluronic acid (HA) happens to be more effective. Fragment 176-191 both independently and in combination with HA helps to improve the conditions of osteoarthritis. Thus there is the scope of a better and more beneficial treatment involving this synthetic fragment which will overcome the requirement of surgery.

Research on Fragment 176-191 peptide

The principal areas of research on Fragment 176-191 explore its role in fat metabolism and weight loss. The findings have led to further research on the interesting domain of the mechanism of energy homeostasis in the body. The secondary areas of interest include the effect of Fragment 176-191 in the repair of cartilage and connective tissue regeneration.

All orders ship same day if placed by 2pm PST.  Synthesized and lyophilized in the USA.
This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law.  Only qualified and licensed professionals should handle these products.  Any information found on Biotech Peptides is strictly for educational purposes only.  Refer to our terms and conditions for more details.

Additional information


Biotech Peptides

18 reviews for Fragment 176-191 (5mg)

  1. Emily Roy

    Ordering was simple

  2. Christopher Adams

    Very pure and legit products. The best I have tried until now. I will only order from them from now on. Very reliable source

  3. Dean McCaughan

    they are the only company that offers custom synthesis and thats something new in this industry

  4. Alex Lin

    the quantity discounts justify the cost. happy customer here

  5. Loren Brinley

    These guys go above and beyond in everything they do. I’m definitely a customer for life, I don’t care how much they cost (their prices are great anyway), the peace of mind I have with this team is worth double the price of their product alone.

  6. Kevin Jones

    The product works great and the shipping was fast. I just ordered my 3rd bottle

  7. Susan Onuoha

    This whole experience was so great that I felt I had to come back and write a review. I was recommended to this place by a colleague who has been shopping here for a while. They told me this was the first place where they didn’t have trouble getting products in and did not have to deal with an automated service that gets them nowhere when you need a rep to help you out. So the place i typically order from was out of stock of the product I needed and decided to see if they would have it. After checking it out, they were also out of stock but I did see a few products that would be helpful in future research so I decided to order those. The payment was processed, got my shipping number and was informed that because I ordered before 2 pm that it would be shipped out the same day. Amazing because that means it’s less likely to get a damaged product with the temp and all that. The product came in two days and everything was in perfect condition and ready to go. I’ll definitely wait and see if they restock and try those out as well.

  8. William Poulson

    I wish all companies had CS like them!

  9. Barb Ruess

    The whole process is easy. Check out is a breeze since my information is already saved and all I need to do is click a few buttons. It is a headache sometimes to have to always type in the address, card number, and details, and also like that I can see what I ordered previously.

  10. John Malvin

    I appreciate the promo code they sent me after my first purchase !!

  11. Bob Marshall

    The company is legit. Have had to deal with BS from other companies with fraud products. Biotech has proved in the past 6 months that I’ve been using them that the peptides are of excellent quality and help my research rather than hinder it.

  12. Ian Marshall

    Customer service is always quick. I had an instance where I was charged for my order two times. I was able to get in contact with someone right away to fix that and get the charge cleared.

  13. Juan Carlo Romero

    Prices are avg but the products are 100% above average.

  14. Nicholas Porter

    My peptides came in with no issues. Been with them for a while and have not had any major complaints.

  15. lawrence gonzales

    Noticed this peptide has been out of stock for a bit but noticed you restocked it and jumped to but it. Got to be quick with them.

  16. Annie Matthews

    Wish they had a way to let me know when peptides are back in stock. It gets frustrating having to check back in everyday to see if there’s been one or not.

  17. David Polito

    Got them within 2 days and Im on the other side of the country. No breaks or damage.

  18. Ryan Garrison

    Customer service can’t be beat, they train the employees well

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