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What is Ipamorelin?
Ipamorelin is one of the most sought-after and versatile synthetic peptides. Composed of only five amino acids, it is a potent growth hormone secretagogue receptor (GHS-R) agonist controlling aging and obesity. Animal studies have revealed its diverse beneficial roles, promoting gut function, lean body mass, muscle growth, and bone health without affecting hair growth and sexual drive.
Ipamorelin is gentle compared to other peptides like Sermorelin or GHRP-6, affecting only the growth hormone axis. Hence it is useful in studying isolated effects of growth hormone secretagogue agonists.
How Does Ipamorelin Peptide Work?
The binding of Ipamorelin activates the ghrelin (growth hormone secretagogue) receptor. The ghrelin receptor (a.k.a. GHS-R) found in the brain, liver, heart, and skin muscle regulates energy and body weight. It is highly exclusive for growth hormone release from the pituitary gland. Having a half-life of just 2 hours, it is ideal for various biological studies.
How Does Ipamorelin Peptide Fight Aging?
Ipamorelin reduces age-related physiological changes such as bone and muscle loss, reduction in appetite, and decline in memory and cognitive function. It helps to reset the youthful physiological state by realigning the metabolic states. High osteoclast cellular activity in bones triggers their breakdown during aging. Ipamorelin controls bone density reduction by bringing a balance between bone mineralization and deposition.
Ipamorelin and Fat Loss
The peptide expedites lipolysis (breakdown of fat) in murine models. The effect is mediated through both stimulations of hGH release and secretion of insulin. Insulin being an anabolic hormone promotes glucose uptake in the least resistant pathway. The combined stimulation of hGH and Insulininsulin causes glucose uptake by muscles rather than fat cells leading to muscle development. Thus combined with a proper diet, the peptide shifts body metabolism from fat deposition to lean muscle mass and repair.
Learning and Memory
The GHS-R stimulation by Ipamorelin increases long-term potentiation and dendritic spine density. Long-term potentiation is an enhanced strength of connections between neurons, whereas dendritic spine density estimates neuronal connections. Thus it enhances mental capabilities like memory and cognitive strength.
Ipamorelin Alters the Sleep Cycle
As a secondary effect to boosting cognitive strength, Ipamorelin also promotes sleep. Improved sleeping pattern promotes immunity, reduces the effect of aging and obesity, and improves concentration, learning, and general health.
Ipamorelin promotes Bone Density
The current treatment regimen against loss of bone density includes expensive monoclonal antibodies, parathyroid hormone, and bisphosphonates. They also exhibit adverse effects on the body. Ipamorelin is a reliable, economical, and sustainable alternative that promotes bone formation (up to 4 fold) and prevents bone loss.
The body tends to adapt to Ipamorelin with prolonged use. The peptide stimulates GHS-R activity, causing increased release of HGH. However, continued stimulus reduces the density of the GHS-Rs. Hence, the peptide treatment should proceed cyclically with three weeks and three weeks off. The withdrawal period allows for the improvement of GHS-R density for the next round of effective peptide treatment.
Ipamorelin Fights Pain
Like other ghrelin mimetics, the molecule helps alleviate both neuropathic and inflammatory pain. It is very useful in hypersensitivity of GI, and the effect extends to anxiety management. Ipamorelin regulates GHS-Rs in both central and peripheral tissues and thus helps manage visceral and chronic pain.
Onset of Effect
The onset of effect upon Ipamorelin administration depends on the parameters studied. Changes in biochemical factors like blood glucose and insulin levels due to the molecule are very rapid. In contrast, the change of the biochemical pathways such as bone development, muscle mass, and synaptic density takes longer. Hence, the natural progression rate of the physiological process should be considered when studying the effect of Ipamorelin.
Ipamorelin Synergistic Effects
Ipamorelin often acts synergistically with diverse hormones like Hexarelin and ghrelin and peptides that bind to the growth hormone-releasing hormone receptor, such as CJC-1295. The synergism helps in studies as diverse as tissue regeneration, anti-aging, and endocrine dysfunction.
Studies have shown the peptide to be biologically safe with negligible side effects. However, the challenge lies in administering the molecule into the animal system. Until now, the only subcutaneous introduction has been successful and not the oral intake. This causes a challenge in small animal studies.
Ipamorelin Before and After
Ipamorelin is thus a wonder peptide with diverse potential. It exhibits diverse effects such as weight loss, muscle and bone development, cognitive strength, and general energy levels. Animals studied before and after the peptide treatment show significant agility, muscle build, mental prowess, and lean body mass. They lose their “soft” appearance and lethargy and exhibit overall improved energy. The molecule’s effect is similar to that of an extensive exercise regime as they mimic each other’s effects. The use of Ipamorelin is strictly for research purposes only and can be procured from authorized manufacturers.
Disclaimer: The products mentioned are not for human or animal consumption. All the information shared in this article is for educational purposes only.
Dr. Usman (BSc, MBBS, MaRCP) completed his studies in medicine at the Royal College of Physicians, London. He is an avid researcher with more than 30 publications in internationally recognized peer-reviewed journals. Dr. Usman has worked as a researcher and a medical consultant for reputable pharmaceutical companies such as Johnson & Johnson and Sanofi.