Oxytocin (10mg)

(28 customer reviews)

$45.00

Oxytocin peptides are Synthesized and Lyophilized in the USA.

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Description

Oxytocin Peptide

Oxytocin is a small peptide comprising only nine amino acids, naturally produced in the hypothalamus and secreted by the posterior pituitary gland cells. It has also been isolated from placenta, ovaries, testes, adrenal glands, thymus, retina, and pancreas tissues. The active hormone is obtained by proteolytic cleavage of a larger precursor protein. It is no longer considered merely a neurohypophyseal hormone as its actions are considered to be far-reaching and include interaction with additional peptides. Oxytocin appears to be a protein with two independent natural functions. First, it appears to act as a neuropeptide produced by the hypothalamus to regulate bonding, reproduction, and birth. Oxytocin appears to be bloodborne and secreted by the placenta of pregnant animals to influence birth, milk production, and bonding with their young. Small amounts of the protein produced from testes may promote mating behavior and pair bonding.

Specifications

Other Known Titles: Endopituitrina, Pitocin

Molecular Formula: C43H66N12O12S2

Molecular Weight: 1007.19 g/mol

Sequence: Cys-Tyr-lle-Gln-Asn-Cys-Pro-Leu-Gly

Oxytocin Research

Oxytocin and Wound Recovery
Oxytocin appears to regulate inflammation through inflammatory cytokines. Increased social interaction in one research study was observed to trigger Oxytocin (Pitocin) levels, which researchers speculated may have led to faster tissue repair and wound recovery. Similarly, studies in hostile equations between animals appear to suppress oxytocin production and delay wound recovery, potentially by up to 40%.[1] The researchers conclude, “These data confirm and extend prior evidence implicating oxytocin and vasopressin in positive and negative communication behaviors, and also provide further evidence of their role in an important [variable].” These hostile couples also exhibited reduced IL-6, tumor necrosis factor-alpha, and IL-1beta at the wound site.[2]

Oxytocin and Cardiovascular Risk
The hormone has been speculated to protect cardiac and vascular systems. It may act to dissipate and burn off fat cell accumulation, influence blood pressure and glucose intolerance, and potentially block or mitigate the secretion of stress hormones.[3] These factors may influence cardiovascular disease (CVD); thus, Oxytocin (Pitocin) may be a potential compound in the study of CVD. Reduced Oxytocin receptors may cause atherosclerosis.[4] The primary scientist in the cited study reports that “The major pathophysiological basis of CAD is atherosclerosis in association with varieties of immunometabolic disorders that can suppress oxytocin (OT) receptor (OTR) signaling in the cardiovascular system (CVS).” Oxytocin exposure appears to overcome the drawback of reduced receptor density and helps maintain cardiac integrity. Exposure of the peptide in rodent hearts during a heart attack appeared to assist in preventing the cellular death of cardiomyocytes. Jankoski et. al. suggested that chronic Oxytocin (Endopituitrina) exposure may address late-term development of dilated cardiomyopathy.

It also appears to help to prime the cardiac stem cells for “tissue regeneration through direct differentiation, secretion of protective and cardiomyogenic factors, and/or their fusion with injured cardiomyocytes.” It further appears to mitigate cases of cardiac damage due to diabetes in mice. The fat accumulation in these mice was reported to be reduced by 19%, and the fasting glucose levels by about 23%. Oxytocin (Endopituitrina) appears to increase insulin resistance in the animals, possibly establishing proper systolic and diastolic functions over control animals, leading to decreased cardiomyocyte hypertrophy, fibrosis, and apoptosis.[5] It also appears to protect against ischemic injuries in other tissues as well, outside of the heart. Studies in rat models of priapism indicate the potential action of Oxycotin (Pitocin) against ischemia-reperfusion injury by reducing nitric oxide levels.

Oxytocin and Diabetes
The peptide appears to improve skeletal muscles’ glucose uptake by boosting insulin sensitivity. It may further support lipid utilization, dyslipidemia, and fat mass reduction. Oxytocin deficiency has also been suggested to correlate to body mass, irrespective of external factors, suggesting its role in energy homeostasis.[6] Oxytocin appears to affect insulin, glucose, and body composition in obese mice but not lean mice. Research observations suggest that the peptide might be impactful only in certain conditions; for instance, the backdrop of diabetes appears to trigger different actions in diabetes models compared to controls. As per Barengolts, “circulating oxytocin is lower in type 2 diabetes versus normoglycemic subjects and negatively correlated with glycosylated hemoglobin A1C and insulin resistance.

Oxytocin and Cognitive Performance
Maternal deprivation may induce irreversible cognitive and behavioral functioning changes. Studies in murine models suggest Oxytocin changes due to decreased parental bonding may be a prominent cause. Oxytocin exposure in maternally deprived mice appeared to increase hormone levels for neuronal development in the prefrontal cortex. Overall behavior appeared to remain constant, but the cognitive ability was observed to be improved in the cohort exposed to Oxytocin.[7] The researchers therefore felt they had grounds to speculate that Oxytocin may improve learning in mice under stress.

Oxytocin Peptide Research and Anxiety
The hormone has been studied for its potential to minimize anxiety and depression. The genetic polymorphisms in the Oxytocin (Endopituitrina) receptor gene related to anxiety disorder and problems with attachment. Animals exhibiting chronic anxious behavior have also displayed epigenetic changes in the Oxytocin receptor.[8] This indicates a possible compensatory pathway for pathologically suppressed Oxytocin levels. This indicates that anxiety may be partially induced by diminished Oxytocin signaling.

Oxytocin and Hunger
Research on a condition marked by uncontrolled appetite has suggested that at least part of the pathology may result from increased suppression of Oxytocin (pitocin) signaling.[9] Therefore, Oxytocin (Endopituitrina) has been suggested to potentially regulate the state of hunger in the organism and its feeding behavior.

Oxytocin and Old Muscle
Oxytocin also appears to regulate muscle maintenance. Age-associated reduction in molecule levels appears to lead to muscle wasting (sarcopenia). The research carried out at Berkeley suggests that both blood levels of the peptide and its receptors on muscle stem cells decrease over time. Exogenous exposure to Oxytocin appears to allow muscles to recover much of their potential. According to Elabd, one of the authors of the study, “repair of muscle in the old mice was at about 80%” compared to younger mice after Oxytocin was presented.[10] Thus, it can potentially be studied in relation to organ degeneration further, as it may slow down dysfunction.

Oxytocin and Neurotransmitter Regulation
Oxytocin is posited to engage with G-protein coupled receptors, which may increase intracellular calcium levels and, therefore, might regulate neurotransmission and excitation.[11] Further, Oxytocin’s potential influence on the brain may extend to neurogenesis and synaptic plasticity, which may impact the intricate formation and function of neural circuits. The presence of Oxytocin receptors across various neural cell types hints at the peptide’s broad potential impact, possibly modulating the behavior of neural progenitor cells and influencing the fate of these cells. Oxytocin might also affect newly formed neural circuits by modulating neurotransmitter dynamics, including those of glutamate and gamma-aminobutyric acid (GABA), which serve as the brain’s primary excitatory and inhibitory signals.

At the synaptic level, Oxytocin’s actions appear to diverge, potentially enhancing neurotransmitter release in some contexts while diminishing it in others. This dual action may reflect Oxytocin’s potential to modulate the balance between excitation and inhibition within the neural circuits, a balance considered crucial for maintaining the functional integrity of the brain. Such modulation may manifest through alterations in the release of neurotransmitters or changes in membranes, indirectly influencing neuronal excitability and the flow of neural information. The interactions of Oxytocin with glial cells, such as astrocytes, further complicate its role in neurotransmitter dynamics, suggesting a broader regulatory influence that extends beyond the neurons to the supportive environment that nurtures and maintains synaptic connections. This interaction may influence the synaptic plasticity and overall function of neural circuits, offering a glimpse into the complex regulatory roles Oxytocin might play in the neural ecosystem.

Oxytocin and Sexual Behavior
Oxytocin is hypothesized to potentially influence sexual behavior by modulating dopamine activity in central nervous system regions believed integral to the reward system, specifically the ventral tegmental area (VTA) and the nucleus accumbens.[12] More specifically, the peptide may enhance dopamine release or increase the responsiveness of dopamine-releasing neurons. Such alterations in dopaminergic activity may conceivably elevate sexual drive and support the perception of reward, thereby playing a role in the anticipatory behaviors associated with mating and copulation.

The interaction between Oxytocin and these neurons may trigger a cascade of biological events leading to a significant release of dopamine in the nucleus accumbens. One component of this cascade might involve nitric oxide production within the VTA, suggesting a complex interaction between Oxytocin, dopamine, and nitric oxide in this context.

Furthermore, Oxytocin might also exert indirect action on dopamine levels in other brain regions, such as the hippocampus and amygdala, thus contributing to its multifaceted role in modulating behavior. These indirect actions might regulate the activities of neurons that release glutamate or GABA, neurotransmitters that may then influence the activity of dopaminergic neurons in the VTA and nucleus accumbens. Such a mechanism underscores the intricate and potentially widespread influence of Oxytocin on brain functions related to sexual behavior.

Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.

 

References

  1. Gouin JP, Carter CS, Pournajafi-Nazarloo H, Glaser R, Malarkey WB, Loving TJ, Stowell J, Kiecolt-Glaser JK. Marital behavior, oxytocin, vasopressin, and wound healing. Psychoneuroendocrinology. 2010 Aug;35(7):1082-90. doi: 10.1016/j.psyneuen.2010.01.009. Epub 2010 Feb 9. PMID: 20144509; PMCID: PMC2888874.
  2. Kiecolt-Glaser JK, Loving TJ, Stowell JR, Malarkey WB, Lemeshow S, Dickinson SL, Glaser R. Hostile marital interactions, proinflammatory cytokine production, and wound healing. Arch Gen Psychiatry. 2005 Dec;62(12):1377-84. doi: 10.1001/archpsyc.62.12.1377. PMID: 16330726.
  3. Reiss AB, Glass DS, Lam E, Glass AD, De Leon J, Kasselman LJ. Oxytocin: Potential to mitigate cardiovascular risk. Peptides. 2019 Jul;117:170089. doi: 10.1016/j.peptides.2019.05.001. Epub 2019 May 18. PMID: 31112739.
  4. Wang P, Wang SC, Yang H, Lv C, Jia S, Liu X, Wang X, Meng D, Qin D, Zhu H, Wang YF. Therapeutic Potential of Oxytocin in Atherosclerotic Cardiovascular Disease: Mechanisms and Signaling Pathways. Front Neurosci. 2019 May 21;13:454. doi: 10.3389/fnins.2019.00454. PMID: 31178679; PMCID: PMC6537480.
  5. Plante E, Menaouar A, Danalache BA, Yip D, Broderick TL, Chiasson JL, Jankowski M, Gutkowska J. Oxytocin treatment prevents the cardiomyopathy observed in obese diabetic male db/db mice. Endocrinology. 2015 Apr;156(4):1416-28. doi: 10.1210/en.2014-1718. Epub 2015 Jan 6. PMID: 25562615.
  6. Ding C, Leow MK, Magkos F. Oxytocin in metabolic homeostasis: implications for obesity and diabetes management. Obes Rev. 2019 Jan;20(1):22-40. doi: 10.1111/obr.12757. Epub 2018 Sep 25. PMID: 30253045; PMCID: PMC7888317.
  7. Dayi A, Kiray M, Sisman A, Ozbal S, Baykara B, Aksu I, Uysal N. Dose dependent effects of oxytocin on cognitive defects and anxiety disorders in adult rats following acute infantile maternal deprivation stress. Biotech Histochem. 2019 Oct;94(7):469-480. doi: 10.1080/10520295.2018.1528384. Epub 2019 May 20. PMID: 31104534.
  8. Ziegler C, Dannlowski U, Bräuer D, Stevens S, Laeger I, Wittmann H, Kugel H, Dobel C, Hurlemann R, Reif A, Lesch KP, Heindel W, Kirschbaum C, Arolt V, Gerlach AL, Hoyer J, Deckert J, Zwanzger P, Domschke K. Oxytocin receptor gene methylation: converging multilevel evidence for a role in social anxiety. Neuropsychopharmacology. 2015 May;40(6):1528-38. doi: 10.1038/npp.2015.2. Epub 2015 Jan 7. PMID: 25563749; PMCID: PMC4397412.
  9. Atasoy D, Betley JN, Su HH, Sternson SM. Deconstruction of a neural circuit for hunger. Nature. 2012 Aug 9;488(7410):172-7. doi: 10.1038/nature11270. PMID: 22801496; PMCID: PMC3416931.
  10. Elabd C, Cousin W, Upadhyayula P, Chen RY, Chooljian MS, Li J, Kung S, Jiang KP, Conboy IM. Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration. Nat Commun. 2014 Jun 10;5:4082. doi: 10.1038/ncomms5082. PMID: 24915299; PMCID: PMC4512838.
  11. Bakos, Jan et al. “Molecular Mechanisms of Oxytocin Signaling at the Synaptic Connection.” Neural plasticity vol. 2018 4864107. 2 Jul. 2018, doi: 10.1155/2018/4864107
  12. Melis, Maria Rosaria, and Antonio Argiolas. “Oxytocin, Erectile Function and Sexual Behavior: Last Discoveries and Possible Advances.” International journal of molecular sciences vol. 22,19 10376. 26 Sep. 2021, doi: 10.3390/ijms221910376
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Dr. Usman

Dr. Usman (BSc, MBBS, MaRCP) completed his studies in medicine at the Royal College of Physicians, London. He is an avid researcher with more than 30 publications in internationally recognized peer-reviewed journals. Dr. Usman has worked as a researcher and a medical consultant for reputable pharmaceutical companies such as Johnson & Johnson and Sanofi.

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Biotech Peptides

28 reviews for Oxytocin (10mg)

  1. Gabriel Collins

    I was a bit unsure at first, especially ordering such products, but they made it very easy and the whole process was seamless. I will come back for more

  2. Laron Hall

    I will always get my peptides from Biotech in the future

  3. Adeline Reid

    So far everything seems decent. I havent put it to the test yet but Im happy so far

  4. Laron Hall

    This was my second attempt at ordering peptides from an online supplier, Im just glad I actually recieved my order. My first attempt didnt go so well and I had to file a chargeback because I never received the products. thanks for the top notch service.

  5. Velvet Viper

    For Growth hormone secretagogues, this is my go-to vendor. Getting in contact with the company was smooth and quick.

  6. Avani Ross

    First-time customer. Ordering was easy, needed one product that is out of stock. Will see how this first-order goes and then maybe try again with the product that was out of stock as well.

  7. Sebastian Cook

    They’re a little smaller than I imagined, still good though! wish it was a little bigger.

  8. Lea Ceasrine

    they are really great at making the customer feel heard and the whole “customer is always right” motto. called and let them know my stuff was late and feels like because of that the peptides were damaged. didn’t argue or give me a hard time. they sent out new ones. it was relieving because I’ve had other companies just leave me stranded with nothing. so real nice service and this time stuff came in a day.

  9. Jeremy Chidester

    Haven’t needed a peptide they didn’t have yet. Very large range of products

  10. Peilin Hu

    海關無問題 純正貨品

  11. Dylan Lou

    I have tested the peptides out, and they are legitimate. They help my research floruish and I see more of a difference with these peptides then with my previous supplier.

  12. Brett Loewenstein

    They came highly recommended by a buddy of mine at work. I see what all the rave is about. Good stuff!

  13. Dennis Burcaw

    Stuggled to find a permenant peptide supplier. I belive my struggle has ended. Incredible company.

  14. Aaron Grant

    My peptides came in quickly and safley! Packaging was great and didn’t feel like the peptides would be unsafe.

  15. Eric Wilson

    The peptides are proving themselves to be of the highest quality. I have used different companies in the past few years and nothing compares to Biotechs bunch.

  16. Jon L.

    They came highly recommeneded by many so had to test them out. From my expeirnce everything that’s been reported to me is ture. They do have great cutomer service, I think I had been going back and forth with taylor. Did not wait long for responces and my package came in less than 2 days. Nothing was broken but have seem some reviews stating it could happen, so i’ll be on the lookout for a potential situation. All is good with biotech however.

  17. Allie Thompson

    I was struggeling To place my order as it seems the site was glitching. I eventually was able to order it but seems strange that was happening.

  18. marc dennings

    There’s no where else i’d suggest to anybody looking to purchase peptides.

  19. Liz Brooks

    Reading their up-to-date blogs is something I look forward to doing. They’re informative and keep me up to date on the newest developments in the field of peptides. There is a particular peptide mentioned in the blog, which saves me time by not having to hunt it up on my own. It’s one of my favorite aspects of the website.

  20. Seth Kluesner

    Exceptional customer service and clear, timely communication are the norm at this company.

  21. josh brooks

    I was concerned about the temperature and making certain that no goods was damaged or wrecked, but they all seemed to be in fine condition to me when I examined them.

  22. Gabe ting

    I think you guys should definitely switch your delivery company. You have amazing products, but you are gonna lose a lot of customers by letting the delivery company ruin your packaging. Not worth it for you

  23. Zachary Kosloy

    Great quality peptides, long shelf life as well when you follow the correct directions.

  24. Nathan Glasswell

    Staff is trained well and were able to help me locate my order that looked to be stuck in transit. Danny was able to send me discount code for my next purchase and even resent this order as the delay would most probably affect the peptides.

  25. Kev Nguyen

    Very happy customer here.

  26. Angelo Mae de Vera

    Very quick process. In and out in a breeze. Very cool

  27. Geroge Boerstler

    Best peptide hormone out there

  28. cam Comer

    Good Peptide, just placed another order for Melanotin 1 as well.

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