Thymosin Beta-4 (TB-500) Research

by | Apr 15, 2022 | Research

What is Thymosin Beta-4?

Thymosin Beta-4 is a central actin-sequestering molecule. It is undergoing extensive investigation.

Thymosin is the hormonal product of the thymus gland. The thymus is a gland in the chest that produces white blood cells called the T-lymphocytes. It, therefore, is involved in immune system regulation and healing processes.

Thymosin Beta-4 (TB-500) is a multi-functional product of the thymus and can play a significant role in the healing and repair processes of the body. It can protect tissues exposed to injury and promotes regeneration and repair in damaged tissues.

It finds use in acute injuries, post-surgical wound healing, and repair.


How Does TB-500 Work?

Thymosin Beta-4 is present in the smooth muscles of the heart and the body’s skeletal muscles. Any injury to these tissues activates a pathway where Thymosin Beta-4 is upregulated as a response. The increased levels of TB-500 initiate an anti-inflammatory response in the body. It expedites the wound healing processes and can reduce scar formation due to the injury. Research has also shown potential in its role in vascularization after injury and reducing the risk of adhesion formation.

Thymosin Beta-4 binds to actin and promotes cell migration, including the mobilization, migration, and differentiation of stem/progenitor cells, forming new blood vessels and regenerating tissue. Thymosin Beta-4 also decreases the number of myofibroblasts in wounds, resulting in decreased scar formation and fibrosis.

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