The Anti-Depressant Research in Protirelin Peptide (TRH Thyrotropin)

by | Jun 22, 2022 | Research

TRH, also known as Protirelin, is a peptide hormone generated by the hypothalamus. Its primary role is to promote the anterior pituitary gland’s secretion of thyroid-stimulating hormone and prolactin. TRH is utilized in clinical settings to test the function of the anterior pituitary gland in thyroid disease laboratory investigations.

TRH (Protirelin) can be clinically used as an anti-depressant and anti-suicidal peptide.

The Benefits of Protirelin (TRH)

The Role of Protirelin (TRH) in Depressed Patients

The US Army gave research funding to Indiana University’s School of Medicine in 2012 to create a Protirelin (TRH)-based nasal spray that might prevent troops from committing suicide. Since the 1970s, there has been speculation and evidence that Protirelin (TRH) can lessen the onset of suicidal thoughts.

In a study on individuals with severe depression, about five to eight individuals administered with TRH responded favorably, with a 50% or more reduction in depressive symptoms, including thoughts of suicide.

Clinicians expanded this study to depressed women, and administration of Protirelin (TRH) proved more potent in women with depression with no symptoms of anxiety.

TRH injection straight into the spine to treat depression is not the most convenient treatment form. As a result, an additional study was done to evaluate if delivery of Protirelin (TRH) via IV will be as effective as the latter and it proved to be equally effective.

TRH is more potent in depression when delivered at night, according to clinical trials in bipolar patients. Scientists believe this impact is due to nighttime TRH treatment aligning with TRH’s natural circadian cycle.

The Role of Protirelin (TRH) in the Aging Process

TRH has been shown in animal studies to help protect some organs from oxidative damage and normal aging. TRH can also slow the formation of amyloid plaque in the kidneys, a common cause of reduced kidney function with age. As a result, TRH can preserve kidney function even as people age. The testes of elderly male mice show similar outcomes.

Amyloid plaques are associated with Alzheimer’s Disease (AD); therefore, scientists are interested in Protirelin’s capacity to inhibit the presence of amyloid in the brain as it does in the kidneys. While Protirelin can promote alertness in aged rats, research has yet to show its effects on the formation of amyloid plaque. Although TRH levels in the hippocampus appear to decrease in AD patients.

According to Luguang Luo, the paper’s primary author and professor of regenerative medicine, research shows that TRH inside the hippocampus regulates the activity of numerous proteins via phosphorylation/dephosphorylation, which is vital in AD pathogenesis.

Disease Development and Protirelin (TRH) Deficiency

Clinicians and researchers have also seen TRH alterations and other thyroid hormones in several non-thyroid disorders.

Research is ongoing on TRH supplementation to see whether it can lower the severity of non-thyroidal disorders in conjunction with other treatments.

The Role of Protirelin (TRH) in the Fight Against Opioid Overdose

Long-term or overdose administration of opioids, such as heroin and oxycontin, can decrease the respiratory drive (desire to breathe) in the brainstem. Naloxone is the solely available therapy for opioid overdose (Narcan).

According to scientific evidence, Protirelin (TRH) increases blood pressure and breathing rate. Protirelin (TRH) increases the pace of breathing with the dose when taken intravenously or by spraying directly into the lungs but has no impact on pain management. Protirelin (TRH) also prevented death in all animal subjects.

Protirelin therapies have different modes of action and can be in tandem. One can be used if the other fails.

The Role of Protirelin (TRH) in Motor Memory

Motor memory is a result of motor learning, which involves the development of new muscle coordination. This allows us to maintain motor coordination and learn to interact with our surroundings. Examples include learning to play the piano, driving a car, and typing on a keyboard. This sort of memory is a part of the hindbrain—important for motor control, coordination, balance, and posture.

A scientific study with mice lacking the TRH gene reveals that they acquire certain motor activities at a slower pace but are induced by injecting exogenous Protirelin (TRH).

Further study in mice suggests that using Protirelin (TRH) supplements may help reduce the consequences of cerebellar disorders. TRH analogs, for example, can slow ataxia in human models with cerebellar-degenerative disease. They accomplish this directly through motor learning effects.

The Function of the Synthetic Equivalent of Protirelin (TRH) in Trauma

Protirelin’s synthetic equivalent is Taltirelin. TRH in trials can improve mean arterial blood pressure and rate of breathing. The findings of this study indicate that it is comparable to conventional therapies for acute bleeding. TRH can improve blood pH and avoid a decrease in arterial oxygen saturation, making it a potent adjunct in treating blood loss and hypovolemic shock. Protirelin (TRH) might be used permanently in treating acute shock in ambulances due to the lack of adverse effects associated with its use.


It is important to note that Protirelin (TRH) for sale is limited to scientific and education research purposes, not for human use/consumption.

Disclaimer: The products mentioned are not for human or animal consumption. All the information shared in this article is for educational purposes only.