What is Semax peptide?
Semax is a synthetic analogue of adrenocorticotropic hormone (ACTH) comprising amino acids 4-10 of ACTH.
Semax, a Russian product, has proven to be beneficial in stroke, cognitive impairment, dementia, and inflammation of the optic nerve. It boosts the immune system, is an antidepressant, and possesses anxiolytic properties as well. Semax has been observed to increase production of brain-derived neurotrophic factor (BDNF) in the central nervous system, serotonin and dopamine levels as well.
Molecular Formula: C37H51N9O10S
Molecular Weight: 813.920 g/mol
PubChem: CID 122178
CAS Number: 4037-01-8
Semax in the Setting of Stroke
In Russia Semax is used to treat acute cerebral hypoxia caused by stroke or traumatic brain injury. As per studies in rats, Semax promotes the expression of 24 genes in the brain and spinal cord through various molecular mechanisms. These genes modulate various functions from smooth muscle cell migration to red blood cell formation and angiogenesis. The peptide promotes the survival of neurons, stabilizes mitochondria and thus energy production, as well as enhances the supply of nutrition to the brain.
As per studies in Russia, Semax accelerates the rate of rehabilitation in patients of stroke and results in a greater overall level of function upon completing the treatment. Gusev et.al. stated, “early rehabilitation and administration of Semax increase BDNF plasma levels, speed functional recovery, and improve motor performance.”
BDNF is a natural brain peptide that promotes learning and memory. Through BDNF stimulation, enhances neuroplasticity in the brain and helps undamaged regions of the brain to learn tasks for which damaged regions were responsible. Semax is already known to activate the default mode network, which is crucial for resting attention and social function.
Resting Brain Structure
Semax has been observed through functional magnetic resonance imaging to trigger the function of what is known as the default mode network. The default mode network includes areas of brain which remain more active during rest than during any activity. Recent studies reveal this region of brain to be engaged in social cognition and monitoring of the environment. It is like a general-purpose system for observing the world around us without being specific. The network is thus an important part of attention as it helps in changing from a “rest” state to a more attentive form. In diseases compromising cognitive power like Alzheimer’s, the default mode network is often affected thereby proving its involvement in general social awareness.
Semax boosts the network activity and improves our general level of awareness even during rest. This brings about greater attention and focus and be attentive to social environment. Thus it helps the brain to readily switch from a resting state to a focused state.
Increased activity in default mode network corresponds to improved neural connections within the brain. This leads to better problem solving, enhanced memory, and creativity. The peptide is thought to boost global brain function.
Semax and Gene Expression in the Brain
Semax mediated changes in gene expression in brain does not pertain to stroke only. Single intranasal injection of the peptide triggers differential gene regulation in both frontal cortex and hippocampus of rats. This is relevant as the hippocampus regulates memory and learning whereas the frontal cortex helps in concentration, planning, and organizing information. In both regions of the brain, gene expression spikes within 20 minutes of Semax administration and specifically influences nerve growth factor (NGF) and BDNF. The peptide can therefore help to study the mechanisms of learning and information processing. It can further assist in exploring cognition and easier and permanent learning.
Semax is an effective way for learning and memory enhancement, especially when these functions get neurologically impaired. ACTH, the natural protein source of Semax, preserves memory function and learning in murine models of epilepsy as shown in studies from Canada, China and the United States. It has been used as the first line of treatment for epileptic disorder.
According to Dr. Scantlebury, Semax is a very potent derivative of ACTH and provides benefits absent in the natural peptide. Preliminary reports suggest that even low doses of ACTH help to prevent learning and memory dysfunction following a seizure. This indicates ACTH and Semax possess nootropic properties and can also promote cognitive performance when used regularly in minimal doses.
Semax and Depression
Murine studies have shown that elevated BDNF influences the function of the brain in the setting of depression. Current antidepressants, like SSRIs, indirectly regulate serotonin signaling in the brain for alleviating the condition, but prolonged treatment is required for any visible effect. Neurobiologists have thus always wanted a more immediate solution. It is now known that SSRIs take prolonged duration due to their slow ability to increase BDNF in depressed brain. According to Deltheil et. al., a combination of Semax and SSRI could majorly improve treatment of depression through prompt induction of BDNF.
Semax exhibits minimal side effects, low oral bioavailability and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not scale to humans. Semax is strictly sold by Biotech Peptides for educational and research applications only, not for human use.
Buy Semax peptide, only if you are a licensed researcher.