Semax (25mg)

Semax Peptide

Semax is a synthetic analog of adrenocorticotropic hormone (ACTH) comprising amino acids 4 through10 of ACTH. Semax has primarily been implicated in research in cognitive impairment and the aftermath of stroke. The peptide has also been studied closely within the context of dementia and certain inflammations of the optic nerve. Researchers posit that the peptide may exert neurotrophic action, suggesting that the peptide may act to increase the production of brain-derived neurotrophic factor (BDNF) in the central nervous system, with consequences in serotonin and dopamine release.

Specifications

Molecular Formula: C₃₇H₅₁N₉O₁₀S

Molecular Weight: 813.920 g/mol

Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-lle-GluLys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-LysThr-Glu-Thr-Gin-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-GluThy-lleGlu-Gin-Glu-Lys-Gin-Ala-Gly-Glu-Ser

Semax Research

Semax and Stroke
In Russia, Semax has been researched in the context of acute cerebral hypoxia resulting from stroke or traumatic brain injury. As per studies in rats, Semax appears to promote the expression of 24 genes in the brain and spinal cord through various molecular mechanisms. These genes modulate various functions from smooth muscle cell migration to red blood cell formation and angiogenesis. The peptide has been suggested to promote the survival of neurons and potentially stabilize mitochondria.^[1] The scientists report that “The immunomodulating effect of the peptide discovered in our research and its impact on the vascular system during ischemia are likely to be the key mechanisms underlying the neuroprotective effects of the peptide.” ^[2] Gusev et al. observe, “early rehabilitation and [introduction] of Semax increased BDNF plasma levels, speed functional recovery, and improve motor performance.” BDNF is a natural brain peptide that is considered to aid in cognitive development. BDNF stimulation may enhance neuroplasticity as well.

Semax and Brain Structure
Semax has been suggested by researchers via functional magnetic resonance imaging to trigger the function of what is known as the default mode network.^[3] The default mode network includes areas of the brain which remain more active during rest than during any activity. It is a general-purpose system for monitoring the organism’s environment, without focusing on specific elements. The network is an important part of attention as it helps the organism change from a “rest” state to alertness.^[4] Researchers suggest that any increased activity in the default mode network corresponds to improved neural connections within the brain. These connections may support the organism’s functional cognitive processes. Through closer research into Semax, the peptide is considered to support global brain function through a domino chain of cognitive functioning.

Semax and Gene Expression
Semax appears to mediate changes in gene expression in the brain. Study findings indicate that introduction to the peptide may trigger differential gene regulation in rats’ frontal cortex and hippocampus. This is relevant as the hippocampus regulates memory and learning, whereas the frontal cortex helps process and organize information. In both regions of the brain, scientists observed that gene expression appears to spike within 20 minutes of Semax exposure, and specifically appeared to influence nerve growth factor (NGF) and BDNF.^[5] The researchers concluded that “Semax … results in rapid, long-term, and specific activation of Bdnf and Ngf expression changes in different rat brain departments.”

Semax and Cognitive Function
ACTH, the natural protein source of Semax, appears to preserve memory function and learning in murine models of epilepsy, as shown in studies from Canada, China, and the United States. It has also been an object of speculation for its potential in epileptic disorder research. According to Dr. Scantlebury, Semax is a potentially potent derivative of ACTH and may provide ancillary action that absent in the natural peptide.^[6] Preliminary reports suggest that even low concentrations of ACTH may mitigate the risk of dysfunction following a seizure. This research indicates ACTH and Semax may possess nootropic characteristics. Research is ongoing.

Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.

References