Semax (25mg)

(13 customer reviews)


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5 - 95%$54.15
10 +10%$51.30
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What is Semax peptide?

Semax is a synthetic analog of adrenocorticotropic hormone (ACTH) comprising amino acids 4-10 of ACTH.
Semax, a Russian product, has proven beneficial in stroke, cognitive impairment, dementia, and inflammation of the optic nerve. It boosts the immune system, is an antidepressant, and possesses anxiolytic properties. Semax has been observed to increase the production of brain-derived neurotrophic factor (BDNF) in the central nervous system and serotonin and dopamine levels.


Molecular Formula: C37H51N9O10S

Molecular Weight: 813.920 g/mol

Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-lle-GluLys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-LysThr-Glu-Thr-Gin-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-GluThy-lleGlu-Gin-Glu-Lys-Gin-Ala-Gly-Glu-Ser

PubChem: CID 122178

CAS Number: 4037-01-8

Reconstitution: Required


Semax in the Setting of Stroke
In Russia, Semax is used to treat acute cerebral hypoxia caused by stroke or traumatic brain injury. As per studies in rats, Semax promotes the expression of 24 genes in the brain and spinal cord through various molecular mechanisms. These genes modulate various functions from smooth muscle cell migration to red blood cell formation and angiogenesis. The peptide promotes the survival of neurons, stabilizes mitochondria, and energy production, and enhances the supply of nutrition to the brain.
As per studies in Russia, Semax accelerates the rate of rehabilitation in stroke patients and results in a greater overall level of function upon completing the treatment. Gusev et al. stated, “early rehabilitation and administration of Semax increase BDNF plasma levels, speed functional recovery, and improve motor performance.”
BDNF is a natural brain peptide that promotes learning and memory. BDNF stimulation enhances neuroplasticity in the brain and helps undamaged regions of the brain learn tasks for which damaged regions were responsible. Semax is already known to activate the default mode network, which is crucial for resting attention and social function.

Resting Brain Structure
Semax has been observed through functional magnetic resonance imaging to trigger the function of what is known as the default mode network. The default mode network includes areas of the brain which remain more active during rest than during any activity. Recent studies reveal this brain region to be engaged in social cognition and monitoring of the environment. It is like a general-purpose system for observing the world around us without being specific. The network is thus an important part of attention as it helps change from a “rest” state to a more attentive form. In diseases compromising cognitive power like Alzheimer’s, the default mode network is often affected, proving its involvement in general social awareness.
Semax boosts the network activity and improves our general level of awareness even during rest. This brings about greater attention and focus and being attentive to the social environment. Thus it helps the brain readily switch from a resting state to a focused state.
Increased activity in the default mode network corresponds to improved neural connections within the brain. These connections lead to better problem solving, enhanced memory, and creativity. The peptide is thought to boost global brain function.

Semax and Gene Expression in the Brain
Semax-mediated changes in gene expression in the brain and does not pertain to stroke only. Single intranasal injection of the peptide triggers differential gene regulation in rats’ frontal cortex and hippocampus. This is relevant as the hippocampus regulates memory and learning, whereas the frontal cortex helps concentrate, plan, and organize information. In both regions of the brain, gene expression spikes within 20 minutes of Semax administration and specifically influences nerve growth factor (NGF) and BDNF. Therefore, the peptide can help study the mechanisms of learning and information processing. It can further assist in exploring cognition and easier and permanent learning.

Cognitive Performance
Semax is an effective way for learning and memory enhancement, especially when these functions get neurologically impaired. ACTH, the natural protein source of Semax, preserves memory function and learning in murine models of epilepsy, as shown in studies from Canada, China, and the United States. It has been used as the first line of treatment for the epileptic disorder.
According to Dr. Scantlebury, Semax is a potent derivative of ACTH and provides benefits absent in the natural peptide. Preliminary reports suggest that even low doses of ACTH help prevent learning and memory dysfunction following a seizure. This indicates ACTH and Semax possess nootropic properties and can also promote cognitive performance when used regularly in minimal doses.

Semax and Depression
Murine studies have shown that elevated BDNF influences the function of the brain in the setting of depression. Current antidepressants, like SSRIs, indirectly regulate serotonin signaling in the brain to alleviate the condition, but prolonged treatment is required for any visible effect. Neurobiologists have thus always wanted a more immediate solution. It is now known that SSRIs take a prolonged duration due to their slow ability to increase BDNF in the depressed brain. According to Deltheil et al., a combination of Semax and SSRI could majorly improve the treatment of depression through prompt induction of BDNF.
Semax exhibits minimal side effects, low oral bioavailability, and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not scale to humans.

All orders ship same day if placed by 2pm PST.  Synthesized and lyophilized in the USA.
This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law.  Only qualified and licensed professionals should handle these products.  Any information found on Biotech Peptides is strictly for educational purposes only.  Refer to our terms and conditions for more details.

Additional information


Biotech Peptides

13 reviews for Semax (25mg)

  1. Ava Thompson

    A little gold mine of peptides. Glad I found them

  2. Sebastian Cook

    QUALITY. Its really the only thing that matters to me. Been satisfied so far.

  3. Chloe Hamilton

    Oustanding products. You are and will be my go to from now on. Taylor from customer service was extremely helpful. Looking forword to the next set.

  4. Raymond LaReaux Raymond LaReaux

    The supplies are excellent and shipping to France was lightning quick. I eagerly await the arrival of my next shipment.

  5. Sebastian Cook

    Love the prices, sales prices aren’t the greatest but better than nothing

  6. Brenda Nelson

    HIghly efficient company with great customer service! They’re knowledgeable and know what they’re selling. I had a few products that weren’t in stock but they had the alternative peptides for it! Happy the person was able to point that out to me or else I wouldn’t have been able to place an order. Products just arrived too and I ordered them Friday afternoon!

  7. Ankur Yadav

    Best site, love the price range!

  8. Sawyer Myers

    Big fan of their peptide quality. I haven’t bought them from any other supplier in months.

  9. richard donavan

    Thanks for the Bac water! Nice surprise when I opened it to find 2 instead of 1.

  10. eli conner

    Quality is out of this world and the prices can’t be beat either.

  11. Gilbert James

    Pleased with Biotech in all aspects.

  12. Weston E.

    Shelf life is fantastic! Saves me money to not have to rebuy products for spaced out projects.

  13. April Durham

    Products came safely packaged and in great condition. The summer heat had me worried but no problems. I did also appreciate the complimentary bacteriostatic water they sent out as well.

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