Semax (25mg)

(13 customer reviews)


Semax peptides are Synthesized and Lyophilized in the USA.

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Semax Peptide

Semax is a synthetic analog of adrenocorticotropic hormone (ACTH) comprising amino acids 4 through10 of ACTH. Semax has primarily been implicated in research in cognitive impairment and the aftermath of stroke. The peptide has also been studied closely within the context of dementia and certain inflammations of the optic nerve. Researchers posit that the peptide may exert neurotrophic action, suggesting that the peptide may act to increase the production of brain-derived neurotrophic factor (BDNF) in the central nervous system, with consequences in serotonin and dopamine release.


Molecular Formula: C37H51N9O10S

Molecular Weight: 813.920 g/mol

Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-lle-GluLys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-LysThr-Glu-Thr-Gin-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-GluThy-lleGlu-Gin-Glu-Lys-Gin-Ala-Gly-Glu-Ser

Semax Research

Semax and Stroke
In Russia, Semax has been researched in the context of acute cerebral hypoxia resulting from stroke or traumatic brain injury. As per studies in rats, Semax appears to promote the expression of 24 genes in the brain and spinal cord through various molecular mechanisms. These genes modulate various functions from smooth muscle cell migration to red blood cell formation and angiogenesis. The peptide has been suggested to promote the survival of neurons and potentially stabilize mitochondria.[1] The scientists report that “The immunomodulating effect of the peptide discovered in our research and its impact on the vascular system during ischemia are likely to be the key mechanisms underlying the neuroprotective effects of the peptide.” [2] Gusev et al. observe, “early rehabilitation and [introduction] of Semax increased BDNF plasma levels, speed functional recovery, and improve motor performance.” BDNF is a natural brain peptide that is considered to aid in cognitive development. BDNF stimulation may enhance neuroplasticity as well.

Semax and Brain Structure
Semax has been suggested by researchers via functional magnetic resonance imaging to trigger the function of what is known as the default mode network.[3] The default mode network includes areas of the brain which remain more active during rest than during any activity. It is a general-purpose system for monitoring the organism’s environment, without focusing on specific elements. The network is an important part of attention as it helps the organism change from a “rest” state to alertness.[4] Researchers suggest that any increased activity in the default mode network corresponds to improved neural connections within the brain. These connections may support the organism’s functional cognitive processes. Through closer research into Semax, the peptide is considered to support global brain function through a domino chain of cognitive functioning.

Semax and Gene Expression
Semax appears to mediate changes in gene expression in the brain. Study findings indicate that introduction to the peptide may trigger differential gene regulation in rats’ frontal cortex and hippocampus. This is relevant as the hippocampus regulates memory and learning, whereas the frontal cortex helps process and organize information. In both regions of the brain, scientists observed that gene expression appears to spike within 20 minutes of Semax exposure, and specifically appeared to influence nerve growth factor (NGF) and BDNF.[5] The researchers concluded that “Semax … results in rapid, long-term, and specific activation of Bdnf and Ngf expression changes in different rat brain departments.”

Semax and Cognitive Function
ACTH, the natural protein source of Semax, appears to preserve memory function and learning in murine models of epilepsy, as shown in studies from Canada, China, and the United States. It has also been an object of speculation for its potential in epileptic disorder research. According to Dr. Scantlebury, Semax is a potentially potent derivative of ACTH and may provide ancillary action that absent in the natural peptide.[6] Preliminary reports suggest that even low concentrations of ACTH may mitigate the risk of dysfunction following a seizure. This research indicates ACTH and Semax may possess nootropic characteristics. Research is ongoing.

Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.



  1. Medvedeva EV, Dmitrieva VG, Povarova OV, et al. The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis. BMC Genomics. 2014;15:228. Published 2014 Mar 24. doi:10.1186/1471-2164-15-228.
  2. Gusev EI, Martynov MY, Kostenko EV, Petrova LV, Bobyreva SN. Éffektivnost’ semaksa pri lechenii bol’nykh na raznykh stadiiakh ishemicheskogo insul’ta [The efficacy of semax in the tretament of patients at different stages of ischemic stroke]. Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(3. Vyp. 2):61-68. doi:10.17116/jnevro20181183261-68.
  3. Lebedeva IS, Panikratova YR, Sokolov OY, et al. Effects of Semax on the Default Mode Network of the Brain. Bull Exp Biol Med. 2018;165(5):653-656. doi:10.1007/s10517-018-4234-3.
  4. Mars RB, Neubert FX, Noonan MP, Sallet J, Toni I, Rushworth MF. On the relationship between the “default mode network” and the “social brain”. Front Hum Neurosci. 2012;6:189. Published 2012 Jun 21. doi:10.3389/fnhum.2012.00189.
  5. Agapova TIu, Agniullin IaV, Silachev DN, et al. Mol Gen Mikrobiol Virusol. 2008;(3):28-32.
  6. Scantlebury MH, Chun KC, Ma SC, Rho JM, Kim DY. Adrenocorticotropic hormone protects learning and memory function in epileptic Kcna1-null mice. Neurosci Lett. 2017;645:14-18. doi:10.1016/j.neulet.2017.02.069
  7. Deltheil T, Guiard BP, Cerdan J, et al. Behavioral and serotonergic consequences of decreasing or increasing hippocampus brain-derived neurotrophic factor protein levels in mice. Neuropharmacology. 2008;55(6):1006-1014. doi:10.1016/j.neuropharm.2008.08.001
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13 reviews for Semax (25mg)

  1. Ava Thompson

    A little gold mine of peptides. Glad I found them

  2. Sebastian Cook

    QUALITY. Its really the only thing that matters to me. Been satisfied so far.

  3. Chloe Hamilton

    Oustanding products. You are and will be my go to from now on. Taylor from customer service was extremely helpful. Looking forword to the next set.

  4. Raymond LaReaux Raymond LaReaux

    The supplies are excellent and shipping to France was lightning quick. I eagerly await the arrival of my next shipment.

  5. Sebastian Cook

    Love the prices, sales prices aren’t the greatest but better than nothing

  6. Brenda Nelson

    HIghly efficient company with great customer service! They’re knowledgeable and know what they’re selling. I had a few products that weren’t in stock but they had the alternative peptides for it! Happy the person was able to point that out to me or else I wouldn’t have been able to place an order. Products just arrived too and I ordered them Friday afternoon!

  7. Ankur Yadav

    Best site, love the price range!

  8. Sawyer Myers

    Big fan of their peptide quality. I haven’t bought them from any other supplier in months.

  9. richard donavan

    Thanks for the Bac water! Nice surprise when I opened it to find 2 instead of 1.

  10. eli conner

    Quality is out of this world and the prices can’t be beat either.

  11. Gilbert James

    Pleased with Biotech in all aspects.

  12. Weston E.

    Shelf life is fantastic! Saves me money to not have to rebuy products for spaced out projects.

  13. April Durham

    Products came safely packaged and in great condition. The summer heat had me worried but no problems. I did also appreciate the complimentary bacteriostatic water they sent out as well.

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