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Melanotan 1 (10mg)

(31 customer reviews)

$38.00

Melanotan 1 peptides are Synthesized and Lyophilized in the USA.

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Price $36.10$34.20
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SKU: Melanotan-1-10mg Category:

Description

Melanotan 1 Peptide

Melanotan 1 (MT-1) is a synthetic equivalent of alpha-melanocyte-stimulating hormone (alpha-MSH). The peptide has been exhaustively researched in research models of erythropoietic protoporphyria to potentially reduce phototoxicity or UV-related damage.[1] It was suggested to have the potential to influence diverse physiological processes like feeding patterns, central nervous system operations, blood pressure, etc. The molecule’s clinical trials are currently in phase II stage for keratosis. The more severe squamous cell carcinoma is in phase III stage within the context of polymorphous light eruption.

Specifications

Other Known Titles: MT-1

Molecular Formula: C78H111N21O19

Molecular Weight: 1646.8 g/mol

Sequence: Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2

Melanotan 1 Research

Melanotan 1 is structurally and functionally similar to the physiological alpha-melanocyte-stimulating hormone (alpha-MSH). Alpha-MSH is primarily considered to impact melanocytes, skin cells, and hair follicle cells responsible for pigmentation. This hormone appears to interact with melanocortin receptor 1, potentially thus mediating its role. Alpha-MSH is considered to be a non-selective agonist of melanocortin receptors 1, 3, 4, and 5. MT-1 varies from alpha-MSH by a single amino acid and was initially developed to induce melanin production and pigmentation. Subsequent research on the peptide and other melanocortin-binding proteins helped scientists to explore the melanocortin signaling system better.

Melanotan 1 and Melanin
MT-1 has been studied in phase I clinical trials for its melanin-inducing potential in research models exposed to ultraviolet radiation.[2] The work observed that models exposed to MT-1 exhibited a reported 75% increase in pigmentation and roughly 47% less burn. Melanotan 1 appeared to induce similar pigmentation in models compared to controls even with 50% less ultraviolet light exposure. The pigmentation persisted on these subjects for three weeks longer than those exposed only to UV light. Variant MC1 receptors may induce less skin pigmentation than wild-type MC1 receptors. In this genetic backdrop, the exposure of MT-1 may increase melanin density, induce substantial pigmentation, and potentially mediate photoprotection.

MT-1 is also studied in the context of Vitiligo. Studies noted that combinatorial exposure of the peptide with UVB light appeared to promote both syntheses of melanin and proliferation of melanocytes. About 50 % of the MT-1 exposed vitiligo models exhibited apparent rapid re-pigmentation and a decrease of vitiligo patching. MT-1 may impact hypopigmented scars based on the outcome of vitiligo research study. Overexposure to UV light may lead to scaly growth known as actinic or solar keratosis. This precancerous lesion has been associated with the development of squamous cell carcinoma.

Melanotan 1 and Cognitive Decline, Alzheimer’s Disease
MT-1 exposure appeared to protect transgenic mice brains from cognitive decline and the onset of Alzheimer’s disease (AD).[3] The researchers suggested that the melanocortin receptor activation by MT-1 “restores the impaired homeostatic processes and microglial reactivity in the hippocampus in APP/PS1 mice.” Even minute amounts of the peptide were observed in an experimental study to decrease amyloid-beta plaques and neuronal apoptosis in the brains of mice suffering from moderate AD. This may enhance cognitive function and synaptic transmission in the MT-1 exposed animals. In the same study, inhibiting the effects of MT-1 at the MC4 receptor appeared to prevent all of the peptide’s considered favorable impacts. MC4 receptor stimulation may lead to neurogenesis and cognitive function recovery in murine AD models. All AD-linked biomarkers appeared to decrease significantly even with limited exposure to the peptide. The MC4 receptor is the sole melanocortin receptor to be expressed on astrocytes, the feeder cells that help to protect and provide nutrition to neurons. MT-1 is under study for its potential to enhance the production of brain-derived neurotrophic factor (BDNF) and may stimulate astrocyte functioning. BDNF is considered crucial to maintaining the stability of synapses and general neurogenesis.

Melanotan 1 and Blood Pressure, Stroke
MT-1 appears to selectively help control hypertension in murine models without impacting control models with normal blood pressure.[4] This role of MT-1 possibly may avoid instances of hypotension, heart attack, stroke, or other serious manifestations. MT-1 appears in research to alleviate adverse conditions of stroke as well. Studies on the gerbil model have suggested that when the peptide is exposed even 9 hours after a stroke, it may help in controlling brain damage, neuronal death, and improve learning and memory.[5] MT-1 appears to assist the brain to reroute learning and memory circuits. The peptide, researchers suggest, may thereby potentially repair synaptic plasticity and long-term functional recovery of the brain. The most important mediator in this process is the expression of the Zif268 gene. Zif268 is reported to be over-expressed in animals exposed to Melanotan 1.

Melanotan 1 and Neuroinflammatory Disease
MC1 receptor was recently observed to induce inflammation in the central nervous system in mice. T helper cells attack the myelin sheath in neurons leading to neuronal dysfunction and even death in multiple sclerosis. The damage was apparently reversed in research studies through the introduction of MT-1. In fact, the MT-1 appeared to augment myelin recovery and promoted neuron signaling.[6] Uveitis is another inflammatory disorder of the eye which is considered to lead to vision loss. Melanotan 1 may host the potential to mimic alpha-MSH’s role, which may suppress T-cell function through MC4 receptors. Local exposure of the MC4 agonists directly to the eye has also appeared to be potentially effective.[7]

Melanotan 1 and Heart, Circulation functions
Studies in rats have suggested MT-1 and other melanocortins may act in reducing cardiac injury and improving circulatory parameters. The exposure of MT-1 during CPR and in combination with epinephrine appeared to reinstate baseline arterial pressure and cardiac rate, reversing metabolic acidosis, suppressing inflammatory markers, and promoting the expression of genes associated with cardiac function. Overall, the procedure appeared to help increase the survival rate in the rat models by 81%, suggesting the efficacy of Melanotan-1 or a similar melanocortin in a cardiac instances.

Melanotan 1 and Fat Cells
MT-1 appears to work directly on the MC5 receptor, like several melanocortin receptors. This interaction appears to stimulate MC5R into lipid metabolism by muscle cells and may shift the dynamics from fat storage to fat burning. These studies in murine models put forth the theory that lipid metabolism may be a complex physiological process and may incorporate various pathways.[8] Research in mice suggests that exposure to the peptide may lead “to weight loss that affects both the visceral and subcutaneous fat compartments.” MT-1 may act as a experimental molecule to study fatty acid metabolism and the means to alter the baseline physiology.

Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.

 

References

  1. Wensink D, Wagenmakers MAEM, Langendonk JG. Afamelanotide for prevention of phototoxicity in erythropoietic protoporphyria. Expert Rev Clin Pharmacol. 2021 Feb;14(2):151-160. doi: 10.1080/17512433.2021.1879638. PMID: 33507118.
  2. Koikov L, Starner RJ, Swope VB, Upadhyay P, Hashimoto Y, Freeman KT, Knittel JJ, Haskell-Luevano C, Abdel-Malek ZA. Development of hMC1R Selective Small Agonists for Sunless Tanning and Prevention of Genotoxicity of UV in Melanocytes. J Invest Dermatol. 2021 Jul;141(7):1819-1829. doi: 10.1016/j.jid.2020.11.034. Epub 2021 Feb 18. PMID: 33609553; PMCID: PMC9009400.
  3. Lau JKY, Tian M, Shen Y, Lau SF, Fu WY, Fu AKY, Ip NY. Melanocortin receptor activation alleviates amyloid pathology and glial reactivity in an Alzheimer’s disease transgenic mouse model. Sci Rep. 2021 Feb 23;11(1):4359. doi: 10.1038/s41598-021-83932-4. PMID: 33623128; PMCID: PMC7902646.
  4. do Carmo JM, da Silva AA, Wang Z, Fang T, Aberdein N, Perez de Lara CE, Hall JE. Role of the brain melanocortins in blood pressure regulation. Biochim Biophys Acta Mol Basis Dis. 2017 Oct;1863(10 Pt A):2508-2514. doi: 10.1016/j.bbadis.2017.03.003. Epub 2017 Mar 6. PMID: 28274841; PMCID: PMC5587353.
  5. Ahmed TJ, Montero-Melendez T, Perretti M, Pitzalis C. Curbing Inflammation through Endogenous Pathways: Focus on Melanocortin Peptides. Int J Inflam. 2013;2013:985815. doi: 10.1155/2013/985815. Epub 2013 May 7. PMID: 23738228; PMCID: PMC3664505.
  6. Wurtman R. Multiple Sclerosis, Melatonin, and Neurobehavioral Diseases. Front Endocrinol (Lausanne). 2017 Oct 23;8:280. doi: 10.3389/fendo.2017.00280. PMID: 29109699; PMCID: PMC5660121
  7. Sande PH, Dorfman D, Fernandez DC, Chianelli M, Domínguez Rubio AP, Franchi AM, Silberman DM, Rosenstein RE, Sáenz DA. Treatment with melatonin after onset of experimental uveitis attenuates ocular inflammation. Br J Pharmacol. 2014 Dec;171(24):5696-707. doi: 10.1111/bph.12873. PMID: 25131343; PMCID: PMC4290711.
  8. Strader AD, Shi H, Ogawa R, Seeley RJ, Reizes O. The effects of the melanocortin agonist (MT-II) on subcutaneous and visceral adipose tissue in rodents. J Pharmacol Exp Ther. 2007 Sep;322(3):1153-61. doi: 10.1124/jpet.107.123091. Epub 2007 Jun 13. PMID: 17567964.
All orders ship same day if placed by 12 PST.
This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law.  Only qualified and licensed professionals should handle these products.  Any information found on Biotech Peptides is strictly for educational purposes only.  Refer to our terms and conditions for more details.

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Biotech Peptides

31 reviews for Melanotan 1 (10mg)

  1. Maverick King

    Very good price!

  2. Maverick King

    Ill be back. The variety of available products here is amazing. Hope

  3. Logan Turner

    Shopping here was a very fine experience. I will surely try again

  4. Maverick King

    Orders always arrive fast and in great condition

  5. Shea Rain

    I have been buying from here for months now.The process is easy, safe and they have very qualitative products

  6. Raelynn Baker

    It’s always a pleasure shopping from here

  7. Diana Kavadias

    USPS sucks. Lost my package. I wish you offered UPS.

  8. London Wright

    I’ve tried a few companies before this one and even if I liked the products, I didn’t vibe with CS, which I think is a really big part of customer satisfaction. Dropped them and came here. Very good service and very nice people to talk to

  9. Liam Lewis

    Been buying with them for the past year, been very satisfied with all aspects of the company. Danni is my go-to if I have any questions, concerns, or changes with my orders!

  10. Mark Grondahl

    Would highly recommend Biotech Peptides. I was actually recommended to them and have seen their advertisements as well when looking up products. Glad I took the bullet.

  11. Poppy Thomas

    Awesome staff, keep coming back due to the great products and amazing service

  12. Ryan Tripp

    Wish I’d see you guys on social media, to keep up with everythig that’s new on your website

  13. Mary Tiegs

    I experienced an issue with their payment process this week. Typically, I get my confirmation email within moments of purchasing. This time I didn’t bother checking for it. A few days went by and my package never came when it typically is delivered within two days which is strange but with the mail carriers I figured it may have been lost. Decided to check the tracking number and realized I never got a confirmation number. Emailed them and it turns out they had a glitch in their system and my order was not completed on their end. Got it all figured out with Danny and should have my peptides within a day.

  14. Micheal Tran

    I’ve been getting my products from here for the last year and i’ve never had one issue. The products have good quality and the shipping times are great.

  15. Alex Carmichael

    I really care about the blog part on their website. I have read a bunch of articles on a lot of websites, but yours really seemed to be documented, which is reasurring, since we are speaking about peptides

  16. Kj Hiramoto

    great job!!! 🙂

  17. Chris Wong

    Not a bad word to say. Good peptides, customer service is above average.

  18. Cody Aarons

    Recieved a few broken containers, emailed them a pic and had a new order being shipped out within 10 minutes.

  19. Betty McCurdy

    The quality of the product is unmeasurable. Prices are great as well for the quality.

  20. Emran Amin

    My continued purchases are based on the product’s high quality.

  21. DJ Thurman

    Having had a streak of negative experiences with previous providers, Biotech Peptides is my go-to source now. The quality of their products and service has beyond my expectations.

  22. Marty S. Klein

    We haven’t received the goods yet, so we can’t comment on its quality, however the purchasing procedure was really quick and simple. They shipped out my order pretty quickly as well!

  23. Milo wolf

    This is an excellent resource. I was glad to see that all of the information you need is readily available on their website.

  24. Issac Saylor

    Any questions or issues i have Taylor is there to handle it and get it fixed.

  25. Toby Gowins

    Bought Melanotan 1 as well as Melanotan 2 from them. The quality is amazing and they preserve really well

  26. Trey Aseltine

    The express shipping is very impressive and I think it’s worth the few added dollars

  27. Karina Sell

    Amazing service

  28. Ron Foster

    The way we never had any issues with this company is amazing

  29. Allen Brees

    Everything turned out amazing in my study on Melanotan 1 vs Melanotan 2. No complaints on their peptides, great find!

  30. Juan Sanchez

    Mi investigación se ha desarrollado mucho desde que comencé a usar Biotech. Yo lo recomendaría

  31. Rudy Rough

    Thanks BP for always coming in clutch with the best research goods

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