Melanotan 1 (10mg)

(31 customer reviews)


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5 - 95%$36.10
10 +10%$34.20
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What is Melanotan 1 peptide?

Melanotan 1 (MT-1) is a synthetic equivalent of alpha-melanocyte-stimulating hormone (alpha-MSH). In Europe, the peptide is clinically administered to patients suffering from erythropoietic protoporphyria to prevent phototoxicity or sun-related skin damage. It was initially formulated to act as a sunless tanning agent. Interestingly, it was also observed to influence diverse physiological processes like feeding patterns, central nervous system operations, blood pressure, etc. The molecule’s clinical trials are currently in phase II stage for keratosis (a particular kind of skin damage induced by the sun). The more severe squamous cell carcinoma is in phase III stage to treat polymorphous light eruption.



Molecular Formula: C78H111N21O19

Molecular Weight: 1646.8 g/mol

Sequence: Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2

PubChem: CID 16154396

CAS Number: 75921-69-6

Reconstitution: Required

How Does MT-1 Work?

Melanotan 1 is structurally and functionally similar to the physiological alpha-melanocyte-stimulating hormone (alpha-MSH). Alpha-MSH is primarily known to affect melanocytes, skin cells, and hair cells  responsible for pigmentation. The hormone interacts strongly with melanocortin receptor 1, thus mediating its role. Alpha-MSH is a non-selective agonist of melanocortin receptors 1, 3, 4, and 5 and completely stimulates them.
MT-1 varies from alpha-MSH by single amino acid and was initially developed as a sunless tanning agent. It was soon discovered that MT-1 also induces sexual arousal, boosts appetite, and modifies baseline metabolism apart from affecting skin pigmentation. Subsequent research on the peptide and other melanocortin-binding proteins helped scientists to explore the melanocortin signaling system better.

Melanotan 1 Peptide Research

Designed initially for Sunless Tanning
MT-1 has been studied in phase I clinical trials for its tanning effect in humans exposed to ultraviolet radiation. The work showed that volunteers who were administered MT-1 showed 75% more tanning and about 47% less sunburn. Melanotan 1 induced similar tanning in subjects compared to controls even with 50% less ultraviolet light exposure. The tan persisted on these subjects for three weeks longer than those exposed only to UV light. Hence MT-1 can be used for tanning of skin under conditions of high UV exposure, thereby protecting from skin damage as well as melanomas. This would thus be an effective solution for individuals who possess skin types with poor tanning (referred to as type I and type II as per the Fitzpatrick scale).
Variant MC1 receptors in individuals cause less skin tanning than an individual with wild-type MC1 receptors. In this genetic backdrop, the use of MT-1 increases melanin density, induces substantial tanning, and mediates photoprotection. Sunscreen is of limited use for such individuals. Hence they require to reduce their sun exposure to a significant extent to prevent skin cancer. MT-1 is thus a good alternative for UV protection and decreasing the frequency of skin cancer.
MT-1 is also studied to treat vitiligo. A small phase I trial showed that combinatorial use of the peptide with UVB light therapy promotes both syntheses of melanin and proliferation of melanocytes. About 50 % of the MT-1 treated vitiligo patients showed rapid repigmentation and a decrease of vitiligo patches on the skin. MT-1 may be considered to treat hypopigmented scars based on the outcome of vitiligo trial study.
Overexposure to UV light causes scaly and crusty skin growth known as actinic or solar keratosis. This precancerous lesion, if left unattended, can develop into squamous cell carcinoma. There are greater than 400,000 such cases every year. Unlike obvious lesions, which can be surgically corrected, the small and rather invisible ones can be treated with MT-1 to prevent the formation of skin cancer.

Cognitive Decline, Alzheimer’s Disease
MT-1 administration protects transgenic mice brains from cognitive decline and the onset of Alzheimer’s disease (AD). Even minute amounts of the peptide have been shown to decrease amyloid-beta plaques and neuronal apoptosis in the brains of mice suffering from moderate AD. This enhances clinically defined cognitive function and synaptic transmission in the MT-1 treated animals. In the same study, inhibiting the effects of MT-1 at the MC4 receptor prevented all of the peptide’s favorable effects.
MC4 receptor stimulation leads to neurogenesis and cognitive function recovery in murine AD models. All AD-linked biomarkers decrease significantly even with a once-daily dose of the peptide. Thus the drug acts through multiple pathways.
MC4 receptor is the sole melanocortin receptor to be expressed on astrocytes, the feeder cells that help to protect and provide nutrition to neurons.MT-1 enhances the production of brain-derived neurotrophic factor (BDNF) and thus stimulates astrocyte functioning. BDNF is also crucial to maintaining the stability of synapses and general neurogenesis.

MMT-1 Research and Blood Pressure
MT-1 selectively helps control hypertension in murine models without affecting animals with normal blood pressure. This role of MT-1 holds value as existing medication often leads to hypotension, heart attack, stroke, and other serious manifestations. The blood pressure medicines cause more harm in elderly patients due to their age-related frail physiology. MT-1 ability to control hypertension without triggering critically low blood pressure makes it a suitable candidate for new drug development.

Melanotan 1 and Functional Recovery Following Stroke
MT-1 helps to alleviate adverse conditions of stroke as well. Studies on the gerbil model have shown that when the peptide is used even 9 hours after a stroke can help in controlling brain damage, neuronal death, and improve learning and memory. MT-1 helps the brain to reroute learning and memory to the healthier parts. Thus it helps repair synaptic plasticity and long-term functional recovery of the brain. The most important mediator in this process is the expression of the Zif268 gene. Zif268 is over-expressed in animals administered with melanotan-1. It is also overexpressed in models of AD which exhibits improvement in cognitive abilities.

Melanotan 1 Research and Neuroinflammatory Disease
MC1 receptor was recently observed to induce inflammation in the central nervous system in mice. T helper cells attack the myelin sheath in neurons leading to neuronal dysfunction and even death in multiple sclerosis. The damage can be effectively reversed through the use of MT-1. In fact, the administration of MT-1 to these mice augmented myelin recovery and promoted neuron signaling.
Uveitis is another inflammatory disorder of the eye which causes pain and leads to vision loss. Melanotan 1 serves as a good alternative to the existing steroids and other immunosuppressive drugs used to treat the condition. The peptide mimics alpha-MSH’s role, which suppresses T-cell function through MC4 receptors.Local administration of the MC4 agonists directly to the eye has also proven effective and helps avoid the adverse effects of systemic application.

MT-1 Influences Heart and Circulation
Studies in rats have revealed the efficacy of using MT-1 and other melanocortins in reducing cardiac injury and improving circulatory parameters. The use of MT-1 during CPR and in combination with epinephrine helps to reinstate baseline arterial pressure and cardiac rate, reverses metabolic acidosis, suppresses inflammatory markers, and promotes the expression of genes associated with cardiac function. Overall, the therapy helped increase the survival rate by 81%, proving the efficacy of using Melanotan-1 or a similar melanocortin in a cardiac emergency.

MT-1 Investigated in Fat Loss Trials
MT-1 works on the MC5 receptor, just like several melanocortin receptors. This interaction stimulates MC5R into lipid metabolism by muscle cells and shifts the dynamics from fat storage to fat burning. These studies in murine models prove that lipid metabolism is a complex physiological process and involves various pathways. MT-1 acts as a useful molecule to study fatty acid metabolism and means to alter the baseline physiology without the need for exercise. This can be helpful for individuals who cannot exercise due to injury, morbid obesity, or disability.

All orders ship same day if placed by 2pm PST.  Synthesized and lyophilized in the USA.
This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law.  Only qualified and licensed professionals should handle these products.  Any information found on Biotech Peptides is strictly for educational purposes only.  Refer to our terms and conditions for more details.

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Biotech Peptides

31 reviews for Melanotan 1 (10mg)

  1. Maverick King

    Very good price!

  2. Maverick King

    Ill be back. The variety of available products here is amazing. Hope

  3. Logan Turner

    Shopping here was a very fine experience. I will surely try again

  4. Maverick King

    Orders always arrive fast and in great condition

  5. Shea Rain

    I have been buying from here for months now.The process is easy, safe and they have very qualitative products

  6. Raelynn Baker

    It’s always a pleasure shopping from here

  7. Diana Kavadias

    USPS sucks. Lost my package. I wish you offered UPS.

  8. London Wright

    I’ve tried a few companies before this one and even if I liked the products, I didn’t vibe with CS, which I think is a really big part of customer satisfaction. Dropped them and came here. Very good service and very nice people to talk to

  9. Liam Lewis

    Been buying with them for the past year, been very satisfied with all aspects of the company. Danni is my go-to if I have any questions, concerns, or changes with my orders!

  10. Mark Grondahl

    Would highly recommend Biotech Peptides. I was actually recommended to them and have seen their advertisements as well when looking up products. Glad I took the bullet.

  11. Poppy Thomas

    Awesome staff, keep coming back due to the great products and amazing service

  12. Ryan Tripp

    Wish I’d see you guys on social media, to keep up with everythig that’s new on your website

  13. Mary Tiegs

    I experienced an issue with their payment process this week. Typically, I get my confirmation email within moments of purchasing. This time I didn’t bother checking for it. A few days went by and my package never came when it typically is delivered within two days which is strange but with the mail carriers I figured it may have been lost. Decided to check the tracking number and realized I never got a confirmation number. Emailed them and it turns out they had a glitch in their system and my order was not completed on their end. Got it all figured out with Danny and should have my peptides within a day.

  14. Micheal Tran

    I’ve been getting my products from here for the last year and i’ve never had one issue. The products have good quality and the shipping times are great.

  15. Alex Carmichael

    I really care about the blog part on their website. I have read a bunch of articles on a lot of websites, but yours really seemed to be documented, which is reasurring, since we are speaking about peptides

  16. Kj Hiramoto

    great job!!! 🙂

  17. Chris Wong

    Not a bad word to say. Good peptides, customer service is above average.

  18. Cody Aarons

    Recieved a few broken containers, emailed them a pic and had a new order being shipped out within 10 minutes.

  19. Betty McCurdy

    The quality of the product is unmeasurable. Prices are great as well for the quality.

  20. Emran Amin

    My continued purchases are based on the product’s high quality.

  21. DJ Thurman

    Having had a streak of negative experiences with previous providers, Biotech Peptides is my go-to source now. The quality of their products and service has beyond my expectations.

  22. Marty S. Klein

    We haven’t received the goods yet, so we can’t comment on its quality, however the purchasing procedure was really quick and simple. They shipped out my order pretty quickly as well!

  23. Milo wolf

    This is an excellent resource. I was glad to see that all of the information you need is readily available on their website.

  24. Issac Saylor

    Any questions or issues i have Taylor is there to handle it and get it fixed.

  25. Toby Gowins

    Bought Melanotan 1 as well as Melanotan 2 from them. The quality is amazing and they preserve really well

  26. Trey Aseltine

    The express shipping is very impressive and I think it’s worth the few added dollars

  27. Karina Sell

    Amazing service

  28. Ron Foster

    The way we never had any issues with this company is amazing

  29. Allen Brees

    Everything turned out amazing in my study on Melanotan 1 vs Melanotan 2. No complaints on their peptides, great find!

  30. Juan Sanchez

    Mi investigación se ha desarrollado mucho desde que comencé a usar Biotech. Yo lo recomendaría

  31. Rudy Rough

    Thanks BP for always coming in clutch with the best research goods

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