Follistatin-344 (1mg)

(16 customer reviews)


Follistatin-344 peptides are Synthesized and Lyophilized in the USA.

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SKU: Follistatin-344-1mg Category:


What is Follistatin-344?

Follistatin-344 is a synthetic full-sized version of a naturally occurring protein in the body. You can find it in the tissues of all higher animals. Follistatin-344 occurs in two isomers varying based on their gene splicing. Its primary role in the body is to counteract the effect of the Tumor Growth Factor-beta (TGF-beta) family. The TGF-beta family comprises myostatin, activin, and Follicle Stimulating Growth Hormone (FSH). Follistatin-344 acts by stimulating Insulin/IGF-1 pathway, and there is an immense deal of potential in Follistatin-344 research. It’s frequently studied owing to its role in several human conditions ranging from muscle dysfunction to cancer and diabetes.


SYNONYMS: Activin-binding protein, FST, FSH- Suppressing protein



PUBCHEM:CID 178101631


Follistatin-344 Research

1. Effects on Muscle Growth:
Myostatin is a naturally occurring protein in the body that belongs to the TGF-1 family. It inhibits muscle growth in the body. Numerous studies have provided evidence to support the inhibitory effect of Follistattin on myostatin.
A comparative study indicated that animals with this protein tend to have greater muscle mass than naturally lacking it. Follistatin-344 increases muscle mass by hyperplasia (increase in the number of muscle fibers) and hypertrophy (increase in muscle fiber). Interestingly, the administration of Follistatin-344 increased the muscle mass in the mice in the absence of other muscle-building factors[1]. The muscle-building factors refer to exercise and a special diet. It also implies that the administration of Follistatin-344 can provide multiplied benefits when supplemented with a special diet and appropriate training.
This property of Follistatin-344 to promote muscle growth and enhance muscle strength is of great significance in diseases involving muscular dystrophy. Studies have demonstrated the ability of Follistatin-344 to reduce inflammation and fibrosis. Its property promotes muscle growth, which can treat inflammatory muscular dystrophies such as Duchene Muscular Dystrophy[2].
Researchers can do Follistatin-344 administration via the intradermal route. However, studies have indicated that past gene administration of Follistatin-344 provides a sustained duration of effects for as long as two years. These effects on muscle growth are independent of the age of the subject.
Improved Survival for Breast Cancer: A clinical study in breast cancer patients used immune-histochemistry and Reverse Transcription Polymerase Chain Reaction (RT-PCR). The study reported under-expression of Follistatin-344 in a majority while over-expression in a small number of patients[3]. The over-expression of Follistatin was associated with a better prognosis, as per the studies for ABC monomer suggestion. It prevented metastasis of the tumor but increased its growth. On the contrary, under-expression of Follistatin-344 led to higher incidences of metastasis.
A study done on a mouse model of HER-2 positive breast cancer showed that Follistatin-344 prevents activin-induced migration of epithelial cells in breast tissue. This property of Follistatin prevents metastasis without increasing the growth of the tumor mass. A study done on cases involving benign proliferative diseases of the breast indicated over-expression of Follistatin. This fact again shows the anti-metastatic potential of Follistatin.

2. Effect on Esophageal Carcinoma:
Barret’s esophagus is a pre-malignant condition of Esophageal Carcinoma. It involves the conversion of Squamous epithelium into columnar with goblet cells. Bone Morphogenic Protein (BMP) is responsible for this metaplasia. Frequent acid reflux in the esophagus leads to over-activation of BMP and ultimately leads to cancer.
Studies have provided evidence of the role of Follistatin-344 in countering the effects of BMP[4]. This manner is how the administration of Follistatin can prevent the development of esophageal cancer.
There is a varying response towards Follistatin-344 expression in different types of tumors. In Esophageal tumors, it improves survival, whereas it shortens survival in lung and ovarian tumors. This variation is why it is essential to understand how various tumors respond to Follistatin-344 administration. This knowledge will help in its use as adjuvant therapy in treating cancers.
Research involving rats indicated the ability of Follistatin-344 to reduce the extent of fibrosis in the liver by 32%. This capability improves the lifespan of hepatocytes and prevents the progression of fibrosis into liver cancer.

3. Role in Diabetes Mellitus:
An experiment on mice indicated that the over-expression of Follistatin-344 increased the mass of beta-cells in the pancreas[5]. It led to enhanced production of insulin and better control of blood sugar. Treatment with Follistatin-344 doubled the lifespan of these mice as it virtually eliminated all the complications of diabetes. Follistatin-344 provides a physiological control of blood sugar and has an effect similar to insulin.

4. Other Roles
In addition to the roles mentioned above, this peptide can have the following effects on the body:
– Follistatin-344 use during pregnancy ensures optic nerve fusion in the developing fetus.
– Follistatin-344 increases hair density and enhances hair thickness. This effect is more pronounced when FollistAboutgrowth stimulants. It can, therefore, have these animal studies used in the management of conditions such as alopecia.


  1. Haidet AM, Rizo L, Handy C, Umapathi P, Eagle A, Shilling C, Boue D, Martin PT, Sahenk Z, Mendell JR, Kaspar BK. Long-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitors. Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4318-22. doi: 10.1073/pnas.0709144105. Epub 2008 Mar 11. PMID: 18334646; PMCID: PMC2393740.
  2. Chang F, Fang R, Wang M, Zhao X, Chang W, Zhang Z, Li N, Meng Q. The transgenic expression of human follistatin-344 increases skeletal muscle mass in pigs. Transgenic Res. 2017 Feb;26(1):25-36. doi: 10.1007/s11248-016-9985-x. Epub 2016 Oct 27. PMID: 27787698.
  3. Zabkiewicz C, Resaul J, Hargest R, Jiang WG, Ye L. Increased Expression of Follistatin in Breast Cancer Reduces Invasiveness and Clinically Correlates with Better Survival. Cancer Genomics Proteomics. 2017 Jul-Aug;14(4):241-251. doi: 10.21873/cgp.20035. PMID: 28647698; PMCID: PMC5572302.
  4. Shi L, Resaul J, Owen S, Ye L, Jiang WG. Clinical and Therapeutic Implications of Follistatin in Solid Tumours. Cancer Genomics Proteomics. 2016 11-12;13(6):425-435. doi: 10.21873/cgp.20005. PMID: 27807065; PMCID: PMC5219916.
  5. Ozawa T, Morikawa M, Morishita Y, Ogikubo K, Itoh F, Koinuma D, Nygren PÅ, Miyazono K. Systemic administration of monovalent follistatin-like 3-Fc-fusion protein increases muscle mass in mice. iScience. 2021 May 14;24(5):102488. doi: 10.1016/j.isci.2021.102488. PMID: 34113826; PMCID: PMC8170004.
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16 reviews for Follistatin-344 (1mg)

  1. Ina Cox

    Ty for the top notch service. Taylor was very helpful with my specific needs.

  2. Geraldine Cisneros

    One of the newest leading brands that manufacture high-quality peptides right now. Glad I tried them out

  3. Ibrahim Alatas

    My company recently had me search up new peptide suppliers as we were tired of our old one. Long story short supplies never came on time, broken vials, you name it. They’re really happy with what I found. Have had two orders put in the last month. Everything was always delivered on time and so far nothing broke!

  4. Loren Bass

    Love the company, the customer service, and the quality of the products. Has not let me down yet. My only suggestion is better packaging!! Feel Like that may need an update

  5. Tim Ritts

    Keep up the good work!

  6. Ivy Nguyen

    It has been about just shy of a year we’ve been doing business with them now. Everything is great, have had small problems here and there that were fixed in no time. They are efficient and the peptides are always handled with the greatest care. Here and there we’ve had a vial break but understandable with the carriers. As were in New York, with the storm and such we’ve had some delays with products but they were able to send us new ones due to the originals basically being of no use.

  7. Alex Henderson

    Good company, great matto, feel like theyre always for the customer! love the frequent promo codes they send out! helps me save some cash as well! Noticed they send a free Bac water here and there even when my order wasnt too high in price!

  8. Craig Leyton

    They have some issues just like every other peptide supplier but they beat the others out souly due to their customer service and low price. Getting pureproducts for a cheaper price in my opinion.

  9. Ethan Carpio

    This was recommended to me by a person I work with and since I started purchasing from you guys I haven’t bought from another supplier since.

  10. Derek Young

    Impressed by their swift service. Any orders or emails are responded to with such high speed.

  11. Kevin Woods

    Their team is awesome and knows in detail what they are selling.

  12. teddy wilson

    I can say with great assurance their peptides come second to none. Purity is out of this world. Even the bac water they send out is of top quality as well. This peptide really did help with my research on muscle growth.

  13. Frank Druthers

    Jamie was a saint and was able to set up a special code for me as I would be buying in bulk for my lab site. Best deal I have found!

  14. Ross Thompson

    I got all my peptides and nothing was broken or shattered. They all seemed to be in perfect condition as well.

  15. Chris DeGidio

    First time trying them out, did not expect such fast delivery.

  16. Allen Echevarria

    Nice selection of peptides!

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