ACE-031 (1mg)

(7 customer reviews)

$161.00

Discount per Quantity

QuantityDiscountPrice
5 - 95%$152.95
10 +10%$144.90
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FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
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SKU: ACE-031-1mg Category:

Description

What Is ACE-031?

The activin receptor promotes sperm development and boosts muscle mass. ACE-031, a soluble protein comprising the type IIB activin receptor (ACVR2B) and the immunoglobulin G1-Fc (IgG1-Fc), is capable of a similar role by binding and inactivating myostatin, a protein that hampers muscle growth. This has therapeutic potential towards the treatment of muscle-wasting disorders and neuromuscular conditions such as Duchenne muscular dystrophy (DMD) and certain cancers such as those of the prostate or colorectal regions and lipid storage and bone metabolism.

SPECIFICATIONS

AKA: Ramatercept, ActRIIB-IgG1, ACVR2B/Fc

Sequence: Not Available

PubChem: CID 16130571

CAS Number: 1169766-01-1

Reconstitution: Required

ACE-031 Research

Muscle Protection After Menopause
ACE-031 enhances muscle growth, bone metabolism as well as limits lipid accumulation. A notable improvement in lean body mass and thigh muscle volume is seen within a month of ACE-031 administration. The treatment outcome has the added benefits of improved bone and fat metabolic profile.

Muscle Cell Growth
ACE-031 administration reduces muscle wasting by its ability to bind myostatin in muscle cells. The most desirable outcome is supplemented with approaches that promote muscle growth, such as the co-administration of growth hormones like IGF-1.

Energy Metabolism
Research has shown that inhibiting the natural ACE-031 proteins can cause failure to reduce serum lactate levels, prevent metabolic damage to muscles, and improve vascularization of the muscle tissue. These can be overcome by ACE-031 supplementation. It promotes muscle growth by blocking myostatin-mediated wasting and delays the onset of tiredness and oxidative damage by enhancing the oxygenation of the muscle tissues.

Strength
ACE-031 improves muscle function in more ways than one. Other than blocking the effects of myostatin, ACE-031 can improve muscle thermodynamics by promoting oxidative respiration, thereby improving the force-generating capacity of muscles, specifically the maximum force by 50% and total contractile force by 25%. It was also shown that ACE-031 improves muscle strength without affecting energy dynamics or changes in ATP levels or contractile efficiency within the muscle tissues.

Muscle Repair
Muscle wasting disorders such as Duchenne muscular dystrophy (DMD) often result in difficulty walking by the time the patient is 12 years of age. Patients display severe muscle loss due to low protein levels despite the extremely high-fat reserves—the primary reason being that the dystrophin (a group of proteins) in these patients is non-functional. Moreover, the release of myostatin from damaged muscle cells can affect surrounding cells causing their growth to slow down. However, research has shown the ability of ACE-031 to reduce the rate of muscle damage by addressing the effects of myostatin release.
The peptide preserves muscle function, increases lean body mass, improves bone mineral density, and reduces fat reserves when administered once or twice a month subcutaneously, as shown by the improved results in the 6-minute walk test.

Bone Density
ACE-031 improved total body weight, muscle mass, and bone mineral density when administered for seven consecutive weeks at the rate of once per week. A reduction in the population of osteoclasts seems to be responsible for the improved mineral content in bones, which also improved the biomechanics, stiffness, and maximum force that the bones could tolerate.
Research has shown the ability of ACE-031 to increase bone mass by around 30%, highlighting its therapeutic potential for controlling the progression of osteoporosis. Moreover, due to its ability to promote muscle strength and bone density and reduce lipid reserves, the peptide holds promise for improving the physiologic effects caused due to aging.
In addition to its myostatin inhibiting property, studies have shown the ability of ACE-031 to increase bone density by almost 132% in the femur (the thigh bone, which is often damaged with age) and 27% in vertebrae.

Cancer Treatment and Muscle Loss
Molecular cascades resulting in muscle loss either due to death or necrosis are commonly seen in cancer patients or those undergoing chemotherapy. The primary reason is the metabolic stress on muscles due to changes in aerobic respiration status. In addition, there is an increase in the free radical population within cells that indirectly causes muscle damage.
Activating the ERK1/2 pathway by administering ACE-031 averts muscle fiber atrophy due to apoptosis. In addition, the efficiency of energy consumption and mitochondrial metabolism is also seen to improve, which is a significant outcome keeping in mind the limited nutrition in a cancer patient’s body. Moreover, the concentration of free radicals also reduces. Thus, ACE-031, along with anticancer drugs, may have a better potential of preventing chemotherapy-induced muscle atrophy.
Myostatin is produced in certain cancers, which leads to muscle wasting and loss. In addition, these transformed cells are often associated with inactivated activin receptors, loss of mitochondria, and hence ATP levels. Research has shown a reversal of these effects with ACE-031 administration.
The resulting preservation of muscle composition, strength, and lean body mass increases life expectancy in such patients. Some additional benefits of myostatin inhibition include improved insulin sensitivity, reduced fat storage, reduced inflammation, and better bone metabolism and strength.
ACE-031 demonstrates excellent bioavailability upon subcutaneous administration in murine models. The side effects are minimal, and bioavailability through the oral route is low. However, its per kg dosage in rodents is not scalable to humans. ACE-031 usage and sale are limited to educational and scientific research and not suitable for human consumption. Only buy ACE-031 peptide if you are a licensed researcher.

All orders ship same day if placed by 2pm PST.  Peptides synthesized and lyophilized in the USA.
This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law.  Only qualified and licensed professionals should handle these products.  Any information found on Biotech Peptides is strictly for educational purposes only.  Refer to our terms and conditions for more details.

Additional information

Brand

Biotech Peptides USA

7 reviews for ACE-031 (1mg)

  1. Darcy Davies

    Would recommend

  2. Harlow Pham

    Ordered on June third and received it June 6th. Thank you for the speedy shipping.

  3. Alexis Paytas

    Greatful to have such a reliable supplier <3

  4. Anders Tim

    I havent had a bad experience yet. Keep up the good work!

  5. Cairo Burton

    Can’t say much about the quality of the products YET but the service was great. I reached out to customers service and they gave me a discount.

  6. Jesse Martin

    Very good product

  7. Oscar King

    Im quite surprised at the purity. We tested for ourselves at the university lab and the claims are valid.

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