Acetyl Hexapeptide-3 (Argireline) (200mg)


Acetyl Hexapeptide-3 (Argireline) peptides are Synthesized and Lyophilized in the USA.

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SKU: Acetyl-Hexapeptide-3-Argireline-200mg Category:


What is the Acetyl Hexapeptide-3 (Argireline) peptide?

Acetyl Hexapeptide-3 (Argireline) consists of multiple chains of amino acids. It is a fragment of the SNAP-25, a botulinum toxin substrate.[1] Researchers have investigated Acetyl Hexapeptide-3 (Argireline) for its potential as an anti-wrinkling peptide. Continuous muscle movements result in lines and wrinkles, and the devitalization of muscle contractions can inhibit the prevalence of new lines and decrease the depth of existing wrinkles. Acetyl Hexapeptide-3 (Argireline) may prevent muscles from moving or contracting—forming facial expressions, frowning, or smiling. Acetyl Hexapeptide-3 (Argireline) may also enhance collagen production to keep the skin smooth and devoid of wrinkles.


Sequence: Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2

Molecular Formula: C34H60N14O12S

Molecular Weight: 888.99g/mol

PubChem: CID 11228338

Synonyms: Acetyl hexapeptide, Argireline, Argireline Acetate anti-aging cosmetic peptide

Reconstitution: Required

Acetyl Hexapeptide-3 (Argireline) Research

Aging is a natural process, and physical expressions of an organisms aging result from a variety of factors that can speed up or slow down this process. These include factors related to the body and different environmental considerations. One such factor related to the body are frequent and repeated contraction of different body muscles, and muscle spasms. These spasms can lead to visible signs of aging of the overlying skin, including wrinkles, crow’s feet, lines, and so forth. The aging process also initiates a decline in the production of skin proteins such as collagen. Collagen is responsible for skin elasticity and makes skin supple. Skin proteins like collagen also help retain skin moisture and elasticity, and provide a smooth feel and texture. All these features decline significantly with age and lead to the characteristic signs of aging. Acetyl Hexapeptide-3 (Argireline), according to research, may reduce the visible signs associated with aging—decreasing the deep wrinkles and lines around the eye and forehead.[2]Researchers noted that “functional cosmetic ingredients can improve wrinkle with minimal discomfort.” Cosmetic companies have cited Acetyl Hexapeptide-3 (Argireline) as a potential additive to produce anti-aging products such as lotions, body milk, eye creams, gels, creams, serums, and emulsions. Acetyl Hexapeptide-3 (Argireline) shows promise for combating wrinkles and inhibiting aging. Scientific research suggests that it may be a vital ancillary for the arsenal in combating stubborn lines and creases, even as it works extensively to boost collagen production. Acetyl Hexapeptide-3 (Argireline) clinical studies report that its effects on wrinkles appear to be minimal.[3] On the other hand, the International Journal of Cosmetic Science research posits that its actions are functional and evident.[4] According to the research, a topical cream with a 10% concentration of Acetyl Hexapeptide-3 (Argireline) decreased wrinkles by 30% after one month. The open study states that experts utilized a female subject. Researchers used a serum consisting of Acetyl Hexapeptide-3 (Argireline) twice a day for a month. After which, the results posited a decrease in periorbital wrinkle depth appeared to be about 27%. The in vitro experiment suggests that the actions of the neurotransmitter-inhibiting peptide (Acetyl Hexapeptide-3) may halt the release of neurotransmitters. Blanes-Mira et al. noted that “Taken together, these findings demonstrate that Argireline is a non-toxic, antiwrinkle peptide that emulates the action of currently used BoNTs.” Meanwhile, in vivo, the effect of the peptide may cause facial wrinkles to diminish due to a reduction in muscle action.[5]

Acetyl Hexapeptide-3 (Argireline) appears to have the ability to halt the production of the neurotransmitters that influence and control the potency of facial muscle contraction. Consequently, the formation of wrinkles on the face may be alleviated. Below are the subjects researchers are actively investigating:
Formation of Wrinkles: Acetyl Hexapeptide-3 (Argireline) may hamper the protein complex that controls muscle movement and limit muscle contractions via reducing the action of nerves that control contractions.
Collagen Production: Acetyl Hexapeptide-3 (Argireline) may prevent the formation of wrinkles and lines on the skin by enhancing the production of collagen – a protein responsible for healthy and firm skin.
Moisture Retention: Acetyl Hexapeptide-3 (Argireline) may enhance collagen production in symbiont with the smoothing effect on the skin and may help increase the degree of moisture in the skin.
Ease of Use: Unlike many other peptides, Acetyl Hexapeptide-3 (Argireline) may also be used in topical formulations.
Safety Profile: Experimental research indicates that this peptide has an excellent safety profile, exhibiting no significant side effects.

So far, there have been no records of side effects while using the peptide. Although, the reverse may be the case in a situation where the test subject is allergic to the peptide. However, some researchers suggest that using Acetyl Hexapeptide-3 (Argireline) may amount to skin sag as it appears to influence the use of muscles, causing these muscles to wither or weaken. Consequently, Acetyl Hexapeptide-3 (Argireline) may become incompatible with the surrounding skin, amounting to sag.


Acetyl Hexapeptide-3, also known as Argireline, is an anti-wrinkling peptide produced based on natural proteins, and whose efficacy is under active research. It appears to function to cause a reduction in deep wrinkles and lines that appear in the region of the eyes and forehead due to aging. It is worth noting that there is limited scientific research regarding this product. Therefore, its effects are not well known; the same goes for its side effects.


  1. Wang Y, Wang M, Xiao XS, Huo J, Zhang WD. The anti-wrinkle efficacy of Argireline. J Cosmet Laser Ther. 2013 Aug;15(4):237-41. doi: 10.3109/14764172.2013.769273. Epub 2013 Mar 6. PMID: 23464592.
  2. An JH, Lee HJ, Yoon MS, Kim DH. Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin. Ann Dermatol. 2019 Jun;31(3):263-271. doi: 10.5021/ad.2019.31.3.263. Epub 2019 May 1. PMID: 33911590; PMCID: PMC7992733.
  3. Wang Y, Wang M, Xiao S, Pan P, Li P, Huo J. The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study. Am J Clin Dermatol. 2013 Apr;14(2):147-53. doi: 10.1007/s40257-013-0009-9. PMID: 23417317.
  4. Blanes-Mira C, Clemente J, Jodas G, Gil A, Fernández-Ballester G, Ponsati B, Gutierrez L, Pérez-Payá E, Ferrer-Montiel A. A synthetic hexapeptide (Argireline) with antiwrinkle activity. Int J Cosmet Sci. 2002 Oct;24(5):303-10. doi: 10.1046/j.1467-2494.2002.00153.x. PMID: 18498523
  5. Lim SH, Sun Y, Thiruvallur Madanagopal T, Rosa V, Kang L. Enhanced Skin Permeation of Anti-wrinkle Peptides via Molecular Modification. Sci Rep. 2018 Jan 25;8(1):1596. doi: 10.1038/s41598-017-18454-z. Erratum in: Sci Rep. 2018 Apr 20;8(1):6500. PMID: 29371611; PMCID: PMC5785486.
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