Ipamorelin (5mg)

(28 customer reviews)


Ipamorelin peptides are Synthesized and Lyophilized in the USA.

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Quantity 5 - 910 +
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Price $43.70$41.40
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(Required for reconstitution)
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What is the Ipamorelin peptide?

Ipamorelin is a small pentapeptide that binds to the receptor of ghrelin/growth hormone (GH) secretagogue, and research has suggested the peptide to be extremely selective in its mode of action.[1] Ipamorelin also does not appear to induce non-specific release of hormones like prolactin, thyroid-stimulating hormone, ACTH, luteinizing hormone, follicle-stimulating hormone, and cortisol. The high specificity of the peptide makes it an ideal model for the study of selectivity in receptor binding and also a potential candidate for therapeutic use. It appears to function through interaction with cognate receptors on the target cell surface and mediates a cellular response. Ipamorelin may induce secretions from the pituitary gland, promoting growth in animal study models.[2] In addition, it may not only trigger the expression of insulin-like growth factor-1(IGF-1) but also inhibit the secretion of somatostatin. Hence, the peptide has the potential to influence the overall growth and repair of muscles and skeletal tissues in the body.


Molecular Formula: C38H49N9O5

Molecular Weight: 711.85 g/mol

Sequence: Aib-His-D-2Nal-D-Phe-Lys-NH2

PubChem: CID 9831659

CAS Number: 170851-70-4

Reconstitution: Required

Ipamorelin Research

Ipamorelin and Bone Health
Prolonged use of glucocorticoids reduces bone density and can lead to fracture. Bisphosphonates, hormone therapies, and new monoclonal antibodies are used as alternative treatments though they come with their side effects and are often expensive. Reasearch in Ipamorelin therapies suggest a potential for the peptide to become an economic and physiologically safe alternative. Studies in rats have observed that the peptide may prevent bone loss from glucocorticoid treatment, and also may induce up to a four-fold increase in bone formation.[3] The researchers also reported that “the decrease in muscle strength and bone formation found in GC-injected rats was counteracted by simultaneous administration of the growth hormone secretagogue.” The peptide may improve the bone mineral density of both existing and new bones. Additionally, it may reverse side effects like muscle wasting and fat deposition in the body’s visceral organs.

Ipamorelin and Diabetes
Studies in murine models of diabetes have suggested a strong efficacy of Ipamorelin in promoting insulin release from islet cells of the pancreas.[4] Studies observe that the peptide may mediate the release of insulin through the indirect excitation of calcium channels found on the islet cells. The mechanism of Ipamorelin action highlights the limitations of type 2 diabetes, and further research in this area may help develop novel therapeutic medicines, and lead to more strategic and effective preventive measures.

Ipamorelin and Negative Corticosteroid Effects
Glucocorticoids are the kind of corticosteroids that are commonly administered to treat inflammation in diverse conditions ranging from cancer to autoimmune disease. Unfortunately, their adverse side effects restrict their use. Over long durations, a higher dose of these hormones is required to overcome their physiological ill effects. This treatment regimen hence can be near-fatal. Researchers studying the effects of Ipamorelin have observed the peptide’s potential to decrease the side effects of glucocorticoid use.

Ipamorelin and Muscle Growth
GH and GH secretagogues such as Ipamorelin may decrease the catabolic effects of glucocorticoids on muscles. Studies on Ipamorelin posit that it helps to reestablish the nitrogen balance and reduce nitrogen wasting in the liver of rats that were treated with glucocorticoids. Thus the molecule has the potential to help to overcome both muscle wasting and loss of bone density in patients who require glucocorticoids.

Ipamorelin as Ghrelin Receptor Probe
The peptide binds strongly to the ghrelin receptor and acts as a selective agonist. Interestingly, the ghrelin receptor has been observed to increase cardiac failure and certain types of cancer, such as human carcinomas. Researchers have proposed using Ipamorelin as a probe in positron emission tomography (PET) scans to help diagnose patients. In vitro reports have confirmed the possibility of using it.[5] The next approach would be to perform in vivo study and optimize parameters for interpretation of the results.

Ipamorelin and Post-Operative Ileus
Post-operative Ileus (POI) is a common condition that often follows abdominal surgery. It is characterized by an inability of the patients to accept oral nutrition as the GI system stops functioning. It can involve pain leading to prolonged stay in hospitals and extended tenure required for recovery. Ipamorelin has been studied in multiple proof-of-concept clinical trials to determine its efficacy to reduce POI. It was found to shorten the time of uptake of the first meal by about 12 hours in POI patients.[6] The researchers concluded that “ipamorelin accelerates gastric emptying in a rodent model of postoperative ileus through the stimulation of gastric contractility by activating a ghrelin receptor-mediated mechanism involving cholinergic excitatory neurons.” However, the trials were discarded as the company conducting them decided the efficacy of the peptide to be insufficient for a viable product. However, the use of Ipamorelin in combination with other therapies might be more useful in treating POI. Some of the research observations are as follows:
– Residual radiolabeled food remaining in the stomach of rats with POI was less after the use of Ipamorelin, even when compared to rats without POI.
– When administered Ipamorelin, the geometric location of the food was observed to be similar for both rats without POI and those with POI.
– The radiolabeled food was located more distally in the GI tract and is similar to rats without POI, after Ipamorelin is used on rats with POI.

The peptide is still not studied extensively despite its potential, including the treatment of POI. Apart from therapeutic impact, the molecule can be used to study various aspects of human physiology and disease biology in detail. A new approach of study using cutting-edge technology might shift focus back to this novel peptide.[7] The peptide has exhibited moderate side effects, low oral bioavailability, and excellent subcutaneous bioavailability in mice. The dosage (per kg) in mice does not scale to humans.


  1. Raun K, Hansen BS, Johansen NL, Thøgersen H, Madsen K, Ankersen M, Andersen PH. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998 Nov;139(5):552-61. doi: 10.1530/eje.0.1390552. PMID: 9849822.
  2. Johansen PB, Nowak J, Skjaerbaek C, Flyvbjerg A, Andreassen TT, Wilken M, Orskov H. Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats. Growth Horm IGF Res. 1999 Apr;9(2):106-13. doi: 10.1054/ghir.1999.9998. PMID: 10373343.
  3. Andersen NB, Malmlöf K, Johansen PB, Andreassen TT, Ørtoft G, Oxlund H. The growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced decrease in bone formation of adult rats. Growth Horm IGF Res. 2001 Oct;11(5):266-72. doi: 10.1054/ghir.2001.0239. PMID: 11735244.
  4. Adeghate E, Ponery AS. Mechanism of ipamorelin-evoked insulin release from the pancreas of normal and diabetic rats. Neuro Endocrinol Lett. 2004 Dec;25(6):403-6. PMID: 15665799.
  5. Childs MD, Luyt LG. A Decade’s Progress in the Development of Molecular Imaging Agents Targeting the Growth Hormone Secretagogue Receptor. Mol Imaging. 2020 Jan-Dec;19:1536012120952623. doi: 10.1177/1536012120952623. PMID: 33104445; PMCID: PMC8865914.
  6. Greenwood-Van Meerveld B, Tyler K, Mohammadi E, Pietra C. Efficacy of ipamorelin, a ghrelin mimetic, on gastric dysmotility in a rodent model of postoperative ileus. J Exp Pharmacol. 2012 Oct 19;4:149-55. doi: 10.2147/JEP.S35396. PMID: 27186127; PMCID: PMC4863553.
  7. Sigalos JT, Pastuszak AW. The Safety and Efficacy of Growth Hormone Secretagogues. Sex Med Rev. 2018 Jan;6(1):45-53. doi: 10.1016/j.sxmr.2017.02.004. Epub 2017 Apr 8. PMID: 28400207; PMCID: PMC5632578.
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28 reviews for Ipamorelin (5mg)

  1. Isla Phillips

    All is very easy and fast, could not ask for better

  2. Ethan Cooper

    Excellent packaging

  3. Everly Ryan

    I accidentally ordeed the wrong item. Thanks for reshipping for free!

  4. Bailey Maguire

    So far so good. Never had any issues buying here. I really appreciate the ease of this website and the smooth transaction. Was not too hard to get around and had your standard check out method. Got to use a discount code they sent me not too long ago as well. It’s estimated i’ll get my peptide within 2 days of my order too.

  5. Tamara Qonita Mahadi

    Thanks for the fast service and great peptides!

  6. Shannon Porter

    This is a solid company. Honestly I didn’t expect it at first, but I got convinced me with every order

  7. Patrick Pan

    So far I am very impressed by the quality of these products

  8. Samantha Singh

    Wish I would see more lifestyle articles on your blog and how peptides can improve it

  9. Paul Allen

    Danny from CS is a gem. Give that one a raise

  10. Bruno Garcia

    Very knit-picky person here- Could not find a flaw, that is how good they are

  11. Mia Jakh

    Top tier peptides!

  12. Koleen Farrugia

    purest products i’ve found

  13. Jacob Reily

    Other than the A+ quality products and service, I come back becasue of their constant promos or sales to be honest.

  14. Andy Khalaf

    Excellent peptides, One of the best I have used in the last few years. Did not effect the outcome of my research too much but that typically would take a while to show.

  15. Karmen Wheeler

    Everything came packaged safley. I only wish the box was different as I had a hard time figuring out what it was I had just received. Side note, everything came faster than expected.

  16. jose lopez

    Articles are informative and are a pretty reliable source.

  17. J. Begg JR.

    Great site with excellent customer service and open lines of contact. Definitely worth the money!!. My search for certain items was aided by an employee who patiently explained the differences between each item I came across.

  18. Anni Summers

    A joy to work with, Danny is always there for me when I need a little assistance tweaking anything.

  19. Maggie cortez

    Estoy muy impresionada. Compraré de nuevo y lo recomendaré a mis amigos.

  20. Andy Laffon

    For the last year, I’ve been purchasing from them and have been very satisfied. Danni is the person I call when I need help with an order or if I need to make any changes.

  21. Chirag Patel

    Hands down the best company I have ever bought from

  22. Mason Hosek

    Very quick and controlled results from this product. Its quality is very clear in how it manifests itself in research and long-term storage.

  23. Greg Davis

    Will surely buy again

  24. Amir Cibik


  25. Andy Nakajima

    I turned into a repeat customer for sure

  26. Vincient Thomas

    Taylor is extremely helpful and goes above and beyond to help you out and solve any issue you’re having. Very happy to have worked with them. My peptides had issues with customs and thus I was not going to get them on time. I was on a tight schedule and dealing with companies like this can be a headache. It was nice to deal with Taylor who actually helped and did whatever they could to help me out as well and not leave me hanging dry. We ended up canceling and replacing the order but up until then they did everything they could to help get ahold of the shipping company and get this sorted.

  27. Lee Wong

    Happy with the service and Peptides. Been looking for a good peptide supplier for a while now and I feel like I found the place for me. Nicely priced as well!

  28. Tom King

    Ipamorelin is one of the most underrated peptides and I am glad I gave it a chance for my research.

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