ARA-290 (16mg)

(21 customer reviews)

$85.00

Discount per Quantity

QuantityDiscountPrice
5 - 95%$80.75
10 +10%$76.50
Orders over $200 receive:
FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
FREE - USPS priority shipping
SKU: ARA-290-16mg Category:

Description

What is the ARA-290 peptide?

Erythropoietin (EPO) is a kidney-derived glycoprotein that promotes blood vessel growth, tissue repair, cell survival, neuroprotection in diabetic neuropathy, and alters blood pressure. ARA-290 is a peptide derived from the beta-helix domain of EPO. ARA-290 simulates the pain relief and neuroprotective effects of EPO without promoting blood vessel formation. The peptide has completed phase II trials, and phase III trials will begin soon for diabetes and neuropathic sarcoidosis. It is being evaluated for its potential for neuropathic wound healing, immunomodulator, and treatment for Systemic Lupus Erythematosus (SLE).

SPECIFICATIONS

AKA: Cibinetide, PH-BSP

Sequence: ZEQLERALNSS

Molecular Formula: C51H84N16O21

Molecular Weight: 1257.3 g/mol

PubChem: 91810664

CAS Number: 1208243-50-8

Reconstitution: Required

ARA-290 Research

The health of blood vessels
Retinal ischemia can be caused due to various diseases and ultimately leads to damage to retinal epithelial cells. The peptide protects endothelial colony-forming cells to repair the blood vessels and rebuild the damaged tissue. Mice models have revealed the peptide to significantly enhance the proliferation, migration, and homing movement of blood cells as soon as the treatment begins. Hence, ARA-290 helps rebuild vasculature and speeds up the transplant’s success.

Reduction of inflammatory cytokines
ARA-290 inhibits macrophage activation. Thus it enhances the survival and proliferation of transplanted islet cells in diabetic patients. Islet cell transplant has been considered the holy grail of endocrinology for the treatment of chronic diabetes. Islet cell transplant allows for physiological control of blood sugar and helps to avoid the long-term adverse effects of insulin usage. However, the host immune response leads to the death of the transplanted islet cells. ARA-290 suppresses the pro-inflammatory cytokines such as IL-6, IL-2, and TNF-Alpha and allows for an acceptance of the graft.
ARA-290 has been observed to bind to the tissue-protective receptor (TPR) on the cell surface and mediate a protective response against inflammatory cytokines, thereby modulating the immune system response. EPO can also interact with TPR but is not a suitable drug candidate due to its cardiovascular and hematopoietic side effects. ARA-290 mediates the positive responses of EPO while avoiding the adverse effects. This results in reduced cellular apoptosis and lower levels of inflammatory cytokines. Thus the tissue survival and proliferation significantly improve. This function leads to faster wound healing, recovery, decreased mortality and morbidity, reduced scar formation, and rapid post-injury recovery of function.

Regulation of immune system
TPRs are prevalent on immune cell surfaces, such as T lymphocytes, mast cells, macrophages, and dendritic cells. Increasing scientific evidence proves that ARA-290 and similar groups of peptides bind to the receptor directly affect their function. TPR activation by ARA-290 leads to macrophage inactivation and lowering of inflammatory cytokines. This might decrease pathogen clearance in infection but overall lessen the disease build-up. With the macrophage chemokine pathway being restricted by TPR-ARA-290, resident macrophages get recruited to injury sites, leading to faster tissue healing and reduced side effects.
ARA-290 modifies antigen presentation by dendritic cells to T lymphocytes. Thereby it plays a pivotal role in modulating the adaptive immune response. Adaptive immunity is the key determinant of graft acceptance/rejection. Hence, peptides such as ARA-290 help to fine-tune the immune response to allow kidney, heart, and other experimental grafts.
One of the most promising applications of ARA-290 is immune modulation, especially in settings of autoimmune disorders like Colitis. Colitis can not only be caused by infection but also by autoimmune triggers. Immune modulators will help to significantly improve the treatment regimen  compared to injectable alternatives with diverse side effects.
Another significant application of ARA-290 is in the treatment of SLE-Systemic Lupus Erythematosus (SLE). Treatment with ARA-290 significantly reduces the level of autoantibodies like ANA and anti-ds DNA. The peptide thus helps to control the chances of kidney damage and renal failure from SLE.

Pain Perception
The immune system is known to regulate the sensation of pain, especially neuropathic pain. Neuropathic pain is very difficult to treat, like in diabetes. Targeting the innate repair receptor (IRR) helps to alleviate the pain. ARA-290 has been shown to bind to IRR and therefore proves to be of value. The peptide not only binds to IRR but also inhibits TRPV1 channel activity. TRPV1channel is also known as capsaicin receptor, which induces the perception of heat associated with neuropathic pain. Hence the peptide can control pain associated with amputation, chemotherapy, multiple sclerosis, and diabetes.
Small nerve fiber loss is prevalent in diseases like HIV, diabetes, celiac disease, thyroid dysfunction, etc. The small nerve fibers in the skin lead to pain and heat sensation. The onset of neuropathy leads to a burning sensation in the region affected. The peptide has proven fruitful in controlling neuropathy.

Summary
The peptide is a derivative of EPO. Interestingly it shows the positive effects of EPO and overcomes its side effects as well. ARA-290 is significant in controlling neuropathic pain, promotes wound healing, modulates immune response and pro-inflammatory cytokines, vascularization during ischemic insults. It has thus completed Phase II trials and moved to Phase III to treat diabetic and sarcoid neuropathy. It is being considered in multiple other diseases like HIV, multiple sclerosis, systemic lupus erythematosus, and likes. It can thus be considered as the wonder drug.

All orders ship same day if placed by 2pm PST.  Peptides synthesized and lyophilized in the USA.
This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law.  Only qualified and licensed professionals should handle these products.  Any information found on Biotech Peptides is strictly for educational purposes only.  Refer to our terms and conditions for more details.

Additional information

Brand

Biotech Peptides USA

21 reviews for ARA-290 (16mg)

  1. Griffith Turner

    the lineup here is legit. Such a good selection

  2. Brooke Tobin

    Always A1 quality. This product is pretty hard to find out there. There is not one peptide I’ve needed that I have not found on your website yet. I am very pleased and will be recommending you guys! Keep up the good job!

  3. Khaled Hadid

    The charge on my card kinda confused me. Watch out for the strange billing descriptor. Otherwise great.

  4. Shane Youn

    Great service all the way round from customer care to shipping

  5. Dashiell Eaves

    When looking for peptides on the internet, you may come across suspicious websites. This is the real deal. You even get a notice from a real person if there are any changes to your purchase. When you contact them via their website, you’ll get a response soon. This is the second time I’ve bought anything from this website. Typical delivery times will be extended by 7-10 business days due to customs delays. Obviously, the corporation has nothing to do with this. I’ll be making all of my future purchases here.

  6. Rick James

    I spoke with Danni and they were able to help me take my order. I was having a hard time completing the payment so figured I call and try to speak with a human being. So happy it wasn’t those automated help services.

  7. James Avenoso

    I have to admit I was unsure about them as they are a new company, but stuff checks out!

  8. Benjamin Tan

    Amazing products and Outstanding service

  9. John Rowekamp

    I had a bad start with them. They sent me the wrong package which was frustrating. I called right away and dealt with Danny. They apologized and owned up to the mistake and put my order out immediately and gave my money back for the order. That helped a bit. They also sent a discount code I can use for the next few orders. I’m going to give them a try again and hopefully, this won’t happen again. Shocked it happened but at; the east they owned up and made up for it.

  10. Patrick Pan

    Made a return cusomer out of me. Biotech has never given me a hard time with payments or shipping.

  11. Troi Jefferson

    Overall pleased with Biotech. Would recommend

  12. Chad Splindler

    They are a no BS business. Customer service is straight to the point, no extra chit chat. Fast and orderly.

  13. Damian Riley

    I ordered my peptides yesterday and they were at my lab waiting for me in the morning. Fantastic!

  14. Oscar Tremblay

    Found you off a google search! seem great, I do agree that you guys should have a waitlist of some sort to notify about restocks!

  15. Nelson Violet

    Constant discounts they send out are nice, saves me a bit of cash.

  16. Gaeury Reed

    Articles are educational and well written! I’ve fact checked it as well and they prove that they know their stuff and their products.

  17. Ian Barnette

    My research has been doing much better since I transfered my business over to Biotech Peptides. I also love how competent and quick their customer service representivies are!

  18. Gordan Watts

    I don’t go anywhere else to purchase peptides. Their products quality is astounding. If I do have an issue I recommend dealing with Taylor if you can as they truly know the company in and out and get the work done.

  19. Ariel Zvala

    My peptides came safe and sound. Packaging was great as well!

  20. Axel Rogers

    My lab has been using them for some time so Decided to place an order for my own private research and priceses are not too bad.

  21. Carl Kerten

    Anytime I shop here for my company we receive the best service possible. Taylor is amazing and really knows the company inside and out. It’s refreshing to encounter employees that know their job well and can do it well.

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