ARA-290 (16mg)

(23 customer reviews)


ARA-290 peptides are Synthesized and Lyophilized in the USA.

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What is the ARA-290 peptide?

Erythropoietin (EPO) is a kidney-derived glycoprotein that promotes blood vessel growth, tissue repair, cell survival, neuroprotection in diabetic neuropathy, and alters blood pressure. ARA-290 is a peptide derived from the beta-helix domain of EPO[1]. ARA-290 was developed to stimulate the pain relief and neuroprotective effects of EPO without promoting blood vessel formation. The peptide has completed phase II trials, and phase III trials will begin soon for diabetes and neuropathic sarcoidosis. It is being evaluated for its potential for neuropathic wound healing, immunomodulator, and treatment for Systemic Lupus Erythematosus (SLE).


AKA: Cibinetide, PH-BSP


Molecular Formula: C51H84N16O21

Molecular Weight: 1257.3 g/mol

PubChem: 91810664

CAS Number: 1208243-50-8

Reconstitution: Required


ARA-290 and Blood Vessel Health
Retinal ischemia can be caused due to various diseases and ultimately leads to damage to retinal epithelial cells. The peptide has been studied for its potential to protect endothelial colony-forming cells to repair the blood vessels and rebuild the damaged tissue. Mice models have suggested the peptide’s ability to significantly enhance the proliferation, migration, and homing movement of blood cells as soon as the treatment begins. Hence, ARA-290 may help rebuild vasculature and speeds up the transplant’s success[2].

ARA-290 and Inflammatory Cytokines Reduction
ARA-290 appears to inhibit macrophage activation. Thus it may enhance the survival and proliferation of transplanted islet cells in diabetic patients. Islet cell transplant has been considered the holy grail of endocrinology for the treatment of chronic diabetes. Islet cell transplant allows for physiological control of blood sugar and helps to avoid the long-term adverse effects of insulin usage. However, the host immune response leads to the death of the transplanted islet cells. Researchers suggest ARA-290 may suppress the pro-inflammatory cytokines such as IL-6, IL-2, and TNF-Alpha and allows for an acceptance of the graft[3]. ARA-290 has been observed to bind to the tissue-protective receptor (TPR) on the cell surface and mediate a protective response against inflammatory cytokines, thereby modulating the immune system response. EPO can also interact with TPR but is not a suitable medicine candidate due to its cardiovascular and hematopoietic side effects. Contrastingly, studies in ARA-290 suggest it may mediate the positive responses of EPO while avoiding the adverse effects. This results in reduced cellular apoptosis and lower levels of inflammatory cytokines. Thus the tissue survival and proliferation may significantly improve. This function would lead to faster wound healing, recovery, decreased mortality and morbidity, reduced scar formation, and rapid post-injury recovery of function.

ARA-290 and Immune System Regulation
TPRs are prevalent on immune cell surfaces, such as T lymphocytes, mast cells, macrophages, and dendritic cells. Increasing scientific studies suggest that ARA-290 and similar groups of peptides bind to the receptor directly affect their function. TPR activation by ARA-290 appears to lead to macrophage inactivation and lowering of inflammatory cytokines. This might decrease pathogen clearance in infection but overall lessen the disease build-up. With the macrophage chemokine pathway being restricted by TPR-ARA-290, resident macrophages get recruited to injury sites, leading to faster tissue healing and reduced side effects. ARA-290 appears to modify antigen presentation by dendritic cells to T lymphocytes. Through this action it may play a potential role in modulating the adaptive immune response. Adaptive immunity is the key determinant of graft acceptance/rejection. Hence, peptides such as ARA-290 may help to fine-tune the immune response to allow kidney, heart, and other experimental grafts. One of the most promising applications of ARA-290 is in immune modulation, especially in settings of autoimmune disorders like Colitis. Colitis can not only be caused by infection but also by autoimmune triggers. Immune modulators will help to significantly improve the treatment regimen  compared to injectable alternatives with diverse side effects. Another significant potential application of ARA-290 is in the treatment of SLE-Systemic Lupus Erythematosus (SLE)[4]. Experimental treatment with ARA-290 reports significantly reduced levels of autoantibodies like ANA and anti-ds DNA. The peptide thus may help to control the chances of kidney damage and renal failure from SLE.

ARA-290 and Pain Perception
The immune system is known to regulate the sensation of pain, especially neuropathic pain. Neuropathic pain is very difficult to treat, like in diabetes. Targeting the innate repair receptor (IRR) helps to alleviate the pain. ARA-290 has been suggested to bind to IRR and therefore may prove to be of value in pain treatment. The peptide appears to not only bind to IRR but also inhibit TRPV1 channel activity[5]. TRPV1 channel is also known as capsaicin receptor, which induces the perception of heat associated with neuropathic pain. Hence the peptide may control pain associated with amputation, chemotherapy, multiple sclerosis, and diabetes. Small nerve fiber loss is prevalent in diseases like HIV, diabetes, celiac disease, thyroid dysfunction, etc. The small nerve fibers in the skin lead to pain and heat sensation. The onset of neuropathy leads to a burning sensation in the region affected. ARA-290 peptide research has suggested that the peptide may be fruitful in controlling neuropathy.

The peptide is a derivative of EPO. Interestingly, researchers suggest it shows the positive effects of EPO and overcomes its side effects as well. ARA-290 is being studied for its potential ability to control neuropathic pain, promote wound healing, modulate immune response and pro-inflammatory cytokines, vascularize during ischemic insults. It has thus completed Phase II trials and moved to Phase III to treat diabetic and sarcoid neuropathy. It is being considered in multiple other diseases like HIV, multiple sclerosis, systemic lupus erythematosus, and like.


  1. Brines, M., Dunne, A. N., van Velzen, M., Proto, P. L., Ostenson, C. G., Kirk, R. I., Petropoulos, I. N., Javed, S., Malik, R. A., Cerami, A., & Dahan, A. (2015). ARA-290, a nonerythropoietic peptide engineered from erythropoietin, improves metabolic control and neuropathic symptoms in patients with type 2 diabetes. Molecular medicine (Cambridge, Mass.), 20(1), 658–666.
  2. Lois, N., Gardner, E., McFarland, M., Armstrong, D., McNally, C., Lavery, N. J., Campbell, C., Kirk, R. I., Bajorunas, D., Dunne, A., Cerami, A., & Brines, M. (2020). A Phase 2 Clinical Trial on the Use of Cibinetide for the Treatment of Diabetic Macular Edema. Journal of clinical medicine, 9(7), 2225.
  3. Watanabe, M., Lundgren, T., Saito, Y., Cerami, A., Brines, M., Östenson, C. G., & Kumagai-Braesch, M. (2016). A Nonhematopoietic Erythropoietin Analogue, ARA-290, Inhibits Macrophage Activation and Prevents Damage to Transplanted Islets. Transplantation, 100(3), 554–562.
  4. Huang, B., Jiang, J., Luo, B., Zhu, W., Liu, Y., Wang, Z., & Zhang, Z. (2018). Non-erythropoietic erythropoietin-derived peptide protects mice from systemic lupus erythematosus. Journal of cellular and molecular medicine, 22(7), 3330–3339.
  5. Zhang, W., Yu, G., & Zhang, M. (2016). ARA-290 relieves pathophysiological pain by targeting TRPV1 channel: Integration between immune system and nociception. Peptides, 76, 73–79.
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23 reviews for ARA-290 (16mg)

  1. Griffith Turner

    the lineup here is legit. Such a good selection

  2. Brooke Tobin

    Always A1 quality. This product is pretty hard to find out there. There is not one peptide I’ve needed that I have not found on your website yet. I am very pleased and will be recommending you guys! Keep up the good job!

  3. Khaled Hadid

    The charge on my card kinda confused me. Watch out for the strange billing descriptor. Otherwise great.

  4. Shane Youn

    Great service all the way round from customer care to shipping

  5. Dashiell Eaves

    When looking for peptides on the internet, you may come across suspicious websites. This is the real deal. You even get a notice from a real person if there are any changes to your purchase. When you contact them via their website, you’ll get a response soon. This is the second time I’ve bought anything from this website. Typical delivery times will be extended by 7-10 business days due to customs delays. Obviously, the corporation has nothing to do with this. I’ll be making all of my future purchases here.

  6. Rick James

    I spoke with Danni and they were able to help me take my order. I was having a hard time completing the payment so figured I call and try to speak with a human being. So happy it wasn’t those automated help services.

  7. James Avenoso

    I have to admit I was unsure about them as they are a new company, but stuff checks out!

  8. Benjamin Tan

    Amazing products and Outstanding service

  9. John Rowekamp

    I had a bad start with them. They sent me the wrong package which was frustrating. I called right away and dealt with Danny. They apologized and owned up to the mistake and put my order out immediately and gave my money back for the order. That helped a bit. They also sent a discount code I can use for the next few orders. I’m going to give them a try again and hopefully, this won’t happen again. Shocked it happened but at; the east they owned up and made up for it.

  10. Patrick Pan

    Made a return cusomer out of me. Biotech has never given me a hard time with payments or shipping.

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    Overall pleased with Biotech. Would recommend to others.

  12. Chad Splindler

    They are a no BS business. Customer service is straight to the point, no extra chit chat. Fast and orderly.

  13. Damian Riley

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  14. Oscar Tremblay

    Found you off a google search! seem great, I do agree that you guys should have a waitlist of some sort to notify about restocks!

  15. Nelson Violet

    Constant discounts they send out are nice, saves me a bit of cash.

  16. Gaeury Reed

    Articles are educational and well written! I’ve fact checked it as well and they prove that they know their stuff and their products.

  17. Ian Barnette

    My research has been doing much better since I transfered my business over to Biotech Peptides. I also love how competent and quick their customer service representivies are!

  18. Gordan Watts

    I don’t go anywhere else to purchase peptides. Their products quality is astounding. If I do have an issue I recommend dealing with Taylor if you can as they truly know the company in and out and get the work done.

  19. Ariel Zvala

    My peptides came safe and sound. Packaging was great as well!

  20. Axel Rogers

    My lab has been using them for some time so Decided to place an order for my own private research and priceses are not too bad.

  21. Carl Kerten

    Anytime I shop here for my company we receive the best service possible. Taylor is amazing and really knows the company inside and out. It’s refreshing to encounter employees that know their job well and can do it well.

  22. Pete Andrews

    Their blog page is nice and I like that theres articles explaining how to store them!

  23. Kelly Collins

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