Decapeptide-12 (Topical) (200mg)

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Decapeptide-12 peptides are Synthesized and Lyophilized in the USA.

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Decapeptide-12 (Topical) Peptide

Decapeptide-12 is an oligopeptide with proposed anti-tyrosinase activity, composed of twelve amino acids and exhibiting the sequence Try-Arg-Ser-Aar-Lysd-Tyr-Ser-Ser-Trp-Tyr. It appears to function primarily to restrain Tyrosinase—the enzyme responsible for the excessive production of melanin, which may result in patchy pigmentation upon the skin’s surface.[1]


Sequence: Tyr-Arg-Ser-Aar-Lysd-Tyr-Ser-Ser-Trp-Tyr

Molecular Formula: C65H90N18O17

Molecular Weight: 1311.45g/mol

Synonyms: 137665-91-9


Decapeptide-12 Research

Decapeptide-12 and Tyrosinase
Tyrosinase is an enzyme with a copper molecule attached to it. It is present in animal and plant tissues, where it appears to catalyze the production of melanin and other pigments from the oxidation of tyrosine, and dihydroxyphenylalanine (DOPA). It is considered to catalyze the first two steps involved in the biochemical synthesis of melanin, and is expressed by cells of melanocyte antecedents, and may be contained in the melanosomes and is synthesized in the melanocytes. Tyrosinase deficiency is considered to result in Oculocutaneous albinism type I. While hyperpigmentation may occur as a result of melanin synthesis, it may also be caused by a mutation that causes tyrosinase to become overactive.

Decapeptide-12, an apparent Tyrosinase inhibitor, is of interest to researchers through its potential to improve how the enzyme cascade of pigment production functions.[2] In the food industry, Tyrosinase appears to catalyze the oxidation of phenolic compounds in fruits and vegetables to quinones (the phenolic compound is what turns potato to black after it is sliced). This conversion gives food a sour taste and makes it difficult for some proteins to be broken down and digested, and therefore may reduce nutritional value. In contrast, Decapeptide-12 appears to function as a possible food preservative. Decapeptide-12 may potentially help regulate the production of melanin when in symbiont with other peptides, and researchers are actively exploring this possibility.  Tyrosinase is an enzyme that exists in several cells that produce pigments. Decapeptide-12 appears to bind irrevocably to Tyrosinase, preventing the catalyzation of phenol oxidation. In mammals, Tyrosinase appears to exist only in melanosomes, special compartments confined within the pigment-producing cells. The structure of Tyrosine may be dissimilar even in species that are closely related. As a result, the impact of Tyrosine may influence skin tone and slight modifications in the gene of Tyrosine found on chromosomes. In insects, Tyrosinase appears to play several roles. Its functions may likely be evident in parasite encapsulation, wound healing, and the formation of a hard exoskeleton of insects. In this context, Decapeptide-12 may also function as an insecticide.[3]

Decapeptide-12 and Skin Cells
Research in animal models targeted at determining the action of Decapeptide-12 in melasma (photodamage) suggests that Decapeptide-12 may potentially reduce pigmentation.[4] Studies reported that roughly 40% of research models in the experiment acquired “standard” tone across the skin surface (a 100% decrement of pigmentation-hyperpigmentation). Roughly 15% of the models with grade 3 photodamage reportedly acquired a turnaround and moved into grade 1 of photodamage. Models of extreme photodamage (photodamage grade 4) exhibited a reported modest repair, reducing their classification to photodamage grade 3. These results were exhibited after laboratory introduction of Decapeptide-12 for a minimum of 12 weeks. The exposure of Decapeptide-12 in research models of melasma (photodamage) without exception appeared to have exhibited changes in skin tone.

Research studies in cultured melanocytes for over seven days reported an apparent 27% – 43% decrease in melanin content. According to research, exposure to Decapeptide-12 beneath the eye may have alleviated discoloration, structural lapse, and inflammation.[5] Decapeptide-12 may potentially act as a sunscreen, possibly mitigating hyperpigmentation by preventing UV rays from reaching the sensitive layers of the skin and shielding the skin from the harmful interaction of the UV rays with the melanocytes, so avoiding the spread of new damage. Decapeptide-12 appears to be symbiont with glycolic acid, and studies reported the introduction of the combination manifested the removal of dead layers of the stratum corneum concentrated with hyperpigmented cells, consequently stimulating the natural turnover process of the skin. Decapeptide-12 has undergone several types of research in animal models. Dermalinfusion of Decapeptide in symbiont with the exposure to Decapeptide-12 cream may help to accelerate the clearance of post-inflammatory hyperpigmentation in the color of the skin.

Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.



  1. Kassim AT, Hussain M, Goldberg DJ. Open-label evaluation of the skin-brightening efficacy of a skin-brightening system using decapeptide-12. J Cosmet Laser Ther. 2012 Apr;14(2):117-21. doi: 10.3109/14764172.2012.672745. PMID: 22401652.
  2. Jiang L, Hino PD, Bhatia A, Stephens TJ, Jimenez F. Efficacy of Trifecting® Night Cream, a Novel Triple acting Skin Brightening Product: A Double-blind, Placebo-controlled Clinical Study. J Clin Aesthet Dermatol. 2018 Dec;11(12):21-25. Epub 2018 Dec 1. PMID: 30666274; PMCID: PMC6334832.
  3. Heep J, Skaljac M, Grotmann J, Kessel T, Seip M, Schmidtberg H, Vilcinskas A. Identification and Functional Characterization of a Novel Insecticidal Decapeptide from the Myrmicine Ant Manica rubida. Toxins (Basel). 2019 Sep 25;11(10):562. doi: 10.3390/toxins11100562. PMID: 31557881; PMCID: PMC6832575.
  4. Ramírez SP, Carvajal AC, Salazar JC, Arroyave G, Flórez AM, Echeverry HF. Open-label evaluation of a novel skin brightening system containing 0.01% decapeptide-12 in combination with 20% buffered glycolic acid for the treatment of mild to moderate facial melasma. J Drugs Dermatol. 2013 Jun 1;12(6):e106-10. PMID: 23839199.
  5. Chen J, Bian J, Hantash BM, Albakr L, Hibbs DE, Xiang X, Xie P, Wu C, Kang L. Enhanced skin retention and permeation of a novel peptide via structural modification, chemical enhancement, and microneedles. Int J Pharm. 2021 Sep 5;606:120868. doi: 10.1016/j.ijpharm.2021.120868. Epub 2021 Jul 6. PMID: 34242628.
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