Decapeptide-12 (Topical) (200mg)



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What Is Decapeptide-12 (Topical)?

Decapeptide-12 is an oligopeptide with an anti-tyrosinase activity, composed of twelve amino acids – Try-Arg-Ser-Aar-Lysd-Tyr-Ser-Ser-Trp-Tyr. It functions primarily in aiding the skin to restrain Tyrosinase—the enzyme responsible for the excessive production of melanin, which can result in patchy pigmentation, age spots, sun spots, undesirable discoloration, and uneven skin tone.


Sequence: Tyr-Arg-Ser-Aar-Lysd-Tyr-Ser-Ser-Trp-Tyr

Molecular Formula: C65H90N18O17

Molecular Weight: 1311.45g/mol

PubChem: CID 25087629

Synonyms: 137665-91-9

Reconstitution: Required

Decapeptide-12 Research

The effects of Decapeptide-12 on Tyrosinase
Tyrosinase is an enzyme with a copper molecule attached to it. It is present in animal and plant tissues, where it catalyzes the production of melanin and other pigments from the oxidation of tyrosine. It catalyzes dihydroxyphenylalanine (DOPA). It catalyzes the first two steps involved in the biochemical synthesis of melanin and is expressed by cells of melanocyte antecedents. It is contained in the melanosomes – synthesized in the melanocytes.
Tyrosinase deficiency results in Oculocutaneous albinism type I. While hyperpigmentation of the skin occurs as a result of melanin synthesis, it is caused by a mutation that causes tyrosinase to become overactive. Decapeptide-12, a Tyrosinase inhibitor, is of interest to the medical and cosmetic sectors because it is both therapeutic and can help improve how the enzyme cascade of pigment production functions.
In the food industry, Tyrosinase catalyzes the oxidation of phenolic compounds in fruits and vegetables to quinones (the phenolic compound is what turns potato to black after it is sliced). This conversion gives food that sour taste and makes it difficult for some proteins to be broken down and digested. Hence, reducing the nutritional value of food. Meanwhile, Decapeptide-12 functions as a potent food preservative and flavor enhancer.
Decapeptide-12 can help regulate the production of melanin without risk when in symbiont with other peptides.
Tyrosinase is an enzyme that exists in several cells that produce pigments. Decapeptide-12 binds irrevocably to Tyrosinase, hence preventing the catalyzation of phenol oxidation. In mammals, Tyrosinase exists only in the melanosomes, special compartments confined within the pigment-producing cells. The structure of Tyrosine can be dissimilar even in species that are closely related, without exceptions. As a result, the effectiveness of Tyrosine influences skin color and slight modifications in the gene of Tyrosine found on chromosomes.
In insects, Tyrosinase plays several unparallel roles. Its functions can be evident in parasite encapsulation, wound healing, and the formation of a hard exoskeleton of insects. In this context, Decapeptide-12 may function as a potent insecticide.

Decapeptide-12 and its Roles in the Skin
Research in animal models targeted at determining the safety and effectiveness of Decapeptide-12 in melasma (Photodamage) shows that Decapeptide-12 reduces the pigmentation of the skin efficiently. Studies show that about 40% of the subjects in the experiment acquired standard skin tone (a 100% decrement of pigmentation-hyperpigmentation). About 15% of the subjects with grade 3 of photodamage acquired a turnaround and moved into grade 1 of photodamage. Individuals with extreme photodamage (subjects in photodamage grade 4) only received modest repair, lowering them to photodamage grade 3. This was evident after using Decapeptide-12 for a minimum of twelve weeks.
The administration of Decapeptide-12 in about 100% of patients with Melasma (photodamage) shows remarkable changes in skin tone.
Decapeptide-12 is 17 times more powerful than previous hyperpigmentation therapies, including hydroquinone, according to research, with no evidence of melanocyte damage. Clinical studies in cultured melanocytes for over seven days established a 27% – 43% decrease in melanin content.
According to research, administration of Decapeptide-12 to the skin beneath the eye would help alleviate dark circles, eye-area fine lines, wrinkles, dryness, and inflammation. Hence, this results in brighter, finer, and smoother skin under the eye, allowing for a more youthful outlook.
Decapeptide -12 may be an efficient sunscreen because it protects the skin from hyperpigmentation by preventing UV rays from reaching the sensitive layers of the skin and shielding the skin from the harmful interaction of the UV rays with the melanocytes, so avoiding the spread of new damage.
Decapeptide-12 in symbiont with Glycolic acid amounted to the removal of dead layers of the stratum corneum concentrated with hyperpigmented cells – consequently stimulating the natural turnover process of the skin.
Decapeptide-12 has undergone several types of research in animal models and may ultimately be considered a vital ancillary in commercial products for the treatment of post-inflammatory hyperpigmentation.
Dermalinfusion of Decapeptide in symbiont with the application of the Decapeptide-12 cream (Lumixyl) can safely and efficaciously help to accelerate the clearance of post-inflammatory hyperpigmentation in the color of the skin.


Decapeptide-12 has proven to clinically accelerate the clearance of pigmentation in varieties of skin without irritation. It can be used as an ancillary to treat mild to moderate hyperpigmentation, along with sun spots, age spots, post-inflammatory hyperpigmentation, and melasma.
However, Decapeptide-12 is limited to educational and scientific studies, not for human use.

All orders ship same day if placed by 2pm PST. Peptides synthesized and lyophilized in the USA.
This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law. Only qualified and licensed professionals should handle these products. Any information found on Biotech Peptides is strictly for educational purposes only. Refer to our terms and conditions for more details.

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