Follistatin-344 (1mg)

(16 customer reviews)

$162.00

Follistatin-344 peptides are Synthesized and Lyophilized in the USA.

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Description

Follistatin-344 Peptide

Follistatin-344 is a synthetic, full-sized version, of a naturally-occurring protein. Follistatin-344 occurs in two isomers, varying based on their gene splicing. Researchers suggest that its primary role may be to counteract the action of the Tumor Growth Factor-beta (TGF-beta) family. The TGF-beta family comprises of Myostatin, Activin, and Follicle Stimulating Growth Hormone (FSH). Follistatin-344 appears to stimulate the Insulin/IGF-1 pathway, and the reported immense potential of the peptide has been published in Follistatin-344 research.

Specifications

SYNONYMS: Activin-binding protein, FST, FSH- Suppressing protein

MOLECULAR WEIGHT: 3780 g/mol

SEQUENCE: MVRARHQPGG LCLLLLLLCQ FMEDRSAQAG NCWLRQAKNG RCQVLYKTEL SKEECCSTGR LSTSWTEEDV NDNTLFKWMI FNGGAPNCIP CKETCENVDC GPGKKCRMNK KNKPRCVCAP DCSNITWKGP VCGLDGKTYR NECALLKARC KEQPELEVQY QGRCKKTCRD VFCPGSSTCV VDQTNNAYCV TCNRICPEPA SSEQYLCGND GVTYSSACHL RKATCLLGRS IGLAYEGKCI KAKSCEDIQC TGGKKCLWDF KVGRGRCSLC DELCPDSKSD EPVCASDNAT YASECAMKEA ACSSGVLLEV KHSGSCNSIS EDTEEEEEDE DQDYSFPISS ILEW

Follistatin-344 Research

Follistatin-344 and Muscle Cell Proliferation
Myostatin is a naturally occurring protein that belongs to the TGF-1 family. It is considered to inhibit muscle cell proliferation. Studies have extended the hypothesis that Follistatin-344 may inhibit the action and impacts of Myostatin. A comparative study indicated that animals with this protein typically trend towards greater muscle mass, creating a possible correlation between the protein and muscle cell proliferation and function. Follistatin-344 appears to increase muscle mass by hyperplasia (increase in the number of muscle fibers) and hypertrophy (increase in muscle fiber). Interestingly, in this study, the exposure to Follistatin-344 appeared to have increased the muscle mass in mice in the absence of other muscle-building factors.[1] The results implied that Follistatin-344 may promote muscle cell development and enhance contractile force, and has therefore been an object of significance in research studies focused on muscular diseases like muscular dystrophy. Studies have suggests the potential of Follistatin-344 to reduce inflammation and fibrosis. Its primary hypothesized characteristic appears to be enhancing muscle cell development, which may mitigate the severity or impact of muscular dystrophies such as Duchene Muscular Dystrophy[2].

Follistatin-344 and Breast Cancer
A clinical study in research models of breast cancer used immune-histochemistry and Reverse Transcription Polymerase Chain Reaction (RT-PCR). The study reported under-expression of Follistatin-344 in the majority of subjects, while over-expression was only identified in a small number.[3] The over-expression of Follistatin was associated with a better prognosis, as per the studies for ABC monomer. It appeared to prevent metastasis of the tumor, but the study reports that it did appear to increase its growth. Contrastingly, under-expression of Follistatin-344 appeared to lead to higher incidences of metastasis. A study done on a mouse model of HER-2 positive breast cancer suggested that Follistatin-344 may prevent activin-induced migration of epithelial cells in breast tissue. This potential of Follistatin may possibly prevent metastasis without increasing the growth of the tumor mass. A study done on cases involving benign proliferative diseases of the breast indicated over-expression of Follistatin. This result supports the anti-metastatic potential of Follistatin.

Follistatin-344 and Esophageal Carcinoma
Barret’s esophagus is a pre-malignant condition of Esophageal Carcinoma. It involves the conversion of Squamous epithelium into columnar with goblet cells. Bone Morphogenic Protein (BMP) is responsible for this metaplasia. Frequent acid reflux in the esophagus may lead to over-activation of BMP and ultimately may lead to cancer onset. Study findings have posited the potential for Follistatin-344 in countering the action of BMP.[4] There appears to be varying responses towards Follistatin-344 expression in different types of tumors. In Esophageal tumors, it appears to improve survival, whereas it may shorten survival in lung and ovarian tumors. Research involving rats indicated the possibility of Follistatin-344 to reduce the extent of fibrosis in the liver up to 32%. This potential capability may improve the lifespan of hepatocytes and prevent the progression of fibrosis into liver cancer.

Follistatin-344 and Diabetes Mellitus
An experiment on mice indicated that the over-expression of Follistatin-344 appeared to increase the mass of beta-cells in the pancreas.[5] It also appeared to lead to enhanced production of insulin and increased control of blood sugar. Exposure to Follistatin-344 was suggested to have doubled the lifespan of the research mice, and appeared to have virtually eliminated the complications of diabetes as compared to controls. Researchers have proposed that Follistatin-344 may potentially provide a physiological control of blood sugar and may exhibit an effect similar to insulin.

Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.

 

References

  1. Haidet AM, Rizo L, Handy C, Umapathi P, Eagle A, Shilling C, Boue D, Martin PT, Sahenk Z, Mendell JR, Kaspar BK. Long-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitors. Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4318-22. doi: 10.1073/pnas.0709144105. Epub 2008 Mar 11. PMID: 18334646; PMCID: PMC2393740.
  2. Chang F, Fang R, Wang M, Zhao X, Chang W, Zhang Z, Li N, Meng Q. The transgenic expression of human follistatin-344 increases skeletal muscle mass in pigs. Transgenic Res. 2017 Feb;26(1):25-36. doi: 10.1007/s11248-016-9985-x. Epub 2016 Oct 27. PMID: 27787698.
  3. Zabkiewicz C, Resaul J, Hargest R, Jiang WG, Ye L. Increased Expression of Follistatin in Breast Cancer Reduces Invasiveness and Clinically Correlates with Better Survival. Cancer Genomics Proteomics. 2017 Jul-Aug;14(4):241-251. doi: 10.21873/cgp.20035. PMID: 28647698; PMCID: PMC5572302.
  4. Shi L, Resaul J, Owen S, Ye L, Jiang WG. Clinical and Therapeutic Implications of Follistatin in Solid Tumours. Cancer Genomics Proteomics. 2016 11-12;13(6):425-435. doi: 10.21873/cgp.20005. PMID: 27807065; PMCID: PMC5219916.
  5. Ozawa T, Morikawa M, Morishita Y, Ogikubo K, Itoh F, Koinuma D, Nygren PÅ, Miyazono K. Systemic administration of monovalent follistatin-like 3-Fc-fusion protein increases muscle mass in mice. iScience. 2021 May 14;24(5):102488. doi: 10.1016/j.isci.2021.102488. PMID: 34113826; PMCID: PMC8170004.
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This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law.  Only qualified and licensed professionals should handle these products.  Any information found on Biotech Peptides is strictly for educational purposes only.  Refer to our terms and conditions for more details.

Additional information

Brand

Biotech Peptides

16 reviews for Follistatin-344 (1mg)

  1. Ina Cox

    Ty for the top notch service. Taylor was very helpful with my specific needs.

  2. Geraldine Cisneros

    One of the newest leading brands that manufacture high-quality peptides right now. Glad I tried them out

  3. Ibrahim Alatas

    My company recently had me search up new peptide suppliers as we were tired of our old one. Long story short supplies never came on time, broken vials, you name it. They’re really happy with what I found. Have had two orders put in the last month. Everything was always delivered on time and so far nothing broke!

  4. Loren Bass

    Love the company, the customer service, and the quality of the products. Has not let me down yet. My only suggestion is better packaging!! Feel Like that may need an update

  5. Tim Ritts

    Keep up the good work!

  6. Ivy Nguyen

    It has been about just shy of a year we’ve been doing business with them now. Everything is great, have had small problems here and there that were fixed in no time. They are efficient and the peptides are always handled with the greatest care. Here and there we’ve had a vial break but understandable with the carriers. As were in New York, with the storm and such we’ve had some delays with products but they were able to send us new ones due to the originals basically being of no use.

  7. Alex Henderson

    Good company, great matto, feel like theyre always for the customer! love the frequent promo codes they send out! helps me save some cash as well! Noticed they send a free Bac water here and there even when my order wasnt too high in price!

  8. Craig Leyton

    They have some issues just like every other peptide supplier but they beat the others out souly due to their customer service and low price. Getting pureproducts for a cheaper price in my opinion.

  9. Ethan Carpio

    This was recommended to me by a person I work with and since I started purchasing from you guys I haven’t bought from another supplier since.

  10. Derek Young

    Impressed by their swift service. Any orders or emails are responded to with such high speed.

  11. Kevin Woods

    Their team is awesome and knows in detail what they are selling.

  12. teddy wilson

    I can say with great assurance their peptides come second to none. Purity is out of this world. Even the bac water they send out is of top quality as well. This peptide really did help with my research on muscle growth.

  13. Frank Druthers

    Jamie was a saint and was able to set up a special code for me as I would be buying in bulk for my lab site. Best deal I have found!

  14. Ross Thompson

    I got all my peptides and nothing was broken or shattered. They all seemed to be in perfect condition as well.

  15. Chris DeGidio

    First time trying them out, did not expect such fast delivery.

  16. Allen Echevarria

    Nice selection of peptides!

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