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What is the GHRP-2 peptide?
GHRP-2 (also known as pralmorelin) is a synthetic growth hormone secretagogue which interacts with the ghrelin/growth hormone secretagogue receptor. It is a test peptide used to evaluate growth hormone deficiency as well as secondary adrenal failure. GHRP-2 has also been evaluated in stage II clinical trials for the assessment of short stature. Extensive research has also been performed to evaluate its role in the regulation of muscle development, appetite, the immune system, and sleep cycles. GHRP-2 remains orally and sublingually active and hence does not require an intravenous introduction for its physiological efficacy.
AKA: Thymosin Beta 4
Molecular Formula: C45H55N9O6
Molecular Weight: 817.9 g/mol
PubChem: CID 6918245
CAS Number: 158861-67-7
GHRP-2 and Appetite
GHRP-2 has been studied in relation to appetite stimulation and food intake. This holds relevance in the backdrop of chronic diseases where appetite stimulation is an important part of overall health care. The potential of the peptide to easily and reliably stimulate the appetite could be beneficial for chronically ill patients and help to improve long-term outcomes.
GHRP-2 and Muscle Structure
Research in yaks noted that GHRP-2 peptide appeared to stimulate the growth of muscles in two ways: enhanced protein synthesis and accumulation, and reduced protein degradation. The study suggested that GHRP-2 may help to overcome natural growth limitation that occurs in yaks because of food deprivation, adverse environmental conditions (such as cold), and disease. The most significant observation has been the potential benefits of GHRP-2 in reducing muscle atrophy through repression of atrogin-1 and MuRF1- proteins, which regulate muscle degradation pathways. GHRP-2 may one day be employed for conditions associated with decreased catabolism, commonly observed in chronic illnesses such as autoimmune diseases and cancer.
GHRP-2 and the Heart
Studies in fetal heart cell culture lines have theorized that GHRP-2 and its analogs (GHRP-1 and GHRP-6) may help to protect cardiac cells by minimizing apoptosis or programmed cell death. The peptides thus appear to help to protect cardiac muscles from reduced supply of blood and nutrients, which ensues a cardiac arrest. Studies on Hexarelin, a GHRP-2 analog, have posited that these peptides associate with a specific receptor. Identification of new tissue-specific receptors may lead to the discovery of novel pathways for newer medicines, as well as improve our knowledge of the human physiology and mechanisms to avoid dysfunction.
GHRP-2 and the Immune System
GHRP-2 peptide researchers suggest the peptide may enhance the functions of the thymus, an organ that helps protect and mature certain cells of the immune system, especially the T lymphocytes. T lymphocytes are crucial for adaptive immunity and our physiological capacity to combat complex infections. However, the efficacy of the thymus diminishes with age, which causes many age-related problems ranging from insufficient tissue repair to poor immunity. This often leads to an inability to ward off infections, guard against cancer, and perform normal tissue functions. In such cases, GHRP-2 appears to have the capacity to rejuvenate the thymus, possibly promoting the number and diversity of T-cells, thus boosting the body’s general immunity.
GHRP-2 and Pain Perception
Researchers initially thought that GHRP-2 decreases pain associated with osteoarthritis in animal models through the stimulation of growth hormone production and the repair of damaged tissues. However, it has been observed that GHRP-2 may cause pain relief before tissue repair, which happens due to its action on opioid receptors. There are four known opioid receptors. Most opioid pain medications mediate a universal action on all four receptors. The medicines’ generic mode of action can create challenges as the receptors have differential and diverse functions. Some of the receptors influence pain; some affect sensations such as wakefulness and breathing, while still others impact addiction. GHRP-2, on the other hand, appears to be a selective opioid receptor agonist, binding uniquely to the receptors responsible for pain relief, addiction and, sedation. This observation suggests that selective opioid agonists may help avoid unwanted effects like respiratory distress and addiction.
GHRP-2 and Sleep Quality
GHRP-2 has been observed to influence sleep cycle. The peptide may increase the duration of stages 3 and 4 of the sleep cycles by about 50% as well as potentially improve the duration of REM sleep by approximately 20%. It may further diminish deviation in sleeping patterns from “normal sleep”. Overall, improvement in sleep leads to betterment in cognitive function, blood pressure, healing, and energy levels. These findings are relevant for adults but specifically for the elderly population where sleep quality gets affected due to age. GHRP-2 may be useful in the advancement of research in sleep quality and may help subjects attain all the benefits of a complete night’s sleep in a shorter duration. Studies reported the peptide to have minimal to moderate side effects, low oral bioavailability, and excellent subcutaneous bioavailability in murine models. Per kg dosage in mice does not scale up to the requirement for human use.
Dr. Usman (BSc, MBBS, MaRCP) completed his studies in medicine at the Royal College of Physicians, London. He is an avid researcher with more than 30 publications in internationally recognized peer-reviewed journals. Dr. Usman has worked as a researcher and a medical consultant for reputable pharmaceutical companies such as Johnson & Johnson and Sanofi.
Reece Lam –
Very good communication
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Rita Still –
Loved working with them! Customs confiscated my order. Immediately after I contacted them, they sent out a new box in the hopes that it would arrive on time. And it did, supper happy with they were able to do that for me. Thanks again for the help!!!
Ronald Coley –
Excellent customer service and fast product delivery. I’ll certainly be shopping from them again.
Nathan Emond –
My order came this morning after I placed it yesterday. The turnaround time was excellent, and the personnel was helpful and courteous.
Charolette Parmer –
Happy with the purchase I made! The whole purchasing procedure was a breeze. Finally a peptide supplier that accepts credit cards
Jennifer Smith –
LOVE any company that makes my job at buying products easy.
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Grace Orteza –
I had a problem with the address, I had to change the one I had on my account and could not for the life of me figure it out. Taylor was an angel and helped me fix that up right away. The wait for help wasn’t long either, took like 5 minutes at most till someone picked up!
Trey Wilkov –
I love the fact that you can find the same exact product for different quantities. I think that helps a lot
Yingfei Feng –
All lab animals I’ve administered Biotech peptides to showed amazing results. Not even one experiment ended badly or with affected subjects
Erick Sheafer –
Not a problem in sight. I am very pleased
Ketan Datta –
I don’t usually write reviews however this company deserves credit for providing peptides in a timely manner always. Enjoy doing business here.
Cassandra Buitron –
I had a pretty hard time comprehending the difference between GHRP-2 and GHRP-6, but I read some of the articles on their blogs and figured it out
Adrian Junus –
I have been ordering peptides from them for about a month now. Can say with confidence that the product is legit and as pure as can be. My research is flourising and the results are outstanding thus far.
Danny W –
First time buyer here. I like the fact I could pay in different ways. Options were decent when it came to the peptides. I’d say for them to try offer more if they can. just got my package this morning as well and nothing looks broken or damaged.
Damian Ayyote –
Products were great! no breaks at all!
Alice Jenkins –
Found you off a google search. My lab uses a company that honestly has the worst peptides and service so went a little rogue and bought my own to bring in. The peptides are emaculate and have aided my research so much that i’m pushing for my site to switch suppliers.
Evan Bell –
I had a small issue where my payment was not going through. Was surpised to get a phone call from Danny letting my know the situation. Handled it within minutes instead of having to go through email and back and forth for hours. Loved the efficiency.
Rafael Vega –
Had a few missing peptides. I emailed them and heard back within the hour. Seems like there was a mistake in the system and they offered to send me the peptides and offer a discount or give me my money back for that peptide. I chose the money back as I decided I didn’t need them anymore.
Alberto Godoy –
Offered shipment to all the way here in the UK, cost was not too bad for international shipping.
Davite Gabino –
Prices are great!