Fragment 176-191 SPECIFICATIONS
AKA: Frag 176-191
Molecular Formula: C78H125N23O23S2
Molecular Weight: 1817.1 g/mol
CAS Number: 66004-57-7
Mod GRF 1-29 SPECIFICATIONS
AKA: Modified GRF (1-29)
Molecular Formula: C152H252N44O42
Molecular Weight: 3367.95 g/mol
PubChem: CID 56841945
CAS Number: 863288-34-0
Molecular Formula: C38H49N9O5
Molecular Weight: 711.85 g/mol
PubChem: CID 9831659
CAS Number: 170851-70-4
Potential of Fragment 176-191 & Mod GRF 1-29 & Ipamorelin Blend
Studies have proven that the highest output of growth hormone (GH) from the anterior pituitary gland can be attained through a combination of growth hormone-releasing hormone (GHRH) analog and agonist of growth hormone secretagogue receptor (GHSR). The combination of ipamorelin with modified GRF is one of the various combinations which help to achieve the above objective. Interestingly, more specific results can be achieved beyond the increase in GH synthesis through the refinement of the choice of GHRH analog, and GHSR agonist used.
Modified GRF, also an effective GHRH analog has effects beyond the improvement of GH release. It has benefited intestinal inflammation, wound healing, and cardiac function in animal models. The introduction of ipamorelin along with modified GRF triggers the highest expression of GH. Ipamorelin further improves bone growth and the stabilization of the cellular matrix. The above physiological outcomes are in addition to the improvement of bone development caused directly through increased GH release.
Research on Fragment 176-191 & Mod GRF 1-29 & Ipamorelin
The idea behind using a combination of these peptides is to have a potent HGH response minus all the side effects. Below is what research suggests about this peptide combination.
Improved Body Composition
The main benefit of this peptide blend is its ability to promote fat loss and increase muscle mass. The critical component among this peptide blend capable of achieving weight loss is the fragment 176-191. HGH fragment 176-191 is the main ‘lipolytic fragment.’ It acts on the beta-3 adrenergic receptors (ADRB3). This peptide leads to increased fat burning in fatty tissues and increases fat breakdown by triggering ‘thermogenesis’ (heat production) in skeletal muscles by acting on these receptors.
Researchers have noticed that knock-out mice without ADRB3 receptors cannot respond to the effects of fragment 176-191. Interestingly, researchers noticed that fragment 176-191 only led to weight loss in obese mice and did not affect lean mice. It led to a nearly 50% reduction in weight gain in obese mice noticed over three weeks.
Other elements of this blend, such as Mod GRF (1-29), improve body composition by increasing muscle mass. The increase in muscle mass is due to two mechanisms triggered by this peptide: muscle hypertrophy (increase in the size of muscle fibers) and muscle hyperplasia (increase in the number of muscle fibers).
Improved Bone and Joint Health
This blend can be useful in dealing with various bone and joint-related conditions associated with aging. These include conditions such as osteoporosis and joint osteoarthritis.
Researchers noticed that when HGH fragment 176-191 was used in conjunction with hyaluronic acid injections in conditions such as osteoarthritis, it could potentiate joint cartilage growth. The study noticed that using the peptide in animal models of osteoarthritis improved joint cartilage. The improvement was more marked when used in combination with hyaluronic acid.
In addition, peptides such as Mod GRF and Ipamorelin are proven to improve bone health by activating bone cells via GH-mediated pathways. The use of these peptides leads to increased activity, proliferation, and differentiation of bone-forming cells and leads to an increase in Bone Mineral Density (BMD). This is useful in conditions such as osteoporosis.
The levels of growth hormone decline sharply following teenage years and continue to decline even more rapidly after the 40s. The signs of aging are the direct consequence of declining levels of GH. A blend of GH stimulating peptides, such as this one, can stimulate the natural increase in GH levels. An increase in GH levels is associated with an improvement in cell proliferation due to telomere shortening and a reduction in cellular death due to a decline in processes such as oxidative stress.
Other Health Benefits
Other potential health benefits of this peptide blend include:
● Improved cardiovascular health and quicker recovery following Myocardial Infarction (MI)
● Improved gut health
● Improved healing following injury or surgery and better aesthetic outcomes following cosmetic surgery procedures
● Improved mental health and might be helpful in neurodegenerative diseases such as Alzheimer’s dementia and Parkinson’s disease
● Better overall health, energy, and vitality levels
● Mental well-being
● Better thyroid health
● Enhanced recovery following injury and post-workout
Research has shown that fragment 176-191, a synthetic GHRH agonist is a strong catalyst for catabolism of adipocytes. Hence it is now possible to bring about targeted lipolysis by including fragment 176-191 with ipamorelin and Mod GRF 1-29. It is way more effective than most of the GHRH agonists in the burning of fat and hence is popularly called a “lipolytic fragment.” Thus inclusion of fragment 176-191 improves fat metabolism on the premise of increased GH release and modifies physiological metabolism in favor of lean body mass.