CJC-1295 & GHRP-6 Blend (10mg)

(26 customer reviews)


CJC-1295 & GHRP-6 blend is Synthesized and Lyophilized in the USA.

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Price $81.70$77.40
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SKU: CJC-1295-GHRP-6-Blend-10mg Category:


CJC-1295 & GHRP-6 Peptide Blend

The CJC-1295 & GHRP-6 blend have been posited by researchers to display a synergistic action on cells that participate in the release of growth hormone. More specifically, the mix includes CJC-1295, which appears to be similar in action to growth hormone-releasing hormone (GHRH), and GHRP-6 (Growth Hormone Releasing Peptide 6), which appears to bind to the receptors of the hunger hormone ghrelin.This combination of peptides may possibly increase both the strength and the number of growth hormone signals from somatotroph cells. CJC-1295 appears to target the GHRH receptor pathway, while GHRP-6, is considered by researchers to act on the ghrelin receptor pathway. This may explain why the combination of CJC-1295 and GHRP-6 exhibits potential to interact with somatotroph cells in the pituitary gland and the hypothalamus. Both of these regions in the central nervous system are considered to be comprised of cells that are believed to be important in making and controlling growth hormone synthesis.

CJC-1295 (Mod GRF 1-29) Specifications

Molecular Formula: C152H252N44O42

Molecular Weight: 3647.954 g/mol

Sequence: H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys(Mal)-NH2


GHRP-6 Specifications

Molecular Formula: C46H56N12O6

Molecular Weight: 873.032 g/mol

Sequence: His-D-Trp-Ala-Trp-D-Phe-Lys

CJC-1295 & GHRP-6 Blend Research

CJC-1295 (Mod GRF 1-29), or tetra-substituted GRF (1-29), is a synthetically developed peptide equivalent to the naturally occurring GHRH hormone. It includes the smallest possible chain of amino acids that might connect to the GHRH receptors, and comprises the initial 29 amino acids of GHRH. The primary structural differences between CJC-1295 and its naturally occurring GHRH equivalent lies in 4 substituted amino acids of GHRH’s original 29 amino acids, to possibly enhance the peptide’s resistance to breakdown by the enzyme dipeptidyl peptidase-4. More specifically, the amino acids that have been altered and substituted are the 2nd, 8th, 15th, and 27th amino acids.[1] Further, the researchers commented, “CJC-1295 caused an increase in total pituitary RNA and GH mRNA, suggesting that proliferation of somatotroph cells had occurred, as confirmed by immunohistochemistry images.” CJC-1295 appears to bind to and interact with the receptor of GHRH in the anterior pituitary gland.[2] It may potentially maintain the pulsatile production of growth hormone (GH), improving overall physiological levels.

GRHP-6, on the other hand, is an opioid analog of the peptide Met-enkephalin. Yet, researchers suggest it lacks the opioid activity generally associated with these enkephalins.[3] GHRP-6 is a synthetic hexapeptide that researchers have categorized as a hormone-releasing peptide. It has been suggested to exhibit action by possibly attaching to the ghrelin receptor found on pituitary cells and specific neurons in the hypothalamus. When it binds, GHRP-6 appears to activate what is known as the growth hormone secretagogue receptor (GHS-R1a). Thus, it has been studied concerning its interaction with the growth hormone secretagogue receptor. GHRP-6 appears to act by the molecular mimicry of the hormone ghrelin, potentially causing a stimulation of the growth hormone secretion. Since growth hormone receptors are present in many cells, the impact of GHRP-6 may be widespread.[4]

The attachment of CJC-1295 seems to initiate processes that result in the discharge of growth hormone (GH) from small sacs within somatotroph cells. Scientists suggest that this peptide may potentially enhance the growth hormone production by these cells, thereby resulting in elevation of “GH concentrations by 2- to 10-fold.”[5] Moreover, the increase in growth hormone appears to be sufficiently lasting to cause a increase in some of the main anabolic mediators of the hormone, such as the so-called insulin-like growth factor 1 (IGF-1). Another research paper comments that there may be a 46% increase in mean growth hormone levels and 45% increase in mean IGF-1 levels following the influence of CJC-1295 in animal research models.[6] Research studies on GRHP-6 have yielded findings that examine GRHP-6’s potential positive impact with the context of various malignant conditions. The GRHP-6 peptide has been primarily researched in conjunction with growth hormone deficiency disorders, Multiple Organ Failure (MOF), cachexia or wasting, obesity, and various eating disorders.[7] Moreover, GHRP-6 may also show a preference for CD36 receptors. These CD36 receptors may have various functions, such as possibly playing a part in metabolism, serving as a collector receptor for fats, aiding in absorption and altering immune reactions, and controlling the process of engulfing particles and inflammation. The pathways of CD36 may also potentially be involved in the management of blood vessel formation.[8] However, these hypotheses require further scientific exploration. Due to its apparent cytoprotective properties, GHRP-6 has been advocated in myocardial infarction research studies, as it may potentially reduce scarring in tissues affected by reperfusion injuries. GRHP-6 may have potential in inducing anti-aging functions within the cell cycle, in addition to possible sleep improvement and cognitive function. When studied in combination, these peptides appear to act synergistically to bring about changes by increasing the growth hormone levels. GHRP-6 appears to maintain a baseline growth hormone level, whereas CJC-1295 mainly appears to stimulate a pulsatile secretion of the growth hormone. However, both peptides have been hypothesized to positively induce improvements within sleep cycles. As most of growth and cellular repair occurs during sleep, the peptide blend has been hypothesized to aid in cellular regeneration and repair. It may possibly improve wound healing and nerve tissue protection via sleep quality enhancement.

CJC-1295 & GHRP-6 peptides have also been associated with nervous tissue protection and repair. One study explored the impact of GHRP-6 on the brain’s IGF-1 system in murine models. The actions of GH are generally considered to be mediated through IGF-I, so the study centered primarily on the modulation of the brain’s IGF system. Researchers reported that the introduction of GHRP-6 for one week appears to have led to an increase in IGF-I mRNA levels in the hypothalamus, cerebellum, and hippocampus, but not in the cerebral cortex. This may suggest that GH and GHRP-6 may enhance the expression of IGF-I in specific brain areas. The study also explored the expression of the IGF receptor and IGF-binding protein IGFBP-2, but its findings reported no considerable fluctuation in activity following peptide introduction. However, the phosphorylation of Akt and Bad appeared stimulated in areas where IGF-I was increased. The researchers noted that this finding implied that GH and GHRP-6 may activate phosphatidylinositol kinase intracellular pathways involved in cell survival in response to growth factors. Bad is a pro-apoptotic member of the Bcl-2 protein family, which is considered to play a central role in cell death. Akt is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription, and cell migration. No reported changes were observed in MAPK, a protein kinase-specific to the amino acids serine, threonine, and tyrosine, nor were changes reported in glycogen synthase kinase-3beta. Moreover, the antiapoptotic protein Bcl-2 was increased in the areas where IGF-I appeared increased, with no change in the proapoptotic protein Bax. This could potentially indicate a shift towards cell survival and away from apoptosis. IGFBP-5, also reported to be involved in neuron survival processes, was reported to be increased mainly in the hypothalamus, which might suggest a potential neuroendocrine role.[9]

Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.



  1. Scarborough R, Gulyas J, Schally AV, Reeves JJ. Analogs of growth hormone-releasing hormone induce release of growth hormone in the bovine. J Anim Sci. 1988 Jun;66(6):1386-92. doi: 10.2527/jas1988.6661386x. PMID: 3135287.
  2. Alba M, Fintini D, Sagazio A, Lawrence B, Castaigne JP, Frohman LA, Salvatori R. Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1290-4. doi: 10.1152/ajpendo.00201.2006. Epub 2006 Jul 5. PMID: 16822960.
  3. Rico M, Lorenzo MT, Pazo JA, Vega FV, De la Cruz LF. GHRP-6 in heifer and cow adenohypophisial cells separated by elutriation. J Physiol Biochem. 1999 Mar;55(1):33-9. PMID: 10494658.
  4. Martínez R, Hernández L, Gil L, Carpio Y, Morales A, Herrera F, Rodríguez-Mallón A, Leal Y, Blanco A, Estrada MP. Growth hormone releasing peptide-6 enhanced antibody titers against subunit antigens in mice (BALB/c), tilapia (Oreochromis niloticus) and African catfish (Clarias gariepinus). Vaccine. 2017 Oct 9;35(42):5722-5728. doi: 10.1016/j.vaccine.2017.07.060. PMID: 28893476.
  5. Teichman, Sam L., et al. “Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults.” The Journal of Clinical Endocrinology & Metabolism 91.3 (2006): 799-805.
  6. Ionescu M, Frohman LA. Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog. J Clin Endocrinol Metab. 2006 Dec;91(12):4792-7. doi: 10.1210/jc.2006-1702. Epub 2006 Oct 3. PMID: 17018654.
  7. Fujitsuka N, Asakawa A, Uezono Y, Minami K, Yamaguchi T, Niijima A, Yada T, Maejima Y, Sedbazar U, Sakai T, Hattori T, Kase Y, Inui A. Potentiation of ghrelin signaling attenuates cancer anorexia-cachexia and prolongs survival. Transl Psychiatry. 2011 Jul 26;1(7):e23. doi: 10.1038/tp.2011.25. PMID: 22832525; PMCID: PMC3309517.
  8. Demers A, McNicoll N, Febbraio M, Servant M, Marleau S, Silverstein R, Ong H. Identification of the growth hormone-releasing peptide binding site in CD36: a photoaffinity cross-linking study. Biochem J. 2004 Sep 1;382(Pt 2):417-24. doi: 10.1042/BJ20040036. PMID: 15176951; PMCID: PMC1133797.
  9. Frago LM, Pañeda C, Dickson SL, Hewson AK, Argente J, Chowen JA. Growth hormone (GH) and GH-releasing peptide-6 increase brain insulin-like growth factor-I expression and activate intracellular signaling pathways involved in neuroprotection. Endocrinology. 2002 Oct;143(10):4113-22. doi: 10.1210/en.2002-220261. PMID: 12239123.
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26 reviews for CJC-1295 & GHRP-6 Blend (10mg)

  1. Beatriz Davis

    Thank you!!!!!

  2. Ellis Foster

    I’m not one to leave reviews but credit should be given where it’s due. I’m impressed.

  3. Levi Morris

    I have ordered from here before and I have never been let down. I cannot wait for my products to arrive. Peptides have always past my expectations in regards to purity and quality. Their stuff is no joke.

  4. Alexis Bronte

    Very friendly team whos always there to help. I was helped a lot, there were regular replies and excellent communication. Very happy I found Biotech

  5. Harley Dawson

    love how easy the site is to manuever, was in and out super quick. Made my day a lot easier and efficient as I had a few orders to place for the lab. So far have never had to deal with customer service. The peptides get in on time, are the correct batches, and have fortunately not come in broken.

  6. Finley Bell

    Quality second to none is what they claim, I can attest to it.

  7. Hugo Dixon

    I needed my order rushed to me and they upgraded me to overnight shipping for free. My experience with customer service was outstanding.They were definitely trained well and do all they can to help you if the circumstance permits.

  8. Albert Payne

    Excellent customer service and excellent products. A couple friends that I referred had the same experience.

  9. Patcharapun Visetbhakdi

    Thank you Biotech for good prices!

  10. Frank Rawetzki

    Had a hiccup with one of my orders. They sent the wrong vials. Luckily they were easy to get in contact with and were able to send out the correct ones the next day. Even sent free bacteriostatic water as well. Thanks

  11. Rhoda Siggers

    When I placed my order I half-expected for it to come in later than expected due to this happening to me with other online companies, but I was pleasantly surprised when it arrived after 2 days. Thank you!

  12. Tamara Qonita Mahadi

    Good product for a good price

  13. Kim Curtis

    Excellent return time on emails, didn’t wait long for a response from Taylor and they were able to help me fix a payment issue as well. They seemed to charge me in full instead of counting the discount code I had. Taylor reassured me that it must have been a glitch in the system and thankfully I had caught it.

  14. Omar Reyes

    El empaque es excelente, sin roturas ni productos arruinados. Entrega rápida, los recibí a la mañana siguiente.

  15. Daniel Lim

    Luickly have not encountered an issue with regards to payment or products breaing.

  16. Shaun Williams

    No headaches when buying with them, never ran into a problem over the past year that I have been purchasing from them. Sometimes the charge looks different on my account tho so just pay attention to that.

  17. Jamie Morris

    My only complaint would be I wish they had a waitlist for some peptides when they’re out of stock or some sort of way to let people know when they restock.

  18. K. O’Brian

    I enjoy shopping for peptides through them as they are pretty quick at restocking products.

  19. zac riley

    Like that they have multiple ways to take payment, don’t see that everywhere. My peptides also came in pretty fast which I was ecstatic about. I had ordered them a bit late and was fully expecting to have to start my project later than i wanted to but was surprised to see them not even 2 days later. Just a tip, standard shipping is almost as fast as the express in my opinion but it also depends on the location I guess.

  20. Cody Olson

    I’ve been with them a while now and I still think products are great but they could use a change in shipment boxes.One too many times I have had no idea what the package was and it would be nice to have a label or distinct box for the peptides.

  21. Emil Najmi

    Been with Biotech over a year, products are always up to par and love the constant discount codes I get. Helps me save a bit of cash.

  22. Oliver Revolon

    Ask for Danny if you have any questions or help. They get the job done fast and always have an answer. I had an issue where my order was processed twice, meaning the order doubled. Super easy fix with Danny and I was able to ask about what peptides go best or are usually bought with this blend as well.

  23. CJ Campbell

    Package came in one piece. Products looked like what was being advertised.

  24. Jerry Qi

    Deals are good and frequent, they seem to pick a few different peptides every month to discount.

  25. John P.Barajas

    No issues with customs and shipping out from the US. Have had issues before and happy to say it wasn’t an issue with them.

  26. Brent Ryers

    Taylor was able to set me up with a nice discount code because my peptides came in later than expected. Code was also made where It has no expiration date which is great since I do not buy peptides that frequently anyway.

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