CJC-1295 & GRHP-6 are synthetic analogs of the growth hormone-releasing hormone (GHRH) and “hunger hormone” ghrelin. CJC-1295 appears to bind to and interacts with the cognate receptor of GHRH in the anterior pituitary gland[1]. It has the potential to maintain the pulsatile production of growth hormone (GH) in the body, improving the overall physiological levels. GHRP-6, on the other hand, has been studied in relation to its interaction with the growth hormone secretagogue receptor. GHRP-6 appears to act by the molecular mimicry of the hormone ghrelin, causing a stimulation of the growth hormone secretion. Since growth hormone receptors are present in many cells in the body, the benefits of GHRP-6 may be widespread. These could include immune system strengthening, fat-burning properties, anti-aging effects on the skin, improvement of the sleep cycle and cognitive function, and the overall betterment of sexual health and mood[2].
Studies have highlighted that in conjunction, the two synthetic peptides CJC-1295 & GHRP-6 appear to exhibit a synergism towards augmenting the physiological levels of GH. GHRP-6 may improve the basal levels of GH in the body. Thus, GHRP-6 may ensure that even when the GH level declines in the body, it is maintained higher than under normal physiological conditions in the absence of the synthetic peptide. CJC-1295 appears to act on the higher basal level of GH set by GHRP-6. It thus may promote even higher production of GH in a pulsatile fashion. Even though it is an opioid analog of the peptide, Metenkephalin, it appears to lack the opioid activity generally associated with these enkephalins. GRHP-6 is also different from the growth hormone-releasing hormone in that it lacks sequence action. It acts on a completely different receptor that has now been suggested to be ghrelin. Various research conducted on mice reported significant changes in the overall health of animals dosed with GRHP-6. These effects included improved muscle growth, significant changes in body composition, improved glucose metabolism, improved cognitive function, and cardiac function.
Clinical trials on GRHP-6 have yielded results that suggest GRHP-6 may have a beneficial substance that can be used in various conditions. This novel approach suggests using GRHP-6 in growth hormone deficiency disorders, Multiple Organ Failure (MOF), cachexia or wasting, obesity, and various eating disorders[3]. Due to its apparent cytoprotective properties, its use has been advocated in myocardial infarction to reduce scarring in tissues affected by reperfusion injuries. GRHP-6 may be used as an anti-aging agent with the potential benefit of improving sleep and cognitive function. When used in combination, both these peptides appear to act synergistically to bring about changes in the body by considerably increasing the growth hormone levels. GRP-6 appears to maintain a baseline growth hormone level, whereas CJC-1295 mainly appears to stimulate a pulsatile secretion of the growth hormone. The combinational use of these two peptides has been suggested to benefit in improving appetite and sleep cycle. Since most of the growth and repair occurs during sleep, the peptide blend has the potential to aid in cellular regeneration and repair and improves wound healing and nerve tissue protection via sleep quality improvement.
CJC-1295 & GHRP-6 peptides have also been associated with nervous tissue protection and better wound healing[4]. GHRP-6 may provide additional benefits like stimulating appetite and improving the quality of sleep. A higher food intake helps to utilize the elevated GH levels and leads to muscle building, improved bone density, and overall higher growth. Our bodies are most receptive to the influence of GH during sleep. Hence, improved sleep helps to bring about the maximum influence of GH on various biological functions such as wound healing and boosting and regenerating immunity.
References
Alba M, Fintini D, Sagazio A, Lawrence B, Castaigne JP, Frohman LA, Salvatori R. Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1290-4. doi: 10.1152/ajpendo.00201.2006. Epub 2006 Jul 5. PMID: 16822960.
Martínez R, Hernández L, Gil L, Carpio Y, Morales A, Herrera F, Rodríguez-Mallón A, Leal Y, Blanco A, Estrada MP. Growth hormone releasing peptide-6 enhanced antibody titers against subunit antigens in mice (BALB/c), tilapia (Oreochromis niloticus) and African catfish (Clarias gariepinus). Vaccine. 2017 Oct 9;35(42):5722-5728. doi: 10.1016/j.vaccine.2017.07.060. PMID: 28893476.
Fujitsuka N, Asakawa A, Uezono Y, Minami K, Yamaguchi T, Niijima A, Yada T, Maejima Y, Sedbazar U, Sakai T, Hattori T, Kase Y, Inui A. Potentiation of ghrelin signaling attenuates cancer anorexia-cachexia and prolongs survival. Transl Psychiatry. 2011 Jul 26;1(7):e23. doi: 10.1038/tp.2011.25. PMID: 22832525; PMCID: PMC3309517.
This product is strictly for research/laboratory use only. Human or animal use and/or consumption is strictly prohibited by law. Only qualified and licensed professionals should handle these products. Any information found on Biotech Peptides is strictly for educational purposes only. Refer to our terms and conditions for more details.
Dr. Usman (BSc, MBBS, MaRCP) completed his studies in medicine at the Royal College of Physicians, London. He is an avid researcher with more than 30 publications in internationally recognized peer-reviewed journals. Dr. Usman has worked as a researcher and a medical consultant for reputable pharmaceutical companies such as Johnson & Johnson and Sanofi.
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Biotech Peptides
26 reviews for CJC-1295 & GHRP-6 Blend (10mg)
Rated 5 out of 5
Beatriz Davis –
Thank you!!!!!
Rated 5 out of 5
Ellis Foster –
I’m not one to leave reviews but credit should be given where it’s due. I’m impressed.
Rated 5 out of 5
Levi Morris –
I have ordered from here before and I have never been let down. I cannot wait for my products to arrive. Peptides have always past my expectations in regards to purity and quality. Their stuff is no joke.
Rated 5 out of 5
Alexis Bronte –
Very friendly team whos always there to help. I was helped a lot, there were regular replies and excellent communication. Very happy I found Biotech
Rated 5 out of 5
Harley Dawson –
love how easy the site is to manuever, was in and out super quick. Made my day a lot easier and efficient as I had a few orders to place for the lab. So far have never had to deal with customer service. The peptides get in on time, are the correct batches, and have fortunately not come in broken.
Rated 5 out of 5
Finley Bell –
Quality second to none is what they claim, I can attest to it.
Rated 5 out of 5
Hugo Dixon –
I needed my order rushed to me and they upgraded me to overnight shipping for free. My experience with customer service was outstanding.They were definitely trained well and do all they can to help you if the circumstance permits.
Rated 5 out of 5
Albert Payne –
Excellent customer service and excellent products. A couple friends that I referred had the same experience.
Rated 5 out of 5
Patcharapun Visetbhakdi –
Thank you Biotech for good prices!
Rated 5 out of 5
Frank Rawetzki –
Had a hiccup with one of my orders. They sent the wrong vials. Luckily they were easy to get in contact with and were able to send out the correct ones the next day. Even sent free bacteriostatic water as well. Thanks
Rated 5 out of 5
Rhoda Siggers –
When I placed my order I half-expected for it to come in later than expected due to this happening to me with other online companies, but I was pleasantly surprised when it arrived after 2 days. Thank you!
Rated 5 out of 5
Tamara Qonita Mahadi –
Good product for a good price
Rated 5 out of 5
Kim Curtis –
Excellent return time on emails, didn’t wait long for a response from Taylor and they were able to help me fix a payment issue as well. They seemed to charge me in full instead of counting the discount code I had. Taylor reassured me that it must have been a glitch in the system and thankfully I had caught it.
Rated 5 out of 5
Omar Reyes –
El empaque es excelente, sin roturas ni productos arruinados. Entrega rápida, los recibí a la mañana siguiente.
Rated 5 out of 5
Daniel Lim –
Luickly have not encountered an issue with regards to payment or products breaing.
Rated 5 out of 5
Shaun Williams –
No headaches when buying with them, never ran into a problem over the past year that I have been purchasing from them. Sometimes the charge looks different on my account tho so just pay attention to that.
Rated 4 out of 5
Jamie Morris –
My only complaint would be I wish they had a waitlist for some peptides when they’re out of stock or some sort of way to let people know when they restock.
Rated 5 out of 5
K. O’Brian –
I enjoy shopping for peptides through them as they are pretty quick at restocking products.
Rated 5 out of 5
zac riley –
Like that they have multiple ways to take payment, don’t see that everywhere. My peptides also came in pretty fast which I was ecstatic about. I had ordered them a bit late and was fully expecting to have to start my project later than i wanted to but was surprised to see them not even 2 days later. Just a tip, standard shipping is almost as fast as the express in my opinion but it also depends on the location I guess.
Rated 5 out of 5
Cody Olson –
I’ve been with them a while now and I still think products are great but they could use a change in shipment boxes.One too many times I have had no idea what the package was and it would be nice to have a label or distinct box for the peptides.
Rated 5 out of 5
Emil Najmi –
Been with Biotech over a year, products are always up to par and love the constant discount codes I get. Helps me save a bit of cash.
Rated 5 out of 5
Oliver Revolon –
Ask for Danny if you have any questions or help. They get the job done fast and always have an answer. I had an issue where my order was processed twice, meaning the order doubled. Super easy fix with Danny and I was able to ask about what peptides go best or are usually bought with this blend as well.
Rated 5 out of 5
CJ Campbell –
Package came in one piece. Products looked like what was being advertised.
Rated 5 out of 5
Jerry Qi –
Deals are good and frequent, they seem to pick a few different peptides every month to discount.
Rated 5 out of 5
John P.Barajas –
No issues with customs and shipping out from the US. Have had issues before and happy to say it wasn’t an issue with them.
Rated 5 out of 5
Brent Ryers –
Taylor was able to set me up with a nice discount code because my peptides came in later than expected. Code was also made where It has no expiration date which is great since I do not buy peptides that frequently anyway.
Beatriz Davis –
Thank you!!!!!
Ellis Foster –
I’m not one to leave reviews but credit should be given where it’s due. I’m impressed.
Levi Morris –
I have ordered from here before and I have never been let down. I cannot wait for my products to arrive. Peptides have always past my expectations in regards to purity and quality. Their stuff is no joke.
Alexis Bronte –
Very friendly team whos always there to help. I was helped a lot, there were regular replies and excellent communication. Very happy I found Biotech
Harley Dawson –
love how easy the site is to manuever, was in and out super quick. Made my day a lot easier and efficient as I had a few orders to place for the lab. So far have never had to deal with customer service. The peptides get in on time, are the correct batches, and have fortunately not come in broken.
Finley Bell –
Quality second to none is what they claim, I can attest to it.
Hugo Dixon –
I needed my order rushed to me and they upgraded me to overnight shipping for free. My experience with customer service was outstanding.They were definitely trained well and do all they can to help you if the circumstance permits.
Albert Payne –
Excellent customer service and excellent products. A couple friends that I referred had the same experience.
Patcharapun Visetbhakdi –
Thank you Biotech for good prices!
Frank Rawetzki –
Had a hiccup with one of my orders. They sent the wrong vials. Luckily they were easy to get in contact with and were able to send out the correct ones the next day. Even sent free bacteriostatic water as well. Thanks
Rhoda Siggers –
When I placed my order I half-expected for it to come in later than expected due to this happening to me with other online companies, but I was pleasantly surprised when it arrived after 2 days. Thank you!
Tamara Qonita Mahadi –
Good product for a good price
Kim Curtis –
Excellent return time on emails, didn’t wait long for a response from Taylor and they were able to help me fix a payment issue as well. They seemed to charge me in full instead of counting the discount code I had. Taylor reassured me that it must have been a glitch in the system and thankfully I had caught it.
Omar Reyes –
El empaque es excelente, sin roturas ni productos arruinados. Entrega rápida, los recibí a la mañana siguiente.
Daniel Lim –
Luickly have not encountered an issue with regards to payment or products breaing.
Shaun Williams –
No headaches when buying with them, never ran into a problem over the past year that I have been purchasing from them. Sometimes the charge looks different on my account tho so just pay attention to that.
Jamie Morris –
My only complaint would be I wish they had a waitlist for some peptides when they’re out of stock or some sort of way to let people know when they restock.
K. O’Brian –
I enjoy shopping for peptides through them as they are pretty quick at restocking products.
zac riley –
Like that they have multiple ways to take payment, don’t see that everywhere. My peptides also came in pretty fast which I was ecstatic about. I had ordered them a bit late and was fully expecting to have to start my project later than i wanted to but was surprised to see them not even 2 days later. Just a tip, standard shipping is almost as fast as the express in my opinion but it also depends on the location I guess.
Cody Olson –
I’ve been with them a while now and I still think products are great but they could use a change in shipment boxes.One too many times I have had no idea what the package was and it would be nice to have a label or distinct box for the peptides.
Emil Najmi –
Been with Biotech over a year, products are always up to par and love the constant discount codes I get. Helps me save a bit of cash.
Oliver Revolon –
Ask for Danny if you have any questions or help. They get the job done fast and always have an answer. I had an issue where my order was processed twice, meaning the order doubled. Super easy fix with Danny and I was able to ask about what peptides go best or are usually bought with this blend as well.
CJ Campbell –
Package came in one piece. Products looked like what was being advertised.
Jerry Qi –
Deals are good and frequent, they seem to pick a few different peptides every month to discount.
John P.Barajas –
No issues with customs and shipping out from the US. Have had issues before and happy to say it wasn’t an issue with them.
Brent Ryers –
Taylor was able to set me up with a nice discount code because my peptides came in later than expected. Code was also made where It has no expiration date which is great since I do not buy peptides that frequently anyway.