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Gonadorelin (GnRH) (10mg)
$77.00
Gonadorelin (GnRH) peptides are Synthesized and Lyophilized in the USA.
Discount per Quantity
Quantity | 5 - 9 | 10 + |
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Discount | 5% | 10% |
Price | $73.15 | $69.30 |
Out of stock
Description
What is the Gonadorelin (GnRH) Peptide?
Gonadorelin (GnRH) is a decapeptide gonadotropin-releasing hormone agonist.[1] It appears to work by stimulating the synthesis and release of luteinizing hormone and follicle-stimulating hormone. It is being researched in human medicine to treat infertility, irregular menstrual cycles, and hypogonadism. It is also studied for its potential as a diagnostic tool to assess pituitary function. Ongoing research has uncovered potential uses for Gonadorelin in treating breast, prostate, and Alzheimer’s disease.[2]
Specifications
AKA: Growth Hormone Releasing Factor, Somatocrinin, Somatoliberin
Sequence: Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly
Molecular Formula: C55H75N17O13
Molecular Weight: 1182.311 g/mol
PubChem: 638793
CAS Number: 9034-40-6
Reconstitution: Required
Research
Gonadorelin Research and Breast Cancer Prevention
Studies suggest that the higher the lifetime exposure to estrogen, the more likely a woman will develop breast cancer. Women who start menstruating at a young age, start estrogen-based contraceptives, start hormone replacement therapy during menopause, or have late-onset menopause are at risk of developing breast cancer. Fortunately, with oral contraceptives, your risk decreases when you stop taking the pill, and eventually, the increased risk returns to baseline. Of course, contraception is a double-edged sword because its use increases the risk of breast cancer but reduces the risk of ovarian cancer. Some breast cancer cells require estrogen to grow, and minimizing estrogen production or blocking estrogen receptors is an established method for treating certain forms of breast cancer. Gonadorelin’s studies suggest that it can be used to control ovarian cancer, Estrogen production, and exhibits potential to prevent breast cancer.[3] Scientists report that “Fusion of GnRH to hpRNase1 structure produced an enzyme, which could specifically target tumor cells.” This hypothesis is based on the idea that some women are at increased risk of developing breast cancer in the postmenopausal year due to genetic and environmental factors. Gonadorelin appears to be a safe and inexpensive therapy to use in these situations, making it an attractive potential in reducing the burden of cancer.[4] Studies show that ten years of use of Gonadorelin may reduce the risk of breast cancer by up to 50%, and 15 years of use of Gonadorelin can reduce the risk by 70%.[5] Further research is required in this area, however. The potential benefits of Gonadorelin go beyond breast cancer prevention. Studies have suggested that adjuvant anti-estrogen therapy reduces disease progression by 50% if the cancer is estrogen-sensitive. Cancer cells tend to develop resistance to them over time, so their effectiveness is limited. This resistance usually results from increased expression of estrogen receptors. It is impossible to block all estrogen receptors without serious side effects. Gonadorelin may avoid this problem primarily by reducing the expression of estrogen. It appears to directly reduce the growth of estrogen-sensitive cancers and increases receptor efficacy, blocks the substance, and prolongs its lifespan.[6] Studies of postmenopausal women with hyperandrogenism have suggested further that long-term GnRH treatment lowers total estrogen levels and reduces the risk of developing breast cancer. This occurs without serious side effects and therefore may provide an alternative to previous treatments, surgical removal of the ovaries.[7]
Gonadorelin and Prostate Cancer
The use of GnRH in men with prostate cancer began in 1979 and was known as medical castration. However, this treatment eventually led to interesting discoveries. Some androgens are formed locally in the prostate through a mechanism called intracrinology.[8] Of course, this means that GnRH blockade is only partially effective in treating prostate cancer. With deeper investigation into the potential benefits of Gonadorelin, scientists have developed new medications approved by the FDA for the treatment of castration-resistant prostate cancer (CRPC). These substances provide a new line of defense against the progression and metastasis of prostate cancer. They can also be used prophylactically in older men. The use of Gonadorelin and new topical medications in treating prostate cancer is known as complex androgen deprivation (CAB). CAB, which combines effective screening and early detection, is one of the few treatments in oncology that offers treatment and remission.[9] CAB can cure 99% of all prostate cancers when used effectively and with early detection.
Gonadorelin and Dementia
Studies show that sex hormones, especially Luteinizing Hormone (LH), act on the brain in ways beyond the realm of sexual dimorphism and fertility. Indeed, increased menopausal-related LH correlates with an increased incidence of Alzheimer’s disease and reduced memory capacity in humans and animals. Rats treated with LH exhibited poor memory and hippocampal dysfunction. This was a defect that was apparently remedied by the administration of LH blockers.[10] Further research on LH observe that higher hormone levels are associated with increased neuropathology. In particular, LH has been shown to promote the formation of plaques associated with Alzheimer’s disease.[11] The researchers conclude that “Reducing the LH levels by treatment with gonadotropin-releasing hormone agonists could provide therapeutic benefits.” Therefore, it may be assumed that lowering LH levels will help slow the progression of Alzheimer’s disease. Testosterone is beneficial to brain health and helps maintain cognitive function. Therefore, blocking the entire hypothalamus-pituitary-gondola axis is not always effective for treating Alzheimer’s disease. For this reason, scientists have sought to test Gonadorelin derivatives to see if selective disruption of LH production is possible and has potential benefits.[12] One ongoing study suggests that Leuprolide, a common substance used to treat uterine fibroids and GnRH receptor agonists, may effectively reduce the risk of Alzheimer’s disease compared to other Gonadotropin analogs. In this situation, Leuprolide may be used to offset the risk of CAB for Alzheimer’s disease. In particular, researchers studied the apparent ability of Leuprolide to downregulate serum gonadotropin levels (especially LH) and found it generally sufficient to offset the effects of decreased testosterone.[13] Researchers are currently working to understand how the genetic interactions of Alzheimer’s disease can be disrupted to treat and prevent Alzheimer’s disease. Gonadorelin is an important peptide in this study.
The Future of Gonadorelin Research
Gonadorelin has long been researched for its potential for treating human and mammalian diseases. Still, researchers are constantly discovering new ways in which GnRH and GnRH analogs act in normal physiology and disease development. The discovery that Gonadorelin may play a role in treating prostate cancer is a breakthrough that has allowed physicians to develop highly effective treatments. When prostate cancer develops, 99% of people can be completely cured. Experimental studies report Gonadorelin to exhibit minimal side effects and low oral and excellent subcutaneous bioavailability in mice.
References
- Pace JN, Miller JL, Rose LI. GnRH agonists: gonadorelin, leuprolide and nafarelin. Am Fam Physician. 1991 Nov;44(5):1777-82. PMID: 1835275.
- Meethal SV, Smith MA, Bowen RL, Atwood CS. The gonadotropin connection in Alzheimer’s disease. Endocrine. 2005 Apr;26(3):317-26. doi: 10.1385/ENDO:26:3:317. PMID: 16034187.
- Maleksabet A, Zarei Jaliani H, Asgari A, Ramezani A, Erfani N. Specific Targeting of Recombinant Human Pancreatic Ribonuclease 1 using Gonadotropin-Releasing Hormone Targeting Peptide toward Gonadotropin-Releasing Hormone Receptor-Positive Cancer Cells. Iran J Med Sci. 2021 Jul;46(4):281-290. doi: 10.30476/ijms.2020.83234.1219. PMID: 34305240; PMCID: PMC8288496.
- Secreto G, Girombelli A, Krogh V. Androgen excess in breast cancer development: implications for prevention and treatment. Endocr Relat Cancer. 2019 Feb;26(2):R81-R94. doi: 10.1530/ERC-18-0429. PMID: 30403656.
- Spicer DV, Pike MC. Sex steroids and breast cancer prevention. J Natl Cancer Inst Monogr. 1994;(16):139-47. PMID: 7999456.
- Secreto G, Muti P, Sant M, Meneghini E, Krogh V. Medical ovariectomy in menopausal breast cancer patients with high testosterone levels: a further step toward tailored therapy. Endocr Relat Cancer. 2017 Nov;24(11):C21-C29. doi: 10.1530/ERC-17-0251. Epub 2017 Aug 16. PMID: 28814452.
- Vollaard ES, van Beek AP, Verburg FA, Roos A, Land JA. Gonadotropin-releasing hormone agonist treatment in postmenopausal women with hyperandrogenism of ovarian origin. J Clin Endocrinol Metab. 2011 May;96(5):1197-201. doi: 10.1210/jc.2010-1991. Epub 2011 Feb 9. PMID: 21307133.
- Labrie F. GnRH agonists and the rapidly increasing use of combined androgen blockade in prostate cancer. Endocr Relat Cancer. 2014 Aug;21(4):R301-17. doi: 10.1530/ERC-13-0165. Epub 2014 May 13. PMID: 24825748.
- Labrie F. Combined blockade of testicular and locally made androgens in prostate cancer: a highly significant medical progress based upon intracrinology. J Steroid Biochem Mol Biol. 2015 Jan;145:144-56. doi: 10.1016/j.jsbmb.2014.05.012. Epub 2014 Jun 9. PMID: 24925260.
- Burnham V, Sundby C, Laman-Maharg A, Thornton J. Luteinizing hormone acts at the hippocampus to dampen spatial memory. Horm Behav. 2017 Mar;89:55-63. doi: 10.1016/j.yhbeh.2016.11.007. Epub 2016 Nov 12. PMID: 27847314.
- Rao CV. Involvement of Luteinizing Hormone in Alzheimer Disease Development in Elderly Women. Reprod Sci. 2017 Mar;24(3):355-368. doi: 10.1177/1933719116658705. Epub 2016 Jul 20. PMID: 27436369.
- Bowen RL, Butler T, Atwood CS. Not All Androgen Deprivation Therapies Are Created Equal: Leuprolide and the Decreased Risk of Developing Alzheimer’s Disease. J Clin Oncol. 2016 Aug 10;34(23):2800. doi: 10.1200/JCO.2015.66.3997. Epub 2016 Jun 13. PMID: 27298416; PMCID: PMC5019750.
- Smith MA, Bowen RL, Nguyen RQ, Perry G, Atwood CS, Rimm AA. Putative Gonadotropin-Releasing Hormone Agonist Therapy and Dementia: An Application of Medicare Hospitalization Claims Data. J Alzheimers Dis. 2018;63(4):1269-1277. doi: 10.3233/JAD-170847. PMID: 29782310.
Dr. Usman (BSc, MBBS, MaRCP) completed his studies in medicine at the Royal College of Physicians, London. He is an avid researcher with more than 30 publications in internationally recognized peer-reviewed journals. Dr. Usman has worked as a researcher and a medical consultant for reputable pharmaceutical companies such as Johnson & Johnson and Sanofi.
Additional information
Brand | Biotech Peptides |
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22 reviews for Gonadorelin (GnRH) (10mg)
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Mariana Wopat –
I have recommended this to all my colleagues! thumbs up
Sunil Ghuptkur –
Biotech comes highly recommended. Even when I experienced problems with emails not arriving in my Hotmail account, customer care was fast to reply. They assured me that the money had been received and that the package would arrive the following day.
Chee Nguyen –
Like that there’s a lot of information about each peptide. Very educational and helpful when picking out products.
Robert Lesner –
Thanks for offering different payment options and the next business day delivery guarantee. My card kept getting declined so I paid through the Paypal link Taylor from customer service emailed me. Much appreciated.
Brian S. Brian S. Casselberry –
There was this one time one of the bottles came a bit cracked. There was no liquid spill at all and everything was fine, but I was still a bit skeptic so I called CS and they told me the bottle is fine, but they’re still gona sent another one, because safety first and why risk it. I loved that and made me really trust them.
Gerald Nila Jr –
¡Increíble compañía! recomendé a todos
Lisa Berglund –
They came highly recommended by a friend and after shopping with them i see why!
Brian Lewis –
My company has done business with them for a very long time now and we are very pleased and intend to continue choosing Biotech for our peptide needs
Brett Denver –
Everything, from beginning to end, is absolutely flawless
Aleksey Chernyakhovsky –
Had to wait a few days until this product was back in stock but once they got it they sent it over asap. Happy with the service.
Jon Lewis –
Really good products
Austin Bishop –
First found out about Biotech a few months ago, explored their site but wasn’t interested in purchasing at the time. Now had a need for a few peptides with a new project and decided to revsisit and see what they had in stock. Luckily had whatever I needed. Process was basic and easy, not much to it. Everything came in about a span of 24 hours. Pepetides check out and i’ll probbaly purchase from them again.
Stephen Webb –
I love BP’s packaging quality. I know packaging and stuff like this is not that big of a deal compared to the quality of the products, but I’ve gotten vials from other companies where the label was falling off the glass. Not tryna be rude or something but how are you gonna trust the quality of a peptide when the quality of the packaging glue is questionable? Just a thought
Brayden G. –
Standard process of payment and product retrival. Products check out in in regards to purity.
Mike Knowls –
Like how they package everything safely!
Todd Web –
I have noticed they run out of products quick. I also noticed they restock just as fast.
Marcus Downey –
They stock up pretty quickly! I had to place an order last week but they were out of the peptide I needed. Noticed they restocked on a lot of products a few days later.
Janet Heughs –
Their peptides are top teir quality. Their employees are as good as the products they sell. My only comment again is I wish they were a smidge quicker on restocks.
Amy Larson –
Can’t say enough good things about this company. Consistent with their products and great work ethic with their employees.
Reg Sneed Jr. –
Storage life on these are outstanding.
Danny scott –
Biotech Peptides has got to be in my top 3 peptide suppliers. They get my peptides in safe and on time. Peptides are of good quality as well!
Deniz Burduroglu –
Got a 10% off code after my first purchase which was nice.