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Gonadorelin (GnRH) (10mg)

Gonadorelin (GnRH) (10mg)

(22 customer reviews)

$79.00

Gonadorelin (GnRH) peptides are Synthesized and Lyophilized in the USA.

Discount per Quantity

Quantity 5 - 910 +
Discount 5%10%
Price $75.05$71.10
Orders over $200 receive:
FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
FREE - USPS priority shipping
SKU: Gonadorelin-10mg Category:

Description

Gonadorelin (GnRH) Peptide

Gonadorelin (GnRH) is a decapeptide gonadotropin-releasing hormone agonist.[1] It appears to work by stimulating the synthesis and release of luteinizing hormone and follicle-stimulating hormone. It is being researched within the context of infertility and reproductive systems, and hypogonadism. It is also studied for its potential as a diagnostic tool to assess pituitary function.[2]

Specifications

Other Known Titles: Growth Hormone Releasing Factor, Somatocrinin, Somatoliberin

Sequence: Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly

Molecular Formula: C55H75N17O13

Molecular Weight: 1182.311 g/mol

Gonadorelin Research

Gonadorelin Research and Breast Cancer
Research studies in Gonadorelin and ovarian cancer have suggested that the peptide may exhibit the potential to mitigate the onset of certain cancers via estrogen production regulation.[3] Scientists report that “Fusion of GnRH to hpRNase1 structure produced an enzyme, which could specifically target tumor cells.”  [4] Prolonged studies in animal research models of breast cancer have suggested exposure to Gonadorelin may reduce risk of cancer cell proliferation by up to 70%, depending on duration.[5] Studies have also suggested that estrogen-inhibiting measures may reduce disease progression by 50% if the cancer is estrogen-sensitive. Cancer cells are considered to develop resistance over time, usually resulting from increased expression of estrogen receptors. Gonadorelin may directly reduce the growth of estrogen-sensitive cancers and increase receptor efficacy, as posited by researchers.[6] Studies in research models of hyperandrogenism have suggested further that long-term GnRH exposure may lower total estrogen levels and reduce the risk of breast cancer cell growth and proliferation. [7]

Gonadorelin and Prostate Cancer
Exposure to GnRH in research models of prostate cancer began in 1979. Researchers observed that some androgens are formed locally in the prostate through a mechanism called intracrinology.[8] The posited that GnRH acted as a blockade, and appeared only partially effective in mitigating prostate cancer cell growth and proliferation.

Gonadorelin and Dementia
Scientists consider that Luteinizing Hormone (LH), may act on the brain in ways beyond what is typically associated with the hormone, such as sexual dimorphism and fertility. Indeed, increased LH levels have been suggested to hold a positive correlation with incidences of Alzheimer’s disease and reduced memory capacity. Rats exposed to greater LH levels exhibited poor memory and hippocampal dysfunction. This was a defect that was apparently remedied by the influence of LH blockers.[10] Further research on LH observe that higher hormone levels are associated with increased neuropathology. In particular, LH has been suggested to promote the formation of plaques associated with Alzheimer’s disease.[11] The researchers conclude that “Reducing the LH levels by treatment with gonadotropin-releasing hormone agonists could provide [numerous] benefits.” Therefore, researchers assume that lowering LH levels may help slow the progression of Alzheimer’s disease. Testosterone is considered beneficial for maintaining cognitive function. Therefore, blocking the entire hypothalamus-pituitary-gondola axis may not always be recommended for mitigating Alzheimer’s disease. For this reason, scientists have sought to test Gonadorelin derivatives to see if selective disruption of LH production is possible.[12] One ongoing study suggests that Leuprolide, a common substance used with uterine fibroids and GnRH receptor agonists, has been suggested by researchers to potentially reduce the risk of Alzheimer’s disease compared to other Gonadotropin analogs. In this situation, Leuprolide may possibly offset the risk of CAB for Alzheimer’s disease. In particular, researchers studied the apparent ability of Leuprolide to downregulate serum gonadotropin levels (especially LH) and found it generally sufficient to offset the effects of decreased testosterone.[13] Researchers are currently working to understand how the genetic interactions of Alzheimer’s disease may be disrupted. Gonadorelin is an important peptide in this study.

Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.

 

References

  1. Pace JN, Miller JL, Rose LI. GnRH agonists: gonadorelin, leuprolide and nafarelin. Am Fam Physician. 1991 Nov;44(5):1777-82. PMID: 1835275.
  2. Meethal SV, Smith MA, Bowen RL, Atwood CS. The gonadotropin connection in Alzheimer’s disease. Endocrine. 2005 Apr;26(3):317-26. doi: 10.1385/ENDO:26:3:317. PMID: 16034187.
  3. Maleksabet A, Zarei Jaliani H, Asgari A, Ramezani A, Erfani N. Specific Targeting of Recombinant Human Pancreatic Ribonuclease 1 using Gonadotropin-Releasing Hormone Targeting Peptide toward Gonadotropin-Releasing Hormone Receptor-Positive Cancer Cells. Iran J Med Sci. 2021 Jul;46(4):281-290. doi: 10.30476/ijms.2020.83234.1219. PMID: 34305240; PMCID: PMC8288496.
  4. Secreto G, Girombelli A, Krogh V. Androgen excess in breast cancer development: implications for prevention and treatment. Endocr Relat Cancer. 2019 Feb;26(2):R81-R94. doi: 10.1530/ERC-18-0429. PMID: 30403656.
  5. Spicer DV, Pike MC. Sex steroids and breast cancer prevention. J Natl Cancer Inst Monogr. 1994;(16):139-47. PMID: 7999456.
  6. Secreto G, Muti P, Sant M, Meneghini E, Krogh V. Medical ovariectomy in menopausal breast cancer patients with high testosterone levels: a further step toward tailored therapy. Endocr Relat Cancer. 2017 Nov;24(11):C21-C29. doi: 10.1530/ERC-17-0251. Epub 2017 Aug 16. PMID: 28814452.
  7. Vollaard ES, van Beek AP, Verburg FA, Roos A, Land JA. Gonadotropin-releasing hormone agonist treatment in postmenopausal women with hyperandrogenism of ovarian origin. J Clin Endocrinol Metab. 2011 May;96(5):1197-201. doi: 10.1210/jc.2010-1991. Epub 2011 Feb 9. PMID: 21307133.
  8. Labrie F. GnRH agonists and the rapidly increasing use of combined androgen blockade in prostate cancer. Endocr Relat Cancer. 2014 Aug;21(4):R301-17. doi: 10.1530/ERC-13-0165. Epub 2014 May 13. PMID: 24825748.
  9. Labrie F. Combined blockade of testicular and locally made androgens in prostate cancer: a highly significant medical progress based upon intracrinology. J Steroid Biochem Mol Biol. 2015 Jan;145:144-56. doi: 10.1016/j.jsbmb.2014.05.012. Epub 2014 Jun 9. PMID: 24925260.
  10. Burnham V, Sundby C, Laman-Maharg A, Thornton J. Luteinizing hormone acts at the hippocampus to dampen spatial memory. Horm Behav. 2017 Mar;89:55-63. doi: 10.1016/j.yhbeh.2016.11.007. Epub 2016 Nov 12. PMID: 27847314.
  11. Rao CV. Involvement of Luteinizing Hormone in Alzheimer Disease Development in Elderly Women. Reprod Sci. 2017 Mar;24(3):355-368. doi: 10.1177/1933719116658705. Epub 2016 Jul 20. PMID: 27436369.
  12. Bowen RL, Butler T, Atwood CS. Not All Androgen Deprivation Therapies Are Created Equal: Leuprolide and the Decreased Risk of Developing Alzheimer’s Disease. J Clin Oncol. 2016 Aug 10;34(23):2800. doi: 10.1200/JCO.2015.66.3997. Epub 2016 Jun 13. PMID: 27298416; PMCID: PMC5019750.
  13. Smith MA, Bowen RL, Nguyen RQ, Perry G, Atwood CS, Rimm AA. Putative Gonadotropin-Releasing Hormone Agonist Therapy and Dementia: An Application of Medicare Hospitalization Claims Data. J Alzheimers Dis. 2018;63(4):1269-1277. doi: 10.3233/JAD-170847. PMID: 29782310.
All orders ship same day if placed by 12 PST.
This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law.  Only qualified and licensed professionals should handle these products.  Any information found on Biotech Peptides is strictly for educational purposes only.  Refer to our terms and conditions for more details.

Additional information

Brand

Biotech Peptides

22 reviews for Gonadorelin (GnRH) (10mg)

  1. Mariana Wopat –

    I have recommended this to all my colleagues! thumbs up

  2. Sunil Ghuptkur –

    Biotech comes highly recommended. Even when I experienced problems with emails not arriving in my Hotmail account, customer care was fast to reply. They assured me that the money had been received and that the package would arrive the following day.

  3. Chee Nguyen –

    Like that there’s a lot of information about each peptide. Very educational and helpful when picking out products.

  4. Robert Lesner –

    Thanks for offering different payment options and the next business day delivery guarantee. My card kept getting declined so I paid through the Paypal link Taylor from customer service emailed me. Much appreciated.

  5. Brian S. Brian S. Casselberry –

    There was this one time one of the bottles came a bit cracked. There was no liquid spill at all and everything was fine, but I was still a bit skeptic so I called CS and they told me the bottle is fine, but they’re still gona sent another one, because safety first and why risk it. I loved that and made me really trust them.

  6. Gerald Nila Jr –

    ¡Increíble compañía! recomendé a todos

  7. Lisa Berglund –

    They came highly recommended by a friend and after shopping with them i see why!

  8. Brian Lewis –

    My company has done business with them for a very long time now and we are very pleased and intend to continue choosing Biotech for our peptide needs

  9. Brett Denver –

    Everything, from beginning to end, is absolutely flawless

  10. Aleksey Chernyakhovsky –

    Had to wait a few days until this product was back in stock but once they got it they sent it over asap. Happy with the service.

  11. Jon Lewis –

    Really good products

  12. Austin Bishop –

    First found out about Biotech a few months ago, explored their site but wasn’t interested in purchasing at the time. Now had a need for a few peptides with a new project and decided to revsisit and see what they had in stock. Luckily had whatever I needed. Process was basic and easy, not much to it. Everything came in about a span of 24 hours. Pepetides check out and i’ll probbaly purchase from them again.

  13. Stephen Webb –

    I love BP’s packaging quality. I know packaging and stuff like this is not that big of a deal compared to the quality of the products, but I’ve gotten vials from other companies where the label was falling off the glass. Not tryna be rude or something but how are you gonna trust the quality of a peptide when the quality of the packaging glue is questionable? Just a thought

  14. Brayden G. –

    Standard process of payment and product retrival. Products check out in in regards to purity.

  15. Mike Knowls –

    Like how they package everything safely!

  16. Todd Web –

    I have noticed they run out of products quick. I also noticed they restock just as fast.

  17. Marcus Downey –

    They stock up pretty quickly! I had to place an order last week but they were out of the peptide I needed. Noticed they restocked on a lot of products a few days later.

  18. Janet Heughs –

    Their peptides are top teir quality. Their employees are as good as the products they sell. My only comment again is I wish they were a smidge quicker on restocks.

  19. Amy Larson –

    Can’t say enough good things about this company. Consistent with their products and great work ethic with their employees.

  20. Reg Sneed Jr. –

    Storage life on these are outstanding.

  21. Danny scott –

    Biotech Peptides has got to be in my top 3 peptide suppliers. They get my peptides in safe and on time. Peptides are of good quality as well!

  22. Deniz Burduroglu –

    Got a 10% off code after my first purchase which was nice.

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