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Kisspeptin-10 (10mg)
$39.00
Kisspeptin peptides are Synthesized and Lyophilized in the USA.
Discount per Quantity
Quantity | 5 - 9 | 10 + |
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Discount | 5% | 10% |
Price | $37.05 | $35.10 |
Out of stock
Description
What is the Kisspeptin-10 peptide?
Kisspeptin-10 research suggests the peptide is an important mediator of endocrine signaling when a person hits puberty as well as during reproduction. It may affect the mood and behavior of a person and encourage the development and regulation of blood vessels and renal function, discouraging cancer cell proliferation and metastasis. Also known as Metastin, this peptide appears to affect the gonadotropin-releasing hormone or GnRH.[1]
Specifications
AKA: KISS-1, Protein KISS-1, Metastin, Kp-10 peptide
Sequence: YNWNSFGLRF
Molecular Formula: C63H83N17O14
Molecular Weight: 1302.4 g/mol
PubChem: 25240297
Reconstitution: Required
Research
Kisspeptin-10 and Gonadotropin-Releasing Hormones
The Hypothalamus in the brain is responsible for the production and secretion of GnRH. It is secreted at the top of the hypothalamic-pituitary-gonadal axis. It controls the downstream production of follicle-stimulating hormone (FSH) and luteinizing hormones (LH). Primarily, these hormones are associated with the onset of puberty and the maturation of ova and sperm in the female and male reproductive organs, respectively. Administration of Kisspeptin has been studied for its potential to regulate menstruation and early-onset puberty and support certain cancer treatments.
Kisspeptin-10 and Testosterone
Due to Kisspeptin’s potential to affect the hypothalamic-pituitary-gonadal axis, the peptide may also affect levels of LH and FSH in the bloodstream. Studies observe this release brings about an almost 3x increase in testosterone concentration in males within hours of administration.[2] In addition, it the peptide has been suggested to hold potential in regulating the normal pulsatile release of sex hormones. These effects seem to be directly proportional to the amount of Kisspeptin administered. Kisspeptin is suggested to obscure individual pulses at extremely high doses, causing a continuous release of LH from the anterior pituitary glands. Thus, Kisspeptin-10 may have a therapeutic potential for women during specific conditions arising during pregnancy and for individuals suffering from low testosterone levels.
Kisspeptin-10 and Energy Balance
A person’s nutritional or energetic status appears to affect the neurons secreting Kisspeptin-10, resulting in suppression of GnRH release. Extreme variations in this balance can cause infertility in both sexes.[3] Researchers conclude that “the novel role of kisspeptin neurons as active players within the neuronal circuits that govern energy balance is discussed, offering evidence of a bidirectional role of these neurons as a nexus between metabolism and reproduction.” Additionally, Kisspeptin may be responsible for the regulation of energy in an individual. Research has suggested that depleting the Kisspeptin receptor (Kiss1r)may augment lipid retention, simultaneously reducing energy consumption. Hence, Kisspeptin has the potential to help control the neurochemical status of an individual’s energy consumption and reproduction.
Kisspeptin-10 and Cancer Research
Kisspeptin appears to control the malignancy of melanomas very efficiently. This is possibly due to its proposed ability to affect the migration of the cancerous cells by reducing the adhesive capacity of these cells. Cancers affecting organs such as the breast, urinary bladder, gastrointestinal tract, prostate, pancreas, ovaries, skin, and thyroid appear to demonstrate reduced expression of Kisspeptin, which helps in metastasis. Kisspeptin has multiple potential effects other than those on tumor cells which limits its therapeutic usefulness. The peptide may potentially inhibit metastasis to other sites, thereby reducing disease burden and reducing mortality rates. Together, these effects may enable prescribed treatment plans to be executed fruitfully. Research has linked the levels of Kisspeptin and Melatonin to sunlight.[4] Also, some role has been established in suppressing cancerous growths, but not metastasis. Upon exposure to daylight, experimental models observed excess Kisspeptin and Melatonin production, and vice versa. When tumorigenic cells were introduced in these mice, heightened tumor growth and volume were seen upon daylight exposure.
Kisspeptin-10 and Memory Enhancement
In an individual, the memory consolidation and orientation in 3-D space also appear to be affected by Kisspeptin concentrations. Kisspeptin-10 analogs may have the potential to avert the negative effects of alcohol, such as learning disabilities and navigational impairment, due to their possible ability to regulate the neuronal function that is often affected in genetic or chronic learning disorders. Ongoing research suggests the potential of novel nootropics to help manage both health and affected brains for better functioning.
Kisspeptin-10 and Mood
Reproduction, energy levels, and emotion affect one another. Researchers posit that reproduction and energy homeostasis is affected by Kisspeptin levels. Recent studies have also observed enhanced limbic brain activity such as increased reward-seeking behavior, enthusiasm, and general attitude with Kisspeptin administration.[5] Sexual and emotional processing gets linked to reproduction due to the apparent effect of Kisspeptin on mood, motivation, and sex drive in general.
Kisspeptin-10 and Kidney, Heart
Other than its role in controlling tumor metastasis, Kisspeptin appears to regulate kidney and heart function as well. Kisspeptin-10 and its receptors appear to be expressed in renal tissues, and studies have suggested that Kiss1 receptor knockouts fail to regulate glomerular development.[6] The scientists report that “Kisspeptins and kisspeptin receptor are altered in the kidney tissues of chronic renal impairment, raising the possibility of their pathophysiological roles in chronic renal failure.” Furthermore, Kisspeptin has been observed to control vasoconstriction and sometimes cardiac output in specific research settings.[7] Such regulation may be related to Kisspeptin’s potential to control vascular development and response to injury, the exact mechanism of which remains to be elucidated.
Kisspeptin-10 Summary
Kisspeptin’s potential in controlling tumor growth and metastasis has been well researched, possibly due to the peptide’s apparent involvement in vascular growth and functioning. In addition, Kisspeptin also appears to regulate hormone secretion related to human reproduction, testosterone levels, and sex-related behaviors like drive and motivation. One of its analogs, Kisspeptin-10, appears to be the safest per experimental research findings, with minimal reported side effects and acceptable oral and excellent subcutaneous bioavailability in mice. The per kg dosage applicable in mice models is not scalable in humans.
References
- Jayasena CN, Nijher GM, Comninos AN, Abbara A, Januszewki A, Vaal ML, Sriskandarajah L, Murphy KG, Farzad Z, Ghatei MA, Bloom SR, Dhillo WS. The effects of kisspeptin-10 on reproductive hormone release show sexual dimorphism in humans. J Clin Endocrinol Metab. 2011 Dec;96(12):E1963-72. doi: 10.1210/jc.2011-1408. Epub 2011 Oct 5. PMID: 21976724; PMCID: PMC3232613.
- George JT, Veldhuis JD, Roseweir AK, Newton CL, Faccenda E, Millar RP, Anderson RA. Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men. J Clin Endocrinol Metab. 2011 Aug;96(8):E1228-36. doi: 10.1210/jc.2011-0089. Epub 2011 Jun 1. PMID: 21632807; PMCID: PMC3380939.
- Navarro VM. Metabolic regulation of kisspeptin – the link between energy balance and reproduction. Nat Rev Endocrinol. 2020 Aug;16(8):407-420. doi: 10.1038/s41574-020-0363-7. Epub 2020 May 19. PMID: 32427949; PMCID: PMC8852368.
- Pazarci P, Kaplan H, Alptekin D, Yilmaz M, Lüleyap U, Singirik E, Pelit A, Kasap H, Yegani A. The effects of daylight exposure on melatonin levels, Kiss1 expression, and melanoma formation in mice. Croat Med J. 2020 Feb 29;61(1):55-61. doi: 10.3325/cmj.2020.61.55. PMID: 32118379; PMCID: PMC7063558.
- Comninos AN, Wall MB, Demetriou L, Shah AJ, Clarke SA, Narayanaswamy S, Nesbitt A, Izzi-Engbeaya C, Prague JK, Abbara A, Ratnasabapathy R, Salem V, Nijher GM, Jayasena CN, Tanner M, Bassett P, Mehta A, Rabiner EA, Hönigsperger C, Silva MR, Brandtzaeg OK, Lundanes E, Wilson SR, Brown RC, Thomas SA, Bloom SR, Dhillo WS. Kisspeptin modulates sexual and emotional brain processing in humans. J Clin Invest. 2017 Feb 1;127(2):709-719. doi: 10.1172/JCI89519. Epub 2017 Jan 23. PMID: 28112678; PMCID: PMC5272173.
- Shoji I, Hirose T, Mori N, Hiraishi K, Kato I, Shibasaki A, Yamamoto H, Ohba K, Kaneko K, Morimoto R, Satoh F, Kohzuki M, Totsune K, Takahashi K. Expression of kisspeptins and kisspeptin receptor in the kidney of chronic renal failure rats. Peptides. 2010 Oct;31(10):1920-5. doi: 10.1016/j.peptides.2010.07.001. Epub 2010 Jul 17. PMID: 20621140.
- Sato K, Shirai R, Hontani M, Shinooka R, Hasegawa A, Kichise T, Yamashita T, Yoshizawa H, Watanabe R, Matsuyama TA, Ishibashi-Ueda H, Koba S, Kobayashi Y, Hirano T, Watanabe T. Potent Vasoconstrictor Kisspeptin-10 Induces Atherosclerotic Plaque Progression and Instability: Reversal by its Receptor GPR54 Antagonist. J Am Heart Assoc. 2017 Apr 14;6(4):e005790. doi: 10.1161/JAHA.117.005790. PMID: 28411243; PMCID: PMC5533042.
Dr. Usman (BSc, MBBS, MaRCP) completed his studies in medicine at the Royal College of Physicians, London. He is an avid researcher with more than 30 publications in internationally recognized peer-reviewed journals. Dr. Usman has worked as a researcher and a medical consultant for reputable pharmaceutical companies such as Johnson & Johnson and Sanofi.
Additional information
Brand | Biotech Peptides |
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27 reviews for Kisspeptin-10 (10mg)
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Sam Downey –
I accidentally disputed the charge on my card and it was a bit of a problem with my bank but we got it sorted. Just wanna say thank you to customer service for walking me through the reversal process.
Millie Payne –
Excellent in an understatement
Lillie Bales –
Nice packaging. Quality product.
Lyndsey Campbell –
Product selection, customer service, and overall quality are the best I’ve received!
Rossina Koshy –
In terms of pricing, quality, and delivery, they are the finest in the business.
Desiree Clayton –
The online store makes it simple to locate items and place purchases.
Fast and well-packaged shipment.
Gordon Wheeler –
Ordered a few products and am planning on ordering in bulk the next time around.
Moyo Omowabi –
Saw a lot of improvement with research. Very fast results, shows me that its good products and does what is promised.
James Wirch –
Very serious company. Been collaborating with them since my company has started and I can put my word out for them
Rouben Petrov –
You guys have that small business feel to you, caring about customer concerns and not being swallowed by corporative concepts and money. I love how safe I feel here
Cilke Sleet –
Let me just say I will never switch suppliers again
Penny Halloway –
My medical coworkers and I think that this product is best ordered from here. We’ve dealt with other companies and always had issues. But customer service is also amazing to speak with because they show that they care to help.
Sarah Diaz –
Compañía increíble. Biotech peptides ha ganado un cliente de por vida
Jay Mendoza –
seen huge difference in research, will keep using their stuff
Angel Torres –
I was skeptical when you first got on the market, but I followed your reviews and people seem happy with the peptides you offer. This was my second order and so far so good. If everything goes well again I might switch suppliers and make you my no. 1
Hal Baker –
Pleased with the fast service!
jessie gomez –
I sent them an email telling them I’ll need to buy this peptide in bulk soon, so they assured me they’d place an order and have it all by the time I need it. Sure enough they had everything ready for me.
Pat Conlan –
Products have always arrived on schedule and with no damages. Excellent service as well.
jarod buckley –
We’ve been doing business with them for little over a year now. Everything is OK, with just a few minor issues that were quickly resolved. The peptides are always handled with the utmost care, making them effective. We’ve had a few vial breaks, but that’s understandable given the circumstances. Our items have been delayed due to the storm, but they were able to send us new ones since our old ones had become useless.
Marcel Dawson –
10/10 peptides!
Chris Santiago –
A handful of the vials arrived broken. The replacement ones were sent out after I called and spoke with them.
Katie Manguino –
Nothing compares to Biotechs service and peptides. I needed help with checking out. The site did not seem to take my order and was saying unable to complete it. I e-mailed them and they were able to take listen and fix the issue at hand and take my order in. Got a confirmation code right away and order was shipped out within 24 hours.
Carl Ibrahim –
Will buy again
Preston Ibeneme –
Very cool peptides
Dallas Koizumi –
I recommended you guys to all of my coworkers. Very fast shipping and prices are not bad. I’d also suggest just the regular shipping option. No need for expedited, they’ll get your stuff in on time no problem.
Jake Domine –
Been a few months That I have been using this peptide in my research and I’m starting to see a difference in my results. The peptides were easy to synthesize, same process as any peptide.
Brent Katt –
Nice free shipping option at checkout!