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Kisspeptin-10 (10mg)
Kisspeptin-10 (10mg) COA
Kisspeptin-10 (10mg) LC
Kisspeptin-10 (10mg) MS

Kisspeptin-10 (10mg)

(27 customer reviews)

$52.00

Kisspeptin peptides are Synthesized and Lyophilized in the USA.

Discount per Quantity

Quantity 5 - 910 +
Discount 5%10%
Price $49.40$46.80
Orders over $200 receive:
FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
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SKU: Kisspeptin-10-10mg Category:

Description

Kisspeptin-10 Peptide

Research into the Kisspeptin-10 peptide suggests that the compound may act as a mediator of endocrine signaling during crucial reproductive or developmental stages. It may potentially impact development and regulation of blood vessels and renal function, and some studies have suggested it may mitigate cancer cell proliferation and metastasis. Also known as Metastin, this peptide also appears to impact the gonadotropin-releasing hormone or GnRH.[1]

Specifications

Other Known Titles: KISS-1, Protein KISS-1, Metastin, Kp-10 peptide

Sequence: YNWNSFGLRF

Molecular Formula: C63H83N17O14

Molecular Weight: 1302.4 g/mol

Kisspeptin-10 Research

Kisspeptin-10 and Gonadotropin-Releasing Hormones, Testosterone
The Hypothalamus in the brain is considered to be responsible for the production and secretion of Gonadotropin-Releasing Hormones (GnRH). It appears to be secreted at the top of the hypothalamic-pituitary-gonadal axis, and may control the downstream production of follicle-stimulating hormone (FSH) and luteinizing hormones (LH). Primarily, these hormones are associated with the maturation of ova and sperm in the female and male reproductive organs, respectively. Researchers have posited that Kisspeptin may affect the hypothalamic-pituitary-gonadal axis, possibly resulting in an increase of LH and FSH release in the bloodstream. Studies suggest that this release may induce a ~3x increase in testosterone concentration within the bodies of male animals.[2] In addition, it the peptide has been suggested to hold potential in regulating the normal pulsatile release of sex hormones. These effects seem to be directly proportional to the concentration of Kisspeptin present in the organism. Kisspeptin is suggested to obscure individual pulses at extremely high concentrations, appearing to cause a continuous release of LH from the anterior pituitary glands.

Kisspeptin-10 and Energy Metabolism
The nutrient or energetic status of an organism appears to affect neurons which secrete endogenous Kisspeptin-10, potentially resulting in suppression of GnRH release. Extreme variations in this balance have been associated with infertility.[3] Researchers conclude that “the novel role of kisspeptin neurons as active players within the neuronal circuits that govern energy balance is discussed, offering evidence of a bidirectional role of these neurons as a nexus between metabolism and reproduction.” Kisspeptin may be responsible for the regulation of energy, and depleting the Kisspeptin receptor (Kiss1r) may augment lipid retention, simultaneously reducing energy consumption.

Kisspeptin-10 and Cancer Cells
Kisspeptin has been suggested to influence the malignancy of melanomas. This assumption has been contributed to the peptide’s potential to impact the migration of cancerous cells through reducing the adhesive capacity of these cells. Cancer cell cultures taken from organs such as the breast, urinary bladder, gastrointestinal tract, prostate, pancreas, ovaries, epidermis, and thyroid, all appear to exhibit reduced expression of Kisspeptin, which may support environments for metastasis. Research has also linked the levels of natural Kisspeptin and melatonin production to sunlight.[4] Upon extensive sun exposure, murine models were assessed, reporting excess Kisspeptin and melatonin production. When tumorigenic cells were introduced in these mice, heightened tumor growth and volume were reported following extended sun exposure.

Kisspeptin-10 and Mood
Reproductive activites, energy levels, and certain behavioral factors are considered to be influenced by hormonal release cycles. Researchers posit that reproduction and energy homeostasis may be affected by Kisspeptin levels. Recent studies have observed enhanced limbic brain activity such as increased reward-seeking behavior and enthusiasm upon increased Kisspeptin exposure.[5] Research in this area is ongoing.

Kisspeptin-10 and Kidney, Heart
Other than its potential mitigatory role in tumor metastasis, Kisspeptin appears to have regulatory capacity within the kidney and heart. Kisspeptin-10 and its receptors appear to be expressed in renal tissues, and studies have reported that the Kiss-1 receptor knockouts fail to regulate glomerular development.[6] The scientists report that “Kisspeptins and kisspeptin receptor are altered in the kidney tissues of chronic renal impairment, raising the possibility of their pathophysiological roles in chronic renal failure.” Furthermore, Kisspeptin has been observed to control vasoconstriction and sometimes cardiac output under specific laboratory conditions.[7] Such regulation may be related to Kisspeptin’s potential to impact vascular development and response to injury, the exact mechanism of which remains to be elucidated.

Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.

 

References

  1. Jayasena CN, Nijher GM, Comninos AN, Abbara A, Januszewki A, Vaal ML, Sriskandarajah L, Murphy KG, Farzad Z, Ghatei MA, Bloom SR, Dhillo WS. The effects of kisspeptin-10 on reproductive hormone release show sexual dimorphism in humans. J Clin Endocrinol Metab. 2011 Dec;96(12):E1963-72. doi: 10.1210/jc.2011-1408. Epub 2011 Oct 5. PMID: 21976724; PMCID: PMC3232613.
  2. George JT, Veldhuis JD, Roseweir AK, Newton CL, Faccenda E, Millar RP, Anderson RA. Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men. J Clin Endocrinol Metab. 2011 Aug;96(8):E1228-36. doi: 10.1210/jc.2011-0089. Epub 2011 Jun 1. PMID: 21632807; PMCID: PMC3380939.
  3. Navarro VM. Metabolic regulation of kisspeptin – the link between energy balance and reproduction. Nat Rev Endocrinol. 2020 Aug;16(8):407-420. doi: 10.1038/s41574-020-0363-7. Epub 2020 May 19. PMID: 32427949; PMCID: PMC8852368.
  4. Pazarci P, Kaplan H, Alptekin D, Yilmaz M, Lüleyap U, Singirik E, Pelit A, Kasap H, Yegani A. The effects of daylight exposure on melatonin levels, Kiss1 expression, and melanoma formation in mice. Croat Med J. 2020 Feb 29;61(1):55-61. doi: 10.3325/cmj.2020.61.55. PMID: 32118379; PMCID: PMC7063558.
  5. Comninos AN, Wall MB, Demetriou L, Shah AJ, Clarke SA, Narayanaswamy S, Nesbitt A, Izzi-Engbeaya C, Prague JK, Abbara A, Ratnasabapathy R, Salem V, Nijher GM, Jayasena CN, Tanner M, Bassett P, Mehta A, Rabiner EA, Hönigsperger C, Silva MR, Brandtzaeg OK, Lundanes E, Wilson SR, Brown RC, Thomas SA, Bloom SR, Dhillo WS. Kisspeptin modulates sexual and emotional brain processing in humans. J Clin Invest. 2017 Feb 1;127(2):709-719. doi: 10.1172/JCI89519. Epub 2017 Jan 23. PMID: 28112678; PMCID: PMC5272173.
  6. Shoji I, Hirose T, Mori N, Hiraishi K, Kato I, Shibasaki A, Yamamoto H, Ohba K, Kaneko K, Morimoto R, Satoh F, Kohzuki M, Totsune K, Takahashi K. Expression of kisspeptins and kisspeptin receptor in the kidney of chronic renal failure rats. Peptides. 2010 Oct;31(10):1920-5. doi: 10.1016/j.peptides.2010.07.001. Epub 2010 Jul 17. PMID: 20621140.
  7. Sato K, Shirai R, Hontani M, Shinooka R, Hasegawa A, Kichise T, Yamashita T, Yoshizawa H, Watanabe R, Matsuyama TA, Ishibashi-Ueda H, Koba S, Kobayashi Y, Hirano T, Watanabe T. Potent Vasoconstrictor Kisspeptin-10 Induces Atherosclerotic Plaque Progression and Instability: Reversal by its Receptor GPR54 Antagonist. J Am Heart Assoc. 2017 Apr 14;6(4):e005790. doi: 10.1161/JAHA.117.005790. PMID: 28411243; PMCID: PMC5533042.
All orders ship same day if placed by 12 PST.
This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law.  Only qualified and licensed professionals should handle these products.  Any information found on Biotech Peptides is strictly for educational purposes only.  Refer to our terms and conditions for more details.

Additional information

Brand

Biotech Peptides

27 reviews for Kisspeptin-10 (10mg)

  1. Sam Downey –

    I accidentally disputed the charge on my card and it was a bit of a problem with my bank but we got it sorted. Just wanna say thank you to customer service for walking me through the reversal process.

  2. Millie Payne –

    Excellent in an understatement

  3. Lillie Bales –

    Nice packaging. Quality product.

  4. Lyndsey Campbell –

    Product selection, customer service, and overall quality are the best I’ve received!

  5. Rossina Koshy –

    In terms of pricing, quality, and delivery, they are the finest in the business.

  6. Desiree Clayton –

    The online store makes it simple to locate items and place purchases.
    Fast and well-packaged shipment.

  7. Gordon Wheeler –

    Ordered a few products and am planning on ordering in bulk the next time around.

  8. Moyo Omowabi –

    Saw a lot of improvement with research. Very fast results, shows me that its good products and does what is promised.

  9. James Wirch –

    Very serious company. Been collaborating with them since my company has started and I can put my word out for them

  10. Rouben Petrov –

    You guys have that small business feel to you, caring about customer concerns and not being swallowed by corporative concepts and money. I love how safe I feel here

  11. Cilke Sleet –

    Let me just say I will never switch suppliers again

  12. Penny Halloway –

    My medical coworkers and I think that this product is best ordered from here. We’ve dealt with other companies and always had issues. But customer service is also amazing to speak with because they show that they care to help.

  13. Sarah Diaz –

    Compañía increíble. Biotech peptides ha ganado un cliente de por vida

  14. Jay Mendoza –

    seen huge difference in research, will keep using their stuff

  15. Angel Torres –

    I was skeptical when you first got on the market, but I followed your reviews and people seem happy with the peptides you offer. This was my second order and so far so good. If everything goes well again I might switch suppliers and make you my no. 1

  16. Hal Baker –

    Pleased with the fast service!

  17. jessie gomez –

    I sent them an email telling them I’ll need to buy this peptide in bulk soon, so they assured me they’d place an order and have it all by the time I need it. Sure enough they had everything ready for me.

  18. Pat Conlan –

    Products have always arrived on schedule and with no damages. Excellent service as well.

  19. jarod buckley –

    We’ve been doing business with them for little over a year now. Everything is OK, with just a few minor issues that were quickly resolved. The peptides are always handled with the utmost care, making them effective. We’ve had a few vial breaks, but that’s understandable given the circumstances. Our items have been delayed due to the storm, but they were able to send us new ones since our old ones had become useless.

  20. Marcel Dawson –

    10/10 peptides!

  21. Chris Santiago –

    A handful of the vials arrived broken. The replacement ones were sent out after I called and spoke with them.

  22. Katie Manguino –

    Nothing compares to Biotechs service and peptides. I needed help with checking out. The site did not seem to take my order and was saying unable to complete it. I e-mailed them and they were able to take listen and fix the issue at hand and take my order in. Got a confirmation code right away and order was shipped out within 24 hours.

  23. Carl Ibrahim –

    Will buy again

  24. Preston Ibeneme –

    Very cool peptides

  25. Dallas Koizumi –

    I recommended you guys to all of my coworkers. Very fast shipping and prices are not bad. I’d also suggest just the regular shipping option. No need for expedited, they’ll get your stuff in on time no problem.

  26. Jake Domine –

    Been a few months That I have been using this peptide in my research and I’m starting to see a difference in my results. The peptides were easy to synthesize, same process as any peptide.

  27. Brent Katt –

    Nice free shipping option at checkout!

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