LL-37 (5mg)

(27 customer reviews)


LL-37 peptides are Synthesized and Lyophilized in the USA.

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Price $81.70$77.40
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SKU: LL-37-5mg Category:


LL-37 Peptide

LL-37 is a Cathelicidin, a protein family where the members exhibit diverse functions. These peptides, which are produced by macrophages and polymorphonuclear leukocytes (both types of white blood cells), have been suggested to exhibit bactericidal action. They have been suggested to have shown other substantial potential impacts as well. The entire group is classified as antimicrobial peptides (AMPs). LL-37, in particular, has been researched in relation to autoimmune disease, cancer, and wound healing.[1] For example, researchers note that “Corneal and conjunctival epithelia express LL-37 as part of mucosal innate immunity to protect against bacterial and viral ocular infections.”


Other Known Titles: CAP-18

Molecular Formula: C205H340N60O53

Molecular Weight: 4493.33 g/mol

Sequence: Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-GluLys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-ArgThr-Glu-Ser

LL-37 Peptide Research

LL-37 and Inflammatory Diseases
LL-37, although essentially researched as an antimicrobial peptide, has also been examined in research related to different inflammatory diseases such as lupus, rheumatoid arthritis, psoriasis, and atherosclerosis. LL-37 researchers suggest the peptide’s diverse immune system modulating behaviors based on the type of cells involved and the local inflammatory environment. It has been suggested to reduce apoptotic death of keratinocytes, improve IFN-alpha synthesis, suppress signaling through toll-like receptor 4 (TLR4), modify chemotaxis of neutrophils and eosinophils,[2] trigger IL-18 production and potentially reduce levels of atherosclerotic plaques. Interestingly, LL-37 (aka CAP-18) appears to stimulate the immune system in a different manner depending on the trigger. Cell culture studies have observed the importance of the inflammatory environment in determining the immune response to LL-37. T-cells appear to improve inflammatory action via LL-37 when they are not activated, but minimize the inflammatory action when already activated. The peptide appears to mediate homeostasis of immunological response, thus controlling it from being hyperactive in instances of infection. There is a strong correlation between the peptide levels and the extent of the disease. Initially, LL-37 / CAP-18 was thought to promote autoimmune disorders, but recent results have suggested it may actually help to abate the damage.[3] The researchers outline that the peptide has a role in “in the modulation of immune and inflammatory pathways and their effects on autoimmune and inflammatory diseases.” High levels of the peptide may thus help check further increased inflammation.

LL-37 and Antimicrobial Characteristics
LL-37 appears to be an important biomolecule of innate immunity and one of the initial proteins to activate when faced with an infection. Research findings in skin infection studies suggests that the peptide, though present in limited skin cells, appears to accumulate very fast when invading pathogens are present.[4] It may work in conjunction with other proteins, like beta-defensin 2, to potentially fight infection. LL-37 appears to bind to bacterial lipopolysaccharide (LPS) of the outer membrane of gram-negative bacteria. LPS is considered critical for the membrane integrity of these bacteria. The possible action of LL-37 to bind to and interfere with LPS may make it toxic for certain bacteria. LL-37 may exert action against gram-positive pathogens, as suggested in research in staph infections and other serious bacteria. Research indicates that LL-37 / CAP-18 may improve lysozyme’s action, which destroys gram-positive bacteria like Staph aureus.

LL-37 and Lung Disease
LPS is found in several different organisms and, in some instances, may become airborne when an environment is contaminated by mold or other fungi. Normal lung tissue responds by producing mucus upon LPS inhalation. Unfortunately, the response is often insufficient to intercept toxic dust syndrome and respiratory diseases like asthma and COPD. LL-37 has been studied in research of toxic dust syndrome.[5] LL-37 appears to promote the proliferation of epithelial cells and the closure of wounds in lung diseases. The peptide may attract airway epithelial cells to injury sites and help vascularization, wound healing, and supply of nutrition to the newly formed tissue.

LL-37 Peptide and Arthritis
Research in rats models observed high LL-37 levels in joints of rat models of rheumatoid arthritis. It is yet unknown if is the cause or cure for the condition. However, several findings indicate the potential of the peptide in inflammation. LL-37 deficiency does not appear to change the outcomes in animal models of arthritis or lupus.[6] Animals expressing the peptide may show the same disease outcome as those lacking the peptide. These results indicate that the physiological reactions in enhanced levels of cathelicidins in arthritis are incidental. Peptides derived from LL-37 may reduce collagen damage which occurs in inflammatory arthritis. Direct introduction of these peptides to arthritic joints in rats was observed to reduce both the severity of the disease as well as serum levels of antibodies against type II collagen. Direct involvement of interleukin-32 (IL-32) in the severity of inflammatory arthritis has been reported. LL-37 and its derivatives may have the ability to regulate the level of IL-32 response. Researchers consider that it would be reasonable to speculate that the peptide is protective in this disease scenario. Synovial fluid fibroblasts increase toll-like receptor 3 levels, with scientists consider worsens the arthritic condition by increasing inflammatory cytokine expression. LL-37 may interact with TLR4 and either promote pro-inflammatory or anti-inflammatory outcomes.[7] It is yet to be confirmed if LL-37 / CAP-18 mediates the same effect against the backdrop of increased TLR3. The peptide has been examined in experimental studies to selectively decrease pro-inflammatory macrophage responses, and researchers suggest its regulation of inflammation to be selective.

LL-37 and Intestinal Cancer
Cell culture-based research studies have suggested potential multifaceted functions of LL-37 in the intestine. The peptide appears to improve the migration of cells necessary for epithelial barrier maintenance of the intestine. LL-37 may reduce apoptosis when there is intestinal inflammation, helping to decline the causes of inflammation and the associated pathogenesis.  Studies suggest LL-37 pairs with beta-defensin 2 to help in wound healing. Research indicates that the peptides work simultaneously to repair and maintain the intestinal epithelium while decreasing TNF-related cell death.[8] Despite being the principal compounds researched in inflammatory bowel conditions, TNF-alpha inhibitors have been reported to exhibit adverse ancillary impacts. LL-37-exposure may potentially reduce the dependence on TNF-alpha inhibitors. Research in the peptide action on cancer cells has generated mixed reports.

LL-37 and Blood Vessel Growth
The peptide appears to produce prostaglandin E2 (PGE2) in endothelial cells. In endothelial cells, PGE2 promotes the development of blood vessels via a process called angiogenesis. It is crucial to regulate angiogenesis as it impacts cancer development, stroke outcomes, heart disease, wound healing, and more. LL-37 helps to study angiogenesis in-depth to promote it in cardiac disease and discourage cancer milieu.

Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.



  1. Gordon YJ, Huang LC, Romanowski EG, Yates KA, Proske RJ, McDermott AM. Human cathelicidin (LL-37), a multifunctional peptide, is expressed by ocular surface epithelia and has potent antibacterial and antiviral activity. Curr Eye Res. 2005 May;30(5):385-94. doi: 10.1080/02713680590934111. PMID: 16020269; PMCID: PMC1497871.
  2. Alalwani SM, Sierigk J, Herr C, Pinkenburg O, Gallo R, Vogelmeier C, Bals R. The antimicrobial peptide LL-37 modulates the inflammatory and host defense response of human neutrophils. Eur J Immunol. 2010 Apr;40(4):1118-26. doi: 10.1002/eji.200939275. PMID: 20140902; PMCID: PMC2908514.
  3. Kahlenberg JM, Kaplan MJ. Little peptide, big effects: the role of LL-37 in inflammation and autoimmune disease. J Immunol. 2013 Nov 15;191(10):4895-901. doi: 10.4049/jimmunol.1302005. PMID: 24185823; PMCID: PMC3836506.
  4. Reinholz M, Ruzicka T, Schauber J. Cathelicidin LL-37: an antimicrobial peptide with a role in inflammatory skin disease. Ann Dermatol. 2012 May;24(2):126-35. doi: 10.5021/ad.2012.24.2.126. Epub 2012 Apr 26. PMID: 22577261; PMCID: PMC3346901.
  5. Golec M. Cathelicidin LL-37: LPS-neutralizing, pleiotropic peptide. Ann Agric Environ Med. 2007;14(1):1-4. PMID: 17655171.
  6. Moreno-Angarita A, Aragón CC, Tobón GJ. Cathelicidin LL-37: A new important molecule in the pathophysiology of systemic lupus erythematosus. J Transl Autoimmun. 2019 Dec 17;3:100029. doi: 10.1016/j.jtauto.2019.100029. PMID: 32743514; PMCID: PMC7388365.
  7. Singh D, Vaughan R, Kao CC. LL-37 peptide enhancement of signal transduction by Toll-like receptor 3 is regulated by pH: identification of a peptide antagonist of LL-37. J Biol Chem. 2014 Oct 3;289(40):27614-24. doi: 10.1074/jbc.M114.582973. Epub 2014 Aug 4. PMID: 25092290; PMCID: PMC4183800.
  8. Piktel E, Niemirowicz K, Wnorowska U, Wątek M, Wollny T, Głuszek K, Góźdź S, Levental I, Bucki R. The Role of Cathelicidin LL-37 in Cancer Development. Arch Immunol Ther Exp (Warsz). 2016 Feb;64(1):33-46. doi: 10.1007/s00005-015-0359-5. Epub 2015 Sep 22. PMID: 26395996; PMCID: PMC4713713.
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This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law.  Only qualified and licensed professionals should handle these products.  Any information found on Biotech Peptides is strictly for educational purposes only.  Refer to our terms and conditions for more details.

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27 reviews for LL-37 (5mg)

  1. Demi Evans

    Having just moved to the states I browsed around for a reliable peptide vendor and Im glad I found Biotech. I’ve place 3 orders so far and its been a breeze.

  2. Leo Edwards

    Great products and overall a very good shopping experience

  3. Kai Evans

    This is my go-to place for everything peptide related. love the fact that bacteriostatic water is free. – Kai

  4. Zhane Edwards

    Great experience

  5. Janavia Shilo

    My company prefers for us to buy peptides at Biotech due to their reasonable prices and reliability with shipping. We also love how they guarantee money back or even a solution to fix any issues that comes up with peptides. Great service towards customers.

  6. Rae Krechia Jones

    This is a holy grail for antimicrobial purposes. Got amazing results from my research

  7. Maranda Donelle

    I got amazing results from this product. Very solid research

  8. Charolette Parmer

    Top-notch products, not gonna lie. I really wanted to hate you guys when you first came out, since the company I was using was a wee bit cheaper, but you’re really cool and I decided to splurge a bit on more qualitative products.

  9. Joe Tretter

    I’ve been buying from here so much I think I need a 50% discount code, lol. Just kidding. Unless you’re down 😀

  10. Amber Lee

    Wish they had an app as well instead of just a website.

  11. Dillon Tolbert

    Great selection of products, and great service too! The quality on this product is really good too.

  12. Trevor Miles

    This company has never let me down and I cannot say enough good stuff about it

  13. Julian Batista

    Thanks for the free Bac waters!

  14. Aria Naomi

    Peptides came in on time! Our lab runs on a strict schedule so we are very happy nothing came in broken as well.

  15. Natalie Reed

    I work for small research company and our budget can take us so far with purchases. With all the cost going up lately we could no longer afford to buy products from our peptide provider. After shopping around for a week I finally found biotech. The prices are in our range and the products turned out to be have the outmost greatest quality. A happy find!

  16. Jack Agoopi

    Super quick with sending stuff out.

  17. Harold Barns

    Everything arrived without incident. There were no misplaced or shattered vials or bottles. Nothing seems to have been altered or damaged. However, I would have appreciated if the box’s contents were clearly identified by a label.

  18. mark slader

    I’m glad a buddy referred me to this business. Because biotech offers both bargains and speedy delivery, it can’t be beaten in terms of value for money!

  19. Trey Osborn

    The blog section of the website is both educational and entertaining to me. Short, concise, and constantly up-to-date, they’re the best.

  20. Quinn Embers

    As a new client, I had a lot of questions and concerns, but customer support was always there to answer them. Thank you for taking care of all my concerns.

  21. Mario D. G.

    A mistake was made in shipping my order and they swiftly shipped the correct one while allowing me to retain possession of the incorrect product that was first sent to me by mistake.

  22. Robyn Richardson

    its great stuff

  23. Chance Hollingsworth

    Packaging is very slick and neat. I like it

  24. Justin Wade

    The way these peptides preserve is very cool. You can keep them for a really long time if you’re following the guidelines

  25. Dale Leath

    This is the unquestionable quality all over. I do only wish the packaging was different. Too much of a gamble with the fragile vials.

  26. Van Naylor

    Great stuff, no extra stunts or ads on their part. Website is easy to use and no issues with getting the peptides I want and need.

  27. Easton W

    Peptides are good, service is good. Overall great place to buy peptides.

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