Description
Matrixyl Peptide
Matrixyl is a lipopeptide, combining fatty acids with amino acids. It is also considered a synthetic isomer (an isomer is a molecule with an identical structure to another molecule but different atomic components). The active element in Matrixyl is a second peptide known as Micro-collagen.[1] Researchers report that “The conjugation with the palmitoyl moiety [may] result in more effective delivery across the skin and better stability to skin proteases.”
Specifications
OTHER KNOWN TITLES: palmitoyl pentapeptide-3
MOLECULAR FORMULA: C39H75N7O10
MOLECULAR WEIGHT: 802.05 g/mol
SEQUENCE: Pal-Lys-Thr-Thr-Ser-OH or Pal-KTTS-OH
Matrixyl Research
Matrixyl appears to combine two matrikines, namely palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7. It is a small molecule that is considered to be highly porous in the skin. Structurally, it is similar to collagen precursors. Researchers suggest that the peptide may act to promote the process of repair in the lower layers of damaged skin cell tissues, and has also been termed an “anti-wrinkle” peptide due to the apparent impact it has on wrinkle depth and crease development. It appears to participate in the neosynthesis of extracellular matrix macromolecules.[2] For example, the researchers note that “Delicate balance between the wound healing properties and pro-fibrotic abilities of pentapeptide should be considered for … scar prevention.” In the presence of Matrixyl, the dermal layers may begin to heal themselves, possibly resulting in an acceleration of the natural processes of healing and closure of wounds via cells known as fibroblasts. Fibroblasts appear to gradually lose their capacity for collagen production over time.
Matrixyl was discovered through two independent streams of dermatological research: the search for substances that accelerate repair in damaged skin cells and the exploration of the causes of wrinkle development.[3] Matrixyl appears to act as a signaling molecule that may potentially stimulate collagen and elastin production. Similar to copper peptides, Matrixyl has been suggested to stimulate the lower layers of skin cells to repair damaged tissues in an accelerated manner. Matrixyl appears to stimulate the “matrix” layers in the epidermis – primarily collagen and fibronectin. Cell aging has been divided by researchers into intrinsic and extrinsic types. Intrinsic cell aging occurs via a degenerative process characterized by the loss of collagen. This process results in wrinkling and thinning of the skin and loss of elasticity, and increased stiffness. Matrixyl may signal the extracellular matrix to produce elastin and collagen, potentially combatting cell aging phenomenon.
Researchers have suggested that in the course of study findings, that Matrixyl may potentially induce collagen synthesis by up to 117% over control levels, collagen IV synthesis by up to 327%, and hyaluronic acid synthesis by up to 267%. [4] The researchers also noted that certain synergistic compounds may have contributed to an increase in these finding results.[5]
Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.
References
- Errante F, Ledwoń P, Latajka R, Rovero P, Papini AM. Cosmeceutical Peptides in the Framework of Sustainable Wellness Economy. Front Chem. 2020 Oct 30;8:572923. doi: 10.3389/fchem.2020.572923. PMID: 33195061; PMCID: PMC7662462.
- Park H, An E, Cho Lee AR. Effect of Palmitoyl-Pentapeptide (Pal-KTTKS) on Wound Contractile Process in Relation with Connective Tissue Growth Factor and α-Smooth Muscle Actin Expression. Tissue Eng Regen Med. 2017 Jan 19;14(1):73-80. doi: 10.1007/s13770-016-0017-y. PMID: 30603464; PMCID: PMC6171572.
- Robinson LR, Fitzgerald NC, Doughty DG, Dawes NC, Berge CA, Bissett DL. Palmitoyl pentapeptide provides improvement in photoaged human facial skin. Int J Cosmet Sci. 2005 Jun;27(3):155-60. doi: 10.1111/j.1467-2494.2005.00261.x. PMID: 18492182.
- Tałałaj U, Uścinowicz P, Bruzgo I, Surażyński A, Zaręba I, Markowska A. The Effects of a Novel Series of KTTKS Analogues on Cytotoxicity and Proteolytic Activity. Molecules. 2019 Oct 15;24(20):3698. doi: 10.3390/molecules24203698. PMID: 31618846; PMCID: PMC6832239.
- Park H, An E, Cho Lee AR. Effect of Palmitoyl-Pentapeptide (Pal-KTTKS) on Wound Contractile Process in Relation with Connective Tissue Growth Factor and α-Smooth Muscle Actin Expression. Tissue Eng Regen Med. 2017 Jan 19;14(1):73-80. doi: 10.1007/s13770-016-0017-y. PMID: 30603464; PMCID: PMC6171572.
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After placing an order yesterday, my package arrived this morning. There were no issues with the turnaround time and the staff was very helpful and friendly.
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After a colleague suggested this to me, I’ve never looked for a new source of supplies again.
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Their team is always readily available to fix any issues or look at any of my concerns.
Chris Trillo –
This is one if the best topical peptides on the market overall and BP makes it so pure it is crazy how fast you see results in research.
Will Blumrick –
My package came in perfect condition and peptides looked great!
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This company has the fastest shipping I have ever experienced.
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The purity is unmatched. Best quality I have found in the past few years.
Duncan Clark –
I find their blog section very informative and reliable. Any time you lack knowledge about a certain substance, you can just go to their blog and they have some articles that can explain the peptide and what it helps with or research it has been in.
Damien Darkoski –
This is my first time ordering, hopefully everything will go smoothly. Have heard a lot of good things about the peptides and company from my fellow researchers.
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The best topical peptide out there hands down. This is the place to buy the highest quality Matrixyl