Receptor Grade IGF-1 LR3 (100mcg)

(23 customer reviews)


Receptor Grade IGF-1 LR3 peptides are Synthesized and Lyophilized in the USA.

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Price $25.65$24.30

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Receptor Grade IGF-1 LR3 Peptide

Receptor Grade IGF-1 LR3 peptide is a research reagent examined in studies on cellular growth, IGF receptors, and IGF binding proteins. It appears to be more powerful than rH IGF-1 and Media Grade IGF-1 LR3 due to an apparent significant improvement in its biological activity (since it exhibits a stronger affinity for the IGF receptor). This enhanced biological activity distinguishes between Receptor Grade IGF-1 LR3 and Media Grade (standard) IGF-1 LR3. Media grade IGF-1 LR3 is routinely studied in cell cultures. It is also used as a research reagent (at an economical cost) for studies where biological potency is not crucial. Receptor Grade IGF-1 LR3 should be the reagent of choice to achieve optimum results when performing any animal study and cell-based assays. Growth of mammalian cells in the presence of low concentrations of Long R3 IGF-1 appears to result in better productivity than standard concentrations of insulin and/or standard IGF-1.[1] Researchers report that the peptide “demonstrated equivalent or better performance using two recombinant CHO cell lines.” IGF-1 LR3 may be more capable of inducing the type 1 IGF receptor, potentially promoting an elevated level of intracellular signaling, cellular proliferation, and apoptosis inhibition.



Molecular Formula:C990H1528N262O300S7

Molecular Weight: 9,111 da



Receptor Grade IGF-1 LR3 Research

IGFB Binding and Biological Activity of IGF-1 LR3
The peptide appears to bring about a more pronounced impact than IGF-1 through a potential resistance in the association of IGFB.[2] The prolonged duration of action may help mediate the same biological impact while examining smaller concentrations of the receptor. Certain IGF-1 derivatives, including the GPE derivative, comprising only the last three N-terminal amino acids of the IGF-1 protein, have been suggested to exert positive action in animal research models of neurological damage such as stroke. However, the majority of the research aimed to unravel the action of IGF-1 derivatives has been executed in cell cultures.

Insulin-Like Growth Factor Receptor Interactions
Naturally produced IGF-1 hormones interact with at least two cell surface receptors: the IGF-1 receptor (IGF-1R) and the insulin receptor.[3] The researchers also note that “IR and IGF1R act as identical portals to the regulation of gene expression, with differences between insulin and IGF-1 effects due to a modulation of the amplitude of the signal created by the specific ligand-receptor interaction.” The IGF-1R is referred to as the “physiologic” receptor due to its potential higher affinity (approximately 100 times higher) for IGF-1 as compared to the insulin receptor. The association of IGF-1 and IGF-1R apparently leads to changes in metabolism, prevention of cell death (apoptosis), promotion of cell growth (hypertrophy), differentiation and cell division (hyperplasia), normal development, and even malignant growth. IGF-1R has been researched for its involvement in diverse types of cancer, such as prostate, breast, and lung cancer.[4] IGF-1 also appears to stimulate insulin receptors and activate them, thereby promoting glucose uptake from the bloodstream by cells. IGF-1 displays a three-fold influence on muscle cells. At the onset, IGF-1 may promote an increase in the number of muscle cells, also known as hyperplasia. Secondly, IGF-1 appears to influence the life span of satellite cells of the skeletal muscles.[5] Satellite cells provide nutritional support to muscle cells, thereby helping them to operate efficiently. IGF-1 may help to build muscle tissue by improving the lifespan of these cells. Finally, IGF-1 appears to promote the differentiation of myoblasts.[6] In other words, it may encourage the commitment of stem cell progeny from non-specific pluripotent stem cells to dedicated muscle tissue. To conclude, IGF-1 may improve muscle development by enhancing the rate at which generic stem cells are transformed into muscle cells.

Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.



  1. Thomas, James N., and Victor Fung. “Comparison of long R3 IGF-1 with insulin in the support of cell growth and recombinant protein expression in CHO cells.” Animal Cell Technology. Butterworth-Heinemann, 1994. 91-95.
  2. Assefa, Biruhalem, et al. “Insulin-like growth factor (IGF) binding protein-2, independently of IGF-1, induces GLUT-4 translocation and glucose uptake in 3T3-L1 adipocytes.” Oxidative Medicine and Cellular Longevity 2017 (2017).
  3. Boucher J, Tseng YH, Kahn CR. Insulin and insulin-like growth factor-1 receptors act as ligand-specific amplitude modulators of a common pathway regulating gene transcription. J Biol Chem. 2010 May 28;285(22):17235-45. doi: 10.1074/jbc.M110.118620. Epub 2010 Apr 1. PMID: 20360006; PMCID: PMC2878077.
  4. Shanmugalingam T, Bosco C, Ridley AJ, Van Hemelrijck M. Is there a role for IGF-1 in the development of second primary cancers? Cancer Med. 2016 Nov;5(11):3353-3367. doi: 10.1002/cam4.871. Epub 2016 Oct 13. PMID: 27734632; PMCID: PMC5119990.
  5. Yoshida T, Delafontaine P. Mechanisms of IGF-1-Mediated Regulation of Skeletal Muscle Hypertrophy and Atrophy. Cells. 2020 Aug 26;9(9):1970. doi: 10.3390/cells9091970. PMID: 32858949; PMCID: PMC7564605.
  6. Aboalola D, Han VKM. Different Effects of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor-2 on Myogenic Differentiation of Human Mesenchymal Stem Cells. Stem Cells Int. 2017;2017:8286248. doi: 10.1155/2017/8286248. Epub 2017 Dec 14. PMID: 29387091; PMCID: PMC5745708.
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This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law.  Only qualified and licensed professionals should handle these products.  Any information found on Biotech Peptides is strictly for educational purposes only.  Refer to our terms and conditions for more details.

Dr. Usman

Dr. Usman (BSc, MBBS, MaRCP) completed his studies in medicine at the Royal College of Physicians, London. He is an avid researcher with more than 30 publications in internationally recognized peer-reviewed journals. Dr. Usman has worked as a researcher and a medical consultant for reputable pharmaceutical companies such as Johnson & Johnson and Sanofi.

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Biotech Peptides

23 reviews for Receptor Grade IGF-1 LR3 (100mcg)

  1. Alex Morales

    Biotech Peptides is my number one supplier. I always get my stuff on time and they are always very professional

  2. Noah Young

    Zero issues with Biotech so far

  3. Anders Tim

    As a returning customer over the past year, I find the products outstanding with great customer service, always delivered on time and the results from what I test is second to none.

  4. Charles Gill Charles Gill

    Had some issues regarding shipment. The guy working customer service was awesome and fixed it right away. Got the product on time even with the issues! Will defiantly be buying from here again.

  5. Grace Chamberlain

    From their reviews so far I see that they’re great. I just want to compliment how easy it is to buy the products and how simple the site was.

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  7. Rory Dean

    I’ve seen a lot of buzz around this company and their pure products lately and I ordered it myself. Hopefully, it lives up to the expectations

  8. Joy Kim

    They’re great, I just wish they had an easier way to let me know peptides are back in stock instead of having to check everyday.

  9. Alex Mitrushi

    Orders came in without a hitch. Easy process. Great stuff

  10. Heather Knauss

    love the service representatives, cant find better prices either

  11. Patrick O’Brian

    Been buying from them since July, so been with them almsot a year. Great stuff, they never disapoint.

  12. Hanna Byrne

    First timer with biotech. They were recommened to me by a work friend. Seem to have the best prices around AND good quality peptides so giving them a try.

  13. Oliver Walsh

    My company is very satisfied with Biotech. Good products, fast delivery and send out.

  14. James

    using them a year now, only had one vial broken out of maybe a 100 that I have recieved.

  15. Silas Allen

    I believe the products and service speak for themselves. Products are the real deal.

  16. Finley Alvarez

    great stuff!

  17. Steve Krulin

    They carry a lot of of different peptides. Good variety.

  18. Penny Turner

    All their products are of the highest purtiy. Have not had a terrible experince with them.

  19. Andy Vosseler

    Restocks don’t happen as frequently as I’d like. I have had to wait weeks once for a few peptides I needed for my research which set me back.

  20. Alec Beltran

    Taylor is great, My order got lost in the mail and they were able to overnight me my entire order again with no extra charges!

  21. Joan Vega

    Shipment is fast, Recieved my order well before the time I thought it would come.

  22. Troy Kraft

    Been a repeat customer for a while now. Biotech has always met my expectations as a company and with their products. It’s good quality products for a pretty good price which is hard to come by nowadays.

  23. jmjuly1205

    This company is by far the best I’ve delt with, from shipping, to quality…

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