IGF-1 LR3 RECEPTOR GRADE SPECIFICATIONS
Molecular Weight: 9,111 da
Sequence: MFPAMP LSSLF VNGPR TLCGA ELVDA LQFVC GDRGF YFNKP TGYGS SSRRA PQTGIV DECCFR SCDLRR LEMY CAPLK PAKSA
CAS Number: 946870-92-4
What is Receptor Grade IGF-1 LR3 peptide?
Receptor Grade IGF-1 LR3 peptide is a prime research reagent which is used in studies for cellular growth, IGF receptors and IGF binding proteins. It is more powerful than rH IGF-1 and Media Grade IGF-1 LR3 in-vitro because of the significant improvement in its biological activity (since it exhibits a stronger affinity for the IGF receptor). This enhanced biological activity is the distinguishing factor between Receptor Grade IGF-1 LR3 and Media Grade (standard) IGF-1 LR3. Media grade IGF-1 LR3 is routinely used in commercial cell culture as compared to mammalian cell culture. It is also used as a research reagent (at an economical cost) for studies where biological potency is not crucial. Receptor Grade IGF-1 LR3 should be the reagent of choice to achieve optimum results when performing any animal study, in-vitro cell-based assays as well as commercial production. Growth of mammalian cells in the presence of low concentrations of Long R3 IGF-1 results in better productivity as compared to standard concentrations of insulin and/or standard IGF-1. IGF-1 LR3 is more capable of inducing the type 1 IGF receptor and thereby promotes an elevated level of intracellular signaling, cellular proliferation, and apoptosis inhibition.
Receptor Grade IGF-1 LR3 is therefore biologically more potent than standard IGF-1 LR3, in-vitro.
Hence, Receptor Grade IGF-1 LR3 is capable of delivering superior results in comparison to standard IGF-1 LR3.
IGFB Binding and the Increased Biological Activity of IGF-1 LR3
The peptide brings about a more pronounced effect than IGF-1 by resisting the association of IGFB. The prolonged duration of action helps to mediate the same biological effects while using smaller doses of the receptor. Certain IGF-1 derivatives, including the GPE derivative, comprising of only the last three N-terminal amino acids of the IGF-1 protein, have demonstrated therapeutic effects in neurological damages such as stroke. However, the majority of the research aimed to unravel the effects of IGF-1 derivatives have been executed in non-human animal models or cell culture.
Insulin Like Growth Factor Receptor Interactions
IGF-1 interacts with at least two cell surface receptors: IGF-1 receptor (IGF-1R) and the insulin receptor. The IGF-1R is referred to as the “physiologic” receptor due to its significantly higher affinity (approximately 100 times higher) for IGF-1 as compared to the insulin receptor. Association of IGF-1 and IGF-1R leads to changes in metabolism, prevention of cell death (apoptosis), promotion of cell growth (hypertrophy), differentiation and cell division (hyperplasia), normal development, and even malignant growth. IGF-1R has been involved in diverse types of cancer such as prostate, breast, and lung cancer. IGF-1 also stimulates insulin receptors and activates them, thereby promoting the uptake of glucose from the bloodstream by cells. IGF-1 displays a three-fold influence on muscle cells. At the onset, IGF-1 promotes an increase in the number of muscle cells which is also known as hyperplasia. Secondly, IGF-1 strongly influences the life span of satellite cells of the skeletal muscles. Satellite cells provide nutritional support to muscle cells, thereby helping them to operate efficiently. IGF-1 thus helps to build muscle tissue by improving the lifespan of these cells. Finally, IGF-1 promotes the differentiation of myoblasts. In other words, it encourages the commitment of stem cell progeny from non-specific pluripotent stem cells to dedicated muscle tissue. To conclude, IGF-1 improves muscle development by enhancing the rate at which generic stem cells are transformed into muscle cells.
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