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Mod GRF 1-29 (CJC-1295 NO DAC) 2mg

Mod GRF 1-29 (CJC-1295 NO DAC) (2mg)

(26 customer reviews)

$22.00

Mod GRF 1-29 peptides are Synthesized and Lyophilized in the USA.

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Quantity5 - 910 +
Discount5%10%
Price$20.90$19.80

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SKU: Mod-GRF-1-29-2mg Category:

Description

Modified GRF (1-29) Peptide

Modified GRF (1-29), or Mod GRF (1-29), is a synthetic peptide analog of growth hormone-releasing hormone (GHRH). It was first developed in the 1980s when studies indicated that the first 29 amino acids of GHRH may possess all of the biological roles associated with the full-length 44 residue protein.[1] The initially designed peptide, known as GRF (1-29), is the shortest segment of GHRH, and appears to possess all the properties of the full-length hormone. A truncated synthetic form of GHRH known as Sermorelin, or GRF 1-29, also has 29 amino acids. Modified GRF (1-29) undergoes alteration to include four substituted amino groups in its chain.[2] The intention behind these amino modifications is to protect the peptide from both oxidation and degradation during manufacture. The modification also appears to increase the binding affinity to GHRH receptors. Modified GRF (1-29) is also known as Mod GRF, or Tetra-substituted GRF (1-29). The latter name clarifies that the modified peptide differs from GRF (1-29) as a result of changes in four of its amino acids. Modified GRF (1-29) is structurally identical to CJC-1295 without DAC.

 

Specifications

Other Known Titles: Mod GRF (1-29)

Molecular Formula: C152H252N44O42

Molecular Weight: 3367.95 g/mol

Sequence: H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2

Modified GRF (1-29) Research

Modified GRF 1-29 and Cardiac Function
Research in rodent models has suggested that modified GRF and other GHRH derivatives may improve the capacity of the heart to pump blood, even following cardiac dysfunction.[3] More specifically, the researchers comment that “Various studies [suggest] that GHRH agonists promote repair of cardiac tissue, producing improvement of ejection fraction and reduction of infarct size in rats, reduction of infarct scar in swine, and attenuation of cardiac hypertrophy in mice.”

Modified GRF 1-29 and Thyroid, Growth Hormone
Malfunctioning of the thyroid gland is often associated with concomitant issues in growth hormone release. Research studies have suggested that research models of hyperthyroidism under the influence of thyroid replacement hormone may demonstrate stronger reactions to GRF, providing a possible a link between thyroid hormone and growth hormone.[6] The scientists commented that “These data indicate that thyroid hormone […] enhances the responsiveness of the somatotroph to GRF 1-29.”

Modified GRF 1-29 and the Intestine
Research in monkeys suggested that Modified GRF 1-29 may bind with vasoactive intestinal peptide (VIP) receptors to potentially improve bowel motility. Improved bowel movement is considered to be crucial in inflammatory bowel diseases. The peptide appears to interact with VIPC1, present on the smooth muscle of the reproductive, gastrointestinal as well as urinary systems.[4] [5] These conditions may potentially trigger a great deal of morbidity.

Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.

 

References

  1. Cen, L. P., Ng, T. K., Chu, W. K., & Pang, C. P. (2022). Growth hormone-releasing hormone receptor signaling in experimental ocular inflammation and neuroprotection. Neural regeneration research, 17(12), 2643–2648. https://doi.org/10.4103/1673-5374.336135
  2. Jetté, L., Léger, R., Thibaudeau, K., Benquet, C., Robitaille, M., Pellerin, I., Paradis, V., van Wyk, P., Pham, K., & Bridon, D. P. (2005). Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog. Endocrinology, 146(7), 3052–3058. https://doi.org/10.1210/en.2004-1286
  3. Schally, A. V., Zhang, X., Cai, R., Hare, J. M., Granata, R., & Bartoli, M. (2019). Actions and Potential Therapeutic Applications of Growth Hormone-Releasing Hormone Agonists. Endocrinology, 160(7), 1600–1612. https://doi.org/10.1210/en.2019-00111
  4. Ito, T., Igarashi, H., Pradhan, T. K., Hou, W., Mantey, S. A., Taylor, J. E., Murphy, W. A., Coy, D. H., & Jensen, R. T. (2001). GI side-effects of a possible therapeutic GRF analogue in monkeys are likely due to VIP receptor agonist activity. Peptides, 22(7), 1139–1151. https://doi.org/10.1016/s0196-9781(01)00436-3
  5. Waelbroeck, M., Robberecht, P., Coy, D. H., Camus, J. C., De Neef, P., & Christophe, J. (1985). Interaction of growth hormone-releasing factor (GRF) and 14 GRF analogs with vasoactive intestinal peptide (VIP) receptors of rat pancreas. Discovery of (N-Ac-Tyr1,D-Phe2)-GRF(1-29)-NH2 as a VIP antagonist. Endocrinology, 116(6), 2643–2649. https://doi.org/10.1210/endo-116-6-2643
  6. Valcavi, R., Jordan, V., Dieguez, C., John, R., Manicardi, E., Portioli, I., Rodriguez-Arnao, M. D., Gomez-Pan, A., Hall, R., & Scanlon, M. F. (1986). Growth hormone responses to GRF 1-29 in patients with primary hypothyroidism before and during replacement therapy with thyroxine. Clinical endocrinology, 24(6), 693–698. https://doi.org/10.1111/j.1365-2265.1986.tb01666.x
All orders ship same day if placed by 12 PST.
This product is strictly for research/laboratory use only. Human or animal use and/or consumption is strictly prohibited by law. Only qualified and licensed professionals should handle these products. Any information found on Biotech Peptides is strictly for educational purposes only. Refer to our terms and conditions for more details.

Dr. Usman

Dr. Usman (BSc, MBBS, MaRCP) completed his studies in medicine at the Royal College of Physicians, London. He is an avid researcher with more than 30 publications in internationally recognized peer-reviewed journals. Dr. Usman has worked as a researcher and a medical consultant for reputable pharmaceutical companies such as Johnson & Johnson and Sanofi.

Additional information

Brand

Biotech Peptides

26 reviews for Mod GRF 1-29 (CJC-1295 NO DAC) (2mg)

  1. Eric Wilson –

    Best quality peptides

  2. Allie Thompson –

    Up to now everything was good. Past orders were great and they have the best prices I’ve found

  3. Elliot Duffy –

    Im simply leaving this review because Im impressed with the generosity of whoever it was that put together my order. I ordered 10 vials and was sent an extra 2 for free. Thank you.

  4. Liam Culhane –

    The products are always shipped with the same secure packaging and professionally wrapped.

  5. Towers Greg –

    I am very impressed with the stock of this company. Rarely have I seen something out of stock and even if it was, in max 2 days it got restocked. That’s what I love about this company. You never have to wait for anything for too long.

  6. Ana Snyder –

    Have been ordering from Biotech for a few months now. have had 2 instances where I needed to call and update the order and another instance where the wrong product was sent. They sent the correct product and even gave a discount code for 20% for that one!

  7. Cesar Navarro –

    i am in love with the packaging design. Compared to other companies, yours is a pleasure to look at

  8. Taylor Stophlet –

    I appreciate their efficnecy and care with the peptides. Have ordered a few times and never had any broken or tarnished products yet.

  9. Alex Noren –

    Love the blends. very effective way of testing more peptides at once

  10. Allen Detterman –

    From A to Z, great customer service by their employees.

  11. Ellis Khan –

    Just placed my first order. H’ave heard great things about this company, can’t wait to get my peptides in and test them out.

  12. Alexis Paytas –

    I recommended Biotech to everyone who inquires about a reliable peptide site. Biotech employees are always answering their phones and emails when you need them and don’t play a long waiting game either. Staff has been very informative and helpful when ever I have had to make a call as well.

  13. Lexi Ward –

    Always a pleasure doing busniess with them!

  14. sam oren –

    Sent me free bac water even when I didnt meet the minimum buy and sent a disocunt code.

  15. Vinny Lopez –

    Great customer service and overall experience. They even sent me two free Bac waters!

  16. Kristy Blake –

    Both the peptides and the service were top-notch, and I couldn’t be more pleased.

  17. Toni Lee –

    To my surprise, they’ll be able to ship it to my home country. Whenever I have a question, their CS is there and ready to answer all my questions. Customs were no problem, and it was all done safely.

  18. jarod buckley –

    The abundance of peptides is something I like. There aren’t many bells and whistles, but it’s simple enough for me to navigate.They appear to have deals going on all year long, and they’d even emailed me promotional coupons. Vials arrive in excellent shape and the items seem to be of high quality.

  19. Vishnu Prasad –

    Had an okay experience with them. I love their products, but I think they are the same as any other company.

  20. Kendal Bacher –

    Best prices I’ve found.

  21. Hyran Garza –

    I placed a big order and everything got to me intact in just a few days. I was not expecting delivery that fast!

  22. Raul Mancha jr –

    Worth buying. Most other places have ridiculous prices but not here.

  23. NJ Leon –

    Been with them for a while and products don’t disappoint. What can though is the wait for restocks at times, can take just a bit too long.

  24. Ric Cohen –

    Everything you want from a good peptide supplier is here at biotech peptides.

  25. Ash Abbot –

    My order arrived one day late due to some post office mix-up and they sent me a coupon code for 15% off my next order via email.

  26. Chase Burow –

    This is my second time buying this and I am pretty sure not the last. Very good stuff

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