VIP (6mg)

(13 customer reviews)


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What is Vasoactive Intestinal Peptide (VIP) peptide?

Studies highlight the role of VIP in controlling inflammation, especially in neurodegenerative disease, pulmonary fibrosis, inflammatory bowel disease, and cardiac fibrosis. The peptide is effective in the treatment of fibrosis. VIP is also a potent immune system regulator and general anti-inflammatory peptide. It is of active interest for its ability to preserve cognitive function in the setting of neurodegenerative disease.
Vasoactive intestinal peptide (VIP, vasoactive intestinal polypeptide, PHM27) is a short peptide hormone made in the gut, pancreas, and brain of most vertebrate animals, including humans. VIP binds to class II G protein-coupled receptors and is known to:
· Triggers the breakdown of glycogen in liver and muscle
· Reduces blood pressure
· Relaxes smooth muscle throughout the GI tract
· Triggers contraction of cardiac muscle
· Stimulates the secretion of water in the GI tract
· Influences vaginal lubrication
· Regulates prolactin release
· Protects cartilage
· Protects neurons against ischemia and oxidative stress
· Affects autonomic nerve function
· Synchronizes the central nervous system and regulates circadian rhythm.


AKA: PHM27, Vasoactive intestinal polypeptide


Molecular Formula: C147H237N43O43S

Molecular Weight: 3326.8 g/mol

PubChem: 44567960

CAS Number: 37221-79-7

Reconstitution: Required

VIP Research

Bowel Inflammation
VIP is synthesized from the immune nerve fibers in blood vessels of the central and peripheral nervous systems and immune cells. It reduces inflammation in inflammatory bowel diseases (IBDs) like Crohn’s and ulcerative colitis by suppressing the production of interleukin-10 and improving intestinal barrier function. Compromised barrier function leads to increased antigenic material in the space between cells, which interacts with immune cells to trigger an inflammatory response. VIP thus helps to reduce the antigen presentation to immune cells by improving the barrier function.

Vasoactive Intestinal Peptide in Lung Function
VIP impacts lung function through the following two pathways. The first mechanism alters pulmonary vascular remodeling in response to inflammation by suppressing a peptide called NFAT, which is known to activate T cells, leading to increased inflammation. In particular, NFAT suppression may play a very important role in preventing pulmonary fibrosis, the end stage of diverse inflammatory conditions such as COPD, sarcoidosis, etc.
Smooth muscle cell proliferation is one of the long-term consequences of lung inflammation and is a challenge in bronchial asthma that has been uncontrolled for extended periods. VIP is a potential molecule that inhibits smooth muscle proliferation.
Preliminary research shows that VIP lowers blood pressure in the pulmonary artery, leading to increased cardiac output and improved venous oxygen saturation.

VIP in Transplants
Rejection by the body’s immune system is one of the primary challenges faced in organ transplants. Currently, it is addressed through the use of broad-spectrum anti-inflammatory medications. Unfortunately, these medications can lead to susceptibility to serious infections and have side effects, such as scarring and organ fibrosis.
VIP affects dendritic cells (DCs). By reducing DC proliferation and activation, VIP helps suppress immune responses. Hence, VIP selectively inhibits the proliferation of DCs that might cause an autoimmune reaction. This could make VIP/VIP analog the foundation of transplant anti-rejection medicine in the future.

VIP as a Neuroprotectant
VIP plays a three-fold role in the central nervous system: neurotransmitter, neurotrophic/neurogenic, and anti-inflammatory/neuroprotectant. In this case, the peptide helps maintain the very critical function of the blood-brain barrier (BBB). Compromise of the BBB has been implicated in multiple sclerosis, encephalomyelitis, and even stroke.
VIP also offers neuroprotective function in Alzheimer’s disease and Parkinson’s disease. VIP acts as an important neuroprotectant in the developing brain. It helps ward off excitotoxic white matter damage and improves neuron fatty acid myelination.
The exact role of VIP in Alzheimer’s disease (AD) is less clear. Research shows that the processing of VIP is inhibited in AD, with levels of the peptide and amino acid byproducts being lower in the brains of people affected by AD.
The effect of VIP is mediated through VPAC1 and VPAC2 receptors. In both cases, stimulation results in increased secretion of neurotrophic factors like ADNP (activity-dependent neurotrophic factor) and BDNF (brain-derived neurotrophic factor). Both of these peptides help to protect synapses and astrocytes.

Cardiac Fibrosis
As with lung disease, fibrosis is the end stage of several cardiac conditions. Cardiac fibrosis leads to several serious problems, including valve dysfunction, decreases in contractility, changes in cardiac filling, and more. As in lung disease, cardiac fibrosis is the common end-stage of many heart conditions, thus requiring a transplant.
Research on rat models indicates that VIP may not only slow fibrosis down but can reverse scarring. This effect is partly mediated by a massive reduction in the expression of angiotensinogen and angiotensin receptor type 1a. This makes sense as angiotensin receptor blockers and ACE inhibitors have long been known to slow down cardiac modeling/fibrosis and are the first line of prevention for fibrosis.

Vasoactive Intestinal Peptide and COVID 19
A synthetic version of VIP called Aviptadil (RLF-100) may help to improve the lung complications in severe cases of Covid 19. Aviptadil, like VIP, inhibits pro-inflammatory cytokine production. This translates into protecting type-2 alveolar cells, the cells responsible for the bulk of oxygen exchange in the lungs. In fact, Aviptadil may actually block the SARS-2 coronavirus entry into alveolar cells.
Patients on ventilator and ECMO show remarkable recovery just three days after treatment with RLF-100. Any antiviral agent has not demonstrated the rapid recovery from infection and demonstrated inhibition of viral replication the way that Aviptadil has.
VIP is a member of a much larger group of neuro and endocrine peptides. It has been shown to affect the central nervous system, GI tract, pulmonary tissue, and immune system. It is known to play an active role in embryonic growth and development.
VIP has been found to regulate inflammation throughout the body, especially in neurodegenerative disease, pulmonary fibrosis, inflammatory bowel disease, and cardiac fibrosis.
The peptide is also a potent immune system regulator and general anti-inflammatory. It protects the central nervous system and preserves cognitive function in the setting of neurodegenerative disease.
Finally, synthetic variants of VIP have shown promise in treating COVID 19 and have been fast-tracked by the FDA for stage 2/3 clinical trials. This may ultimately prove beneficial for other VIP-related treatments and help pharmaceutical companies to invest in therapeutics. Innovation and research on vasoactive intestinal peptides will be one of the crucial focuses in the upcoming decade.

All orders ship same day if placed by 2pm PST.  Peptides synthesized and lyophilized in the USA.
This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law.  Only qualified and licensed professionals should handle these products.  Any information found on Biotech Peptides is strictly for educational purposes only.  Refer to our terms and conditions for more details.

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Biotech Peptides

13 reviews for VIP (6mg)

  1. Robert Styles

    good stuff

  2. David Lopez

    He estado buscando péptidos de calidad durante mucho tiempo. De donde soy, son muy difíciles de encontrar y me alegró mucho poder encontrar una empresa accesible y cualitativa que realiza envíos a mi país jaja

  3. Chloe Hamilton

    super easy process buying prodcuts from here. They came quickly and were just as described.

  4. Kain R. Heinlein

    I enjoy reading their up to date blogs. They’re educational and keep me informed with the latest news on peptides. I can even access the specific peptide they’re talking about in the blog which saves me time in looking it up. It’s probably my favorite feature on the site.

  5. Bailey Sparks

    They put the pep in the peptide. No, seriously Danni saved me time and money. Packages were delivered on time. However! Damaged and no good. Have never had this happen in the past 9 months we have been doing business with them. It was very unfortunate as we are on a tight schedule. I did remember reading on their page that they would honor orders and send a new one if the damage was done in transit. Guess what? They definitely do resend the order and on top of that threw in expediated shipping PLUS a few extra bottles of each on them! None of this cost me extra. It did take away my time but I understand things happen that are out of people’s control sometimes.

  6. Luna Torres

    they’re my favorite company to order from!!!

  7. Benjamin Tan

    They’re great with timing for shipment, have excellent customer service, amazing prices and deals. Just wish their restock was a smigde faster!! That’s all 🙂

  8. Lynch Clara

    Best part about them is how they work with you if you have a big order or will be a weekly buyer such as myself.

  9. james messar

    Packages came sooner than expected. Ppetides were all in great condition and no cracks or breaks on any vials from what I could see.

  10. Theo Bennet

    Nothing negative to say about Biotech. They’re the most reliable peptide company I have come across.

  11. Julian H.

    Was recommended to you guys by a pal and they swore your peptides were of the highest purity.

  12. Micah Dea

    This is our labs go to company for peptides.

  13. Cyrus Dastur

    Awsome peptides

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