N-Acetyl Selank (10mg)

What is the N-Acetyl Selank peptide?

N-Acetyl Selank is an acetylated form of the Selank peptide. The acetylation of the peptide into N-Acetyl Selank appears to improve its stability. Selank is a synthetic analogue of the natural human tetrapeptide Tuftsin. Tuftsin is an immunomodulatory peptide, and N-Acetyl Selank appears to possess many of its effects. In addition, N-acetyl Selank also appears to exhibit effects on neurotransmitters, brain signaling, and neuroplasticity.

Specifications

Molecular Formula: C₃₅H₅₉N₁₁O₁₀

Molecular Weight: 793.91 g/mol

Sequence: AC-THR-LYS-PRO-ARG-GLY-PRO

Reconstitution: Required

Research

N-Acetyl Selank as a Nootropic
N-Acetyl Selank may have similar effects as Selank, but with the potential for increased efficacy and stability. In research studies with rat subjects, scientists suggest that the peptide activates the serotonin metabolism in the tested animals’ brains.^[1] As a result, administering Selank appeared to enhance memory storage processes compared to a placebo. Researchers have also investigated the effect of Selank on humans when given alongside a control medication to individuals with anxiety-phobic, hypochondriac, and somatoform disorders.^[2] Compared to the control medication alone, the combination of Selank and the medication appeared to have increased efficacy and reduced known side effects of the medication. The patients on combination therapy appeared to experience less attention and memory impairment, asthenia, and sedation. 

N-Acetyl Selank as a Anxiolytic
The anxiolytic effects of Selank have been studied experimentally. In laboratory research, Selank was posited to increase the levels of calming neurotransmitters such as serotonin in the brains of rats.^[4] Serotonin is a primary target of most anxiolytics, and blocking its reuptake is a common mechanism of action for these medications. Additional clinical research in patients with a generalized anxiety disorder (GAD) and neurasthenia compared the effect of Selank to that of a control medication in reducing symptoms and improving quality of life.^[5] The researchers reported that the anxiolytic effects of both the medication and the peptide were similar, but Selank appeared to have additional antiasthenic and psychostimulant effects. They noted that “patients with GAD and neurasthenia had the decreased level of tau(1/2) leu-enkephalin, which was correlated with disease duration, severity of symptoms related to anxiety and asthenia and autonomic disorders”. Selank has an inhibitory effect on enkephalin-degrading enzymes, which is likely the primary mechanism of its supposed anxiolytic activity.^[6]

N-Acetyl Selank and Neuroplasticity
N-Acetyl Selank may upregulate the brain-derived neurotrophic factor (BDNF) levels in the central nervous system. Animal studies show that the administration of Selank may increase BDNF levels in the hippocampus.^[7] BDNF is a growth factor in the brain that supports neurons’ growth and adaptation.^[8]  According to scientists, BDNF may also induce remodeling in the nerve tissue and the formation of new connections.^[9] BDNF may also stimulate neurogenesis, the formation of new neurons in parts of the adult brain that retain stem cells.^[10]  With this research, it is suggested that Selank may protect the brain and stimulate neural plasticity. 

References