N-Acetyl Selank (10mg)

$55.00

N-Acetyl Selank peptides are Synthesized and Lyophilized in the USA.

Discount per Quantity

Quantity5 - 910 +
Discount5%10%
Price$52.25$49.50
Orders over $200 receive:
FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
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SKU: N-Acetyl-Selank-10mg Category:

Description

What is the N-Acetyl Selank peptide?

N-Acetyl Selank is an acetylated form of the Selank peptide. The acetylation of the peptide into N-Acetyl Selank improves its stability. Selank is a synthetic analogue of the natural human tetrapeptide Tuftsin. Tuftsin is an immunomodulatory peptide, and N-Acetyl Selank appears to possess many of its effects. In addition, N-acetyl Selank also appears to exhibit effects on neurotransmitters, brain signaling, and neuroplasticity.

Specifications

Molecular Formula: C35H59N11O10

Molecular Weight: 793.91 g/mol

Sequence: AC-THR-LYS-PRO-ARG-GLY-PRO

Reconstitution: Required

N-Acetyl Selank Research

N-Acetyl Selank as a nootropic
N-Acetyl Selank may have similar effects as Selank, but with the potential for increased efficacy and stability.
In research studies with rat subjects, scientists show that the peptide appears to activate the serotonin metabolism in the tested animals’ brains.[1] As a result, administering Selank appeared to enhance memory storage processes as compared to placebo.

N-Acetyl Selank and anxiolytic effects
The anxiolytic effects of Selank have been studied experimentally. In laboratory research, Selank was posited to increase the levels of calming neurotransmitters such as serotonin in the brains of rats.[2] Serotonin is a primary target of most anxiolytics, and blocking its reuptake is a common mechanism of action for these medications.

N-Acetyl Selank and Neuroplasticity
N-Acetyl Selank may upregulate the brain-derived neurotrophic factor (BDNF) levels in the central nervous system. Animal studies show that administration of Selank can increase BDNF levels in the hippocampus.[3]
BDNF is a growth factor in the brain that supports neurons’ growth and adaptation.[4] According to scientists, BDNF may also induce remodeling in the nerve tissue and the formation of new connections.[5]
BDNF may also stimulate neurogenesis, which is the formation of new neurons in parts of the adult brain that still retain stem cells.[6] Therefore, Selank may have protective effects on the brain and stimulate neural plasticity.

References

  1. Semenova TP, Kozlovskiĭ II, Zakharova NM, Kozlovskaia MM. [Experimental optimization of learning and memory processes by selank]. Eksp Klin Farmakol. 2010 Aug;73(8):2-5. Russian. PMID: 20919548.
  2. Semenova TP, kozlovskiĭ II, Zakharova NM, Kozlovskaia MM. [Comparison of the effects of selank and tuftsin on the metabolism of serotonin in the brain of rats pretreated with PCPA]. Eksp Klin Farmakol. 2009 Jul-Aug;72(4):6-8. Russian. PMID: 19803361.
  3. Lu B, Figurov A. Role of neurotrophins in synapse development and plasticity. Rev Neurosci. 1997 Jan-Mar;8(1):1-12. doi: 10.1515/revneuro.1997.8.1.1. PMID: 9402641.
  4. Deister C, Schmidt CE. Optimizing neurotrophic factor combinations for neurite outgrowth. J Neural Eng. 2006 Jun;3(2):172-9. doi: 10.1088/1741-2560/3/2/011. Epub 2006 May 16. PMID: 16705273.
  5. Lu B, Figurov A. Role of neurotrophins in synapse development and plasticity. Rev Neurosci. 1997 Jan-Mar;8(1):1-12. doi: 10.1515/revneuro.1997.8.1.1. PMID: 9402641.
  6. Zigova T, Pencea V, Wiegand SJ, Luskin MB. Intraventricular administration of BDNF increases the number of newly generated neurons in the adult olfactory bulb. Mol Cell Neurosci. 1998 Jul;11(4):234-45. doi: 10.1006/mcne.1998.0684. PMID: 9675054.
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