What is Selank Peptide?
is a Russian product, is a small peptide showing nootropic and anxiolytic properties. It is a synthetic analogue of naturally occurring Tuftsin, an immunomodulatory peptide regulating T helper cells, IL-6, monoamine neurotransmitters, and brain-derived neurotrophic factor (BDNF). In reality, Selank differ from Tuftsin in additional four amino acids in its chain that enhance metabolic stability and half-life.
It has been tested in clinical trials as a suitable drug for generalized anxiety disorder.
– Anxiety Effects Based on Genes Related to GABA Neurotransmitter
– Selank Peptide & Immune System in Anxiety
– Research about Memory and Learning
– Selank Research and Pain
Molecular Formula: C33H57N11O9
Molecular Weight: 751.89 g/mol
PubChem: CID 11765600
CAS Number: 129954-34-3
Reconstitution : Required
Anxiety Effects Based on Genes Related to GABA Neurotransmitter
To quote Dr. Anastasiya Volkova of the Institute of Molecular Genetics in Russia, “numerous clinical studies have shown that Selank has strong antianxiety and neuroprotective effects in the treatment of anxiety. Selank and classical antianxiety medications such as benzodiazepine have a similar mode of action. Selank allosterically modulates GABAA receptors and increase the inhibitory action of GABA.” The peptide reduces anxiety, improves mood, decreases stress levels, and positively influences memory and learning. Small doses of Selank have a sedating effect like benzodiazepines. However, unlike the latter it is neither habit-forming nor leads to symptoms of withdrawal or amnesia.
It has been observed to strongly influence expression of seven genes and moderately affect expression of 45 other targets from a set of about 84 genes known to be involved in GABA signaling. Thus the peptide stimulates gene expression in neurons and influences affinity of GABA receptor for GABA. Synergism between Selank and benzodiazepines and other GABA receptor agonists is mediated through alteration of the receptor affinity.
Research in rats shows that Selank and benzodiazepines, when used alone, have similar effects on anxiety, particularly generalized anxiety disorder. Selank in spite of being better equipped in relieving anxiety than benzodiazepines, the combined use of the two drugs addresses unpredictable chronic mild stress the best.
Effect of Selank on enkephalin degradation modulates its influence on GABA receptors to certain extent. Studies have shown enkephalins with shorter stability in blood of patients having anxiety and phobic disorders. This is caused by increased enkephalinase activity in their blood which degrades the enkephalins. The peptide inhibits enkephalinase, stabilizes enkephalins, resets the enzymatic pathway and thus preserves the natural anxiolytic peptides of the body. Studies in murine models of anxiety also support the view the above hypothesis.
Selank Peptide & Immune System in Anxiety
Rese Selank inhibits the gene responsible for the production of the inflammatory cytokine IL-6 in patients suffering from depression but not in healthy individuals. Thus it can be useful in patients with anxiety-asthenic disorders, severe anxiety along with fatigue, headache, heart palpitations, high blood pressure, nerve pain, and depression.
Compared to standard anxiolytic treatments, like benzodiazepines, only Selank improves asthenic symptoms such as fatigue and pain. This is due to its stabilization of enkephalins and modification of expression of IL-6.
The peptide affects expression of nearly 34 genes in the inflammatory pathway including those affecting chemokines, cytokines and receptors for both of them. It specifically affects Bcl6 expression which promotes immune development. The above work not only helps to reveal the complex biological effects of the peptide but also improves our understanding of the immune system.
Selank and its truncated versions mediate transient alter gene expression for C3, CAsp1, Il2rf, and Xcr1 in the mouse spleen. Selank is thus able to alter the balance of the immune system and thereby modulate inflammation.
Research about Memory and Learning
Anxiety and learning/memory show strong inverse association. The peptide, like traditional treatment regimens, reduces the impact of anxiety on cognitive function. The peptide, in fact, boosts cognitive power directly.
Selank improves memory traceability and storage in rats. This improvement was independent of the anxiety levels of the rats. The peptide thus boots memory beyond its ability to just reduce stress-related impairment of memory.
Peptide triggers better memory through hippocampal expression of 36 different genes. The majority of the targets are membrane-associated proteins and regulate ion movement across cell membranes. Thus the ion-dependent processes in learning and memory are enhanced by the molecule. Selank has shown preliminary proof towards helping in easy formation and access of memories.
It helps to rescue memory and cognitive abilities after injury in rats administered with neurotoxins. This happens due to inhibition of catecholamines in the brain. It can thereby assist in restoring cognitive function after injury like during the birth process.
Selank Research and Pain
Enkephalins are natural peptides which reduce severity of pain by associating with the opioid receptors. Their levels are high in human brain and adrenal glands during stress response. Selank reduces the levels in brain thereby suppressing stress response and its harmful effects on memory, learning and concentration.
Selank displays minimal side effects, low oral bioavailability and excellent subcutaneous bioavailability in mice. Dose (per kg) used in mice does not scale to humans. It is sold at Biotech Peptides only for educational and scientific research and not for human use.Buy Selank peptide, only if you are a licensed researcher.