NAD+ (100mg & 500mg)

(25 customer reviews)


NAD+ peptides are Synthesized and Lyophilized in the USA.

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What is the Nicotinamide Adenine Dinucleotide (NAD+) peptide?

Nicotinamide Adenine Dinucleotide (NAD+) is an oxidized form of NADH (Nicotinamide Adenine Dinucleotide Hydroxide). NAD+ is a component of the Electron Transport Chain (ETC), apparently carrying electrons from biological reactions. It appears to act as a medium for shuttling energy within and outside the cell. It also appears to act as a mediator for various biological processes in the body, such as post-translational modification of the proteins and activation/deactivation of some enzymes. It may be a critical component in maintaining cell-to-cell communication in the body. The neurons present in blood vessels, intestines, and bladder, release NAD+ which appears to act as an extracellular signaling molecule, regulating bio-functions in the body. It appears to function as a cofactor in numerous bodily processes such as immune defense, DNA repair, circadian cycles, and energy conversion. However, like other naturally occurring mediators in the body, its level generally declines as age advances. Therefore, replenishing the levels of NAD+ in the body may help off-set various age-related progressive and degenerative processes. NAD+ is a naturally occurring compound, and may be used synergistically with other supplements to obtain potentially multiplied benefits.


SYNONYMS: Nicotinamide Adenine Dinucleotide, Beta-NAD, NAD, Endopride

MOLECULAR WEIGHT: 663.43 g/mol




NAD+ Research

NAD+ is of pivotal significance in numerous biological processes and greatly interests researchers. Studies have been developed to explore its natural role in the body and which properties it best exhibits. Listed below are areas of research in which NAD+ has been suggested to play a role:

NAD+ and Anti-aging
Mitochondria are considered the powerhouse of the body. They serve as a platform for primary metabolic functions such as intracellular signaling and regulation of innate immunity. These processes are directly affected by mitochondrial senescence and ultimately alter cellular metabolism, inflammation, and even stem cell activity.[1] These altogether reduce the pace of healing following an injury. This illustrates the extent to which mitochondria are involved in age-related tissue and organ function decline. Potentially manipulating mitochondrial activity can slow, cease or even reverse the process of aging. A deficiency of NAD+ in the cell appears to induce a pseudo-hypoxic state which interrupts signaling within the nucleus. Studies have suggested that NAD+ supplementation may help in reversing at least some of the age-related decline in the function of mitochondria.[2] The scientists concluded that “raising NAD+ levels in old mice restores mitochondrial function to that of a young mouse in a SIRT1-dependent manner.” The mechanism underlying this property appears to involve the activation of the SIRT 1 function, whereby a gene encodes an enzyme called Sirtuin-1 (NAD+ dependent Deacetylase Sirtuin-1). Sirtuin-1 then may regulate the mediators involved in metabolism, inflammation, the longevity of cells, and the processes linked to stress.[3]

NAD+ and Muscle Function
The decline in muscle function related to age is associated with mitochondrial senescence. It occurs in two steps. The first, reversible, step involves declined expression of mitochondrial genes. These genes are responsible for oxidative phosphorylation (the process by which mitochondria produce energy). The second, irreversible, step consists of a decline in genes responsible for oxidative phosphorylation in the nucleus. Mice experiments have observed an apparent  step 1 reversal with the administration of NAD+ before the cell progresses to step 2.[4]
The mechanism behind this intervention in mitochondrial aging may involve stabilizing the activity of Peroxisome Proliferator-activated Receptor Gamma Co-activator 1-alpha (PGC-1-alpha). Studies have suggested that the effect mentioned above produced in the mitochondria may be similar to exercise on the mitochondria of skeletal muscles.[5]

NAD+ and Neurodegenerative Diseases
NAD+ is a cofactor that may play a significant neuroprotective role.[6] It appears to do so by improving mitochondrial function and reducing the production of Reactive Oxidative Stress (ROS). ROS is responsible for inflammatory changes associated with injury and degenerative changes associated with aging. This association provides its basis for treating certain neurodegenerative diseases such as Alzheimer’s, Huntington’s, and Parkinson’s disease. Research conducted on mice suggested the potential for NAD+ to protect against progressive motor deficits and the death of dopamine-producing cells in the substantia nigra.[7] According to the researchers “These results add credence to the beneficial role of NAD against parkinsonian neurodegeneration in mouse models of PD, provide evidence for the potential of NAD for the prevention of PD, and suggest that NAD prevents pathological changes in PD via decreasing mitochondrial dysfunctions.” The research findings implied that although NAD+ doesn’t appear to alleviate the symptoms, it may slow the progression if not entirely prevent the development of Parkinson’s disease.

NAD+ and Inflammation
NAMPT is an enzyme that is associated with inflammation. It appears overexpressed in certain types of cancers. An increase in the levels of NAMPT appears to correlate to NAD+ levels, and vice versa.[8] The NAMPT-associated inflammation appears to occur in cancers, obesity, type 2 diabetes, and nonalcoholic fatty liver disease. NAMPT may be a potent activator of inflammation whose levels may decrease dramatically following the administration of NAD+.

NAD+ and Addiction
Drug and alcohol addiction has been suggested to be associated with a decline in the levels of NAD+. Addiction typically leads to significant nutritional deficiencies and cognitive deterioration. Supplementation with NAD+ may help overcome these changes and can be helpful in various addiction disorders. NAD+ supplementation has the potential to provide a wide range of benefits when used alone and may also be used in conjunction with other therapies to obtain multiplied effects.


  1. Sun N, Youle RJ, Finkel T. The Mitochondrial Basis of Aging. Mol Cell. 2016 Mar 3;61(5):654-666. doi: 10.1016/j.molcel.2016.01.028. PMID: 26942670; PMCID: PMC4779179.
  2. Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA. Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell. 2013 Dec 19;155(7):1624-38. doi: 10.1016/j.cell.2013.11.037. PMID: 24360282; PMCID: PMC4076149.
  3. Imai S, Guarente L. NAD+ and sirtuins in aging and disease. Trends Cell Biol. 2014 Aug;24(8):464-71. doi: 10.1016/j.tcb.2014.04.002. Epub 2014 Apr 29. PMID: 24786309; PMCID: PMC4112140.
  4. Mendelsohn AR, Larrick JW. Partial reversal of skeletal muscle aging by restoration of normal NAD⁺ levels. Rejuvenation Res. 2014 Feb;17(1):62-9. doi: 10.1089/rej.2014.1546. PMID: 24410488.
  5. Kang C, Chung E, Diffee G, Ji LL. Exercise training attenuates aging-associated mitochondrial dysfunction in rat skeletal muscle: role of PGC-1α. Exp Gerontol. 2013 Nov;48(11):1343-50. doi: 10.1016/j.exger.2013.08.004. Epub 2013 Aug 30. PMID: 23994518.
  6. Matthews RT, Yang L, Browne S, Baik M, Beal MF. Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8892-7. doi: 10.1073/pnas.95.15.8892. PMID: 9671775; PMCID: PMC21173.
  7. Shan C, Gong YL, Zhuang QQ, Hou YF, Wang SM, Zhu Q, Huang GR, Tao B, Sun LH, Zhao HY, Li ST, Liu JM. Protective effects of β- nicotinamide adenine dinucleotide against motor deficits and dopaminergic neuronal damage in a mouse model of Parkinson’s disease. Prog Neuropsychopharmacol Biol Psychiatry. 2019 Aug 30;94:109670. doi: 10.1016/j.pnpbp.2019.109670. Epub 2019 Jun 17. PMID: 31220519.
  8. Garten A, Schuster S, Penke M, Gorski T, de Giorgis T, Kiess W. Physiological and pathophysiological roles of NAMPT and NAD metabolism. Nat Rev Endocrinol. 2015 Sep;11(9):535-46. doi: 10.1038/nrendo.2015.117. Epub 2015 Jul 28. PMID: 26215259.
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25 reviews for NAD+ (100mg & 500mg)

  1. Olivia J.

    Very good

  2. Aileen Gomez

    Quality stuff from a great business. Highly recommended

  3. Shane Youn

    Excellent customer service, fast delivery, and excellent stuff. My business will remain with you in the future.

  4. Renee Rosebohm

    Have used them for a few months now. Want to continue business with them since their prices are pretty good in regards to product and shipping (and getting the free bacteriostatic water).

  5. Mel Wade

    Products are good quality, Can’t wait to order some other peptides in the future!

  6. Eddie Smith

    I really appreciate the fact that you bring in new products periodically. I even saw some rare ones you can’t always find easily online

  7. Won Hee Yoo


  8. Dain Kasprak

    Happy paying their prices, wish they did come up with some more bundle options! That could be interesting!

  9. Brooke Bowden

    Fast, well run, and orgaized team they got here!

  10. Cody Davis

    products speak for themselves wish they stocked up more frequently

  11. Parker Findlay

    It’s always unfortunate when your orders come in poor condtioned or broken. That was the case for me this morning. Showed up to work and saw my package had been delovered from Biotech. Great! However, once I looked inside I noticed alot of the vials and containers were broken even though there is a Fragile sticker that the carriers can’t miss. It has happened before so I already knew it would get handled right away. My personal go to is Taylor so I emailed them right away and they were abel to rush me a new order. I got a confirmation numer that it would be delivered soon so fingers crossed it gets here in perfect condition!

  12. Benji Hyrum

    They are consistent with product quality, have had no breaks or damages so far and I have been a customer since April.

  13. Dara Elizabeth

    So far, so good with them

  14. Raven Martinez

    Taylor is always on top of their game, super quick on fixing issues and just helping out. Knows a lot about the company and the ins and out.

  15. brian geralds

    Service is great, placed my order before 2 and was informed my order was shipped and would be at my lab that same evening!

  16. Collin Nicoles

    My research peptides have always come from Biotech Peptides, and I’ve never had anything but good things to say about them and their products. Been with them for over a year now.

  17. Adam bailey

    To obtain peptides, this is one of the best locations to get them! There are also a few goods for sale from time to time. The best part is that they provide discounts for large purchases.

  18. Omar Nobel

    Was worried my vials would come in broken as it seems to happen a bit but glad to report my did not!

  19. Kalee Pierce

    Been searching for NAD for a while now. This is the best price I found

  20. Corey Abowd

    You guys are my go-to peptide supplier of all times. I love everything about you, from peptides, to CS, deals and offers, everything fits

  21. Ron Aguirre

    I recommended this to all of my fellow coworkers, They just deliver amazing peptides every time

  22. Sam Dunley

    They are very straightforward with how they work and deal with issues. Work gets down quick. I recommend E-mailing rather tan calling when issues do arise though. Much faster and easy to document too.

  23. Oleg Ivanova

    Esta es la mejor compañía de péptidos que he conocido.

  24. DJ Morataya

    No issues in slightest for the past 2 years i have been buying peptides from them.

  25. Austin Westrup

    Straightforward transaction okay prices. If they have sales buy buy buy.

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