NAD+ (100mg)

(14 customer reviews)

$46.00

Discount per Quantity

QuantityDiscountPrice
5 - 95%$43.70
10 +10%$41.40
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FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
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SKU: NAD+ - 100mg Category:

Description

What is Nicotinamide Adenine Dinucleotide (NAD+)?

NAD+ is an oxidized form of NADH (Nicotinamide Adenine Dinucleotide Hydroxide). NAD+ is a component of the Electron Transport Chain (ETC) and carries electrons from one biological reaction. That is how it becomes a medium for shuttling energy within and outside the cell. It also acts as a mediator for various biological processes in the body, such as post-translational modification of the proteins and activation/deactivation of some enzymes.
It is the critical component in maintaining cell-to-cell communication in the body. The neurons present in the blood vessels, intestines, and bladder release NAD+, and it acts as an extracellular signaling molecule to regulate bio-functions in the body. It functions as a cofactor in numerous bodily processes such as immune defense, DNA repair, circadian cycles, and energy conversion. However, like other naturally occurring mediators in the body, its level declines as age advances. Therefore, replenishing the levels of NAD+ in the body can help off-setting various age-related progressive and degenerative processes. NAD+ is a naturally occurring compound with virtually few to no side effects. It can also be used synergistically with other supplements to obtain multiplied benefits.

Specifications

SYNONYMS: Nicotinamide Adenine Dinucleotide, Beta-NAD, NAD, Endopride

MOLECULAR WEIGHT: 663.43 g/mol

MOLECULAR FORMULA: C21H27N7O14P2

PUBCHEM:CID 925

RECONSTITUTION: Required

NAD+ Research

NAD+ is of pivotal significance in numerous biological processes and greatly interested researchers. The goal is to study its natural role in the body and how it implies the clinical well-being of people owing to its immense properties. Below are a few of the many implications of NAD+.

Anti-aging effects:
Mitochondria are considered the powerhouse of the body. They serve as a platform for primary metabolic functions such as intracellular signaling and regulation of innate immunity. These processes are directly affected by mitochondrial senescence and ultimately alter cellular metabolism, inflammation, and even stem cell activity. These altogether reduce the pace of healing following an injury. That is how mitochondria are involved in age-related tissue and organ function decline. Any way of modulating mitochondrial activity can slow, cease or even reverse the process of aging.
A deficiency of NAD+ in the cell induces a pseudo-hypoxic state which interrupts signaling within the nucleus. Studies have provided evidence supporting the role of NAD+ supplementation in reversing at least some of the age-related decline in the function of mitochondria. The mechanism underlying this property involves the activation of the SIRT 1 function. A gene encodes an enzyme called Sirtuin-1 (NAD+ dependent Deacetylase Sirtuin-1). Sirtuin-1 regulates the mediators involved in metabolism, inflammation, the longevity of cells, and the processes linked to stress.

Improvement in muscle function:
The decline in muscle function related to age is associated with mitochondrial senescence. It occurs in two steps. The first reversible one involves declined expression of mitochondrial genes. These genes are responsible for oxidative phosphorylation (the process by which mitochondria produce energy). The second irreversible step consists of a decline in genes responsible for oxidative phosphorylation in the nucleus. Mice experiments have demonstrated a step 1 reversal when there is an administration of NAD+ before the cell progresses to step 2.
The mechanism behind this intervention in mitochondrial aging involves stabilizing the activity of Peroxisome Proliferator-activated Receptor Gamma Co-activator 1-alpha (PGC-1-alpha). Studies have proven that the effect mentioned above produced in the mitochondria is similar to exercise on the mitochondria of skeletal muscles. This information helps maintain the skeletal muscles’ oxidative capacity over a long period.

Role in Neurodegenerative Diseases:
NAD+ is a cofactor that plays a significant neuroprotective role. It does so by improving mitochondrial function and reducing the production of Reactive Oxidative Stress (ROS). ROS are responsible for inflammatory changes associated with injury and degenerative changes associated with aging. This association provides its basis for treating certain neurodegenerative diseases such as Alzheimer’s, Huntington’s, and Parkinson’s disease. Research conducted on mice showed that the administration of NAD+ helps protect against progressive motor deficits and the death of dopamine-producing cells in the substantia nigra. It implies that although NAD+ doesn’t alleviate the symptoms, it sure does slow the progression if not entirely prevent the development of Parkinson’s disease.

Reduction of inflammation:
NAMPT is an enzyme that is associated with inflammation. It is overexpressing in some types of cancers. An increase in the levels of NAMPT is related to a decrease in the ranks of NAD+ and vice versa. The NAMPT-associated inflammation occurs in cancers, obesity, type 2 diabetes, and nonalcoholic fatty liver disease. NAMPT is a potent activator of inflammation whose levels tend to decrease dramatically following the administration of NAD+.

Treatment of Addiction:
Drug and alcohol addiction is associated with a decline in the levels of NAD+. This addiction leads to significant nutritional deficiencies and cognitive deterioration. Supplementation with NAD+ can help overcome these changes and can be helpful in various addiction disorders.
NAD+ supplementation provides a wide range of benefits when used alone and can also be used in conjunction with other therapies to obtain multiplied effects.

All orders ship same day if placed by 2pm PST.  Peptides synthesized and lyophilized in the USA.
This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law.  Only qualified and licensed professionals should handle these products.  Any information found on Biotech Peptides is strictly for educational purposes only.  Refer to our terms and conditions for more details.

Additional information

Brand

Biotech Peptides USA

14 reviews for NAD+ (100mg)

  1. Olivia J.

    Very good

  2. Aileen Gomez

    Quality stuff from a great business. Highly recommended

  3. Shane Youn

    Excellent customer service, fast delivery, and excellent stuff. My business will remain with you in the future.

  4. Renee Rosebohm

    Have used them for a few months now. Want to continue business with them since their prices are pretty good in regards to product and shipping (and getting the free bacteriostatic water).

  5. Mel Wade

    Products are good quality, Can’t wait to order some other peptides in the future!

  6. Eddie Smith

    I really appreciate the fact that you bring in new products periodically. I even saw some rare ones you can’t always find easily online

  7. Won Hee Yoo

    他們有很好的純肽

  8. Dain Kasprak

    Happy paying their prices, wish they did come up with some more bundle options! That could be interesting!

  9. Brooke Bowden

    Fast, well run, and orgaized team they got here!

  10. Cody Davis

    products speak for themselves wish they stocked up more frequently

  11. Parker Findlay

    It’s always unfortunate when your orders come in poor condtioned or broken. That was the case for me this morning. Showed up to work and saw my package had been delovered from Biotech. Great! However, once I looked inside I noticed alot of the vials and containers were broken even though there is a Fragile sticker that the carriers can’t miss. It has happened before so I already knew it would get handled right away. My personal go to is Taylor so I emailed them right away and they were abel to rush me a new order. I got a confirmation numer that it would be delivered soon so fingers crossed it gets here in perfect condition!

  12. Benji Hyrum

    They are consistent with product quality, have had no breaks or damages so far and I have been a customer since April.

  13. Dara Elizabeth

    So far, so good with them

  14. Raven Martinez

    Taylor is always on top of their game, super quick on fixing issues and just helping out. Knows a lot about the company and the ins and out.

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