Nonapeptide-1 (Topical) (200mg)


Nonapeptide-1 peptides are Synthesized and Lyophilized in the USA.

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SKU: Nonapeptide-1-Topical-200mg Category:


What is the Nonapeptide-1 (Topical) peptide?

Nonapeptide-1 (topical) also termed Melanostatine-5, is a peptide developed for antimicrobial action. Research on animal models suggests that Nonapeptide-1 may inhibit the synthesis of Melanin, bringing it to the forefront of skin condition treatment research. Studies in animal models posit that Nonapeptide-1 may reduce the synthesis of melanin and help decrease the pigmentation of the skin to a considerable scale.[1] Nonapeptide-1 consists of the amino acids arginine-methionine-lysine-phenylalanine-proline-tryptophan-valine. The human skin contains a variety of cells, with each cell exhibiting a different function. One such cell type are “Melanocytes”. Melanocytes produce a chemical called melanin, and the difference in the levels of melanin imparts color to our skin. Melanin protects the skin against sun damage. Nonapeptide-1 has been extensively researched for its effect on melanin levels and overall efficacy in skin conditioning.


Sequence: Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val

Molecular Formula: C61H87N15O9S

Molecular Weight: 1206.52g/mol

PubChem: CID 10418849

Synonyms: Melanostatine, Oxytocin Intermediate-nine peptide, Melanostatine-5

Reconstitution: Required

Nonapeptide-1 Research

Nonapeptide-1 was first discovered in yeast Streptomyces clavifer, where it was an antimicrobial agent. Recent research suggests that the Nonapeptide-1 may also be a potent inhibitor of the formation of melanin in the laboratory study of melanoma and yeast.[2] The researchers also noted that “Melanostatin strongly inhibited melanin formation in Streptomyces bikiniensis NRRL B-1049 and B16 melanoma cells.” Nonapeptide-1 is of research interest based on its supposed ability to decrease hyperpigmentation by bringing to a halt the activities of Tyrosinase in Melanin-producing cells. The regulation of melanin production is a vital process in the approach of several skin conditions such as photo damage of the skin (Melasma). Scientific research posits that Nonapeptide-1 may function in the Central Nervous System as a Dopaminergic and an Opioid receptor—to modify pain signaling and behavior. Studies on mouse models support the hypothesis that Nonapeptide-1 may play a role in the Central Nervous system—its activities may change behavior patterns and pain.[3]

Nonapeptide-1 and General Functioning
In the cosmetic sector, the Nonapeptide is marketed as a radiance promoter and whitening agent. In the medical field, Nonapeptide is a studied as an inhibitor of melanin synthesis—which functions to inhibit the activities of Tyrosinase, preventing melanocytes from producing melanin. In animal studies, the inhibition of Tyrosinase by Nonapeptide-1 may help reduce hyperpigmentation in the skin and lighten the dark spots following the effects of sun radiation (UV Rays) and certain diseases. All of these procedures are designed to reduce the growth of undesirable pigmentation, allowing for more control over brown patches and skin. Scientific research suggests that Nonapeptide-1 may function to reduce pigmentation, or melanin synthesis, by inhibiting the actions of the melanocyte-stimulating hormone—MSH.[4] Nonapeptide-1 appears to be a biomimetic peptide antagonist of the a-MSH. Biomimetic peptides are more or less identical to skin peptides and act on the physiological mechanisms of the skin with eminent precision. Nonapeptide-1 appears to function to contend against the natural ligand (a-MSH) on its specific receptor, MC1-R, inhibiting about 33% of melanin synthesis induced by the receptor. Therefore, it may function to prevent further activation of Tyrosinase, in turn blocking melanin synthesis. MSH increases in pregnancy due to certain medical conditions (Addison’s disease, diabetes) and over-exposure to the sun (UV Rays). Melanocyte-Stimulating Hormone (MSH) is a by-product of the Adrenocorticotropic hormone. The synthetic equivalents of the Melanocyte-Stimulating Hormone, Melanotan II, imitate the actions of the original molecule, which may result in the darkening of the skin. The activities of MSH are not visible in everyone due to individual differences, for example redheads do not respond to the activity of MSH due to changes in their MSH receptors. This leads to a poor response to MSH in the blood.

Nonapeptide-1 and Skin Lightening
Nonapeptide-1 has been researched for its potential to be used as an additive in whitening or spot corrective products. It appears to close receptor entry, weaken melanocyte activities, decrease the production of melanin, and function to stabilize and brighten skin color. Fungi research on Nonapeptide-1 posits that at a concentration of about 200 ug/mL, it may inhibit the synthesis of melanin II. Fungi are used in this context because they exhibit almost the same reaction to Nonapeptide-1 as humans and also because the resources needed in this experiment are less than that required for humans. Research in animal models reported that after 28 days of Nonapeptide-1 administration, a rapid reduction in pigmentation was noticed and recorded.[4] The scientists also “suggest that peptide-mediated inhibition of melanogenesis is due to reduction in tyrosinase activity.” Nonapeptide-1 may inhibit tyrosinase activities by 25-35 percent in animal models and decrease the melanin content of melanocytes by 27-43 percent at a micromolar concentration of 100.

Nonapeptide-1 Additional Research
Studies suggest that Nonapeptide may have minimal effects in the following areas, though further research to validate these claims is required:
● Anti-cancer
● Allergies and Immunotoxicity
● Reingredientive and Developmental Toxicity

Nonapeptide-1, also known as Melanostatine-5, has been researched for its possible skin-whitening and spot-correction properties, and appears to work effectively to diminish hyperpigmentation. It is well-known for its potential to decrease melanin formation by inhibiting Tyrosinase activity. While Nonapeptide-1 may hold multiple benefits to the skin, it has been reported in experimental studies to exhibit side effects, potentially temporarily blocking chemicals that initiate muscle contraction. Nonapeptide-1 is a research chemical limited to scientific and educational purposes, not for human use or consumption.


  1. Boo YC. Up- or Downregulation of Melanin Synthesis Using Amino Acids, Peptides, and Their Analogs. Biomedicines. 2020 Sep 1;8(9):322. doi: 10.3390/biomedicines8090322. PMID: 32882959; PMCID: PMC7555855.
  2. Ishihara Y, Oka M, Tsunakawa M, Tomita K, Hatori M, Yamamoto H, Kamei H, Miyaki T, Konishi M, Oki T. Melanostatin, a new melanin synthesis inhibitor. Production, isolation, chemical properties, structure and biological activity. J Antibiot (Tokyo). 1991 Jan;44(1):25-32. doi: 10.7164/antibiotics.44.25. PMID: 1672125.
  3. Puciłowski O, Płaźnik A, Kostowski W. Melanostatyna (MIF-1): działania ośrodkowe i próby kliniczne [Melanostatin (MIF-1): central action and clinical use]. Pol Tyg Lek. 1983 Jun 13;38(24):739-41. Polish. PMID: 6139794.
  4. Abu Ubeid A, Zhao L, Wang Y, Hantash BM. Short-sequence oligopeptides with inhibitory activity against mushroom and human tyrosinase. J Invest Dermatol. 2009 Sep;129(9):2242-9. doi: 10.1038/jid.2009.124. Epub 2009 May 14. PMID: 19440221.
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