Nonapeptide-1 (Topical) (200mg)


Melanostatine, Oxytocin Intermediate-nine peptide, Melanostatine-5

Discount per Quantity

5 - 95%$208.05
10 +10%$197.10
SKU: Nonapeptide-1-Topical-200mg Category:


What Is Nonapeptide-1 (Topical)?

Nonapeptide-1, also termed Melanostatine-5, is a peptide earlier developed based on its antimicrobial activities. Research on animal models shows that Nonapeptide-1 can inhibit the synthesis of Melanin, bringing it to light for treating certain skin conditions. The research in animal models posits that Nonapeptide-1 may reduce the synthesis of melanin and help decrease the pigmentation of the skin to a considerable scale.
Nonapeptide-1 consists of the amino acids arginine-methionine-lysine-phenylalanine-proline-tryptophan-valine.
The human skin contains a variety of cells. Each cell has a different function. One of these cell types is melanocytes. Melanocytes produce a chemical called melanin. The difference in the levels of melanin imparts color to our skin. Melanin protects the skin against sun damage.


Sequence: Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val

Molecular Formula: C61H87N15O9S

Molecular Weight: 1206.52g/mol

PubChem: CID 10418849

Synonyms: Melanostatine, Oxytocin Intermediate-nine peptide, Melanostatine-5

Reconstitution: Required

Nonapeptide-1 Research

Nonapeptide-1 was first discovered in yeast Streptomyces clavifer, where it was an antimicrobial agent. Recent research proves that Nonapeptide may also be a potent inhibitor of the formation of melanin in the laboratory study of melanoma and yeast.
Nonapeptide-1 is of research interest based on its ability to decrease hyperpigmentation by bringing to a halt the activities of Tyrosinase in Melanin-producing cells. The regulation of melanin production is a vital process in the approach of several skin conditions such as photodamage of the skin (Melasma).
Scientific research posits that Nonapeptide-1 may function in the Central Nervous System as a Dopaminergic and an Opioid receptor—to modify pain signaling and behavior. Studies on mouse models back the hypothesis that Nonapeptide-1 may play a role in the Central Nervous system—its activities may change behavior patterns and pain.

The Functions of Nonapeptide-1
In the cosmetical sector, the term Nonapeptide is a radiance promoter and whitening agent. In the medical field, Nonapeptide is a potent inhibitor of melanin synthesis—which functions to inhibit the activities of Tyrosinase, preventing melanocytes from producing melanin.
In animal studies, the inhibition of Tyrosinase by Nonapeptide-1 may help reduce hyperpigmentation in the skin and lighten the dark spots following the effects of sun radiation (UV Rays) and certain diseases.
All of these procedures are designed to reduce the growth of undesirable pigmentation, allowing for more control over brown patches and skin.
Some scientific research suggests that Nonapeptide-1 may function to reduce pigmentation—melanin synthesis, by inhibiting the actions of the melanocyte-stimulating hormone—MSH.
Nonapeptide-1 is a biomimetic peptide antagonist of the a-MSH. Biomimetic peptides are more or less identical to skin peptides and act on the physiological mechanisms of the skin with eminent precision. Nonapeptide-1 functions to contend against the natural ligand (a-MSH) on its specific receptor—MC1-R, inhibiting about 33% of melanin synthesis induced by the receptor. Therefore, preventing further activation of Tyrosinase in turn blocking melanin synthesis.
MSH increases in pregnancy due to certain medical conditions (Addison’s disease, Diabetes) and over-exposure to the sun (UV Rays). Melanocyte stimulating hormone is a by-product of the Adrenocorticotropic hormone. The synthetic equivalents of the melanocyte-stimulating hormone—Melanotan II, imitate the actions of the original molecule, which can result in the darkening of the skin.
The activities of MSH are not visible in everyone due to individual differences—redheads do not respond to the activity of MSH due to changes in their MSH receptors. This leads to a poor response to MSH in the blood.

The Role of Nonapeptide-1 in Skin Lightening
Here Nonapeptide-1 can be used as an additive in whitening or spot corrective products. It closes receptor entry, weakens melanocyte activities, decreases the production of melanin, and functions to stabilize and brighten skin color.
Fungi research on Nonapeptide posits that at a concentration of about 200 ug/mL, it can inhibit the synthesis of melanin II. Fungi are used in this context because they exhibit almost the same reaction to Nonapeptide-1 as humans and also because the resources needed in this experiment are less than that required for humans.
Research in animal models shows that after 28 days of Nonapeptide-1 administration, a rapid reduction in pigmentation was noticed and recorded. Nonapeptide-1 may inhibit tyrosinase activities by 25-35 percent in animal models and decrease the melanin content of melanocytes by 27-43 percent at a micromolar concentration of 100.

Other Effects of Nonapeptide-1
Studies show that Nonapeptide may have minimal effects in the following areas:
● Cancer
● Allergies and Immunotoxicity
● Reingredientive and Developmental Toxicity


Nonapeptide-1, also known as Melanostatine-5, is a skin-whitening and spot-correction agent that works to diminish hyperpigmentation. It is well-known for its ability to decrease melanin formation by inhibiting Tyrosinase activity.
While Nonapeptide-1 has lots of benefits to the skin, it can have side effects—It may temporarily block chemicals that initiate muscle contraction.
Nonapeptide-1 is a research chemical limited to scientific and educational purposes, not for human use or consumption.

All orders ship same day if placed by 2pm PST. Peptides synthesized and lyophilized in the USA.
This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law. Only qualified and licensed professionals should handle these products. Any information found on Biotech Peptides is strictly for educational purposes only. Refer to our terms and conditions for more details.

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